Protection by schisanhenol against adriamycin toxicity in rat heart mitochondria.


:The effects of schisanhenol (Sal) on Adriamycin (ADM)-induced rat heart mitochondrial toxicity in vitro were investigated. Malondialdehyde formation, lysis, disintegration and membrane rigidification in mitochondria treated with ADM were reduced significantly by Sal. In the electron spin resonance studies, Sal did not affect significantly the formation of ADM semiquinone radicals (AQ.), whereas hydroxyl radicals generated by electron transfer from H2O2 were scavenged by Sal dose dependently. These results indicate that Sal could protect against ADM-induced rat heart mitochondrial toxicity.


Biochem Pharmacol


Biochemical pharmacology


Lin TJ,Liu GT,Pan Y,Liu Y,Xu GZ




Has Abstract


1991-10-09 00:00:00














  • Regulatory effects of zinc and copper on the calcium transport system in rat liver nuclei. Relation to SH groups in the releasing mechanism.

    abstract::In isolated hepatic nuclei, the heavy metals Zn2+ and Cu2+ (10 microM) inhibited Ca2+ uptake and caused a prompt release of Ca2+ from preloaded nuclei in a concentration-dependent manner, with Zn2+ being more effective than Cu2+. The sulfhydryl group reducing agent dithiothreitol (DTT) protected the nuclei from the ef...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Yamaguchi M

    更新日期:1993-02-24 00:00:00

  • Inhibition of carcinogen-bioactivating cytochrome P450 1 isoforms by amiloride derivatives.

    abstract::We examined the effects of amiloride derivatives, especially 5-(N-ethyl-N-isopropyl)amiloride (EIPA), on the activity of cytochrome P450 (CYP) 1 isoforms, known to metabolize carcinogenic polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene (BP), into mutagenic metabolites and whose cellular expression can ...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Sparfel L,Huc L,Le Vee M,Desille M,Lagadic-Gossmann D,Fardel O

    更新日期:2004-05-01 00:00:00

  • The bone marrow microenvironment as a sanctuary for minimal residual disease in CML.

    abstract::Bcr-abl kinase inhibitors have provided proof of principal that targeted therapy holds great promise for the treatment of cancer. However, despite the success of these agents in treating chronic myelogenous leukemia (CML), the majority of patients continue to present with minimal residual disease contained within the ...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章,评审


    authors: Nair RR,Tolentino J,Hazlehurst LA

    更新日期:2010-09-01 00:00:00

  • Mouse brain opioid receptor identification by direct ultraviolet photoaffinity labeling.

    abstract::[3H]Morphine, PL-017[prolyl-3,4-3H,D-prolyl,3,4-3H] ([3H]PL-017) and enkephalin-(2-D-penicillamine,5-D-penicillamine)[tyrosyl-2,6-3H] ([3H]DPDPE) were directly cross-linked to mouse brain opiate receptors by an ultraviolet (254 nm) irradiation procedure. [3H]Morphine preferentially and specifically labeled a 58 kDa pr...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Nagamatsu K,Tagawa Y,Uchida S,Hasegawa A

    更新日期:1993-10-05 00:00:00

  • Nephrotoxicity of mercapturic acids of three structurally related 2,2-difluoroethylenes in the rat. Indications for different bioactivation mechanisms.

    abstract::The biotransformation and the hepato- and nephrotoxicity of the mercapturic acids (N-acetyl-1-cysteine S-conjugates) of three structurally related 2,2-difluoroethylenes were investigated in vivo in the rat. All mercapturic acids appeared to cause nephrotoxicity, without any measureable effect on the liver. The mercapt...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Commandeur JN,Brakenhoff JP,De Kanter FJ,Vermeulen NP

    更新日期:1988-12-01 00:00:00

  • Evidence for involvement of tyrosine phosphorylation in taxol-induced apoptosis in a human ovarian tumor cell line.

    abstract::Taxol is an antineoplastic agent with significant activity against ovarian as well as breast cancer. To investigate mechanisms by which taxol exerts its cytotoxic action, taxol-induced apoptosis, characterized by morphologic changes and internucleosomal DNA fragmentation, was examined in a human ovarian tumor cell lin...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Liu Y,Bhalla K,Hill C,Priest DG

    更新日期:1994-09-15 00:00:00

  • Dual cytotoxic mechanisms of submicromolar taxol on human leukemia HL-60 cells.

