Inflammatory biomarkers and cardiovascular risk: association or cause and effect?

Abstract:

:With the current understanding that atherosclerosis is an inflammatory disorder, markers of the associated systemic inflammatory response have been extensively studied as predictors of cardiovascular disease. Recently the use of high-sensitivity C-reactive protein (hsCRP) has been proposed for risk assessment in individuals at intermediate risk of coronary heart disease. The traditional view of inflammatory biomarkers, including CRP, regards them as risk markers rather than risk factors. Either category of marker would serve a diagnostic role, monitor disease activity, and indicate the efficacy of therapy or changing prognosis. However a risk factor with a causal role would be a potential target for therapy. This review discusses the available evidence that argues for and against a causal role for inflammatory biomarkers, with specific reference to CRP, in the atherosclerotic process.

journal_name

Semin Dial

journal_title

Seminars in dialysis

authors

Rao M,Jaber BL,Balakrishnan VS

doi

10.1111/j.1525-139X.2006.00138.x

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

129-35

issue

2

eissn

0894-0959

issn

1525-139X

pii

SDI138

journal_volume

19

pub_type

杂志文章,评审
  • Withholding and withdrawing renal support in acute kidney injury.

    abstract::Management of critically ill patients with acute kidney injury (AKI) is mainly limited to supportive therapy, with dialysis as one of the main components. Whether or not to offer dialysis and when to withdraw dialysis is a one of the many choices physicians face in daily clinical practice. Withholding or withdrawing r...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1525-139X.2011.00832.x

    authors: Claure-Del Granado R,Mehta RL

    更新日期:2011-03-01 00:00:00

  • Highlights and hotspots of protein glycation in end-stage renal disease.

    abstract::Analysis of tissues, plasma, urine, other body fluids, and dialysate for glycation adducts has revealed the presence of two major forms: glycation adduct residues of proteins and related glycated amino acids--called glycation free adducts. The major effect on protein glycation in uremia is loss of clearance of glycati...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1525-139X.2009.00589.x

    authors: Thornalley PJ,Rabbani N

    更新日期:2009-07-01 00:00:00

  • The impact of arteriovenous fistulae on the myocardium: the impact of creation and ligation in the transplant era.

    abstract::Cardiac hypertrophy is a relatively common complication seen in patients with advanced chronic kidney disease (CKD) and end-stage renal disease (ESRD). Moreover, cardiac hypertrophy is even more frequently seen in patients with ESRD who have an arteriovenous (AV) access. There has been substantial evidence pertaining ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/sdi.12313

    authors: Duque JC,Gomez C,Tabbara M,Alfonso CE,Li X,Vazquez-Padron RI,Asif A,Lenz O,Briones PL,Salman LH

    更新日期:2015-05-01 00:00:00

  • Beta blockers in patients with end-stage renal disease-Evidence-based recommendations.

    abstract::For patients who require hemodialysis, beta blockers offer a simultaneous opportunity and challenge in the treatment of cardiovascular disease. Beta blockers are well supported by data from nondialysis populations and directly mitigate the sympathetic overactivity that links chronic kidney disease with cardiovascular ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/sdi.12691

    authors: Weir MA,Herzog CA

    更新日期:2018-05-01 00:00:00

  • Use of androgens in patients with renal failure.

    abstract::Anabolic steroids have been used for the treatment of the anemia of chronic renal failure for more than 25 years. Due to concerns over adverse effects, their use historically has been limited to nandrolone decanoate given to men, usually over age 50, who have intact kidneys. The introduction of epoetin alfa in 1989 ha...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1046/j.1525-139x.2000.00011.x

    authors: Johnson CA

    更新日期:2000-01-01 00:00:00

  • The risk of sedation/analgesia in hemodialysis patients undergoing interventional procedures.

    abstract::Data derived from a large cohort of hemodialysis patients (12,896) undergoing dialysis access maintenance procedures being performed by interventional nephrologists were analyzed to determine the safety of sedation/analgesia (S/A) in a freestanding facility. Data collected included patient demographics, procedures per...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1111/j.1525-139X.2011.00844.x

    authors: Beathard GA,Urbanes A,Litchfield T,Weinstein A

    更新日期:2011-01-01 00:00:00

  • Functional Assessment in End-Stage Renal Disease: Enhancing Quality of Life.

