Safety and Efficacy of Blue Light Laser Treatment in Hereditary Hemorrhagic Telangiectasia.

Abstract:

BACKGROUND AND OBJECTIVES:Hereditary hemorrhagic telangiectasia (HHT) is a hereditary condition that is associated with arteriovenous malformations. A common site for these malformations is the nasal mucosa, which is associated with severe epistaxis and debilitation for affected patients. We evaluated the efficacy and safety of blue light laser technology in treating these endonasal manifestations in a retrospective chart analysis. Additionally, we compared blue light laser technology to bipolar coagulation in an animal model. STUDY DESIGN/MATERIALS AND METHODS:We performed a retrospective chart analysis of all patients that were diagnosed with HHT and received endonasal blue light laser treatment between 10/2017 and 04/2019. In addition, we performed bipolar or blue light laser coagulation of all macroscopically visible vessels on thyroid gland lobes (n = 4) from Dunkin-Hartley Guinea Pigs. Hematoxylin-eosin (HE) staining was then used to visualize depth and area of coagulation surrounding these vessels. RESULTS:One hundred and fifty-one treatments in 23 patients were analyzed. Under regular blue light laser treatment, quality of life (QOL), indicated on a visual analog scale from 1 to 10, gradually increased significantly from 5.6 ± 0.5 (before the first treatment) to 7.5 ± 0.9 (after the second treatment). Following this, QOL remained steady throughout additional treatments. Adverse effects were not recorded. HE staining showed that coagulation depth (162 ± 56 vs. 586 ± 192 µm) and area (74 ± 35 vs. 1015 ± 449 µm2 ) were significantly lower after laser treatment. CONCLUSION:Blue light laser therapy is safe and efficient in treating HHT. Damage to the surrounding tissue is significantly lower compared with bipolar coagulation. © 2020 The Authors. Lasers in Surgery and Medicine published by Wiley Periodicals LLC.

journal_name

Lasers Surg Med

authors

Bertlich M,Kashani F,Weiss BG,Wiebringhaus R,Ihler F,Freytag S,Gires O,Kühnel T,Haubner F

doi

10.1002/lsm.23289

subject

Has Abstract

pub_date

2020-06-23 00:00:00

eissn

0196-8092

issn

1096-9101

pub_type

杂志文章
  • Flashlamp pulsed dye laser (PDL) suppression of keloid proliferation through down-regulation of TGF-beta1 expression and extracellular matrix expression.

    abstract:BACKGROUND AND OBJECTIVES:Keloids have been treated with flashlamp pulsed dye lasers (PDLs) with good results. We investigated whether PDL treatments induced keloid regression by decreasing growth factor-beta(1) (TGF-beta(1)) induction, thereby reducing fibroblast proliferation and collagen deposition. STUDY DESIGN/MA...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.10206

    authors: Kuo YR,Jeng SF,Wang FS,Chen TH,Huang HC,Chang PR,Yang KD

    更新日期:2004-01-01 00:00:00

  • Histologic changes associated with talaporfin sodium-mediated photodynamic therapy in rat skin.

    abstract:BACKGROUND AND OBJECTIVE:Alternative treatments are needed to achieve consistent and more complete port wine stain (PWS) removal, especially in darker skin types; photodynamic therapy (PDT) is a promising alternative treatment. To this end, we previously reported on Talaporfin Sodium (TS)-mediated PDT. It is essential ...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.22677

    authors: Moy WJ,Yao J,de Feraudy SM,White SM,Salvador J,Kelly KM,Choi B

    更新日期:2017-10-01 00:00:00

  • Evaluation of a transparent perfluorodecalin-infused patch as an adjunct to laser-assisted tattoo removal: A pivotal trial.

    abstract:BACKGROUND AND OBJECTIVE:Laser-assisted treatment of tattoos is well recognized to produce opaque epidermal whitening that prevents multiple sequential passes during a single treatment session. The amount of epidermal whitening produced in association with the procedure can be minimized by topical application of perflu...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/lsm.22659

    authors: Biesman BS,Costner C

    更新日期:2017-04-01 00:00:00

  • Increasing the efficiency of photodynamic therapy by improved light delivery and oxygen supply using an anticoagulant in a solid tumor model.

