Protection by schisanhenol against adriamycin toxicity in rat heart mitochondria.

abstract：:The primary objective of this research was to test the hypothesis that low level lead (Pb) exposure during early life leads to disruption in blood-brain barrier (BBB) function in the young rat. Newborn rats received lead via milk from lactating dams that were drinking water containing 0.1% lead acetate Pb(Ac)2. Pups w...

journal_title：Biochemical pharmacology

authors： Michaelson IA,Bradbury M

更新日期：1982-05-15 00:00:00

abstract：:Elevated glucose levels in diabetes mellitus is associated with increased oxidized low density lipoprotein (oxLDL). High glucose (HG) and oxLDL are key inducers of oxidative stress and inflammatory processes responsible for diabetic vascular disorders. Rosmarinic acid is a polyphenol with antioxidant, anti-inflammator...

journal_title：Biochemical pharmacology

authors： Nyandwi JB,Ko YS,Jin H,Yun SP,Park SW,Kim HJ

更新日期：2020-12-01 00:00:00

abstract：:Glutathione reductase (GR) one of the enzymes of the glutathione redox cycle, plays a salient role in maintaining appropriate cellular levels of reduced glutathione. The enzyme in human red blood cells is inhibited in vitro by the anticonvulsant drug valproic acid (VPA). The inhibition is dose-dependent, reversible, u...

journal_title：Biochemical pharmacology

authors： Cotariu D,Evans S,Lahat E,Theitler J,Bistritzer T,Zaidman JL

更新日期：1992-02-04 00:00:00

abstract：:Chemosensitization of bifunctional alkylators by misonidazole (MISO) and related nitroimidazoles in vitro has been shown to require hypoxic exposures. Presumably, reductive metabolism of the nitroimidazole under hypoxic conditions results in generation of a chemosensitizing intermediate(s) in a manner analogous to tha...

journal_title：Biochemical pharmacology

authors： Mulcahy RT,Gipp JJ,Ublacker GA,McClelland RA

更新日期：1990-12-15 00:00:00

abstract：:Limitations in efficacy and high relapse rates of currently available smoking cessation agents reveal the need for more efficacious pharmacotherapies. One strategy is to develop subtype-selective nicotinic receptor (nAChR) antagonists that inhibit nicotine-evoked dopamine (DA) release, the primary neurotransmitter inv...

journal_title：Biochemical pharmacology

authors： Dwoskin LP,Joyce BM,Zheng G,Neugebauer NM,Manda VK,Lockman P,Papke RL,Bardo MT,Crooks PA

更新日期：2007-10-15 00:00:00

abstract：:The recombinant plasmid pBHIV1 carrying the long terminal repeat (LTR) of the human immunodeficiency virus 1 (HIV-1), linked to the chloramphenicol acetyl transferase (CAT) gene, was introduced into human and rat fibroblasts. Stable transfectants resistant to geneticin expressed CAT activity from the HIV-1 LTR. It was...

journal_title：Biochemical pharmacology

authors： Zoumpourlis V,Kerr DJ,Spandidos DA

更新日期：1992-02-04 00:00:00

abstract：:Oxidative damage of creatine kinase (CK) induced by Adriamycin((R)) (ADM) with peroxidase was investigated using horseradish peroxidase (HRP). ADM oxidatively inactivated CK during its interaction with HRP in the presence of H(2)O(2) (HRP-H(2)O(2)). The red color of ADM was lost during oxidation by HRP-H(2)O(2). Addin...

journal_title：Biochemical pharmacology

authors： Miura T,Muraoka S,Fujimoto Y

更新日期：2000-07-01 00:00:00

abstract：:The influence of delta 9-tetrahydrocannabinol (delta 9-THC) on the cellular levels of histone mRNAs and ribosomal RNAs was examined in several normal and transformed human cell lines--HeLa S3 cells, WI-38 human diploid fibroblasts, SV40-transformed WI-38 cells, and A549 lung carcinoma cells. RNA sequences were quantit...

journal_title：Biochemical pharmacology

authors： Green LG,Stein JL,Stein GS

更新日期：1984-04-01 00:00:00

abstract：:When human saliva obtained after cigarette smoking was incubated in the presence of tryptamine, the formation of 1,2,3,4-tetrahydro-beta-carboline (TBC) and 1-methyl-1,2,3,4-tetrahydro-beta-carboline (MTBC) was observed in a short time. After incubation with tryptamine (2.5 micrograms/microliter) for 10 min, the conce...

journal_title：Biochemical pharmacology

authors： Tsuchiya H,Ohtani S,Yamada K,Tajima K,Sato M

更新日期：1995-12-22 00:00:00

abstract：:In a previous report we described the export of hyaluronan from Streptococcus pyogenes by an ABC transporter. Extending these findings a sequence homology search against human proteins revealed a strong homology to the multidrug resistance transporter ABC-B (MDR-1) and ABC-C (MRP 5). Using several inhibitors directed ...

