The serum pepsinogen test as a predictor of gastric cancer: the Hisayama study.

Abstract:

:The authors examined whether a serum pepsinogen test (SPT) based on the combination of the serum pepsinogen I level and pepsinogen I/II ratio is a good predictor of gastric cancer occurrence in a general Japanese population. A total of 2,446 subjects aged > or =40 years were classified into negative, positive, and strong-positive SPT groups and were followed prospectively for 14 years (1988-2002). Compared with that for the negative SPT group (26 men, 10 women), gastric cancer incidence increased significantly for both men (n = 17; age-adjusted hazard ratio = 4.56, 95% confidence interval: 2.42, 8.60) and women (n = 6; age-adjusted hazard ratio = 5.84, 95% confidence interval: 2.00, 17.11) in the strong-positive SPT group. It was also significantly higher in the positive SPT group for men (n = 23; age-adjusted hazard ratio = 3.91, 95% confidence interval: 2.23, 6.86). These associations did not attenuate even after adjustment for other comprehensive risk factors. Stratified analysis revealed significant associations between the SPT and development of intestinal-type gastric cancer as well as of cancer in both Helicobacter pylori-negative and -positive subjects. These findings suggest that the SPT can serve as a predictor of intestinal-type gastric cancer, irrespective of H. pylori infection.

journal_name

Am J Epidemiol

authors

Oishi Y,Kiyohara Y,Kubo M,Tanaka K,Tanizaki Y,Ninomiya T,Doi Y,Shikata K,Yonemoto K,Shirota T,Matsumoto T,Iida M

doi

10.1093/aje/kwj088

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

629-37

issue

7

eissn

0002-9262

issn

1476-6256

pii

kwj088

journal_volume

163

pub_type

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