Abstract:
PURPOSE:To evaluate the 12-month U.S. phase II clinical trial results of the Crystalens AT-45 (eyeonics, Inc.) intraocular lens (IOL) used to provide uncorrected distance, intermediate, and near visual acuities in patients having cataract extraction and to compare in a substudy the contrast sensitivity and near visual acuity in patients with the Crystalens AT-45 IOL and those receiving a standard IOL. SETTING:Fourteen clinical sites throughout the U.S. for efficacy and 3 non-U.S. sites for safety and efficacy. METHODS:Patients 50 years or older had small-incision cataract extraction with implantation of the Crystalens AT-45 IOL. Unilateral implantation was followed by fellow-eye implantation. Postoperatively, uncorrected distance, near, and intermediate visual acuities were determined. Near and intermediate visual acuities were tested through a distance correction to eliminate potential pseudoaccommodative effects of residual myopia and corneal cylinder. A substudy tested contrast sensitivity under mesopic conditions with and without glare, as well as visual acuity in a subset of Crystalens AT-45 patients and a control group receiving a standard IOL. RESULTS:A total of 263 patients participated in the U.S. clinical trial and had 1 year of follow-up. Near visual acuities through the distance correction of 20/40 (J3) or better, monocularly and bilaterally, respectively, were seen in 90.1% and 100%; intermediate near visual acuities were seen in 99.6% and 100%. More than half the bilaterally implanted Crystalens AT-45 patients achieved uncorrected near acuity of 20/25 (J1) or better through the distance correction, and 84% achieved 20/32 (J2) or better. In the substudy, monocular near vision through the distance correction of 20/25 (J1) or better was seen in 50.4% with the Crystalens AT-45 IOL and in 4.7% with the standard IOLs. Mesopic contrast sensitivity results with and without glare for the Crystalens AT-45 were similar to those with standard monofocal IOLs. Nearly all patients (74 patients; 97.3%) who bilaterally were within 0.50 diopter of plano postoperatively achieved 20/32 (J2) or better uncorrected near, intermediate, and distance visual acuities. CONCLUSIONS:The Crystalens AT-45 accommodating IOL provided good uncorrected near, intermediate, and distance vision in pseudophakic patients. Contrast sensitivity with the Crystalens AT-45 was not diminished relative to standard monofocal IOLs, and near and intermediate visual performance was significantly better than with standard IOLs.
journal_name
J Cataract Refract Surgjournal_title
Journal of cataract and refractive surgeryauthors
Cumming JS,Colvard DM,Dell SJ,Doane J,Fine IH,Hoffman RS,Packer M,Slade SGdoi
10.1016/j.jcrs.2006.02.007subject
Has Abstractpub_date
2006-05-01 00:00:00pages
812-25issue
5eissn
0886-3350issn
1873-4502pii
S0886-3350(06)00153-2journal_volume
32pub_type
杂志文章,多中心研究abstract::We describe a technique for stromal expansion of thin and ultrathin corneas in keratoconus patients that uses refractive stromal lenticules of patients having small-incision lenticule extraction for myopic correction. The stromal lenticule is placed and spread over the host cornea following epithelial debridement so t...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2015.04.007
更新日期:2015-05-01 00:00:00
abstract::The anterior chamber depth was measured in 15 eyes with sulcus placed (Group 1) and 12 eyes with bag placed (Group 2) IOGEL PC-12 lenses, and in 11 eyes with bag placed IOGEL 1103 lenses (Group 3). The mean anterior chamber depth was 3.29 mm in Group 1, 4.17 mm in Group 2, and 4.16 mm in Group 3. The difference betwee...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(13)81017-6
更新日期:1990-11-01 00:00:00
abstract:PURPOSE:To compare measured and calculated postoperative anterior chamber depths (ACDs). SETTING:Department of Ophthalmology and Institute of Medical Physics, University of Vienna, Vienna, Austria, and Department of Ophthalmology, University of Mainz, Mainz, Germany. METHODS:The postoperative ACD was measured in 189 ...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(03)00414-0
更新日期:2003-11-01 00:00:00
abstract:PURPOSE:To evaluate 1-year outcomes of corneal collagen crosslinking (CXL) for treatment of keratoconus and corneal ectasia. SETTING:Cornea and refractive surgery subspecialty practice. DESIGN:Prospective randomized controlled clinical trial. METHODS:Collagen crosslinking was performed in eyes with keratoconus or ec...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jcrs.2010.07.030
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:To determine the reproducibility of morphoscopic contrast sensitivity test values in healthy subjects using the Visual Capacity Analyzer (VCA) (L2 Informatique). SETTING:Institute of Vision Research, Department of Ophthalmology, Yong-Dong Severance Hospital, Yonsei University, Seoul, South Korea. METHODS:Five...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(03)00044-0
更新日期:2003-09-01 00:00:00
abstract:PURPOSE:To determine whether vault measurements after placement of a hole implantable collamer lens (hole ICL) (KS-AquaPORT) can be predicted by angle-to-angle (ATA) and white-to-white (WTW) measurements obtained with anterior segment optical coherence tomography (AS-OCT). SETTING:Sanno Hospital, Tokyo, Japan. DESIGN...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2019.02.020
