Effects of exercise training on mortality in patients with coronary heart disease.


:Endothelial dysfunction not only precedes the development of significant coronary artery stenosis, it has also been identified as a general phenomenon predicting future cardiovascular events in patients who are at risk. As regular physical activity as a part of a multifactorial intervention has been shown to affect symptoms beneficially, increase myocardial perfusion and--most importantly--reduce mortality in patients with coronary heart disease or myocardial infarction, this review will elucidate potential mechanisms responsible for the improvement in survival as a result of regular physical activity. The importance of exercise training-mediated regression of coronary stenosis, collateral formation, correction of endothelial dysfunction including the adaptation at the molecular level, as well as vasculogenesis will be discussed as possible underlying key players, and their potential contribution to the training-induced survival benefit in patients with coronary heart disease will be critically evaluated.


Coron Artery Dis


Coronary artery disease


Erbs S,Linke A,Hambrecht R




Has Abstract


2006-05-01 00:00:00














  • Risk stratification for malignant arrhythmic events in patients with an acute myocardial infarction: role of an open infarct-related artery and the signal-averaged ECG.

    abstract:BACKGROUND:There is increasing evidence that an open infarct-related artery results in increased electrical stability of the heart and that this effect is at least in part responsible for the favorable outcome of these patients. In the thrombolytic era the optimal strategy for risk stratification remains controversial....

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Hermosillo AG,Araya V,Casanova JM

    更新日期:1995-12-01 00:00:00

  • Increased left ventricular non-uniformity in hypertensive patients with angina.

    abstract:AIM:To determine how hypertension affects the left ventricular diastolic function of patients with effort angina. METHODS:We performed radionuclide ventriculography in 14 patients with isolated stenosis of the left anterior descending coronary artery and in seven healthy volunteers. RESULTS:Neither global nor regiona...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Nii T,Arakawa K

    更新日期:1994-10-01 00:00:00

  • Clinical outcomes of SeQuent Please paclitaxel-coated balloons for de novo small coronary artery lesion in a Japanese multicenter post-approval registry.

    abstract:OBJECTIVE:Drug-coated balloon (DCB) angioplasty has emerged as an effective management strategy worldwide. In June 2016, DCB became available for the treatment of de novo small coronary lesions in Japan; however, there has been no multicenter analysis in a post-approval real-world clinical setting to date. The aim of t...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Funayama N,Muratsubaki S,Kawahatsu K,Miyata M,Katou Y,Oikawa T

    更新日期:2020-01-01 00:00:00

  • Heart cell implantation after myocardial infarction.

    abstract::In the last 15 years, heart cell implantation to regenerate infarcted myocardium has gone from the bench to clinical trial. Several phase I and II controlled randomized trials showed the feasibility, the side effects and the potential efficacy of cell implantation after myocardial infarction in humans. Preclinical exp...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审


    authors: Sam J,Angoulvant D,Fazel S,Weisel RD,Li RK

    更新日期:2005-03-01 00:00:00

  • Red cell distribution width as a novel prognostic marker in patients undergoing primary angioplasty for acute myocardial infarction.

    abstract:OBJECTIVES:Red cell distribution width (RDW), a measure of red blood cell size heterogeneity, was evaluated in patients undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). BACKGROUND:Higher RDW is associated with mortality in patients with symptomatic car...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Uyarel H,Ergelen M,Cicek G,Kaya MG,Ayhan E,Turkkan C,Yıldırım E,Kırbas V,Onturk ET,Erer HB,Yesilcimen K,Gibson CM

    更新日期:2011-05-01 00:00:00

  • Dimensions and anatomic variations of left main coronary artery in normal population: multidetector computed tomography assessment.

    abstract:OBJECTIVES:The aim of our study was to determine the dimensions, morphology and anatomic variations of the left main coronary artery (LMCA) in normal participants, on multidetector computed tomography. BACKGROUND:Accurate imaging of LMCA dimensions and configuration is crucial to avoid misdiagnosis of LMCA disease. M...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Zeina AR,Rosenschein U,Barmeir E

    更新日期:2007-09-01 00:00:00

  • A brief review of the past and future of platelet P2Y12 antagonist.

    abstract::ADP plays a pivotal role in localized platelet activation and recruitment, and, with that, in the maintenance of thrombus integrity, making it a suitable target for the control of intravascular thrombosis. The limited distribution of one of its receptors, the P2Y12 receptor, primarily to platelets makes it an especial...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审


    authors: Barn K,Steinhubl SR

    更新日期:2012-09-01 00:00:00

  • Improved anemia is associated with favorable long-term clinical outcomes in patients undergoing PCI.

    abstract:BACKGROUND:Anemia is associated with an increased risk of mortality in patients who underwent percutaneous coronary intervention (PCI) in the bare-metal stent era. However, there have been no data concerning the clinical importance of anemia improvement during the follow-up period after discharge from the hospital duri...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Kim TH,Koh YS,Chang K,Seo SM,Kim CJ,Park HJ,Kim PJ,Her SH,Kim DB,Lee JM,Park CS,Kim HY,Yoo KD,Jeon DS,Park JH,Chung WS,Seung KB,CathOlic university of Korea – percutAneous Coronary inTervention registry investigators.