    abstract::Why do functional assessments in patients with end-stage renal disease (ESRD) matter? Multiple studies show that new dialysis patients undergo a substantial decline among activities of daily living. Moreover, poor functional status in ESRD patients is associated with early morality. That is why CMS has developed new c...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1111/sdi.12466

    authors: Saby A,Miller LS

    更新日期:2016-03-01 00:00:00

  • Therapeutic plasma exchange for renal-related conditions in the elderly: ten years experience in one center.

    abstract::The elderly people, 65 years old and above, are growing in number. The structural and functional changes associated with aging place the elderly at risk when challenged by extracorporeal therapies, such as therapeutic plasma exchange (TPE). We retrospectively analyzed data on all patients who underwent TPE for renal i...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1111/j.1525-139X.2011.01027.x

    authors: Hayes JS,Balogun RA,Chang J,Abdel-Rahman EM

    更新日期:2012-03-01 00:00:00

  • Platelet dysfunction and end-stage renal disease.

    abstract::Patients with end-stage renal disease (ESRD) develop hemostatic disorders mainly in the form of bleeding diatheses. Hemorrhage can occur at cutaneous, mucosal, or serosal sites. Retroperitoneal or intracranial hemorrhages also occur. Platelet dysfunction is the main factor responsible for hemorrhagic tendencies in adv...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1525-139X.2006.00179.x

    authors: Kaw D,Malhotra D

    更新日期:2006-07-01 00:00:00

  • Anemia management in cancer patients with chronic kidney disease.

    abstract::Cancer and kidney disease are linked by causality and comorbidities. Observational data show an increased risk of malignancy as renal function declines. Erythropoietin stimulating agents (ESAs), which are the cornerstone therapy for anemia patients with chronic kidney disease and cancer, are associated with increased ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/sdi.12841

    authors: Latcha S

    更新日期:2019-11-01 00:00:00

  • Thigh grafts: a preferable alternative to catheters when upper extremity access sites are exhausted.

    abstract::Hemodialysis patients with failed upper extremity (arm) access sites comprise 5-10% of the dialysis population. In these patients, arm vessels are either unsuitable for access placement due to trauma or peripheral vascular disease, or have been exhausted following dialysis usage. Synthetic grafts in the lower extremit...

    journal_title:Seminars in dialysis

    pub_type: 社论

    doi:10.1111/j.1525-139X.2009.00613.x

    authors: Abreo KD,Ram SJ

    更新日期:2009-09-01 00:00:00

  • APD in the elderly.

    abstract::Few elderly patients with end-stage renal disease (ESRD) are treated with peritoneal dialysis (PD). Among dialysis patients >or=65 years of age reported by the U.S. Renal Data System (USRDS), the percentage treated with chronic peritoneal dialysis (CPD) is lower than in any other age group. To evaluate the effectivene...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1046/j.1525-139x.2002.00106.x

    authors: Kadambi P,Troidle L,Gorban-Brennan N,Kliger AS,Finkelstein FO

    更新日期:2002-11-01 00:00:00

  • Antidiabetic Therapy in End-Stage Renal Disease.

    abstract::There has been substantial growth in the variety of available antidiabetic agents during the last decade and a half. The role of these newer agents in patients with diabetes and end-stage renal disease (ESRD) population, and their relative benefits and risks in this population compared to patients without ESRD are not...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/sdi.12368

    authors: Boyle SM,Simon B,Kobrin SM

    更新日期:2015-07-01 00:00:00

  • The use of iodinated contrast media in patients with end-stage renal disease.

    abstract::Iodinated contrast agents are well tolerated in ESRD patients. Certain types of ICM, i.e., LOCM and the nonionic agents are associated with better safety profiles. Current available evidence, although not optimal, does not support the need for additional hemodialysis for ICM removal to preserve residual renal function...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1111/sdi.12268

    authors: Khan SF,Kalantari K

    更新日期:2014-11-01 00:00:00

  • Cardiovascular abnormalities and hypertension in the elderly dialysis patient.

