A very efficient bioconversion of soybean phytosterols mixtures to androstanes by mycobacteria.

Abstract:

:The production of several high value steroid drugs, used as progestational, adrenocortical, estrogenic and contraceptive agents, is mostly derived from 4-androstene-dione (AD) and 1,4 androsta-diene-3,17-dione (ADD). Three Vietnamese phytosterols mixtures named VN-1, VN-2 and VN-3, isolated from soybean oil may be efficiently converted into these key compounds by mycobacterial cells. Their general phytosterol composition was 55.39, 70.55, 70.19% for VN-1, VN-2 and VN-3, respectively. Moreover, values of campesterol, beta-sitosterol and stigmasterol were determined. After 120 h of shaking in suitable culture media and temperature, maximal yield conversion to ADD was higher than 70% and up to 64% to AD, for the various phytosterols mixtures assays. These results may be better when scaling-up such a procedure of phytosterols conversion.

authors

Pérez C,Falero A,Duc HL,Balcinde Y,Hung BR

doi

10.1007/s10295-006-0148-6

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

719-23

issue

8

eissn

1367-5435

issn

1476-5535

journal_volume

33

pub_type

杂志文章
  • Antimicrobial compounds produced by Lactobacillus sakei subsp. sakei 2a, a bacteriocinogenic strain isolated from a Brazilian meat product.

    abstract::Bacteriocins produced by lactic acid bacteria are gaining increased importance due to their activity against undesirable microorganisms in foods. In this study, a concentrated acid extract of a culture of Lactobacillus sakei subsp. sakei 2a, a bacteriocinogenic strain isolated from a Brazilian pork product, was purifi...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-009-0684-y

    authors: de Carvalho KG,Bambirra FH,Kruger MF,Barbosa MS,Oliveira JS,Santos AM,Nicoli JR,Bemquerer MP,de Miranda A,Salvucci EJ,Sesma FJ,Franco BD

    更新日期:2010-04-01 00:00:00

  • Improved cell growth and biosynthesis of glycolic acid by overexpression of membrane-bound pyridine nucleotide transhydrogenase.

    abstract::The non-conventional D-xylose metabolism called the Dahms pathway which only requires the expression of at least three enzymes to produce pyruvate and glycolaldehyde has been previously engineered in Escherichia coli. Strains that rely on this pathway exhibit lower growth rates which were initially attributed to the p...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-018-2117-2

    authors: Cabulong RB,Valdehuesa KNG,Bañares AB,Ramos KRM,Nisola GM,Lee WK,Chung WJ

    更新日期:2019-02-01 00:00:00

  • Effects of acetoacetyl-CoA synthase expression on production of farnesene in Saccharomyces cerevisiae.

    abstract::Efficient production of sesquiterpenes in Saccharomyces cerevisiae requires a high flux through the mevalonate pathway. To achieve this, the supply of acetyl-CoA plays a crucial role, partially because nine moles of acetyl-CoA are necessary to produce one mole of farnesyl diphosphate, but also to overcome the thermody...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-017-1911-6

    authors: Tippmann S,Ferreira R,Siewers V,Nielsen J,Chen Y

    更新日期:2017-06-01 00:00:00

  • Spatial expression of a mercury-inducible green fluorescent protein within a nanoporous latex-based biosensor coating.

    abstract::Optimizing the reactivity of cell coatings developed as biosensors or biocatalysts requires measurements of gene expression in the immobilized cells. To quantify and localize gene expression within a latex-based mercury biosensor, a plasmid, pmerGFP, was constructed, which contains the green fluorescent protein (GFP) ...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-007-0288-3

    authors: Schottel JL,Orwin PM,Anderson CR,Flickinger MC

    更新日期:2008-04-01 00:00:00

  • Molecular and phenotypic comparison of phaeochromycin-producing strains of Streptomyces phaeochromogenes and Streptomyces ederensis.

    abstract::Streptomyces strain LL-P018 produces the phaeochromycins, novel anti-inflammatory polyketides. This organism was identified as a strain of Streptomyces phaeochromogenes by physiological and genetic taxonomic analysis. In order to gain greater taxonomic perspective, LL-P018 was compared to related strains from major cu...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-008-0367-0

    authors: Ritacco FV,Eveleigh DE

    更新日期:2008-09-01 00:00:00

  • Model-based biotechnological potential analysis of Kluyveromyces marxianus central metabolism.

