Methodological approaches to exploring epileptic disorders in the human brain in vitro.

Abstract:

:Brain surgery, and in particular epilepsy surgery, offers the unique opportunity to study viable human central nervous tissue in vitro. This does not only open a window to address the basic mechanisms underlying human disease, such as epilepsy, but it allows to venture into investigating neurophysiological functions per se. In the present paper, we describe the most commonly used methods in the electrophysiological (and, at least to some extent, also histochemical and molecular) analysis of human tissue in vitro. In addition, we consider the pitfalls and limitations of such studies, in particular regarding the issue of tissue sampling procedures and control experiments.

journal_name

J Neurosci Methods

authors

Köhling R,Avoli M

doi

10.1016/j.jneumeth.2006.04.009

subject

Has Abstract

pub_date

2006-07-15 00:00:00

pages

1-19

issue

1

eissn

0165-0270

issn

1872-678X

pii

S0165-0270(06)00192-0

journal_volume

155

pub_type

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