SUIT, secretory units of islets in transplantation: An index for therapeutic management of islet transplanted patients and its application to type 2 diabetes.

Abstract:

:Evaluation of a patient's pancreatic beta-cell function is important in both diagnosis and treatment of diabetes. We sought to determine beta-cell function with a single sampling of blood. Examination of fasting blood glucose (F-BG, mM) and C-peptide (F-CPR, nM) levels in seven post-islet-transplanted states of four patients revealed a linear relationship between F-BG and F-CPR. Assuming that normal subjects aged <40 years have 100% pancreatic beta-cell function, we developed the secretory units of islets in transplantation (SUIT) as an index of beta-cell function by the formula: 250 x F-CPR/(F-BG-3.43). The SUIT index was correlated with the stimulated C-peptide levels not only in islet-transplanted patients (R2 = 0.68, P < 0.05) but also in type 2 patients (R2 = 0.34, P < 0.001). Since the SUIT index can be calculated from data obtained at a single fasting blood sampling and predict the pancreatic beta-cell function, the formula may be a useful tool in clinical management of diabetes.

authors

Yamada Y,Fukuda K,Fujimoto S,Hosokawa M,Tsukiyama K,Nagashima K,Fukushima M,Suzuki H,Toyoda K,Sassa M,Funakoshi S,Inagaki N,Taniguchi A,Sato TS,Matsumoto S,Tanaka K,Seino Y

doi

10.1016/j.diabres.2006.03.030

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

222-6

issue

3

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(06)00151-3

journal_volume

74

pub_type

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