    abstract::Taxol-induced mitotic block and apoptosis were investigated using taxol-sensitive human leukemia HL-60 cells at submicromolar concentrations of the drug. Cells exposed to either 20 nM taxol for 1 hr or 10 nM taxol for 12 hr were able to resume normal growth, whereas cells exposed to 60 nM taxol for 1 hr or 10 nM taxol...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Lieu CH,Chang YN,Lai YK

    更新日期:1997-06-01 00:00:00

  • Derivatized dextrans modulate collagen synthesis in aortic smooth muscle cells.

    abstract::The effect of specifically derivatized dextrans, with or without antiproliferative activity on smooth muscle cells (SMC), was investigated on type I and type III collagen biosynthesis and mRNA levels in post-confluent SMC cultures. Our results indicate that dextran derivatives decreased total protein and collagen synt...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Benazzoug Y,Logeart D,Labat-Robert J,Robert L,Jozefonvicz J,Kern P

    更新日期:1995-03-15 00:00:00

  • DUP 785 (NSC 368390): schedule-dependency of growth-inhibitory and antipyrimidine effects.

    abstract::DUP 785 (NSC 368390; Brequinar sodium) is a new inhibitor of pyrimidine de novo biosynthesis with antitumor activity against several experimental tumors. DUP 785 inhibits the mitochondrial enzyme dihydroorotate dehydrogenase, blocking the conversion of dihydroorotate to orotate. We examined the influence of exposure t...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Schwartsmann G,Peters GJ,Laurensse E,de Waal FC,Loonen AH,Leyva A,Pinedo HM

    更新日期:1988-09-01 00:00:00

  • Methionine restriction selectively targets thymidylate synthase in prostate cancer cells.

    abstract::Tumor cells are more sensitive to methionine restriction than normal tissues, a phenomenon known as methionine auxotrophy. Previous studies showed that 5-fluorouracil and methionine restriction act synergistically against a variety of tumors. The purpose of the current studies was to determine the molecular mechanism(...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Lu S,Chen GL,Ren C,Kwabi-Addo B,Epner DE

    更新日期:2003-09-01 00:00:00

  • Participation of active oxygen species in 6-hydroxydopamine toxicity to a human neuroblastoma cell line.

    abstract::Catalase, superoxide dismutase, and dimethylsulfoxide were tested for their ability to prevent the cytotoxic effect of 6-hydroxydopamine (6-OHDA) on the human neuroblastoma line SY5Y. Viability was measured at two time points after 6-OHDA treatment: at 3 hr by means of amino acid incorporation and at 24 hr by trypan b...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Tiffany-Castiglioni E,Saneto RP,Proctor PH,Perez-Polo JR

    更新日期:1982-01-15 00:00:00

  • kappa-Opioid receptor recognition sites are not modulated by local anaesthetics.

    abstract::Local anaesthetics and opioid drugs function synergistically to provide analgesia. In the present study, the nature of this synergy has been investigated using in vitro radioligand binding to determine whether the local anaesthetics bupivacaine and tetracaine modulate the binding of two kappa-opioid receptor ligands, ...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Fraser GL,Fowler CJ

    更新日期:1995-03-30 00:00:00

  • Evaluation of in vitro PXR-based assays and in silico modeling approaches for understanding the binding of a structurally diverse set of drugs to PXR.

    abstract::The pregnane X-receptor (PXR) is a promiscuous nuclear receptor primarily responsible for the induction of genes from the cytochrome P450 3A family. In this study, we used a previously described PXR/SRC tethered protein to establish two in vitro assays for identifying PXR ligands: automated ligand identification syste...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Xiao L,Nickbarg E,Wang W,Thomas A,Ziebell M,Prosise WW,Lesburg CA,Taremi SS,Gerlach VL,Le HV,Cheng KC

    更新日期:2011-03-01 00:00:00

  • The use of corticosteroids encapsulated in erythrocytes in the treatment of adjuvant induced arthritis in the rat.

    abstract::Corticosteroid esters have been encapsulated into intact erythrocytes and used as an intravenous treatment for adjuvant induced arthritis in the rat. The treatment consisted of injections of the encapsulated steroids with the effects monitored for up to 14 days. On an equivalent weight basis both encapsulated cortisol...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Pitt E,Lewis DA,Offord RE

    更新日期:1983-11-15 00:00:00

  • On the specificity of verapamil as a calcium channel-blocker.

    abstract::The stimulated uptake of 45Ca2+ into incubated cerebrocortical synaptosomes caused by veratrine (75 microM) was blocked by low concentrations of verapamil (0.5-30 microM) which did not prevent or reduce depolarization as judged by efflux of potassium (K+). However, verapamil did not prevent amino acid neutrotransmitte...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Norris DK,Bradford HF

