Effect of antireceptor antibodies in dilated cardiomyopathy on the cycling of cardiac beta receptors.


:A substantial proportion of patients with dilated cardiomyopathy have circulating autoantibodies directed against the cardiac beta-adrenoceptor. These antireceptor antibodies inhibit both ligand binding to membrane beta-receptors and isoproterenol-sensitive adenylate cyclase. The functional consequences of antibody-receptor interactions were further studied by examining their influence on beta-adrenoceptor cycling. Sera from eight patients with cardiomyopathy induced a loss of beta-receptors from the surface of cardiac myocytes consistent with internalization. This loss was inhibited by concanavalin A, suggesting that receptor sequestration preceded internalization but was unaffected by the cytoskeleton inhibitors colchicine and cytochalasin. In cell-free preparations, serum-induced desensitization of beta-receptors was prevented by heparin but not the inhibitor of protein kinase A; this is consistent with a requirement for receptor phosphorylation by the beta-receptor kinase. In contrast to isoproterenol-mediated endocytosis, beta-receptors internalized under the influence of cardiomyopathic sera do not recycle to the plasma membrane. These results indicate that antireceptor antibodies in human dilated cardiomyopathy induced downregulation by interfering at several steps in the cycling of beta-receptors. These effects would contribute to the reported decline in beta-receptor responsiveness in cardiomyopathic myocardium.


Am Heart J


American heart journal


Limas CJ,Goldenberg IF,Limas C




Has Abstract


1991-07-01 00:00:00




1 Pt 1










  • Effects of ryanodine on cat papillary muscle and isolated rat heart.

    abstract::The neutral alkaloid, ryanodine, has several actions on cardiac muscle. To delineate better its mode of action, we studied ryanodine's effect upon contracting cat papillary muscles under changing loading conditions and stimulation frequencies. We also studied ryanodine's physiologic and metabolic effects upon isolated...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Blumlein SL,Sievers R,Wikman-Coffelt J,Parmley WW,Rouleau JL

    更新日期:1985-08-01 00:00:00

  • Implementation of a Brazilian Cardioprotective Nutritional (BALANCE) Program for improvement on quality of diet and secondary prevention of cardiovascular events: A randomized, multicenter trial.

    abstract:BACKGROUND:Appropriate dietary recommendations represent a key part of secondary prevention in cardiovascular disease (CVD). We evaluated the effectiveness of the implementation of a nutritional program on quality of diet, cardiovascular events, and death in patients with established CVD. METHODS:In this open-label, m...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Weber B,Bersch-Ferreira ÂC,Torreglosa CR,Marcadenti A,Lara ES,da Silva JT,Costa RP,Santos RHN,Berwanger O,Bosquetti R,Pagano R,Mota LGS,de Oliveira JD,Soares RM,Galante AP,da Silva SA,Zampieri FG,Kovacs C,Amparo FC,

    更新日期:2019-09-01 00:00:00

  • High- and low-dose superoxide dismutase plus catalase does not reduce myocardial infarct size in a subhuman primate model.

    abstract::Oxygen free radical scavengers have been found to decrease infarct size in dogs subjected to myocardial ischemia-reperfusion injury. A baboon open-chest model was used to determine if superoxide dismutase (SOD), an oxygen free radical scavenger, together with catalase would be equally effective in subhuman primates (b...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Watanabe BI,Premaratne S,Limm W,Mugiishi MM,McNamara JJ

    更新日期:1993-10-01 00:00:00

  • Including patients with diabetes mellitus or coronary artery bypass grafting decreases the association between heart rate variability and mortality after myocardial infarction.

    abstract:BACKGROUND:Decreased heart rate variability (HRV) is often assumed to be associated with mortality in all patients after myocardial infarction (MI), independent of clinical factors or time after MI. METHOD:HRV was determined from Holter tapes in the Cardiac Arrhythmia Suppression Trial (CAST). Patients were 71 +/- 120...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Stein PK,Domitrovich PP,Kleiger RE,CAST Investigators.

    更新日期:2004-02-01 00:00:00

  • Present state of alpha and beta adrenergic drugs. II. The adrenergic blocking agents.

    abstract::There are selective blocking agents (antagonists) for alpha receptors and beta receptors. These blocking agents prevent the response to injected agonists and neurogenically released norepinephrine. The principal cardiovascular response to alpha blockade is postural hypotension with reflexly induced cardiac stimulation...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Ahlquist RP

    更新日期:1976-12-01 00:00:00

  • A comparison of prasugrel and clopidogrel loading doses on platelet function: magnitude of platelet inhibition is related to active metabolite formation.