更新日期:2019-08-01 00:00:00
abstract:PURPOSE:To estimate the ability of the Ocular Response Analyzer parameters to aid in the diagnosis of keratoconus in pre-laser in situ keratomileusis (LASIK) patients. SETTING:Department of Ophthalmology, Bordeaux 2 University, Bordeaux Cedex, France. DESIGN:Evaluation of diagnostic test. METHODS:This study compared...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2011.06.029
更新日期:2011-12-01 00:00:00
abstract:PURPOSE:To evaluate incidence, features, risk factors, and prognosis of iridocyclitis after angle-supported phakic intraocular lens (IOL) implantation. SETTING:Private practice, Siena, Italy. METHODS:This retrospective analysis comprised 356 consecutive eyes of 212 patients. In myopic eyes, the ZSAL-4 IOL (205 eyes o...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2006.02.030
更新日期:2006-06-01 00:00:00
abstract:PURPOSE:To identify risk factors and describe the effects of antibiotic prophylaxis on the incidence of postoperative endophthalmitis after cataract surgery based on analysis of the findings of the European Society of Cataract & Refractive Surgeons (ESCRS) multicenter study. SETTING:Twenty-four ophthalmology units in ...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.jcrs.2007.02.032
更新日期:2007-06-01 00:00:00
abstract::A candidate for refractive surgery presented with classic (type I) Ehlers-Danlos syndrome (EDS). Clinical examination revealed blue sclera, limbus-to-limbus corneal thinning, myopia, and astigmatism. Orbscan (Bausch & Lomb) pachymetry mapping provided a striking demonstration of the limbus-to-limbus thinning with a ce...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2004.05.002
更新日期:2004-08-01 00:00:00
abstract:PURPOSE:To compare carticaine 4% and lidocaine 2% for peribulbar anesthesia in cataract surgery. SETTING:Ain Shams and Cairo University Hospitals, Cairo, Egypt. METHODS:This prospective double-blind randomized study comprised 200 cataract patients assigned to 1 of 2 groups of 100 each based on type of anesthesia: car...
journal_title:Journal of cataract and refractive surgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0886-3350(01)01140-3
更新日期:2002-03-01 00:00:00
abstract::We compared the effect of biconvex and convex-plano (posterior plano) intraocular lenses on posterior capsule opacification (PCO) following continuous curvilinear capsulorhexis (CCC) in 212 eyes. During the three years following surgery, the cumulative frequency of neodymium:YAG laser posterior capsulotomy, calculated...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(13)80569-x
更新日期:1995-11-01 00:00:00
abstract:UNLABELLED:We describe a technique that uses the vitrector to perform successful lens aspiration and posterior chamber intraocular lens (IOL) implantation in children with spherophakia and anterior lens subluxation. After an anterior chamber maintainer is placed, the ocutome is introduced through a limbal incision to p...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2012.05.001
更新日期:2012-07-01 00:00:00
abstract:PURPOSE:To objectively evaluate the image quality obtained with toric intraocular lenses (IOLs) when misaligned from the intended axis. SETTING:University Eye Clinic and the Department of Industrial and Information Engineering, University of Trieste, Trieste, Italy. DESIGN:Experimental study. METHODS:An experimental...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2017.10.053
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:To evaluate the intraocular pressure (IOP) change and associated factors 6 months after phacoemulsification in eyes with primary angle-closure suspect (PACS) and eyes with primary angle closure (PAC) that had no medical therapy. SETTING:Singapore National Eye Center, Singapore, Singapore. DESIGN:Retrospective...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2017.03.031
更新日期:2017-06-01 00:00:00
abstract:PURPOSE:To evaluate the agreement of ocular measurements obtained with a new optical biometer (AL-Scan) and a previously validated optical biometer (Lenstar). SETTING:Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. DESIGN:Prospective observational cross-sectional study. METHODS:For a comprehens...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2015.05.042
更新日期:2016-01-01 00:00:00
abstract::Corneal scrapings were collected from a case of keratitis and microbiological investigations done. Coagulase-negative Staphylococcus (Staphylococcus epidermidis) was identified on culture, and antibiotic susceptibility tests were performed. Treatment was started with topical cefazolin sulfate 5% and gatifloxacin 0.3%;...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2007.04.015
更新日期:2007-08-01 00:00:00
abstract::We used ultrasound to measure axial length in 66 eyes before and three months after extracapsular cataract extraction with implantation of a posterior chamber lens. An ultrasound velocity of 2,718 m/s for poly(methyl methacrylate) was assumed. The intraindividually measured difference (postoperative--preoperative axia...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(89)80035-5