journal_title：Biochemical pharmacology

authors： Prehm P,Schumacher U

更新日期：2004-10-01 00:00:00

abstract：:The widely used muscarinic receptor ligand [3H]quinuclidinyl benzilate ([3H]QNB) was found to bind in a site-specific but artifactual manner to rat intestinal mucus, obscuring specific binding to muscarinic receptors on intestinal epithelial cells. Atropine inhibited [3H]QNB binding to mucus with an apparent IC50 of 2...

journal_title：Biochemical pharmacology

authors： Rimele TJ,Gaginella TS

更新日期：1982-02-15 00:00:00

abstract：:The protective action of cysteine or mercaptopropionylglycine (MPG) in acute ethanol-induced liver injury has been investigated in the rat. Cysteine accelerated clearance of ethanol and acetaldehyde from blood and liver and prevented an increase in hepatic content of triglyceride and serum ornithine carbamoyl transfer...

journal_title：Biochemical pharmacology

authors： Hirayama C,Kishimoto Y,Wakushima T,Murawaki Y

更新日期：1983-01-15 00:00:00

abstract：:α6β2-Containing nicotinic acetylcholine receptors (α6β2* nAChRs) are predominantly expressed in midbrain dopaminergic neurons, including substantia nigra pars compacta (SNc) neurons and their projections to striatal regions, where they regulate dopamine release and nigrostriatal activity. It is well established that n...

journal_title：Biochemical pharmacology

authors： van Hout M,Klein J,Ahring PK,Brown DT,Thaneshwaran S,Dos Santos AB,Jensen AA,Kohlmeier KA,Christophersen P,Dyhring T

更新日期：2020-04-01 00:00:00

abstract：:Two pyrophosphate analogues, dichloromethane diphosphonate (Cl2MDP), and 1-hydroxyethane-1,1-diphosphonate (EHDP), at concentrations of 0.5-1 mM, efficiently inhibited the growth of amoebae of the slime mould Dictyostelium discoideum. Cell viability decreased markedly upon incubation with the diphosphonates. The mecha...

journal_title：Biochemical pharmacology

authors： Pelorgeas S,Martin JB,Satre M

更新日期：1992-12-01 00:00:00

abstract：:The need to protect human spermatozoa from oxidative stress during assisted reproductive technology, has prompted a detailed analysis of the impacts of phenolic compounds on the functional integrity of these cells. Investigation of 16 individual compounds revealed a surprising variety of negative effects including: (i...

journal_title：Biochemical pharmacology

authors： Aitken RJ,Muscio L,Whiting S,Connaughton HS,Fraser BA,Nixon B,Smith ND,De Iuliis GN

更新日期：2016-12-01 00:00:00

abstract：:We have studied the effects of TPA on the metabolism of porcine thyroid cells cultured for 1-4 days in the absence (control cells) and in the presence of 0.1 mU/ml TSH (TSH cells). The phospholipid turnover, evaluated after a 2 hr incorporation of 32P-phosphate into phospholipids, is markedly modified by the presence ...

journal_title：Biochemical pharmacology

authors： Haye B,Aublin JL,Champion S,Lambert B,Jacquemin C

更新日期：1985-11-01 00:00:00

abstract：:Adult hepatocytes from rat and man were maintained for 2 weeks between two gel layers in a sandwich configuration to study the influence of this culture technique on the preservation of basal activities of xenobiotic-metabolizing phase I and phase II enzymes. The response of these enzyme activities to an enzyme induce...

journal_title：Biochemical pharmacology

authors： Kern A,Bader A,Pichlmayr R,Sewing KF

更新日期：1997-10-01 00:00:00

abstract：:The spectrum of cytotoxicity of menadione (MD) was examined in a panel of human cancer cell lines. MD was equipotent against multidrug-resistant and parental leukemia cell lines with IC50 values of 13.5 +/- 3.6 and 18 +/- 2.4 microM respectively. A cervical carcinoma cell line resistant to the antimetabolite, methotre...

journal_title：Biochemical pharmacology

authors： Nutter LM,Cheng AL,Hung HL,Hsieh RK,Ngo EO,Liu TW

更新日期：1991-05-01 00:00:00

abstract：:Histone deacetylases (HDAC) play a key role in regulating gene expression by deacetylating histones. Some HDAC isoforms can also modulate the function of nonhistone proteins implicated in regulatory processes, and therefore HDACs are recognized as useful targets for therapeutic purposes. HDAC inhibitors have generated...

journal_title：Biochemical pharmacology

authors： Dallavalle S,Pisano C,Zunino F

更新日期：2012-09-15 00:00:00

abstract：:Infliximab (IFX), a chimeric monoclonal antibody against tumor necrosis factor-α (TNF-α), is widely used to treat autoimmune diseases and chronic diseases associated with inflammation. TNF-α was reported to inhibit klotho, reactivate β-catenin and cause tubular cell injury in vitro. Whether the inhibition of TNF-α can...

journal_title：Biochemical pharmacology

authors： Younis NN,Mohamed HE,Shaheen MA,Abdelghafour AM,Hammad SK

更新日期：2021-01-19 00:00:00

abstract：:Bovine serum albumin (BSA) catalyzes the o-rearrangement of the reactive electrophile, N-sulfooxy-2-acetylaminofluorene (NSF), a potential ultimate hepatocarcinogen in the rat, to the nonmutagenic sulfuric acid esters of 1- and 3-hydroxy-2-acetylaminofluorene. Conversion of NSF was proportional to BSA concentrations r...