    abstract:BACKGROUND AND OBJECTIVE:The main factors in photodynamic therapy (PDT) are: photosensitizer retention, photon absorption, and oxygen supply. Each factor has its unique set of problems that poses limitation to the treatment. Both light delivery and oxygen supply are significant bottlenecks in PDT. Vascular closure duri...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.20951

    authors: Yang L,Wei Y,Xing D,Chen Q

    更新日期:2010-09-01 00:00:00

  • Effects of low intensity laser irradiation during healing of skin lesions in the rat.

    abstract:OBJECTIVE:To determine whether laser light can improve healing of skin wounds by killing wound bacteria while simultaneously accelerating host tissue activity. MATERIALS AND METHODS:Wounds on the rat dorsum were irradiated or sham-irradiated three times weekly from days 1 to 19 using 635 or 808 nm diode lasers at 1 or...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.20769

    authors: Nussbaum EL,Mazzulli T,Pritzker KP,Heras FL,Jing F,Lilge L

    更新日期:2009-07-01 00:00:00

  • Laser recannalization of atheromatous vessels using fiber optics.

    abstract::A laser endoscope was devised using optic fibers in order to provide a means of visualization and removal of atheromatous plaques from arteries in cadavers and experimental animals. Atheromatous plaques were satisfactorily lased off in a few seconds, although contraction of lased vessels was observed. A self-focusing ...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.1900040408

    authors: Ward H

    更新日期:1984-01-01 00:00:00

  • Optical coherence tomography as a method to identify parathyroid glands.

    abstract:BACKGROUND AND OBJECTIVE:The identification of parathyroid glands can be a major problem in parathyroid surgery. The purpose of this study was to evaluate the feasibility of optical coherence tomography (OCT) in distinguishing between parathyroid tissue, thyroid tissue, lymph nodes, and adipose tissue. METHODS:Ex vivo...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.22195

    authors: Ladurner R,Hallfeldt KK,Al Arabi N,Stepp H,Mueller S,Gallwas JK

    更新日期:2013-12-01 00:00:00

  • Current status of infrared fiber optics for medical laser power delivery.

    abstract::There are a host of fiber-optic delivery devices available for use with the Er:YAG, HF, CO, and CO2 lasers at 2.9, 2.8, 5.3, and 10.6 microns wavelengths, respectively. While many of these fibers are not as convenient to use as conventional silica fibers, they offer the ability to deliver infrared laser energy for a w...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章,评审

    doi:10.1002/lsm.1900130513

    authors: Merberg GN

    更新日期:1993-01-01 00:00:00

  • Laser oncology in Italy: experimental research and clinical applications at the National Cancer Institute, Milan.

    abstract::CO2, Nd:YAG, and argon lasers have been used for 5 years for experimental and clinical procedures at the National Cancer Institute of Milan under the auspices of the National Research Council. Experimental data regarding tumor cell spread through lymphatic and hematic channels and cell viability in the fumes after CO2...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.1900020409

    authors: Emanuelli H,Bandieramonte G,Marchesini R,Fava G,Rodari A,Colombo MP,Costa A,Spinelli P,Zunino F,Chiesa F,Cascinelli N,Andreola S,Pariente R,Canti GF

    更新日期:1983-01-01 00:00:00

  • Parameters in fractional laser assisted delivery of topical anesthetics: Role of laser type and laser settings.

    abstract:BACKGROUND AND OBJECTIVES:Efficacy of topical anesthetics can be enhanced by pretreatment of the skin with ablative fractional lasers. However, little is known about the role of parameters such as laser modality and laser density settings in this technique. Aims of this study were to compare the efficacy of pretreatmen...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/lsm.22936

    authors: Meesters AA,Nieboer MJ,Kezic S,de Rie MA,Wolkerstorfer A

    更新日期:2018-10-01 00:00:00

  • Temperature along the surface of modified fiber tips for Nd:YAG laser angioplasty.