    更新日期:2012-09-01 00:00:00

  • Comparative effectiveness of different contemporary drug-eluting stents in routine clinical practice: a multigroup propensity score analysis using data from the stent-specific, multicenter, prospective registries.

    abstract:OBJECTIVE:Data on the comparative effectiveness of contemporary drug-eluting stents (DES) in the unrestricted, real-world setting are limited. We investigated the long-term effectiveness and safety of contemporary different drug-eluting stents by means of multiple treatment propensity score weighting. PATIENTS AND MET...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,多中心研究


    authors: Kwon O,Kang SH,Lee JB,Ahn JM,Lee CH,Kang DY,Lee PH,Kang SJ,Lee SW,Kim YH,Lee CW,Park SW,Park DW,Park SJ,IRIS-DES Registry Investigators.

    更新日期:2019-06-01 00:00:00

  • Impact of metabolic syndrome on the outcome of patients with stable coronary artery disease: 2-year follow-up of the MASS II study.

    abstract:OBJECTIVE:We characterized the impact of the metabolic syndrome (MetS) and its components on cardiovascular adverse events in patients with symptomatic chronic multivessel coronary artery disease, which have been followed prospectively for 2 years. METHODS:Patients enrolled in the MASS II study were evaluated for each...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Lopes NH,Paulitsch FS,Pereira AC,Góis AF,Gagliardi A,Garzillo CL,Ferreira JF,Stolf NA,Hueb W

    更新日期:2008-09-01 00:00:00

  • Early versus delayed percutaneous coronary intervention in patients with non-ST elevation acute coronary syndromes.

    abstract:BACKGROUND:The optimal timing of angiography and percutaneous coronary intervention (PCI) in patients with non-ST elevation acute coronary syndromes (NSTEACS) remains uncertain. We sought to assess clinical characteristics and outcomes of patients in real-world contemporary practice who have early versus delayed PCI fo...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,多中心研究


    authors: Yudi MB,Ajani AE,Andrianopoulos N,Duffy SJ,Farouque O,Ramchand J,Gurvitch R,Lefkovits J,Freeman M,Brennan A,Clark DJ,Reid C,Eccleston D,Melbourne Interventional Group.

    更新日期:2016-08-01 00:00:00

  • Nitroglycerin-induced changes in myocardial sestamibi uptake to detect tissue viability: radionuclide comparison before and after revascularization.

    abstract:BACKGROUND:Nitroglycerin (NTG) is known to increase the blood supply to the myocardium, and would thus increase the delivery of a perfusional tracer such as sestamibi (MIBI) to the tissue. The latter, in turn, would take up and concentrate the tracer to a greater extent than in basal conditions only if energy-dependent...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Greco C,Tanzilli G,Ciavolella M,Sinatra R,Banci M,Schillaci O,Macrina F,Scopinaro F,Marino B,Campa PP

    更新日期:1996-12-01 00:00:00

  • Metabolic syndrome negatively impacts early patency of saphenous vein grafts.

    abstract:BACKGROUND:Coronary artery bypass grafting has been performed for a long period utilizing saphenous vein grafts, the fate of which might be crucial to prognosis following the operation. Metabolic syndrome, on the other hand, has become an increasingly important part of cardiovascular practice. We examined whether there...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Yilmaz MB,Guray U,Guray Y,Biyikoglu SF,Tandogan I,Sasmaz H,Korkmaz S

    更新日期:2006-02-01 00:00:00

  • Comparison of a low-osmolar contrast medium, iopamidol, and an iso-osmolar contrast medium, iodixanol, in MDCT coronary angiography.

    abstract:OBJECTIVE:To prospectively compare iopamidol 370, which is a low-osmolar contrast medium and iodixanol 320, which is an iso-osmolar contrast medium, in terms of image quality and nonserious adverse effects that have the potential to influence the image quality in a 16-slice multi-detector row computed tomography corona...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,随机对照试验


    authors: Ozbulbul NI,Yurdakul M,Tola M

    更新日期:2010-11-01 00:00:00

  • Drug-eluting balloons in the treatment of de-novo coronary lesions: a meta-analysis of randomized-controlled trials.