    更新日期:1985-06-01 00:00:00

  • Differentiation of human hepatoma cells during confluence as revealed by gene expression profiling.

    abstract::Certain human hepatocarcinoma cells undergo differentiation when grown at confluence. In order to understand the basis for this differentiation, we investigated the phenotypic changes occurring during confluent growth of the human hepatoma B16A2 cell line. The global gene expression profile of B16A2 cells grown during...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Butura A,Johansson I,Nilsson K,Wärngård L,Ingelman-Sundberg M,Schuppe-Koistinen I

    更新日期:2004-04-01 00:00:00

  • Inhibition of indoleamine 2,3-dioxygenase activity in IFN-gamma stimulated astroglioma cells decreases intracellular NAD levels.

    abstract::Astroglia provide essential metabolic and neurotropic support to cells within the CNS and participate in the cellular immune response with microglia/macrophages following activation by the pro-inflammatory cytokine IFN-gamma. Activation of glial cells results in local oxidative stress and induction of a number of prot...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Grant R,Kapoor V

    更新日期:2003-09-15 00:00:00

  • Dependence of endothelin-1 secretion on Ca2+.

    abstract::The role of Ca2+ and protein kinase C (PKC) activity in the release of immunoreactive endothelin-1 (ET-1) from cultured porcine aortic endothelial cells of first or second passage has been studied. ET-1 accumulation within cells and secretion into cell-conditioned medium over 3 and/or 5 hr was measured. Confluent cell...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Brunner F

    更新日期:1995-06-16 00:00:00

  • Flt3 is a target of coumestrol in protecting against UVB-induced skin photoaging.

    abstract::While skin aging is a naturally occurring process by senescence, exposure to ultraviolet (UV) radiation accelerates wrinkle formation and sagging of skin. UV induces skin aging by degrading collagen via activating matrix metalloproteinases (MMPs). In this study, we show that coumestrol, a metabolite of the soybean iso...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Park G,Baek S,Kim JE,Lim TG,Lee CC,Yang H,Kang YG,Park JS,Augustin M,Mrosek M,Lee CY,Dong Z,Huber R,Lee KW

    更新日期:2015-12-01 00:00:00

  • Evidence that relaxation of hog biliary muscle is mediated by the interaction between the protein inhibitor of cyclic AMP dependent protein kinase and cholecystokinin C-terminal peptides.

    abstract::The interaction of various cholecystokinin (CCK) peptides with the protein inhibitor (PK-I) of cyclic AMP dependent protein kinase (A-PK) has been studied. The order of the affinities (ED50) for relaxation of hog biliary muscle by a series of C-terminal peptides of CCK correlated with the order of the potencies for A-...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Kimura M,Kobayashi S,Kimura I

    更新日期:1983-03-01 00:00:00

  • Distamycin inhibits the binding of a nuclear factor to the -278/-256 upstream sequence of the human HLA-DR alpha gene.

    abstract::In this study we analyse the effects of the anti-tumor compound distamycin on the binding of nuclear factor(s) to a synthetic oligonucleotide (GTATA/IFN-gamma) mimicking a putative regulatory region of the human HLA-DR alpha gene. This region contains the sequence (GTATA), that is required for nuclear protein binding ...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Gambari R,Barbieri R,Nastruzzi C,Chiorboli V,Feriotto G,Natali PG,Giacomini P,Arcamone F

    更新日期:1991-02-15 00:00:00

  • Similar pyruvate kinase modifications in glioblastoma cells by 7β-hydroxycholesterol and glutamine withdrawal.

    abstract::Oxysterols possess anti-proliferative properties that may be used with much effect in the treatment of cancer. We have demonstrated previously that 7 beta-hydroxycholesterol (7b-HC) provokes both metabolic stress, as witnessed by AMPK activation, and changes in lipid raft composition in C6 glioblastoma cells. These ob...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: de Weille J,Fabre C,Gaven C,Bakalara N

    更新日期:2013-07-01 00:00:00

  • Alteration of rat liver endoplasmic reticulum Ca(2+)-ATPase thiol integrity by ciprofibrate, a peroxisome proliferator.

    abstract::Ciprofibrate (CP), a peroxisome proliferator, has been shown to reduce rat liver endoplasmic reticulum (ER) Ca(2+)-ATPase activity both in vitro and in vivo. The ER Ca(2+)-ATPase is highly susceptible to thiol reactivity, and maintenance of maximal enzyme activity is critically dependent upon the integrity of these th...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Bennett AM,Williams GM