    abstract::The non-conventional yeast Kluyveromyces marxianus is an emerging industrial producer for many biotechnological processes. Here, we show the application of a biomass-linked stoichiometric model of central metabolism that is experimentally validated, and mass and charge balanced for assessing the carbon conversion effi...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-017-1946-8

    authors: Pentjuss A,Stalidzans E,Liepins J,Kokina A,Martynova J,Zikmanis P,Mozga I,Scherbaka R,Hartman H,Poolman MG,Fell DA,Vigants A

    更新日期:2017-08-01 00:00:00

  • An overview of rapamycin: from discovery to future perspectives.

    abstract::Rapamycin is an immunosuppressive metabolite produced from several actinomycete species. Besides its immunosuppressive activity, rapamycin and its analogs have additional therapeutic potentials, including antifungal, antitumor, neuroprotective/neuroregenerative, and lifespan extension activities. The core structure of...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章,评审

    doi:10.1007/s10295-016-1834-7

    authors: Yoo YJ,Kim H,Park SR,Yoon YJ

    更新日期:2017-05-01 00:00:00

  • Strain-specific proteogenomics accelerates the discovery of natural products via their biosynthetic pathways.

    abstract::The use of proteomics for direct detection of expressed pathways producing natural products has yielded many new compounds, even when used in a screening mode without a bacterial genome sequence available. Here we quantify the advantages of having draft DNA-sequence available for strain-specific proteomics using the l...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-013-1373-4

    authors: Albright JC,Goering AW,Doroghazi JR,Metcalf WW,Kelleher NL

    更新日期:2014-02-01 00:00:00

  • A recombinant vaccine against hydatidosis: production of the antigen in Escherichia coli.

    abstract::A commercial process was developed for producing a recombinant vaccine against hydatidosis in farm animals. The vaccine antigen consisting of a surface protein of the oncospheres of the hydatid worm (Echinococcus granulosus), was produced as inclusion bodies in Escherichia coli. Fed-batch cultures of E. coli using Ter...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-005-0046-3

    authors: Manderson D,Dempster R,Chisti Y

    更新日期:2006-03-01 00:00:00

  • Genetic switches and related tools for controlling gene expression and electrical outputs of Geobacter sulfurreducens.

    abstract::Physiological studies and biotechnology applications of Geobacter species have been limited by a lack of genetic tools. Therefore, potential additional molecular strategies for controlling metabolism were explored. When the gene for citrate synthase, or acetyl-CoA transferase, was placed under the control of a LacI/IP...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-016-1836-5

    authors: Ueki T,Nevin KP,Woodard TL,Lovley DR

    更新日期:2016-11-01 00:00:00

  • A simulation study comparing the impact of experimental error on the performance of experimental designs and artificial neural networks used for process screening.

    abstract::Many variables and their interactions can affect a biotechnological process. Testing a large number of variables and all their possible interactions is a cumbersome task and its cost can be prohibitive. Several screening strategies, with a relatively low number of experiments, can be used to find which variables have ...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-004-0171-4

    authors: Soria MA,Gonzalez Funes JL,Garcia AF

    更新日期:2004-11-01 00:00:00

  • An economically and environmentally acceptable synthesis of chiral drug intermediate L-pipecolic acid from biomass-derived lysine via artificially engineered microbes.

    abstract::Deficiency in petroleum resources and increasing environmental concerns have pushed a bio-based economy to be built, employing a highly reproducible, metal contaminant free, sustainable and green biomanufacturing method. Here, a chiral drug intermediate L-pipecolic acid has been synthesized from biomass-derived lysine...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-018-2044-2

    authors: Cheng J,Huang Y,Mi L,Chen W,Wang D,Wang Q

    更新日期:2018-06-01 00:00:00

  • A strategy to prevent the occurrence of Lactobacillus strains using lactate-tolerant yeast Candida glabrata in bioethanol production.

    abstract::Contamination of Lactobacillus sp. in the fermentation broth of bioethanol production decreases ethanol production efficiency. Although the addition of lactate to the broth can effectively inhibit the growth of Lactobacillus sp., it also greatly reduces the fermentation ability of Saccharomyces cerevisiae. To overcome...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-008-0390-1

    authors: Watanabe I,Nakamura T,Shima J

    更新日期:2008-10-01 00:00:00

  • Harmful algal blooms: causes, impacts and detection.

    abstract::Blooms of autotrophic algae and some heterotrophic protists are increasingly frequent in coastal waters around the world and are collectively grouped as harmful algal blooms (HABs). Blooms of these organisms are attributed to two primary factors: natural processes such as circulation, upwelling relaxation, and river f...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章,评审

    doi:10.1007/s10295-003-0074-9

    authors: Sellner KG,Doucette GJ,Kirkpatrick GJ

    更新日期:2003-07-01 00:00:00

  • A comparison of stress tolerance in YPD and industrial lignocellulose-based medium among industrial and laboratory yeast strains.