    abstract::Elderly individuals comprise an ever-increasing proportion of patients on renal replacement therapy (RRT). As in younger patients, cardiovascular events are the major cause of death in the elderly on RRT, although the relative proportion succumbing to cardiovascular events is similar to that in young patients. An impo...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1046/j.1525-139x.2002.00037.x

    authors: Dikow R,Zeier M,Ritz E

    更新日期:2002-03-01 00:00:00

  • We Offer Renal Replacement Therapy to Patients Who Are Not Benefitted by It.

    abstract::Nephrologists offer renal replacement therapy (RRT) to patients who are unlikely to benefit in part because of our discomfort discussing goals of care in the setting of an uncertain prognosis for a given individual. Permanent neurological impairment, terminal illness (life expectancy <6 months), medical conditions pre...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1111/sdi.12492

    authors: Holley JL

    更新日期:2016-07-01 00:00:00

  • Hemodialysis for the treatment of severe accidental hypothermia.

    abstract::Severe hypothermia is defined as a core body temperature <28°C and is associated with in-hospital mortality rates of 50% or higher. Delays in rewarming and slower rates of rewarming are the most important prognostic factors associated with increased mortality. Arrhythmias are the most common cause of mortality in pati...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1111/sdi.12156

    authors: Singh T,Hallows KR

    更新日期:2014-05-01 00:00:00

  • Complications of continuous renal replacement therapy.

    abstract::Continuous renal replacement therapy (CRRT) is commonly used in critically ill patients with acute kidney injury. Many studies show that compared with intermittent hemodialysis, continuous therapy has superior hemodynamic stability, metabolic clearance, and volume control. Despite these benefits, no survival advantage...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1525-139X.2008.00550.x

    authors: Finkel KW,Podoll AS

    更新日期:2009-03-01 00:00:00

  • Niacin and related compounds for treating hyperphosphatemia in dialysis patients.

    abstract::Recent experimental and clinical studies suggest the possible utility of niacin (nicotinic acid, vitamin B3) and its metabolite nicotinamide as a means of lowering phosphate levels in dialysis patients via direct inhibition of the Na-Pi-2b sodium-dependent phosphate co-transporter in the GI tract. While the possibilit...

    journal_title:Seminars in dialysis

    pub_type: 社论

    doi:10.1111/j.1525-139X.2008.00426.x

    authors: Berns JS

    更新日期:2008-05-01 00:00:00

  • Pulmonary hypertension in hemodialysis patients: an unrecognized threat.

    abstract::Pulmonary hypertension (PH) is a progressive, fatal pulmonary circulatory disease that accompanies many conditions (including left to right side shunt) with compensatory elevated cardiac output. PH also complicates chronic hemodialysis (HD) therapy immediately after the creation of an arteriovenous (AV) access, even b...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1525-139X.2006.00186.x

    authors: Yigla M,Abassi Z,Reisner SA,Nakhoul F

    更新日期:2006-09-01 00:00:00

  • Policies to promote timely referral for kidney transplantation.

    abstract::There are numerous patient, provider, and health system barriers to accessing kidney transplantation. Patient barriers such as sociocultural and clinical characteristics and provider factors such as provider knowledge and awareness of transplantation play important roles in facilitating transplant. Health system facto...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1111/sdi.12860

    authors: Patzer RE,Pastan SO

    更新日期:2020-01-01 00:00:00

  • Ultrapure dialysate: a desirable and achievable goal for routine hemodialysis.

    abstract::United States standards for the microbiologic quality of dialysate are not very stringent and have remained unchanged for more than 20 years, despite significant changes in the patient population and in the technology of hemodialysis. Numerous studies have demonstrated that bacterial products can cross dialysis membra...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1046/j.1525-139x.2000.00103.x

    authors: Ward RA

    更新日期:2000-11-01 00:00:00

  • Are dialysate sodium levels too high?

    abstract::Universal lower dialysate [Na+] is often advocated as a means of improving the dire cardiovascular plight of our dialysis patients. However, there is evidence associating lower dialysate [Na+] and increased morbidity and mortality especially in frailer patients, probably as a result of more frequent intra-dialytic hyp...