    abstract::For laser angioplasty probes, the thermal properties of the probes will primarily determine their mechanism of action. We examined the absorption, temperature increase, and probe degradation of transparent contact probes (hemispherical contact probe and ball-shaped fibers) and metal laser probes coupled to a continuou...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.1900110304

    authors: Verdaasdonk RM,Holstege FC,Jansen ED,Borst C

    更新日期:1991-01-01 00:00:00

  • The Use of a 1,540 nm Fractional Erbium-Glass Laser in Treatment of Alopecia Areata.

    abstract:BACKGROUND AND OBJECTIVES:Varieties of laser and light sources have been tried for treatment of alopecia areata (AA) and some success has been reported. To assess the effectiveness of 1,540  nm fractional erbium-glass laser in treatment of AA. STUDY DESIGN/MATERIALS AND METHODS:The patches of AA were divided into two ...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.23133

    authors: Al-Dhalimi MA,Al-Janabi MH,Abd Al Hussein RA

    更新日期:2019-12-01 00:00:00

  • Morphological analysis of cementum and root dentin after Er:YAG laser irradiation.

    abstract:BACKGROUND AND OBJECTIVES:To investigate the morphology of cementum and root dentin after Er:YAG laser irradiation with and without water coolant, compared to that after CO(2) laser irradiation and an untreated surface. STUDY DESIGN/MATERIALS AND METHODS:Ten extracted healthy human teeth were used. Er:YAG and CO(2) la...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.10074

    authors: Sasaki KM,Aoki A,Ichinose S,Ishikawa I

    更新日期:2002-01-01 00:00:00

  • Laser-activated solid protein bands for peripheral nerve repair: an vivo study.

    abstract:BACKGROUND AND OBJECTIVE:Severed tibial nerves in rats were repaired using a novel technique, utilizing a semiconductor diode-laser-activated protein solder applied longitudinally across the join. Welding was produced by selective laser denaturation of solid solder bands containing the dye indocyanine green. STUDY DES...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9101(1997)21:2<134::aid-lsm4>3.

    authors: Lauto A,Trickett R,Malik R,Dawes JM,Owen ER

    更新日期:1997-01-01 00:00:00

  • Low intensity monochromatic infrared therapy: a preliminary study of the effects of a novel treatment unit upon experimental muscle soreness.

    abstract:BACKGROUND AND OBJECTIVE:The current study (for which ethical approval was obtained) sought to assess the effect of low intensity monochromatic infrared therapy (LIMIRT) on experimentally induced delayed onset muscle soreness (DOMS). STUDY DESIGN/MATERIALS AND METHODS:Healthy volunteers were recruited (n = 24, 12M:12F...

    journal_title:Lasers in surgery and medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1096-9101(2001)28:1<33::AID-LSM1012>3.0.CO

    authors: Glasgow PD,Hill ID,McKevitt AM,Lowe AS,Baxter D

    更新日期:2001-01-01 00:00:00

  • Nonmonotonic behavior of the dose dependence of the radiation effect on cells in vitro exposed to pulsed laser radiation at lambda = 820 nm.

    abstract:BACKGROUND AND OBJECTIVE:In recent years, clinical low-intensity laser therapy practice has used pulsed radiation, mainly from semiconductor lasers. Experimental works devoted to the study of relationships between biological and clinical effects and parameters of pulsed radiation are practically absent. STUDY DESIGN/M...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9101(1997)21:5<485::aid-lsm11>3

    authors: Karu TI,Pyatibrat LV,Ryabykh TP

    更新日期:1997-01-01 00:00:00

  • HeNe laser irradiation delivered transcutaneously: its effect on the sciatic nerve of rats.

    abstract::For our study of the effect of low energy laser irradiation (LELI) on living tissue we used HeNe laser on rats. The exponential absorption was reaffirmed in the living tissues overlying the sciatic nerve. An optimal range of energy between 3.5 and 7 J--associated with energy concentration of 4-10 J/cm2 delivered trans...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.1900060502

    authors: Nissan M,Rochkind S,Razon N,Bartal A

    更新日期:1986-01-01 00:00:00

  • Low level laser therapy for the management of breast cancer-related lymphedema: A randomized controlled feasibility study.