    abstract::In general, it is believed that fermentation by yeast under harsh industrial conditions, especially if substrates such as wood hydrolysate or lignocellulosic substrates are used, requires the use of so-called industrial strains. In order to check whether this is always true, a comparison of performance was made using ...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-009-0592-1

    authors: Albers E,Larsson C

    更新日期:2009-08-01 00:00:00

  • Whole cell microbial transformation in cloud point system.

    abstract::Cloud point system, consisting of nonionic surfactant in an aqueous solution, has been developed as a novel medium for whole cell microbial transformation. The basic properties of cloud point system including phase separation and solubilization are introduced. The application of cloud point system for extractive micro...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章,评审

    doi:10.1007/s10295-008-0345-6

    authors: Wang Z,Xu JH,Chen D

    更新日期:2008-07-01 00:00:00

  • Expression, characterization, and improvement of a newly cloned halohydrin dehalogenase from Agrobacterium tumefaciens and its application in production of epichlorohydrin.

    abstract::A gene encoding halohydrin dehalogenase (HHDH) from Agrobacterium tumefaciens CCTCC M 87071 was cloned and expressed in Escherichia coli. To increase activity and stability of HHDH, 14 amino acid residues around the active site and substrate-binding pocket based on the structural analysis and molecular docking were se...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-014-1443-2

    authors: Liu ZQ,Gao AC,Wang YJ,Zheng YG,Shen YC

    更新日期:2014-07-01 00:00:00

  • Linking species concepts to natural product discovery in the post-genomic era.

    abstract::A widely accepted species concept for bacteria has yet to be established. As a result, species designations are inconsistently applied and tied to what can be considered arbitrary metrics. Increasing access to DNA sequence data and clear evidence that bacterial genomes are dynamic entities that include large numbers o...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章,评审

    doi:10.1007/s10295-009-0683-z

    authors: Jensen PR

    更新日期:2010-03-01 00:00:00

  • Evaluation of the catalytic specificity, biochemical properties, and milk clotting abilities of an aspartic peptidase from Rhizomucor miehei.

    abstract::In this study, we detail the specificity of an aspartic peptidase from Rhizomucor miehei and evaluate the effects of this peptidase on clotting milk using the peptide sequence of k-casein (Abz-LSFMAIQ-EDDnp) and milk powder. Molecular mass of the peptidase was estimated at 37 kDa, and optimum activity was achieved at ...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-016-1780-4

    authors: da Silva RR,Souto TB,de Oliveira TB,de Oliveira LC,Karcher D,Juliano MA,Juliano L,de Oliveira AH,Rodrigues A,Rosa JC,Cabral H

    更新日期:2016-08-01 00:00:00

  • Application of acetate buffer in pH adjustment of sorghum mash and its influence on fuel ethanol fermentation.

    abstract::A 2 M sodium acetate buffer at pH 4.2 was tried to simplify the step of pH adjustment in a laboratory dry-grind procedure. Ethanol yields or conversion efficiencies of 18 sorghum hybrids improved significantly with 2.0-5.9% (3.9% on average) of relative increases when the method of pH adjustment changed from tradition...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-008-0474-y

    authors: Zhao R,Bean SR,Crozier-Dodson BA,Fung DY,Wang D

    更新日期:2009-01-01 00:00:00

  • Reduction of L-phenylalanine in protein hydrolysates using L-phenylalanine ammonia-lyase from Rhodosporidium toruloides.

    abstract::L-Phenylalanine ammonia-lyase (PAL, EC 4.3.1.25) from Rhodosporidium toruloides was utilized to remove L-phenylalanine (L-Phe) from different commercial protein hydrolysates. A casein acid hydrolysate (CAH, L-Phe ~2.28 %) was employed as a model substrate. t-Cinnamic acid resulting from deamination of L-Phe was extrac...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-015-1664-z

    authors: Castañeda MT,Adachi O,Hours RA

    更新日期:2015-10-01 00:00:00

  • A study on the pretreatment of a sugarcane bagasse sample with dilute sulfuric acid.

    abstract::Experiments based on a 2(3) central composite full factorial design were carried out in 200-ml stainless-steel containers to study the pretreatment, with dilute sulfuric acid, of a sugarcane bagasse sample obtained from a local sugar-alcohol mill. The independent variables selected for study were temperature, varied f...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-010-0931-2

    authors: Canilha L,Santos VT,Rocha GJ,Almeida e Silva JB,Giulietti M,Silva SS,Felipe MG,Ferraz A,Milagres AM,Carvalho W

