Protection by schisanhenol against adriamycin toxicity in rat heart mitochondria.

abstract：:The influence of delta 9-tetrahydrocannabinol (delta 9-THC) on the cellular levels of histone mRNAs and ribosomal RNAs was examined in several normal and transformed human cell lines--HeLa S3 cells, WI-38 human diploid fibroblasts, SV40-transformed WI-38 cells, and A549 lung carcinoma cells. RNA sequences were quantit...

journal_title：Biochemical pharmacology

authors： Green LG,Stein JL,Stein GS

更新日期：1984-04-01 00:00:00

abstract：:Alpha2-adrenoceptor agents as well as stress affect the activity of several hepatic monoxygenases including those related to CYP1A enzymes. This study was therefore designed to assess the role of central and/or peripheral catecholamines and, in particular, of adrenoceptors in the regulation of B(alpha)P-induced cytoch...

journal_title：Biochemical pharmacology

authors： Konstandi M,Kostakis D,Harkitis P,Marselos M,Johnson EO,Adamidis K,Lang MA

更新日期：2005-01-15 00:00:00

abstract：:PepT1 (SLC15A1) is a high-capacity low-affinity transporter that is important in the absorption of digested di/tripeptides from dietary protein in the small intestine. PepT1 is also crucial for the intestinal uptake and absorption of therapeutic agents such as the β-lactam aminocephalosporins and antiviral prodrugs. S...

journal_title：Biochemical pharmacology

authors： Hu Y,Smith DE

更新日期：2016-05-01 00:00:00

abstract：:It has been reported that chelerythrine chloride, a benzophenanthridine alkaloid, with a wide variety of biologic effects stimulates the phosphorylation of an approximately 20 kDa protein present in the mitochondrial fraction of the rat retina. It has also been shown previously that both the serine and threonine resid...

journal_title：Biochemical pharmacology

authors： Lombardini JB

更新日期：1996-07-26 00:00:00

abstract：:The mammalian thioredoxin reductase (TrxR) isoenzymes, TrxR1 in cytosol or nucleus, TrxR2 in mitochondria, and TrxR3 in testis, are essential seleno-flavoenzymes with a conserved penultimate selenocysteine (Sec) residue at the C-terminus, and have attracted increasing interests as potential targets for development of ...

journal_title：Biochemical pharmacology

authors： Zhang J,Li Y,Duan D,Yao J,Gao K,Fang J

更新日期：2016-02-15 00:00:00

abstract：:The remarkable effects exhibited by classical psychedelics in recent clinical trials have spawned considerable interest in 5-HT2A receptor (5-HT2AR) activation as a treatment strategy for several psychiatric/cognitive disorders. In this study we have continued our development of 25CN-NBOH, one of the most 5-HT2AR-sele...

journal_title：Biochemical pharmacology

authors： Jensen AA,Halberstadt AL,Märcher-Rørsted E,Odland AU,Chatha M,Speth N,Liebscher G,Hansen M,Bräuner-Osborne H,Palner M,Andreasen JT,Kristensen JL

更新日期：2020-07-01 00:00:00

abstract：:Plasma hyaluronan (HA) concentration and the rate of HA uptake by the isolated, perfused liver were measured in rats treated with saline, D-galactosamine (GaI-NH2, 50 mg/100 g body wt), gadolinium chloride (GdCl3) (0.5 mg/100 g body wt), and GdCl3 + GaI-NH2. GdCl3 was given 24 hr before GaI-NH2 or saline. Plasma L-ala...

journal_title：Biochemical pharmacology

authors： Deaciuc IV,Bagby GJ,Spitzer JJ

更新日期：1993-08-17 00:00:00

abstract：:The mechanisms by which amiloride and 4,4'-diisothiocyano-2,2'-disulfonic stilbene (DIDS) inhibit hepatic uptake of cholate and taurocholate (TC) were investigated in isolated rat hepatocytes. Amiloride inhibited Na(+)-dependent uptake of cholate and TC only when hepatocytes were preincubated with amiloride, indicatin...

journal_title：Biochemical pharmacology

authors： Anwer MS,Branson AU,Atkinson JM

更新日期：1991-12-11 00:00:00

abstract：:Nicotinic acetylcholine receptors (nAChRs) are widely distributed throughout the central nervous system, being expressed in neurons and non-neuronal cells, where they participate in a variety of physiological responses like memory, learning, locomotion, attention, among others. We will focus on the α7 nAChR subtype, w...

journal_title：Biochemical pharmacology

authors： Egea J,Buendia I,Parada E,Navarro E,León R,Lopez MG

更新日期：2015-10-15 00:00:00

abstract：:Angiogenesis has emerged as a critical process for tumour progression. Identifying key pathways involved in the regulation and promotion of angiogenesis has resulted in the development of numerous approaches targeting pro-angiogenic signalling pathways. The most prominent and characterised pro-angiogenic pathway is th...

