Comparing and combining light dose fractionation and iron chelation to enhance experimental photodynamic therapy with aminolevulinic acid.

abstract：BACKGROUND AND OBJECTIVES:Hereditary hemorrhagic telangiectasia (HHT) is a hereditary condition that is associated with arteriovenous malformations. A common site for these malformations is the nasal mucosa, which is associated with severe epistaxis and debilitation for affected patients. We evaluated the efficacy and ...

journal_title：Lasers in surgery and medicine

authors： Bertlich M,Kashani F,Weiss BG,Wiebringhaus R,Ihler F,Freytag S,Gires O,Kühnel T,Haubner F

更新日期：2020-06-23 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Low-intensity laser irradiation is claimed to enhance wound healing. Healing after myocardial infarction results in ventricular enlargement and wall thinning. If laser treatment accelerated cardiac healing, we speculated that ventricular remodeling would be attenuated. STUDY DESIGN/MATERIALS A...

journal_title：Lasers in surgery and medicine

authors： Whittaker P,Patterson MJ

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The goal of this study was to use an inexpensive macroscopic imaging system to monitor tumor progression in mouse models in real-time with minimal intervention. STUDY DESIGN/MATERIALS AND METHODS:Illumination is provided via a xenon arc lamp and a fiber optic probe which delivers white light o...

journal_title：Lasers in surgery and medicine

authors： Carlson AL,Hoffmeyer MR,Wall KM,Baugher PJ,Richards-Kortum R,Dharmawardhane SF

更新日期：2006-12-01 00:00:00

abstract：:Since most techniques of refractive surgery currently in use or being developed have the potential for significant side effects, there is a need for investigating alternative procedures. We herein report on the use of a pulsed CO2 laser beam delivered through a pair of complementary axicons to produce a ring of stroma...

journal_title：Lasers in surgery and medicine

authors： Chandonnet A,Bazin R,Sirois C,Bélanger PA

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:For the past 15 years we have used photodynamic therapy (PDT) to treat endobronchial tumors. Unfortunately patients who have non-primary lung cancer metastatic to bronchi and who have failed other treatment regimens may not be offered endobronchial tumor management. Thirteen patients with endobronchial tumor...

journal_title：Lasers in surgery and medicine

authors： McCaughan JS Jr

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Cutaneous and mucocutaneous leishmaniasis are diseases characterized by skin or mucosal manifestations. In the new world, Leishmania braziliensis is the main etiological agent of cutaneous leishmaniasis, condition that may evolve to the mucocutaneous form. The therapeutic arsenal routinely empl...

journal_title：Lasers in surgery and medicine

authors： Barbosa AF,Sangiorgi BB,Galdino SL,Barral-Netto M,Pitta IR,Pinheiro AL

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVES:While controlled thermal changes in subcutaneous tissue have been used to trigger apoptosis of fat cells and have been proven clinically efficacious, another mechanism of electromagnetic stress suggests that fat apoptosis could be achieved by a non-thermal manner as well. This animal model study investigates...

journal_title：Lasers in surgery and medicine

authors： Weiss RA,Bernardy J

更新日期：2019-01-01 00:00:00

abstract：:Intestinal welding by means of low-power laser has been reported as an efficient method for intestinal anastomosis. We designed an experimental model in rats to investigate collagen and DNA concentrations in CO2 laser-welded anastomoses as compared with those in sutured anastomoses on the 4th, 7th, and 10th postoperat...

journal_title：Lasers in surgery and medicine

authors： Rabau MY,Wasserman I,Shoshan S

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Acne scarring is a common disfiguring sequela of acne vulgaris which can lead to serious psychosocial problems and have a negative effect on patients' quality of life. Although a variety of approaches can be used to treat atrophic acne scars, disadvantages such as long-healing time, dyspigmentation, infectio...

journal_title：Lasers in surgery and medicine

authors： Lan T,Xiao Y,Tang L,Hamblin MR,Yin R

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Cryogen spray cooling (CSC) has become an integral part of dermatologic laser surgery because of its ability to remove selectively large amounts of heat from human skin in short periods of time, thereby protecting the epidermis from unintended thermal injury. The objective of the present study...