    更新日期:2011-09-01 00:00:00

  • Selection of an autochthonous Saccharomyces strain starter for alcoholic fermentation of Sherry base wines.

    abstract::Several indigenous Saccharomyces strains from musts were isolated in the Jerez de la Frontera region, at the end of spontaneous fermentation, in order to select the most suitable autochthonous yeast starter, during the 2007 vintage. Five strains were chosen for their oenological abilities and fermentative kinetics to ...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-013-1251-0

    authors: Rodríguez-Palero MJ,Fierro-Risco J,Codón AC,Benítez T,Valcárcel MJ

    更新日期:2013-06-01 00:00:00

  • Nitrogen deprivation of microalgae: effect on cell size, cell wall thickness, cell strength, and resistance to mechanical disruption.

    abstract::Nitrogen deprivation (N-deprivation) is a proven strategy for inducing triacylglyceride accumulation in microalgae. However, its effect on the physical properties of cells and subsequently on product recovery processes is relatively unknown. In this study, the effect of N-deprivation on the cell size, cell wall thickn...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-016-1848-1

    authors: Yap BH,Crawford SA,Dagastine RR,Scales PJ,Martin GJ

    更新日期:2016-12-01 00:00:00

  • Engineering Yarrowia lipolytica for the production of cyclopropanated fatty acids.

    abstract::Traditional synthesis of biodiesel competes with food sources and has limitations with storage, particularly due to limited oxidative stability. Microbial synthesis of lipids provides a platform to produce renewable fuel with improved properties from various renewable carbon sources. Specifically, biodiesel properties...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-018-2067-8

    authors: Markham KA,Alper HS

    更新日期:2018-10-01 00:00:00

  • Production and characterisation of a biosurfactant isolated from Pseudomonas aeruginosa UW-1.

    abstract::Pseudomonas aeruginosa UW-1 produced 17-24 g L-1 rhamnolipid in vegetable oil-containing media in shake flask cultures in 13 days. In time course studies of growth and rhamnolipid production in a salts medium containing 6% canola oil, total bacterial count reached 2.6 x 10(10) CFU ml-1 after 48 h and a maximum rhamnol...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1038/sj.jim.2900450

    authors: Sim L,Ward OP,Li ZY

    更新日期:1997-10-01 00:00:00

  • Insights into the fluoride-resistant regulation mechanism of Acidithiobacillus ferrooxidans ATCC 23270 based on whole genome microarrays.

    abstract::Acidophilic microorganisms involved in uranium bioleaching are usually suppressed by dissolved fluoride ions, eventually leading to reduced leaching efficiency. However, little is known about the regulation mechanisms of microbial resistance to fluoride. In this study, the resistance of Acidithiobacillus ferrooxidans ...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-016-1827-6

    authors: Ma L,Li Q,Shen L,Feng X,Xiao Y,Tao J,Liang Y,Yin H,Liu X

    更新日期:2016-10-01 00:00:00

  • Characterization of product capture resin during microbial cultivations.

    abstract::Various bioactive small molecules produced by microbial cultivation are degraded in the culture broth or may repress the formation of additional product. The inclusion of hydrophobic adsorber resin beads to capture these products in situ and remove them from the culture broth can reduce or prevent this degradation and...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-006-0088-1

    authors: Frykman S,Tsuruta H,Galazzo J,Licari P

    更新日期:2006-06-01 00:00:00

  • Enhanced thermostability of keratinase by computational design and empirical mutation.

    abstract::Keratinases are proteolytic enzymes capable of degrading insoluble keratins. The importance of these enzymes is being increasingly recognized in fields as diverse as animal feed production, textile processing, detergent formulation, leather manufacture, and medicine. To enhance the thermostability of Bacillus lichenif...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1007/s10295-013-1268-4

    authors: Liu B,Zhang J,Fang Z,Gu L,Liao X,Du G,Chen J

    更新日期:2013-07-01 00:00:00

  • Kinetic analysis on formation of poly(3-hydroxybutyrate) from acetic acid by Ralstonia eutropha under chemically defined conditions.

    abstract::Batch cultures of Ralstonia eutropha in chemically defined media with acetic acid (HAc) as the sole carbon source were conducted to investigate acetate utilization, formation of poly(3-hydroxybutyrate) (PHB) and growth of active biomass (ABM) under different carbon to nitrogen (C/N) weight ratios. The specific acetate...

    journal_title:Journal of industrial microbiology & biotechnology

    pub_type: 杂志文章

    doi:10.1038/sj.jim.7000097

    authors: Wang J,Yu J

    更新日期:2001-03-01 00:00:00