    abstract:AIM:The aim of this meta-analysis was to evaluate the efficacy of drug-eluting balloons (DEBs) plus bare-metal stents (BMS) for the treatment of de-novo coronary lesions. METHODS AND RESULTS:Eleven trials involving 1279 patients were included in this study. The main endpoints were as follows: late lumen loss (LLL), bi...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,meta分析


    authors: Li Y,Wang C,Zuo G,Wang K,Cao Z,Du X

    更新日期:2016-09-01 00:00:00

  • Head-to-head comparison between technetium-99m-sestamibi and thallium-201 tomographic imaging for the detection of coronary artery disease using combined dipyridamole-exercise stress.

    abstract:AIM:The purpose of this study was a head-to-head comparison of tomographic imaging (SPECT) with technetium-99m (Tc-99m)-sestamibi and thallium-201 (Tl-201) using dipyridamole-low-level bicycle exercise stress for the assessment of coronary artery disease. METHODS:We studied 38 consecutive patients referred for the eva...

    journal_title:Coronary artery disease

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Cramer MJ,Verzijlbergen JF,Van der Wall EE,Niemeyer MG,Zwinderman AH,Ascoop CA,Pauwels EJ

    更新日期:1994-09-01 00:00:00

  • Patterns of coronary plaque progression: phasic versus gradual. A combined optical coherence tomography and intravascular ultrasound study.

    abstract:OBJECTIVE:Some plaques grow slowly in a linear manner, whereas others undergo a rapid phasic progression. However, the detailed in-vivo relationship between plaque characteristics and plaque progression pattern has not been reported. The current study aimed to investigate the plaque progression patterns with serial int...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Xie Z,Hou J,Yu H,Jia H,Du H,Lee H,Yu B,Tian J,Jang IK

    更新日期:2016-12-01 00:00:00

  • Comparison of peripheral arterial tonometry and flow-mediated vasodilation for assessment of the severity and complexity of coronary artery disease.

    abstract:OBJECTIVE:Noninvasive flow-mediated vasodilation (FMD) is a widely used method to assess endothelial function, but its technical difficulty and problems remain obstacles for use in clinical practice. Reactive hyperemia-peripheral arterial tonometry (RH-PAT) was developed as a simpler and more reproducible method. We co...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Woo JS,Jang WS,Kim HS,Lee JH,Choi EY,Kim JB,Kim WS,Kim KS,Kim W

    更新日期:2014-08-01 00:00:00

  • Comparison of serum levels of inflammatory markers and allelic variant of interleukin-6 in patients with acute coronary syndrome and stable angina pectoris.

    abstract:OBJECTIVES:Although the relationship between atherosclerosis and inflammatory cells has been recognized in recent years, the effect of interleukin-6 (IL-6) genetic variants associated with atherosclerosis is still controversial. Therefore, we investigated the association between IL-6 polymorphism and levels of IL-6 in ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Ozdemir O,Gundogdu F,Karakelleoglu S,Sevimli S,Pirim I,Acikel M,Arslan S,Serdar S

    更新日期:2008-02-01 00:00:00

  • New carotid plaque, but not the progression of intima-media thickness, predicts the progression of high-risk coronary plaque.

    abstract:BACKGROUND:Carotid intima-media thickness (CIMT) is regarded as a controversial risk marker for cardiovascular disease (CVD). We aimed to evaluate the role of CIMT and carotid plaque progression as predictors for the progression of coronary plaque and compositions. METHODS:In the Garlic 4 study, asymptomatic patients ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Chao CJ,Lakshmanan S,Ceponiene I,Luo Y,Nakanishi R,Nezarat N,Kanisawa M,Budoff MJ

    更新日期:2021-01-06 00:00:00

  • Infectious agents in coronary lesions obtained by endatherectomy: pattern of distribution, coinfection, and clinical findings.

    abstract:BACKGROUND:Cytomegalovirus (CMV), Chlamydia pneumoniae (C. pneumoniae), and Helicobacter pylori (H. pylori) have been implicated in atherosclerosis and restenosis after angioplasty. The patterns of distribution within coronary lesions and possible coinfections of these pathogens in the coronary vasculature had not prev...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Radke PW,Merkelbach-Bruse S,Messmer BJ,vom Dahl J,Dörge H,Naami A,Vogel G,Handt S,Hanrath P

    更新日期:2001-02-01 00:00:00

  • Correlation between coronary artery calcium score and aortic diameter in a high-risk population of elderly male hypertensive patients.

    abstract:BACKGROUND:Studies on the relationship between coronary artery calcium and aortic diameter are scarce. The aim of the current study was to evaluate the correlation between coronary artery calcium score (CACS) and maximal thoracic and abdominal aortic diameters in a population of elderly (>65 years) male hypertensive pa...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Cho IJ,Heo R,Chang HJ,Shin S,Shim CY,Hong GR,Min JK,Chung N

