Antidiabetic Therapy in End-Stage Renal Disease.

Abstract:

:There has been substantial growth in the variety of available antidiabetic agents during the last decade and a half. The role of these newer agents in patients with diabetes and end-stage renal disease (ESRD) population, and their relative benefits and risks in this population compared to patients without ESRD are not yet clear. This stems from the altered state of glucose homeostasis in ESRD, which places patients at high risk for hypoglycemia and, in certain situations, hyperglycemia. In addition, there is a dearth of evidence to support a benefit of tight glycemic control on either micro- or macrovascular outcomes in ESRD patients; furthermore, the metrics by which glycemic control is conventionally measured are less valid in ESRD. In this review, we will discuss noninsulin and insulin-based therapies as well as unique challenges, contraindications, advantages, and disadvantages to their use in ESRD. We will also review issues pertinent to both hemodialysis (HD) and peritoneal dialysis (PD) patients.

journal_name

Semin Dial

journal_title

Seminars in dialysis

authors

Boyle SM,Simon B,Kobrin SM

doi

10.1111/sdi.12368

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

337-44

issue

4

eissn

0894-0959

issn

1525-139X

journal_volume

28

pub_type

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