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High serum oxytocin is associated with metabolic syndrome in older men - The MINOS study.

Abstract：

AIM:Oxytocin regulates food intake, carbohydrate and lipid metabolism, and urinary sodium excretion. We assessed the association between serum oxytocin levels and presence of metabolic syndrome (MetS) in older men. METHODS:Cross-sectional study was performed in 540 volunteer men aged 50-85yrs from the MINOS cohort. Oxytocin was measured in fasting serum by radioimmunoassay (Oxytocin RIA, Phoenix Pharmaceuticals). MetS was diagnosed using the harmonized definition. RESULTS:Serum oxytocin was higher in 166 men with MetS vs. controls (p<0.005). After adjustment for confounders including leptin, higher oxytocin was associated with higher odds of MetS (OR=1.38 per SD, 95%CI: 1.10-1.71, p<0.005). Men with serum oxytocin >0.74pg/mL (median) had higher odds of MetS vs. men with oxytocin ⩽0.74pg/mL (OR=2.06, 95%CI: 1.33-3.18, p<0.005). Higher oxytocin levels and low testosterone levels (total or free) were significantly associated with higher odds of MetS jointly and independently of each other. Men having oxytocin >0.74pg/mL and total testosterone <300ng/dL (<10.4nmol/L) had higher odds of MetS vs. men without these characteristics (OR=3.95, 95%CI: 1.65-9.46, p<0.005). Men having 25-hydroxycholecalciferol levels <30ng/mL and oxytocin >0.74pg/mL had higher odds of MetS vs. men without these characteristics (OR=2.86, 95%CI: 1.47-5.58, p<0.01). Men having oxytocin >0.74pg/mL and osteocalcin levels <14.6ng/mL (lowest quartile) had higher odds of MetS vs. men without these characteristics (OR=4.12, 95%CI: 2.07-8.20, p<0.001). CONCLUSION:In older men, higher serum oxytocin levels are associated with higher odds of MetS regardless of potential confounders.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Szulc P,Amri EZ,Varennes A,Panaia-Ferrari P,Fontas E,Goudable J,Chapurlat R,Breuil V

doi

10.1016/j.diabres.2016.09.022

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

17-27

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(16)30669-6

journal_volume

122

pub_type

杂志文章

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