    更新日期:2014-12-01 00:00:00

  • The antiarrhythmic effect and clinical consequences of ischemic preconditioning.

    abstract::Potentially hazardous short ischemic episodes increase the tolerance of myocardium to ischemia paradoxically. This condition decreases the infarct area markedly caused by a longer duration of coronary occlusion. This phenomenon is known as 'ischemic preconditioning' and its powerful cardioprotective effect has been sh...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审


    authors: Evrengul H,Seleci D,Tanriverdi H,Kaftan A

    更新日期:2006-05-01 00:00:00

  • PAI-1 4G/5G gene polymorphism is associated with angiographic patency in ST-elevation myocardial infarction patients treated with thrombolytic therapy.

    abstract:BACKGROUND:In this study, we examined the relationship between PAI-1 4G/5G polymorphism and patency of the infarct-related artery after thrombolysis in patients with ST-elevation myocardial infarction (STEMI). METHODS:Acute STEMI patients who received thrombolytic therapy within first 12 h were included in our study. ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Ozkan B,Cagliyan CE,Elbasan Z,Uysal OK,Kalkan GY,Bozkurt M,Tekin K,Bozdogan ST,Ozalp O,Duran M,Sahin DY,Cayli M

    更新日期:2012-09-01 00:00:00

  • Association of lymphocyte-to-monocyte ratio with total coronary plaque burden in patients with coronary artery disease.

    abstract:BACKGROUND:Lymphocyte-to-monocyte ratio (LMR) is involved in all stages of coronary atherosclerosis and related to coronary artery disease (CAD). However, the correlation between LMR and the coronary plaque burden of CAD is not clearly elucidated. Therefore, this study aimed to investigate their correlation in patients...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Si Y,Liu J,Shan W,Zhang Y,Han C,Wang R,Sun L

    更新日期:2020-11-01 00:00:00

  • Reactive coagulation induced by plasmin in patients treated with recombinant tissue-type plasminogen activator.

    abstract:BACKGROUND:We and others have demonstrated that administration of thrombolytic agents causes the generation of thrombosis-promoting agents. At present, we have studied whether formation in vivo of excessive amounts of plasmin is responsible for the activation of coagulation in patients treated with recombinant tissue-t...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Gram J,Munkvad S,Leebeek FW,Kluft C,Jespersen J

    更新日期:1993-04-01 00:00:00

  • Meeting the challenge of chronic ischaemic heart disease with trimetazidine.

    abstract::The risk of cardiovascular events in patients with diabetes is similar to that of patients with previous history of ischaemic heart disease and the prevalence of ischaemic heart disease complicating diabetic syndromes is growing rapidly. Management of ischaemic heart disease in diabetic patients remains a challenge. T...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审


    authors: Marzilli M,Affinito S

    更新日期:2005-11-01 00:00:00

  • Stent strut thickness and acute vessel injury during percutaneous coronary interventions: an optical coherence tomography randomized clinical trial.

    abstract:AIMS:Compare the degree of acute vascular injury caused by a polymer-free, thin-strut drug-eluting stent (DES) to that caused by a bioresorbable polymer, thick-strut DES using optical coherence tomography (OCT). METHODS AND RESULTS:Fifty patients requiring nonurgent PCI were randomized to receive either a thin or a th...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Vilchez-Tschischke JP,Salazar C,Gil-Romero J,Mori R,Nuñez-Gil I,Quirós A,Nombela L,Del Trigo M,Jimenez-Quevedo P,Salinas P,Escaned J,Macaya C,Gonzalo N

    更新日期:2020-08-19 00:00:00

  • Cardiac rotation and relaxation after anterolateral myocardial infarction.

    abstract:BACKGROUND:Both systolic and diastolic dysfunction have been observed in patients with anterolateral myocardial infarction. Diastolic dysfunction is related to disturbances in relaxation and diastolic filling. OBJECTIVE:To analyse cardiac rotation, regional shortening and diastolic relaxation in patients with anterola...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Nagel E,Stuber M,Lakatos M,Scheidegger MB,Boesiger P,Hess OM

    更新日期:2000-05-01 00:00:00

  • Predictors of 30-day and 1-year mortality after primary percutaneous coronary intervention for ST-elevation myocardial infarction.

    abstract:OBJECTIVE:Predictors of 30-day mortality may differ from predictors of mortality at 1 year among 30-day survivors of ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI). We aimed to evaluate the predictors of 30-day and 1-year mortality in unselected patients with ST...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Rasoul S,Ottervanger JP,de Boer MJ,Dambrink JH,Hoorntje JC,Marcel Gosselink AT,Zijlstra F,Suryapranata H,van 't Hof AW,Zwolle Myocardial Infarction Study Group.

    更新日期:2009-09-01 00:00:00