journal_title：Biochemical pharmacology

authors： Bridges EM,Harris AL

更新日期：2011-05-15 00:00:00

abstract：:Metformin, a commonly used agent in the treatment of type 2 diabetes, is also associated with reduced risk of cancer development and improvement in cancer survival. Although much is known about metformin, the mechanisms behind its anti-cancer properties are not fully understood. In this study we addressed the role of ...

journal_title：Biochemical pharmacology

authors： Zhao Q,Zhou X,Curbo S,Karlsson A

更新日期：2018-10-01 00:00:00

abstract：:In eukaryotic cells, the DNA molecule is found in the form of a nucleoprotein complex named chromatin. The basic unit of the chromatin is the nucleosome, which comprises 147 base pairs of DNA wrapped around an octamer of core histones (made of two molecules of each H2A, H2B, H3, and H4 histones). Each nucleosome is li...

journal_title：Biochemical pharmacology

authors： Quina AS,Buschbeck M,Di Croce L

更新日期：2006-11-30 00:00:00

abstract：:Rats treated with six to eight doses (80 mg/kg, i.p.) of 4-pentenoic acid, an inhibitor of mitochondrial fatty acid oxidation in vitro, during a 48-hr starvation period developed microvesicular fatty infiltration of the liver similar to that observed in Reye's Syndrome. Hepatic triglycerides were elevated an average o...

journal_title：Biochemical pharmacology

authors： Thayer WS

更新日期：1984-04-15 00:00:00

abstract：:Epothilones constitute a novel class of antitubulin agents that are active in patients who relapse after treatment with other chemotherapeutics. This study investigated the molecular mechanisms leading to the onset of epothilone-B (patupilone) resistance in ovarian cancer. Results demonstrated that the Gli family of t...

journal_title：Biochemical pharmacology

authors： Mozzetti S,Martinelli E,Raspaglio G,Prislei S,De Donato M,Filippetti F,Shahabi S,Scambia G,Ferlini C

更新日期：2012-12-01 00:00:00

abstract：:Sepsis is an etiologically complex and often fatal inflammatory process involving a multitude of cytokine signaling pathways. Tumor necrosis factor α (TNFα) acts as a central regulator of the acute-phase inflammatory response by recruiting immune cells, including circulating monocyte/macrophages, to sites of infection...

journal_title：Biochemical pharmacology

authors： Terashima-Hasegawa M,Ashino T,Kawazoe Y,Shiba T,Manabe A,Numazawa S

更新日期：2019-01-01 00:00:00

abstract：:The effect of bucillamine (BA) on glutathione (GSH) and GSH-related enzymes was investigated in C57 mouse. Administration of high doses of BA (150-400 mg/kg) produced a dose-dependent depletion (20-44%) of hepatic GSH, which was similar in magnitude to that produced by equimolar doses of other sulphydryl drugs studied...

journal_title：Biochemical pharmacology

authors： Yeung JH

更新日期：1991-07-25 00:00:00

abstract：:We have demonstrated that the simplest steady-state random sequential Bi Bi mechanism is sufficient to explain the previously reported non-hyperbolic kinetics of glutathione S-transferase 3-3 [Pabst MJ et al., J Biol Chem 249: 7140-7150, 1974; Jakobson I et al., Biochem J 177: 861-868, 1979]. The metabolism of 1-chlor...

journal_title：Biochemical pharmacology

authors： Ivanetich KM,Goold RD,Sikakana CN

更新日期：1990-06-15 00:00:00

abstract：:Vanadate (VO3-) was found to activate adenylyl cyclase (AC) in ocular ciliary process membrane. This response was additive to that of isoproterenol (ISO) and vasoactive intestinal peptide (VIP), but it was potentiative with forskolin (FSK) and also with Ca2+/calmodulin activation of AC activity. The potentiated respon...

journal_title：Biochemical pharmacology

authors： Mittag TW,Guo WB,Taniguchi T

更新日期：1993-03-24 00:00:00

abstract：:Dichlorodi[U-14C]phenyltrichloroethane ( [14C]DDT), incubated with rat hepatic microsomes and NADPH, produced reactive intermediates which covalently bound to microsomal protein and lipids. In atmospheric oxygen, DDT bound to microsomal protein; however, binding was increased up to approximately 70% by oxygen depletio...

journal_title：Biochemical pharmacology

authors： Baker MT,Van Dyke RA

更新日期：1984-01-15 00:00:00

abstract：:This review has highlighted some of the well-described differences in endothelial cells derived from different sites of the vascular tree. In presenting a select group of endothelial properties, there was no intention to imply that these are the only properties of endothelial cells that exhibit heterogeneity. Nonethel...

journal_title：Biochemical pharmacology

authors： Gerritsen ME

更新日期：1987-09-01 00:00:00

abstract：:We reported previously that the flavoprotein inhibitor diphenyleneiodonium sulfate (DPI) irreversibly inhibited the metabolic activation of glyceryl trinitrate (GTN) in isolated aorta, possibly through inhibition of vascular NADPH-cytochrome P450 reductase (CPR). We report that the content of CPR represents 0.03 to 0....