    abstract:BACKGROUND:The aim of this study was to compare rate of onset, magnitude, and consistency of platelet inhibition after administration of prasugrel or clopidogrel and to relate platelet inhibition to systemic exposure to each active metabolite. Thienopyridines are prodrugs, metabolized in vivo to active metabolites that...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验


    authors: Brandt JT,Payne CD,Wiviott SD,Weerakkody G,Farid NA,Small DS,Jakubowski JA,Naganuma H,Winters KJ

    更新日期:2007-01-01 00:00:00

  • Technetium 99m-Q12 kinetics in perfused rat myocardium: effects of hypoxia and low flow.

    abstract::Technetium 99m-Q12 is a new cationic myocardial perfusion imaging agent that produces excellent images in human beings. The purpose of this study was to examine the separate effects of hypoxia and low flow on myocardial clearance kinetics. After a 1 mCi bolus injection, myocardial 99mTc-Q12 clearance was monitored for...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Okada RD,Nguyen KN,Lauinger M,Allton IL,Johnson G 3rd

    更新日期:1996-07-01 00:00:00

  • Comparative hemodynamic effects of digoxin vs nitroprusside in conscious dogs with aortocaval fistula-induced chronic left ventricular volume overload and normal systolic performance.

    abstract::We compared the effects of IV digoxin (0.04 mg/kg) and nitroprusside (NP) (1.2 and 1.8 microgram/kg/min) on left ventricular (LV) performance in six preinstrumented conscious dogs with 3 and 6 hours after digoxin administration (serum level, 3.5 +/- 0.6 ng/ml), there were no changes in heart rate, LV systolic (LVSP) a...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: O'Rourke RA,Badke FR,Forst D

    更新日期:1982-04-01 00:00:00

  • Diastolic wall motion abnormality after myocardial infarction: relation to neurohormonal activation and prognostic implications.

    abstract:BACKGROUND:Systolic wall motion abnormality (WMA) after acute myocardial infarction (AMI) is a major determinant of outcome; the presence and importance of diastolic WMA after AMI are unknown. We therefore sought to detect diastolic WMA using color kinesis and to assess its relation to neurohormonal activation and its ...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Husic M,Nørager B,Egstrup K,Lang RM,Møller JE

    更新日期:2005-10-01 00:00:00

  • Serial thallium-201 imaging after dipyridamole for coronary disease detection: quantitative analysis using myocardial clearance.

    abstract::After dipyridamole, canine studies have demonstrated a slower rate of myocardial thallium-201 clearance from zones distal to a coronary artery stenosis compared to normal zones. To determine if criteria based on canine myocardial thallium-201 clearance rates could be applied clinically, 40 patients with and 26 patient...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Okada RD,Dai YH,Boucher CA,Pohost GM

    更新日期:1984-03-01 00:00:00

  • The development of cardiac myxomas and papillary endocardial lesions from mural thrombus.

    abstract::A morphologic study of 466 cardiac mural thrombi, 66 examples of nonbacterial thrombotic endocarditis, 25 myxomas, and 12 papillary endocardial lesions was performed. It appeared that three different sequences of organization of endocardial thrombi are possible. (1) Ordinary mural thrombi are converted into a flat, fi...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Salyer WR,Page DL,Hutchins GM

    更新日期:1975-01-01 00:00:00

  • Everolimus-eluting stent versus bare metal stent in proximal left anterior descending ST-elevation myocardial infarction: insights from the EXAMINATION trial.

    abstract:BACKGROUND:ST-elevation myocardial infarctions (STEMI) caused by proximal left-anterior descending (LAD) lesions have more myocardium at risk and worse outcomes than those located in other segments. The aim is to compare outcomes of patients with STEMI and proximal-LAD lesions treated with bare-metal stents (BMS) versu...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Gomez-Lara J,Brugaletta S,Gomez-Hospital JA,Ferreiro JL,Roura G,Romaguera R,Martin-Yuste V,Masotti M,Iñiguez A,Serra A,Hernandez-Antolin R,Mainar V,Valgimigli M,Tespili M,den Heijer P,Bethencourt A,Vazquez N,Serruys P,

    更新日期:2013-07-01 00:00:00

  • Response of high-sensitivity C-reactive protein to exercise training in an at-risk population.

    abstract:BACKGROUND:High-sensitivity C-reactive protein (hsCRP) is promoted as an independent predictor of atherosclerotic risk. In addition, cardiorespiratory fitness is inversely related to hsCRP in single-sex cross-sectional analyses. Our objective was to determine if modulating fitness with exercise training imposes changes...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验


    authors: Huffman KM,Samsa GP,Slentz CA,Duscha BD,Johnson JL,Bales CW,Tanner CJ,Houmard JA,Kraus WE