journal_title：Lasers in surgery and medicine

authors： Franco W,Liu J,Romero-Méndez R,Jia W,Nelson JS,Aguilar G

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Variable square pulse (VSP) Er:YAG laser should be quicker than older Er:YAG lasers. The objectives were: (1) comparison of VSP laser and mechanical handpiece efficacy for apicectomy and (2) determination of optimal pulse width/energy/frequency combination. STUDY DESIGN/MATERIALS AND METHODS:...

journal_title：Lasers in surgery and medicine

authors： Grgurević J,Grgurević L,Miletić I,Karlović Z,Krmek SJ,Anić I

更新日期：2005-06-01 00:00:00

abstract：:The advantages of the laser have been extolled in the literature but, in contrast, there is a paucity of information on the hazards involved in its surgical use. Recognition and prevention of risks is a mandatory requirement. The experience by encounter is described with counsel as to the prerequisite of taking precau...

journal_title：Lasers in surgery and medicine

authors： Lobraico RV

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:To analyze the impact of humidity and temperature on excimer laser ablation of polyethylene terephthalate (PET), polymethylmethacrylate (PMMA) and porcine corneal tissue, and an ablation model to compensate for the temperature and humidity changes on ablation efficiency. STUDY DESIGN/MATERIAL...

journal_title：Lasers in surgery and medicine

authors： Verma S,Kehrer T,Hesser J,Arba Mosquera S

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:To evaluate the potentials of a 1310-nm optical coherence tomography (OCT) system to penetrate the highly backscattering sclera in enucleated human eyes and provide visualization of intraocular structures by transscleral imaging. STUDY DESIGN/MATERIALS AND METHODS:OCT-images were generated by ...

journal_title：Lasers in surgery and medicine

authors： Hoerauf H,Winkler J,Scholz C,Wirbelauer C,Gordes RS,Koch P,Engelhardt R,Laqua H,Birngruber R

更新日期：2002-01-01 00:00:00

abstract：:Hyperthermia induced by a microwave source (2,450 MHz) was used alone and in combination with photodynamic therapy (PDT) to treat the SMT-F, EMT-6, and RIF animal tumors in vivo. PDT was administered using either Photofrin I or II as the photosensitizer and an argon-pumped tunable dye laser (630 nm) as the light sourc...

journal_title：Lasers in surgery and medicine

authors： Waldow SM,Henderson BW,Dougherty TJ

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Infrared neural stimulation (INS) has recently evoked interest as an alternative to electrical stimulation. The mechanism of activation is the heating of water, which induces changes in cell membrane potential but may also trigger heat sensitive receptors. To further elucidate the mechanism, wh...

journal_title：Lasers in surgery and medicine

authors： Liljemalm R,Nyberg T,von Holst H

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Complete neurosurgical resection of intracranial meningiomas is essential to avoid residual tumor tissue and thus minimize the risk of tumor recurrence. However, local recurrence of meningiomas is not uncommon mainly due to insufficient intraoperative detection of residual tumor tissue within ...

journal_title：Lasers in surgery and medicine

authors： Wadiura LI,Millesi M,Makolli J,Wais J,Kiesel B,Mischkulnig M,Mercea PA,Roetzer T,Knosp E,Rössler K,Widhalm G

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:To investigate the morphology of cementum and root dentin after Er:YAG laser irradiation with and without water coolant, compared to that after CO(2) laser irradiation and an untreated surface. STUDY DESIGN/MATERIALS AND METHODS:Ten extracted healthy human teeth were used. Er:YAG and CO(2) la...

journal_title：Lasers in surgery and medicine

authors： Sasaki KM,Aoki A,Ichinose S,Ishikawa I

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:To produce controlled, spatially confined thermal effects in dermis. STUDY DESIGNS/MATERIALS AND METHODS:A 1 W, 1,500 nm fiber-coupled diode laser was focused with a high numerical aperture (NA) objective to achieve a tight optical focus within the upper dermis of skin held in contact with a ...

journal_title：Lasers in surgery and medicine

authors： Khan MH,Sink RK,Manstein D,Eimerl D,Anderson RR

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The difficulties typically encountered in studying the effects of restorations on tooth reinforcement are often due to the 3-dimensional (3D) nature of deformation. Therefore, electronic 3D-Speckle-Interferometry (3D-ESPI) was used to assess the impact of different restorative materials on the...