journal_title：Biochemical pharmacology

authors： McGuire JJ,Anderson DJ,McDonald BJ,Narayanasami R,Bennett BM

更新日期：1998-10-01 00:00:00

abstract：:An intestinal active transport system specific to small peptides and peptide-like drugs such as beta-lactam antibiotics was functionally expressed in Xenopus laevis oocytes after microinjection of messenger RNA (mRNA) derived from rat intestinal mucosal cells. The transport activity was evaluated by measuring the upta...

journal_title：Biochemical pharmacology

authors： Tamai I,Tomizawa N,Kadowaki A,Terasaki T,Nakayama K,Higashida H,Tsuji A

更新日期：1994-08-30 00:00:00

abstract：:Studies have been carried out to analyze the phosphoprotein composition of plasma membranes from Chinese hamster lung cells resistant to the action of adriamycin. Gel electrophoretic analysis of [32Pi]-labeled proteins revealed that plasma membranes from resistant cells contain a phosphoprotein of 180,000 molecular we...

journal_title：Biochemical pharmacology

authors： Garman D,Albers L,Center MS

更新日期：1983-12-01 00:00:00

abstract：:Treatment of rat parotid acinar cells with 4 beta-phorbol 12-myristate 13-acetate (PMA) significantly inhibited an increase in cytosolic free Ca2+ concentration ([Ca2+]i) induced by carbachol (CCh), a muscarinic agonist. The CCh-induced increase in [Ca2+]i was also inhibited by another active phorbol ester, 4 beta-pho...

journal_title：Biochemical pharmacology

authors： Tojyo Y,Tanimura A,Matsumoto Y

更新日期：1994-06-01 00:00:00

abstract：:Naturally soluble rat germ cell adenylate cyclase was inhibited by adenosine and the adenosine analogs, 9-beta-D-arabinofuranosyl adenine (AFA) and 2',5'-dideoxyadenosine (DDA), all of which inhibited hormone-sensitive adenylate cyclases at the "P" site. The IC50 values for adenosine and DDA were approximately 0.1 and...

journal_title：Biochemical pharmacology

authors： Onoda JM,Braun T,Wrenn SM Jr

更新日期：1987-06-15 00:00:00

abstract：:The antiinflammatory effect of superoxide dismutase was studied in rats with kidney intoxication induced by the injection of nephrotoxic serum. The urinary excretion of protein was increased significantly by the administration of an intravenous injection of nephrotoxic serum. The daily injection of superoxide dismutas...

journal_title：Biochemical pharmacology

authors： Adachi T,Fukuta M,Ito Y,Hirano K,Sugiura M,Sugiura K

更新日期：1986-01-15 00:00:00

abstract：:Chemokine receptor (CKR) signaling forms the basis of essential immune cellular functions, and dysregulated CKR signaling underpins numerous disease processes of the immune system and beyond. CKRs, which belong to the seven transmembrane domain receptor (7TMR) superfamily, initiate signaling upon binding of endogenous...

journal_title：Biochemical pharmacology

authors： Kleist AB,Getschman AE,Ziarek JJ,Nevins AM,Gauthier PA,Chevigné A,Szpakowska M,Volkman BF

更新日期：2016-08-15 00:00:00

abstract：:It was shown recently that the antiaggregating agent ticlopidine and some of its analogues inhibit the energy-conserving mechanism in mitochondria [Abou-Khalil et al., Biochem. Pharmac. 33, 3893 (1984)]. In the present investigation, the mechanism of inhibition by these drugs was investigated by studying their effects...

journal_title：Biochemical pharmacology

authors： Abou-Khalil S,Abou-Khalil WH,Yunis AA

更新日期：1986-06-01 00:00:00

abstract：:Pyridine N-oxide derivatives represent a new class of anti-HIV compounds for which some members exclusively inhibit HIV-1 RT, whereas other members act, additionally or alternatively, at a post-integrational event in the replicative cycle of HIV. A prototype pyridine N-oxide derivative, JPL-32, inhibited tumor necrosi...

journal_title：Biochemical pharmacology

authors： Stevens M,Pannecouque C,De Clercq E,Balzarini J

更新日期：2006-04-14 00:00:00

abstract：:Bupropion is a widely used antidepressant and smoking cessation aid and a strong inhibitor of CYP2D6 in vivo. Bupropion is administered as a racemic mixture of R- and S-bupropion and has stereoselective pharmacokinetics. Four primary metabolites of bupropion, threo- and erythro-hydrobupropion and R,R- and S,S-OH-bupro...

journal_title：Biochemical pharmacology

authors： Sager JE,Tripathy S,Price LS,Nath A,Chang J,Stephenson-Famy A,Isoherranen N

更新日期：2017-01-01 00:00:00