    更新日期:1993-05-25 00:00:00

  • Cyclic AMP response element-binding protein (CREB) phosphorylation: a mechanistic marker in the development of memory enhancing Alzheimer's disease therapeutics.

    abstract::CREB-mediated transcription can be initiated by membrane receptor stimulation and subsequent activation of intracellular pathways to the cell nucleus, and has been described as a molecular switch required for learning and memory. While CREB dimers are thought to be constitutively bound to response elements on DNA unde...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Scott Bitner R

    更新日期:2012-03-15 00:00:00

  • 5-Substituted 2'-deoxyuridines: correlation between inhibition of tumor cell growth and inhibition of thymidine kinase and thymidylate synthetase.

    abstract::A large variety of 5-substituted 2'deoxyuridines (dUrds) and 2'-deoxyuridylates (dUMPs) have been evaluated for their inhibitory effects on the thymidine (dThd) kinase or thymidylate (dTMP) synthetase isolated from mouse leukemia L1210 cells. The most potent inhibitors of dThd kinase were 5-chloro-, 5-bromo- and 5-iod...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Balzarini J,De Clercq E,Mertes MP,Shugar D,Torrence PF

    更新日期:1982-11-15 00:00:00

  • Dipyridamole analogs as pharmacological inhibitors of equilibrative nucleoside transporters. Identification of novel potent and selective inhibitors of the adenosine transporter function of human equilibrative nucleoside transporter 4 (hENT4).

    abstract::To identify needed human equilibrative nucleoside transporter 4 (hENT4) inhibitors, we cloned and stably expressed the recombinant protein in PK15NTD (nucleoside transporter deficient) cells, and, investigated its interaction with a series of dipyridamole analogs synthesized in our laboratory. Compounds were tested in...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Wang C,Lin W,Playa H,Sun S,Cameron K,Buolamwini JK

    更新日期:2013-12-01 00:00:00

  • In vitro formation of glutathione conjugates of the dimethylester of bilirubin.

    abstract::Rat hepatic microsomes catalyzed the formation of two distinct glutathione conjugates of bilirubin dimethylester (DMB). The two conjugates were identical to those isolated from the bile of Gunn rats infused with DMB. The microsomal reaction was dependent on NADPH, oxygen and glutathione and was inhibited by nitrogen a...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Shore LJ,Mogilevsky WS,Smith PB,Fenselau C,Odell GB

    更新日期:1991-10-24 00:00:00

  • Potent and selective hydroxynaphthoquinone inhibitors of mitochondrial electron transport in Eimeria tenella (Apicomplexa: Coccidia).

    abstract::Novel hydroxynaphthoquinones have been shown to be potent and selective inhibitors of mitochondrial electron transport in the protozoan Eimeria tenella, inhibiting at concentrations of 10(-10) to 10(-11)M. The primary site of electron transport inhibition has been localized to the ubiquinol-cytochrome c reductase span...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Fry M,Hudson AT,Randall AW,Williams RB

    更新日期:1984-07-01 00:00:00

  • Differences in the biochemical properties of aldrin epoxidase, a cytochrome P-450-dependent monooxygenase, in various tissues.

    abstract::Aldrin epoxidase, a cytochrome P-450-dependent monooxygenase, was studied in the lung and kidney of male rats. The sensitivity of the liver enzyme activity to different chemicals in vitro was influenced by the treatment of the animals with phenobarbital or methylcholanthrene. These results confirm that more than one f...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Van Cantfort J,Léonard-Poma M,Sèle-Doyen J,Gielen JE

    更新日期:1983-09-15 00:00:00

  • Stereoselective and substrate-dependent inhibition of hepatic mitochondria beta-oxidation and oxidative phosphorylation by the non-steroidal anti-inflammatory drugs ibuprofen, flurbiprofen, and ketorolac.

    abstract::Non-steroidal anti-inflammatory drugs (NSAIDs) cause a range of adverse effects, some of which have been associated with perturbances of lipid metabolic pathways. Previous data demonstrating stereoselective formation of the CoA thioester of R-ibuprofen in particular were suggestive of possible stereoselective effects ...

    journal_title:Biochemical pharmacology

    pub_type: 杂志文章


    authors: Browne GS,Nelson C,Nguyen T,Ellis BA,Day RO,Williams KM

    更新日期:1999-04-01 00:00:00