journal_title：Biochemical pharmacology

authors： Smith BA,Gutmann HR,Springfield JR

更新日期：1989-11-15 00:00:00

abstract：:Stimulation of lipolysis in murine adipocytes in response to a lipid-mobilizing factor produced by a cachexia-inducing murine adenocarcinoma was inhibited by eicosapentaenoic acid (EPA) with a Ki value of 104 microM. The inhibitory effect was strictly structurally specific, since other related fatty acids of both the ...

journal_title：Biochemical pharmacology

authors： Tisdale MJ,Beck SA

更新日期：1991-01-01 00:00:00

abstract：:MOLT-4 (T-), RAJI (B-), and KM-3 (non-B-non-T-, common ALL) malignant lymphoblasts demonstrated significant differences in their activities of purine de novo synthesis (PDNS) and purine salvage pathway and in their cell-kinetic parameters. Incubations with concentrations of methotrexate (0.02 and 0.2 microM), which ca...

journal_title：Biochemical pharmacology

authors： Bökkerink JP,De Abreu RA,Bakker MA,Hulscher TW,van Baal JM,Schretlen ED,De Bruijn CH

更新日期：1988-06-15 00:00:00

abstract：:Change in the membrane fluidity of human erythrocytes on transformation to stomatocytes was observed by ESR spectroscopy using 12-doxyl stearic acid or its methyl ester as a probe. When the transformation to stomatocytes was induced by four qualitatively different methods, i.e. (a) addition of cationic amphiphilic age...

journal_title：Biochemical pharmacology

authors： Noji S,Takahashi T,Kon H

更新日期：1982-10-15 00:00:00

abstract：:Multidrug resistance in tumor cells is often associated with the presence of an approximately 170 kDa plasma membrane glycoprotein (Pgp) that acts as a drug-efflux pump and decreases intracellular antitumor drug concentration. We measured the uptake of seven anthracyclines (daunorubicin, doxorubicin, 4'-epi-doxorubici...

journal_title：Biochemical pharmacology

authors： Praet M,Stryckmans P,Ruysschaert JM

更新日期：1996-05-17 00:00:00

abstract：:CYP3A4 is the most important drug-metabolizing enzyme that is involved in biotransformation of more than 50% of drugs. Pregnane X receptor (PXR) dominantly controls CYP3A4 inducibility in the liver, whereas vitamin D receptor (VDR) transactivates CYP3A4 in the intestine by secondary bile acids. Four major functional P...

journal_title：Biochemical pharmacology

authors： Pavek P,Pospechova K,Svecova L,Syrova Z,Stejskalova L,Blazkova J,Dvorak Z,Blahos J

更新日期：2010-01-15 00:00:00

abstract：:Sustained activation of AMP-activated protein kinase (AMPK) induces apoptosis in several cell types. In pancreatic beta cells this occurs under glucose limitation, or in the presence of the pharmacological AMPK activator 5-aminoimidazole-4-carboxamide-riboside (AICAR). It is unknown whether Akt activation can countera...

journal_title：Biochemical pharmacology

authors： Cai Y,Wang Q,Ling Z,Pipeleers D,McDermott P,Pende M,Heimberg H,Van de Casteele M

更新日期：2008-05-15 00:00:00

abstract：:The signal transducer and activator of transcription 3 is a constitutively activated oncogenic protein in various human tumors and represents a valid target for anticancer drug design. In this study, we have achieved a new type of STAT3 inhibitors based on structural modifications on shikonin scaffold, guided by compu...

journal_title：Biochemical pharmacology

authors： Qiu HY,Fu JY,Yang MK,Han HW,Wang PF,Zhang YH,Lin HY,Tang CY,Qi JL,Yang RW,Wang XM,Zhu HL,Yang YH

更新日期：2017-12-15 00:00:00

abstract：:Endomorphin-2 (Tyr-Pro-Phe-PheNH(2)) was discovered as an endogenous ligand for the mu-opioid receptor. The physiological function of endomorphin-2 as a neurotransmitter or neuromodulator may cease through the rapid enzymatic process in the synapse of brain, as for other neuropeptides. The present study was conducted ...

journal_title：Biochemical pharmacology

authors： Sakurada C,Sakurada S,Hayashi T,Katsuyama S,Tan-No K,Sakurada T

更新日期：2003-08-15 00:00:00

abstract：:Cholesterol 7 alpha-hydroxylase (CH-7 alpha) activity in HepG2 cells depleted of glutathione (GSH) was reduced significantly (P < 0.05) compared to that in untreated controls. Northern blot analysis of poly A+ mRNA isolated from GSH-depleted and control HepG2 cells showed that there was a reduction in mRNA for CH-7 al...

journal_title：Biochemical pharmacology

authors： Hassan AS,Bunick D,Lund LA,Bottje WG

更新日期：1992-10-06 00:00:00