Abstract：
:The phosphorylating of the lysine-rich histone at various stages in the cell cycle has been studied. In rapidly dividing cell populations the lysine-rich histone is phosphorylated rapidly after synthesis and more slowly once bound to the chromosome. The half-life of hydrolysis of such interphase phosphorylation in 5 hr except during mitosis when the phosphata hydrolysis increases almost three-fold. During mitosis there is extensive phosphorylation at sites different from those phosphorylated during interphase and a smaller measure of sites common to both mitotic and interphase cells. The sites of mitotic phosphorylation are most critically distinguished from those phosphorylated in interphase by the rapidly hydrolysis of M-phase phosphohistone when the cells divide and enter the G1 phase of the cell cycle.
journal_name
Biochemistryjournal_title
Biochemistryauthors
Balhorn R,Jackson V,Granner D,Chalkey Rdoi
10.1021/bi00682a033subject
Has Abstractpub_date
1975-06-03 00:00:00pages
2504-11issue
11eissn
0006-2960issn
1520-4995journal_volume
14pub_type
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