    journal_title:Seminars in dialysis

    pub_type: 社论

    doi:10.1111/j.1525-139X.2012.01072.x

    authors: Marshall MR,Dunlop JL

    更新日期:2012-05-01 00:00:00

  • The impact of dialysis modality and membrane characteristics on intradialytic hypotension.

    abstract::The risk of intradialytic hypotension (IDH) is determined by various factors, among them dialysis modality and dialyzer membrane. We conducted a literature search in PubMed on November 1, 2016 and selected relevant randomized controlled and cross-over trials, and prospective and retrospective cohort studies published ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/sdi.12636

    authors: Patel S,Raimann JG,Kotanko P

    更新日期:2017-11-01 00:00:00

  • Surface-area-normalized Kt/V: a method of rescaling dialysis dose to body surface area-implications for different-size patients by gender.

    abstract::Dialysis is measured as Kt/V, which scales the dose (Kt) to body water content (V). Scaling dialysis dose to body surface area (S(dub)) has been advocated, but the implications of such rescaling have not been examined. We developed a method of rescaling measured Kt/V to S(dub) and studied the effect of such alternativ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1111/j.1525-139X.2008.00482.x

    authors: Daugirdas JT,Depner TA,Greene T,Kuhlmann MK,Levin NW,Chertow GM,Rocco MV

    更新日期:2008-09-01 00:00:00

  • Vancomycin use in patients requiring hemodialysis: a literature review.

    abstract::Vancomycin, a glycopeptide antibiotic, has remained a popular antimicrobial agent throughout the past five decades, and is often included in empiric antibiotic regimens. With gram-positive coverage, it has found a niche in the treatment of methicillin-resistant Staphylococcus aureus. Although vancomycin has been in ex...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1525-139X.2007.00333.x

    authors: Pallotta KE,Manley HJ

    更新日期:2008-01-01 00:00:00

  • Clinical experience with continuous flow and flow-through peritoneal dialysis.

    abstract::Concern over the inherent inefficiency of solute removal by conventional peritoneal dialysis (PD) has led to renewed interest in continuous flow PD (CFPD). We present clinical data from two experiences with CFPD. In the first, two catheters were used to recirculate a fixed intraperitoneal volume through an external ci...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1046/j.1525-139x.2001.00099.x

    authors: Amerling R,DeSimone L,Inciong-Reyes R,Pangilinan A,Folden T,Ronco C,Gotch FA,Levin N

    更新日期:2001-09-01 00:00:00

  • What the non-nephrologist needs to know about dialysis.

    abstract::The End-Stage Renal Disease (ESRD) program now serves approximately 675,000 individuals in the United States at a cost of $26.1 billion to the Medicare system. Given the size of this population, healthcare providers from all disciplines will deliver care to patients on dialysis. Mortality remains high among patients o...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/sdi.12671

    authors: Foy M,Sperati CJ

    更新日期:2018-03-01 00:00:00

  • Longitudinal assessment of hemodynamic endpoints in predicting arteriovenous fistula maturation.

    abstract::Arteriovenous fistula (AVF) nonmaturation is currently a significant clinical problem; however, the mechanisms responsible for this have remained unanswered. Previous work by our group and others has suggested that anatomical configuration and the corresponding hemodynamic endpoints could have an important role in AVF...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1111/j.1525-139X.2012.01112.x

    authors: Rajabi-Jagahrgh E,Krishnamoorthy MK,Roy-Chaudhury P,Succop P,Wang Y,Choe A,Banerjee RK

    更新日期:2013-03-01 00:00:00

  • An Unusual yet "Mg"nificent Indication for Hemodialysis.

    abstract::Hypermagnesemia is an uncommon electrolyte abnormality, due to the fact that magnesium toxicity is only seen in the setting of a massive exposure to exogenous magnesium, often in the setting of renal insufficiency. Here, we report a case of severe hypermagnesemia that resulted in complete paralysis that was secondary ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1111/sdi.12479

    authors: Bansal AD,Negoianu D,Warburton KM

    更新日期:2016-05-01 00:00:00