Methodological approaches to exploring epileptic disorders in the human brain in vitro.


:Brain surgery, and in particular epilepsy surgery, offers the unique opportunity to study viable human central nervous tissue in vitro. This does not only open a window to address the basic mechanisms underlying human disease, such as epilepsy, but it allows to venture into investigating neurophysiological functions per se. In the present paper, we describe the most commonly used methods in the electrophysiological (and, at least to some extent, also histochemical and molecular) analysis of human tissue in vitro. In addition, we consider the pitfalls and limitations of such studies, in particular regarding the issue of tissue sampling procedures and control experiments.


J Neurosci Methods


Köhling R,Avoli M




Has Abstract


2006-07-15 00:00:00














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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Updyke BV

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    abstract:BACKGROUND:Evaluation of motor deficits in rodents is mostly restricted to limb motor tests that are often high stressors for the animals. NEW METHOD:To test rodents for orofacial motor impairments in a stress-free environment, we established the pasta gnawing test by measuring the biting noise of mice that eat a piec...

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    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章


    authors: Sick TJ,Rosenthal M

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    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章


    authors: Lee ST,Park JE,Lee K,Kang L,Chu K,Kim SU,Kim M,Roh JK

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  • An optimized method for enumerating CNS derived memory B cells during viral-induced inflammation.

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    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章


    authors: DiSano KD,Stohlman SA,Bergmann CC

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    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章


    authors: Alam M,Shuaib A

    更新日期:2013-05-30 00:00:00

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    abstract::Thermal laser stimulation of the skin is an efficient exploratory tool to characterize the nociceptive system. In the present study, finite element simulations are done to calculate the intra-cutaneous spatio-temporal temperature profiles following the delivery of such laser stimuli. The proposed computer-aided modeli...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章


    authors: Marchandise E,Mouraux A,Plaghki L,Henrotte F

    更新日期:2014-02-15 00:00:00