journal_title：Lasers in surgery and medicine

authors： Lang H,Rampado M,Müllejans R,Raab WH

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Many studies have investigated the application of micro-insulated needles with radio frequency (RF) to treat acne in humans; however, the use of a micro-insulated needle RF applicator has not yet been studied in an animal model. The purpose of this study was to evaluate the effectiveness of a ...

journal_title：Lasers in surgery and medicine

authors： Kwon TR,Choi EJ,Oh CT,Bak DH,Im SI,Ko EJ,Hong HK,Choi YS,Seok J,Choi SY,Ahn GY,Kim BJ

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:In the last decade, many different kinds of therapies have emerged as a consequence of advances in the field of applied technology. It is known that low level laser therapy contributes to tissue healing; however, the use of photodynamic therapy (PDT) in healing and the scar formation processes...

journal_title：Lasers in surgery and medicine

authors： Silva JC,Lacava ZG,Kuckelhaus S,Silva LP,Neto LF,Sauro EE,Tedesco AC

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Photodynamic therapy (PDT) may be a less invasive treatment for lung cancer. Our newly developed surface layer-preserving PDT (SPPDT) technique enables us to irradiate deep tumor while preserving the overlying tissue. The aim of this basic study was to verify that the SPPDT technique might be ...

journal_title：Lasers in surgery and medicine

authors： Kawakubo M,Eguchi K,Arai T,Kobayashi K,Hamblin MR

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Progressive ascending telangiectasia (PAT) is a distinct entity with telangiectatic superficial vessels on lower extremities as its main clinical feature. A relationship with occult infections and response to antibiotic and antifungal drugs have been described, although not all cases can be suc...

journal_title：Lasers in surgery and medicine

authors： Pérez B,Núñez M,Boixeda P,Harto A,Ledo A

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Sutures are currently the gold standard for wound closure but they are still unable to seal tissue and may induce scarring or inflammation. Biocompatible glues, based on polysaccharides such as chitosan, are a possible alternative to conventional wound closure. In this study, the adhesion of l...

journal_title：Lasers in surgery and medicine

authors： Lauto A,Stoodley M,Marcel H,Avolio A,Sarris M,McKenzie G,Sampson DD,Foster LJ

更新日期：2007-01-01 00:00:00

abstract：:Serial gross and histopathologic examinations of the prostate following interstitial laser prostatectomy in the canine model demonstrated distinct zonal thermal changes around the entire active area of the interstitial thermal therapy (ITT) fiber. A large, well-demarcated area of acute coagulative necrosis immediately...

journal_title：Lasers in surgery and medicine

authors： Johnson DE,Cromeens DM,Price RE

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The risk of adverse skin effects following light-based hair removal is greater in pigmented skin based on the theory of selective photothermolysis. Thus sunlight-induced pigment i.e., facultative pigmentation, increases the risk of adverse skin effects, perhaps disproportionately. The aim of t...

journal_title：Lasers in surgery and medicine

authors： Thaysen-Petersen D,Lin JY,Nash J,Beerwerth F,Wulf HC,Philipsen PA,Haedersdal M

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Herein an overview is provided of the causes, consequences, and significance of photodynamic therapy (PDT)-mediated effects on tumor oxygenation and blood flow during illumination. STUDY DESIGN/MATERIALS AND METHODS:Techniques particularly valuable to this research have included tissue oxygen ...

journal_title：Lasers in surgery and medicine

authors： Busch TM

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Although the empirical characteristics of ArF excimer laser corneal ablation have been well documented, the exact ablation mechanisms are not well understood. The present paper reports a quantitative analysis of corneal ablation plumes using in situ time resolved laser light scattering and Rama...

journal_title：Lasers in surgery and medicine

authors： Hahn DW,Ediger MN,Pettit GH

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Verteporfin is a new photosensitizer with short-term skin photosensitivity. The objective of this preclinical study was to find the light dose that effectively ablates canine esophageal mucosa when delivered 30 minutes after Verteporfin injection. STUDY DESIGN/MATERIALS AND METHODS:Verteporfin...

journal_title：Lasers in surgery and medicine

authors： Panjehpour M,DeNovo RC,Petersen MG,Overholt BF,Bower R,Rubinchik V,Kelly B

更新日期：2002-01-01 00:00:00