    更新日期:2006-10-01 00:00:00

  • Study design for the Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatment in Emergency Care (IMMEDIATE) Trial: A double-blind randomized controlled trial of intravenous glucose, insulin, and potassium for acute coronary syndr

    abstract:BACKGROUND:Experimental studies suggest that metabolic myocardial support by intravenous (IV) glucose, insulin, and potassium (GIK) reduces ischemia-induced arrhythmias, cardiac arrest, mortality, progression from unstable angina pectoris to acute myocardial infarction (AMI), and myocardial infarction size. However, tr...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Selker HP,Beshansky JR,Griffith JL,D'Agostino RB,Massaro JM,Udelson JE,Rashba EJ,Ruthazer R,Sheehan PR,Desvigne-Nickens P,Rosenberg YD,Atkins JM,Sayah AJ,Aufderheide TP,Rackley CE,Opie LH,Lambrew CT,Cobb LA,Macleod BA

    更新日期:2012-03-01 00:00:00

  • Percutaneous transluminal coronary recanalization: procedure, results, and acute complications.

    abstract::Percutaneous transluminal coronary recanalization, a new therapeutic procedure used in acute myocardial infarction, offers significant reduction in mortality, as well as more effective limitation of the zone of infarction than has been possible with other pharmacologic treatment employed in the past. The risk of coron...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Rutsch W,Schartl M,Mathey D,Kuck K,Merx W,Dörr R,Rentrop P,Blanke H

    更新日期:1981-12-01 00:00:00

  • Analysis of pulmonary venous flow velocity patterns in hypertensive hearts: its complementary value in the interpretation of mitral flow velocity patterns.

    abstract::Although the Doppler mitral flow velocity pattern changes in accordance with the degree of left ventricular diastolic dysfunction, it is "normalized" in the presence of heart failure. In this study the pulmonary venous flow velocity pattern was characterized in 43 hypertensive patients with and without heart failure t...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Masuyama T,Lee JM,Yamamoto K,Tanouchi J,Hori M,Kamada T

    更新日期:1992-10-01 00:00:00

  • Sexual function, satisfaction, and association of erectile dysfunction with cardiovascular disease and risk factors in cardiovascular high-risk patients: substudy of the ONgoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial/Telm

    abstract:BACKGROUND:Erectile dysfunction (ED) is a common disorder in middle-aged men and is significantly influenced by cardiovascular risk factors (CVRFs) and cardiovascular disease. The substudy of the ONTARGET/TRANSCEND trials evaluates the relationship of erectile function to baseline characteristics and current treatment ...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Böhm M,Baumhäkel M,Probstfield JL,Schmieder R,Yusuf S,Zhao F,Koon T,ONTARGET\/TRANSCEND ED-Investigators.

    更新日期:2007-07-01 00:00:00

  • Effects of carvedilol therapy on restrictive diastolic filling pattern in chronic heart failure.

    abstract:BACKGROUND:Carvedilol therapy during congestive heart failure demonstrated a good efficacy in mortality rate reduction and in improvement of left ventricular (LV) systolic performance. However, currently there is not any finding about the drug's effect on diastolic filling. The aim of this study was to evaluate the eff...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Palazzuoli A,Carrera A,Calabria P,Puccetti L,Pastrorelli M,Pasqui AL,Auteri A,Bruni F

    更新日期:2004-01-01 00:00:00

  • Implications of inferior ST-segment depression in anterior acute myocardial infarction: electrocardiographic and angiographic correlation.

    abstract::This study assesses the significance of inferior ST-segment depression during anterior acute myocardial infarction (AMI) by investigating the relationship between inferior ST-segment depression and (1) the site of the left anterior descending (LAD) coronary artery lesion and (2) ST-segment deviation in the various ant...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Birnbaum Y,Solodky A,Herz I,Kusniec J,Rechavia E,Sulkes J,Sclarovsky S

    更新日期:1994-06-01 00:00:00

  • Effects of hyperoxia on myocardial injury following cardioversion-A randomized clinical trial.

    abstract::Oxygen has long been assumed beneficial for all ill and injured patients. However, hyperoxia may be harmful and aggravate myocardial injury such as that caused by myocardial infarction. We aimed to investigate if hyperoxia increases myocardial injury following direct current cardioversion compared with room air. METH...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验


    authors: Lauridsen KG,Schmidt AS,Adelborg K,Bach L,Hornung N,Jepsen SM,Deakin CD,Rickers H,Løfgren B

    更新日期:2018-02-01 00:00:00

  • Secular trends of heart failure among US male physicians.

    abstract:BACKGROUND:Heart failure (HF) remains a major public health issue. Data on long-term trends in the incidence of HF and survival after its onset are limited. METHODS:A prospective cohort study conducted between 1985 and 2004 in 21,906 participants of the Physicians' Health Study I who were alive and free of HF on Janua...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Djoussé L,Kochar J,Gaziano JM

    更新日期:2007-11-01 00:00:00

  • Dronedarone and vitamin K antagonists: a review of drug-drug interactions.