更新日期:1989-11-01 00:00:00
abstract:PURPOSE:To assess the visual results after bilateral implantation of the bifocal Acri.LISA 366D intraocular lens (IOL) (Acri.Tec AG). SETTING:Fernández-Vega Ophthalmological Institute, Oviedo, Spain. METHODS:Eighty-one patients had bilateral implantation of the distance-dominant bifocal Acri.LISA 366D IOL in a prospe...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2007.06.067
更新日期:2007-11-01 00:00:00
abstract:PURPOSE:To compare the postoperative outcomes between femtosecond laser-assisted cataract surgery (FLACS) and conventional phacoemulsification in eyes with shallow anterior chamber depth (ACD). SETTING:Eye Clinic, NEUROFARBA Department, University of Florence, Italy. DESIGN:Prospective case series. METHODS:Forty eye...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1097/j.jcrs.0000000000000341
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:To assess the ability of corneal power measurements by a rotating Scheimpflug camera to measure the refractive change induced by myopic excimer laser surgery. SETTING:G.B. Bietti Foundation-IRCCS, Rome, Italy. DESIGN:Evaluation of diagnostic test. METHODS:The following corneal power measurements by the Penta...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2012.12.031
更新日期:2013-04-01 00:00:00
abstract:PURPOSE:To evaluate the visual, refractive, contrast sensitivity, and aberrometric outcomes as well as the patient quality of life and photic phenomena disturbances after cataract surgery with implantation of a new trifocal toric intraocular lens (IOL). SETTINGS:Premium Clinic, Regional Hospital in Havlickuv Brod, Cze...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2015.07.033
更新日期:2015-12-01 00:00:00
abstract:PURPOSE:To evaluate forward light scattering and straylight in single-piece hydrophobic acrylic intraocular lenses (IOLs) (Acrysof) removed from cadaver eyes and design- and power-matched controls, as well as the effect of subsurface nanoglistenings on other optical quality and performance indicators. SETTING:John A. ...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2015.07.043
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:To evaluate long-term intraocular pressure (IOP) control after extracapsular cataract extraction (ECCE) with posterior chamber intraocular lens (IOL) implantation in patients with primary angle-closure glaucoma. SETTING:Ophthalmology Department, Groote Schuur Hospital, Cape Town, South Africa. METHODS:This re...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(97)80255-6
更新日期:1997-07-01 00:00:00
abstract:PURPOSE:To evaluate and compare the tear-film dynamics in normal eyes and in eyes with mild dry-eye symptoms using a new noninvasive optical method based on a double-pass instrument. SETTING:Hospital Universitario Virgen de la Arrixaca, Murcia, Spain. DESIGN:Evaluation of diagnostic test or technology. METHODS:Dynam...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2011.03.036
更新日期:2011-08-01 00:00:00
abstract:PURPOSE:To study the effect of glistenings on the optical quality of a hydrophobic acrylic intraocular lens (IOL). SETTING:David J. Apple Laboratory, Heidelberg, Germany. DESIGN:An in vitro laboratory study. METHODS:An accelerated aging protocol was used to induce glistenings (microvacuoles) in 38 hydrophobic acryli...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2019.01.025
更新日期:2019-07-01 00:00:00
abstract:PURPOSE:To evaluate the formation of glistenings in foldable intraocular lenses (IOLs) of various materials after cataract surgery. SETTING:University Eye Clinic of Trieste, Trieste, Italy. METHODS:In this prospective study, 273 patients were randomized to have implantation of 1 of 7 types of foldable IOLs in the cap...
journal_title:Journal of cataract and refractive surgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0886-3350(02)01353-6
更新日期:2002-07-01 00:00:00
abstract:PURPOSE:To compare corneal endothelial damage after cataract surgery in eyes with low endothelial cell density (ECD) and eyes with normal ECD. SETTING:Hayashi Eye Hospital, Fukuoka, Japan. DESIGN:Case-control study. METHODS:Cataract surgery was performed in eyes with a low ECD (500 to 1000 cells/mm(2)) (low-density ...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2011.02.025
更新日期:2011-08-01 00:00:00
abstract::A 59-year-old patient who had photorefractive keratectomy (PRK) to correct high unilateral myopia developed a progressive nuclear cataract. Phacoemulsification and intraocular lens (IOL) implantation were performed. However, determination of IOL power using automated keratometry and computerized videokeratography was ...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(99)80024-8
更新日期:1999-01-01 00:00:00
abstract:PURPOSE:To compare 2 ultrasound (US) frequencies for phacoemulsification for moderate to hard cataract to determine a frequency that makes phacoemulsification safer and more efficacious. SETTING:Post Graduate Institute of Medical Education and Research, New Delhi, India. DESIGN:Randomized controlled trial. METHODS:P...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jcrs.2019.04.015
更新日期:2019-09-01 00:00:00