    abstract:OBJECTIVES:This study aimed to determine the feasibility of conducting a full scale randomized controlled trial investigating the effectiveness of low level laser therapy (LLLT), also known as photobiomodulation (PBM) therapy, used in addition to conventional therapy, for managing breast cancer related lymphedema (BCRL...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/lsm.22947

    authors: Baxter GD,Liu L,Tumilty S,Petrich S,Chapple C,Anders JJ,Laser Lymphedema Trial Team.

    更新日期:2018-09-01 00:00:00

  • Photodynamic therapy using Photofrin in combination with buthionine sulfoximine (BSO) to treat 9L gliosarcoma in rat brain.

    abstract:BACKGROUND AND OBJECTIVE:The reactive oxygen mechanisms associated with cell damage after photodynamic therapy (PDT) may be exploited to enhance tumor destruction. Pharmacological reduction of glutathione (GSH), an inhibitor of reactive oxygen species, can be induced by administration of buthionine sulfoximine (BSO). ...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9101(1998)23:3<161::aid-lsm5>3.

    authors: Jiang F,Lilge L,Belcuig M,Singh G,Grenier J,Li Y,Chopp M

    更新日期:1998-01-01 00:00:00

  • Randomized, double-blind, phase III clinical study of a novel nanotechnological topical anesthetic formulation containing lidocaine 25 mg/g and prilocaine 25 mg/g (nanorap) in skin phototypes I-III patients with ablative fractional CO2 laser treatment ind

    abstract:BACKGROUND AND OBJECTIVES:Nanotechnology may increase the speed of penetration into the skin. This study evaluated the efficacy, safety, and pharmacokinetics of a novel topical anesthetic nanocapsule formulation (2 g) containing 2.5% lidocaine and 2.5% prilocaine (nanorap-test formulation) compared to placebo (control ...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/lsm.23071

    authors: Gobbato C,Gobbato A,Magalhães TB,Mendes GD,Ilha JO,Moreno RA,Antunes NJ,De Nucci G

    更新日期:2019-09-01 00:00:00

  • Water flux from partial-thickness skin wounds: comparative study of the effects of Er:YAG and Ho:YAG lasers.

    abstract:BACKGROUND AND OBJECTIVE:The clinical use of lasers to cut and coagulate tissue necessitates a better understanding of how the residual thermal damage affects healing. This study was designed to evaluate the effects of varying degrees of thermal damage on the healing process. STUDY DESIGN, MATERIALS AND METHODS:Partia...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-9101(1996)18:1<1::AID-LSM1>3.0.

    authors: Jaffe BH,Walsh JT Jr

    更新日期:1996-01-01 00:00:00

  • New device for visual neodymium:YAG laser prostate ablation: acute and chronic canine evaluation.

    abstract::This canine study (n = 6) evaluated the acute and chronic effects of Nd:YAG laser prostatectomy using a Prolase II fiber. The Prolase II device consists of a 1,000 microns quartz fiber which directs a cone of Nd:YAG laser energy, at 45 degrees to the axis of the fiber, into the prostatic urethra under direct visual gu...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.1900150304

    authors: Kopchok GE,Back M,White RA,Cavaye DM,Peng SK,Moriel E,Rajfer J

    更新日期:1994-01-01 00:00:00

  • Practical models for light distribution in laser-irradiated tissue.

    abstract::The distribution of light in laser-irradiated biological medium is computed using four different procedures. Values computed with Beer's law of attenuation, Kubelka-Munk theory, the diffusion approximation, and a seven-flux model are compared. The proper conditions for using each model are discussed. ...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.1900060603

    authors: Welch AJ,Yoon G,van Gemert MJ

    更新日期:1987-01-01 00:00:00

  • Deep localized neodymium (Nd)-YAG laser photocoagulation in liver using a new water cooled and echoguided handpiece.