    abstract::Adverse drug events affect millions of patients each year. An important drug-drug interaction between amiodarone and vitamin K antagonists is encountered frequently in daily clinical practice. Warfarin, a commonly used anticoagulant, is a mixture of 2 optically active isomers (R and S enantiomers). The S enantiomer is...

    journal_title:American heart journal

    pub_type: 杂志文章,评审


    authors: Shirolkar SC,Fiuzat M,Becker RC

    更新日期:2010-10-01 00:00:00

  • Depressed arterial baroreflex sensitivity and not reduced heart rate variability identifies patients with chronic heart failure and nonsustained ventricular tachycardia: the effect of high ventricular filling pressure.

    abstract::In chronic heart failure (CHF) the contributing role of increased sympathetic activity and hemodynamic dysfunction in the genesis of ventricular arrhythmias has not been well established. To assess the relation between severe ventricular arrhythmias, hemodynamic impairment, and autonomic nervous system derangement, 14...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Mortara A,La Rovere MT,Pinna GD,Parziale P,Maestri R,Capomolla S,Opasich C,Cobelli F,Tavazzi L

    更新日期:1997-11-01 00:00:00

  • Rupture of interventricular septum in acute myocardial infarction.

    abstract::Three cases of rupture of the interventricular septum occurring coincident with acute inferior myocardial infarction are reported and the relevant literature is reviewed. One patient under-went successful surgical repair and, in addition, had an aneurysmectomy. Clues and pitfalls in diagnosis as well as the possible c...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Longo EA,Cohen LS

    更新日期:1976-07-01 00:00:00

  • Neopterin levels in patients with coronary artery disease are independent of Chlamydia pneumoniae seropositivity.

    abstract:BACKGROUND:Chronic infection with Chlamydia pneumoniae (Cpn) has been associated with atherosclerotic cardiovascular disease in sero-epidemiological, pathological and animal-model studies. Inflammation and immune activation has been proposed as the pathophysiological link between chronic infection and atherosclerosis. ...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Smith DA,Zouridakis EG,Mariani M,Fredericks S,Cole D,Kaski JC

    更新日期:2003-07-01 00:00:00

  • The use of the systolic time interval for predicting left ventricular ejection fraction ischemic heart disease.

    abstract::A large series of 306 patients with ischemic heart disease was studied with automated systolic time intervals and left ventricular ejection fraction as determined by the angiocardiographic method. It was found the pre-ejection period, left ventricular ejection time, delta values, and PEP/LVET ratio all were related to...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Swatzell RH Jr,Bancroft WH Jr,Baldone JC Jr,Tucker MS

    更新日期:1977-04-01 00:00:00

  • Lack of decreased contractility in hearts from atherosclerotic rabbits.

    abstract::Previous studies have suggested that the contractility of isolated heart muscle removed from rabbits made hypercholesterolemic is decreased. As part of a study evaluating the effects of high-lipid diets on aortic atherosclerosis, we evaluated the contractility of perfused rabbit hearts. Six rabbits were placed on a hi...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Blumlein S,Sievers R,Wikman-Coffelt J,Parmley WW

    更新日期:1983-12-01 00:00:00

  • Spaced administration of PA32540 and clopidogrel results in greater platelet inhibition than synchronous administration of enteric-coated aspirin and enteric-coated omeprazole and clopidogrel.

    abstract:BACKGROUND:A common regimen for patients requiring dual-antiplatelet therapy who are at risk for gastrointestinal complications is the synchronous administration of enteric-coated (EC) aspirin, a proton pump inhibitor, and clopidogrel, although proton pump inhibitors have the potential for pharmacodynamic interaction w...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验


    authors: Gurbel PA,Bliden KP,Fort JG,Jeong YH,Shuldiner A,Chai S,Gesheff T,Antonino M,Gesheff M,Zhang Y,Tantry US

    更新日期:2013-02-01 00:00:00

  • Antiplatelet and antithrombotic treatment after primary percutaneous coronary intervention: balancing safety and efficacy.

    abstract::Antiplatelet therapy has been shown to significantly reduce the risk of serious vascular events in high-risk patients, including those with a prior acute ischemic event. The long-term use of antiplatelet agents is a key component of secondary prevention measures following acute coronary syndromes, including ST-segment...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Valgimigli M,Minarelli M

    更新日期:2010-12-01 00:00:00

  • Unusual manifestations of severe sick sinus syndrome.

    abstract::An extremely athletic 56-year-old male physician was found to have profound sinus bradycardia. His only symptom was markedly increased alertness while actively exercising. During pacemaker insertion he had an episode of prolonged sinus arrest terminated by a precordial thump. This case suggests that exercise can alter...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Marmor BM,Black MM

    更新日期:1980-07-01 00:00:00