    abstract::Thirty-six deep hepatic lesions of localized photocoagulation were induced in 11 pigs by means of a neodymium-YAG laser. Laser applications of 80 W/10 sec (10.190 W/cm2) were transmitted through a handpiece coupled to a water-cooling circulation system to protect the quartz fiber and positioned through an echo-guided ...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.1900080509

    authors: Godlewski G,Rouy S,Pignodel C,Ould-Said H,Eledjam JJ,Bourgeois JM,Sambuc P

    更新日期:1988-01-01 00:00:00

  • Study of the mechanisms of laser-induced release of liposome-encapsulated dye.

    abstract::To differentiate the contributing factors (blood or encapsulated dye) leading to the release of encapsulated dyes from liposomes after laser exposure, we initiated an in vitro experimental study. The release of encapsulated calcein was quantified under various experimental conditions in whole blood and in buffered sol...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.1900100312

    authors: Khoobehi B,Char CA,Peyman GA,Schuele KM

    更新日期:1990-01-01 00:00:00

  • Intracutaneous ALA photodynamic therapy: dose-dependent targeting of skin structures.

    abstract:BACKGROUND:Photodynamic therapy (PDT) using topical aminolevulinic acid (ALA) depends on local drug uptake, metabolism to porphyrins, and depth of light penetration using different wavelengths. Topical ALA-PDT has limited depth of drug penetration. We studied induced porphyrin distribution and PDT after intradermal ALA...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.21073

    authors: Sakamoto FH,Doukas AG,Farinelli WA,Tannous Z,Su Y,Smith NA,Zurakowski D,Anderson RR

    更新日期:2011-09-01 00:00:00

  • Modeling the modification depth of carbon dioxide laser-treated dental enamel.

    abstract:BACKGROUND AND OBJECTIVES:Many studies of laser-induced thermal decomposition of dental enamel have demonstrated a reduction in the rate of acid dissolution, size of artificial caries-like lesions, and acid reactivity. Additionally, studies have correlated the loss of carbonate from dental enamel with a reduction in ac...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9101(1999)25:4<335::aid-lsm8>3.

    authors: Zuerlein MJ,Fried D,Featherstone JD

    更新日期:1999-01-01 00:00:00

  • Injuries as an adverse reaction to clinically used laser devices.

    abstract::Since the first use of lasers in ophthalmology in the early 1960s, applications for the medical laser have been found in many medical specialties. Despite their increasing usefulness, lasers have been reported to induce injuries. Few studies have tried to quantify the number of injuries caused by the clinical use of l...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.1900070603

    authors: Rodriguez JG,Sattin RW

    更新日期:1987-01-01 00:00:00

  • The role of natural and UV-induced skin pigmentation on low-fluence IPL-induced side effects: a randomized controlled trial.

    abstract:BACKGROUND AND OBJECTIVES:The risk of adverse skin effects following light-based hair removal is greater in pigmented skin based on the theory of selective photothermolysis. Thus sunlight-induced pigment i.e., facultative pigmentation, increases the risk of adverse skin effects, perhaps disproportionately. The aim of t...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/lsm.22167

    authors: Thaysen-Petersen D,Lin JY,Nash J,Beerwerth F,Wulf HC,Philipsen PA,Haedersdal M

    更新日期:2014-02-01 00:00:00

  • Effect of helium-neon and infrared laser irradiation on wound healing in rabbits.

    abstract::We examined the biostimulating effects of helium-neon laser radiation (HeNe; 632.8 nm), pulsed infrared laser radiation (IR; 904 nm), and the two combined on skin wound healing in New Zealand white rabbits. Seventy-two rabbits received either 1) no exposure, 2) 1.65 J/cm2 HeNe, 3) 8.25 J/cm2 pulsed IR, or 4) both HeNe...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.1900090111

    authors: Braverman B,McCarthy RJ,Ivankovich AD,Forde DE,Overfield M,Bapna MS

    更新日期:1989-01-01 00:00:00