Abstract:
:Activation of the NO-cGMP pathway is associated with myocardial protection against ischemia. During ischemia, function of this pathway is disturbed. Little is known about the effects of supplements such as Red Palm Oil (RPO) on the myocardial NO- cGMP- signalling pathway. RPO consists of saturated (SFAs), mono-unsaturated (MUFAs) and polyunsaturated (PUFAs) fatty acids and is an antioxidant rich in natural B-carotene and vitamin E (tocopherols and tocotrienols). This study determined whether dietary RPO-supplementation protects against the consequences of ischemia and identified a possible mechanism for this protection. Long-Evans rats were fed a control diet or control diet plus 7 g RPO per kg diet for six weeks. Hearts were excised and mounted on a working heart perfusion apparatus. Cardiac function was measured before and after hearts were subjected to 25 minutes of global ischemia. Left ventricular systolic (LVSP) and diastolic pressure (LVDP), coronary flow (CF), heart rate (HR) and aortic output (AO) were measured. To assess NO-cGMP pathway activity, hearts subjected to the same conditions, were freeze-clamped and analysed for tissue cAMP and cGMP levels using a RIA method. Furthermore, composition of myocardial phospholipid fatty acids by gas chromatography and blood samples were collected for serum lipid determinations. The percentage aortic output recovery of hearts supplemented with RPO was 72.9 +/-3.43% vs 55.4 +/-2.48% for controls (P< 0.05). Ten minutes into ischemia the cGMP levels of the RPO-supplementation group were significantly higher than the control group (26.5+/-2.78 pmol/g vs 10.1+/-1.78 pmol/g. Total myocardial PUFA content in hearts supplemented with RPO increased from 54.45+/-1.11% before ischemia to 59.03 +/- 0.30% after ischemia P<0.05). Results demonstrated that RPO-supplementation protected hearts against the consequences of ischemia/reperfusion injury. These findings suggest that dietary RPO protects via the NO-cGMP pathway and/or changes in PUFA composition during ischemia/reperfusion.
journal_name
Asia Pac J Clin Nutrjournal_title
Asia Pacific journal of clinical nutritionauthors
Esterhuyse AJ,Toit ED,Rooyen JVsubject
Has Abstractpub_date
2005-01-01 00:00:00pages
340-7issue
4eissn
0964-7058issn
1440-6047journal_volume
14pub_type
杂志文章abstract::Ferritin concentrations in circulation reflect iron stores in healthy individuals. However, elevated serum ferritin (SF) concentrations have recently been implicated in the pathogenesis of the metabolic syndrome (MetS). We aim to investigate factors associated with elevated SF and to evaluate the association between S...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:10.6133/apjcn.2013.22.3.07
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Nutrition and inflammation play a crucial role in the development of cancer. The prognostic value of the prognostic nutritional index (PNI) has been confirmed in some types of human cancers. This study analyzed the prognostic significance of the preoperative PNI in patients with stage III gast...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:10.6133/apjcn.072017.03
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abstract::People of Indian origin develop type 2 diabetes at a relatively young age and low body mass index compared to people of other racial groups, possibly because of preferential accumulation of abdominal fat. We examined the relationship between abdominal fat and body mass index (BMI) in healthy premenopausal women of dif...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Body mass index (BMI) is widely used as a surrogate measure of adiposity. The relationship between BMI and body fatness varies by race, sex, and age and more variations have been found among children. This study investigated the relationship between BMI and fat mass among 3-5 year old children...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
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abstract::Zinc nutriture was assessed in 6500 adults aged 35-64 years old in 65 mostly rural counties (two communes per county) in China on the basis of plasma zinc levels and dietary zinc intakes. In addition, the use of plasma albumin and red blood cell superoxide dismutase (SOD) for assessing zinc nutritional status was eval...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
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journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:10.1046/j.1440-6047.2002.00275.x
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journal_title:Asia Pacific journal of clinical nutrition
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doi:
更新日期:2007-01-01 00:00:00
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journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:10.6133/apjcn.092015.17
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journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
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journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1993-12-01 00:00:00
abstract::The relationship between malnutrition, goitre and thyroid hormones was studied among Aborigines and Malays in Ulu Langat, Malaysia. Fifty Aborigines aged >=7years were selected randomly for anthropometric, clinical and hormonal assessment. Fifty Malays of similar age from the nearby Malay village were chosen as contro...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1992-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Dietary patterns have been linked to the risk of obesity in adults but little is known about such a link in young children. To examine the association between dietary patterns, nutrient intake and obesity in a representative population of preschool children in Australia. METHODS AND STUDY DES...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:10.6133/apjcn.032017.19
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journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:10.6133/apjcn.2014.23.4.01
更新日期:2014-01-01 00:00:00
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journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
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journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
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journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章,评审
doi:
更新日期:2009-01-01 00:00:00
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journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
doi:10.6133/apjcn.2015.24.2.17
更新日期:2015-01-01 00:00:00
abstract::Macro mineral contents were estimated in commonly consumed green leafy vegetables in India, namely; Koyyathotakura and Peddathotakura (varieties of Amaranthus species); Erragogu and Tellagogu (variety of Hibiscus species); Gangabayalakura (Portulaca olereceo) and Palak (Spineces olerecea) at three different stages of ...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::Urbanisation runs in parallel with economic growth. Urban areas are characterised by income inequality between population groups. Because of inequality in socioeconomic situation, Indonesian urban areas are confronted with problems of undernutrition and overnutrition. Selected studies conducted by the SEAMEO-TROPMED R...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
abstract::The association between tea consumption and bladder cancer has been confirmed in several animal studies, but one epidemiological study in 2001 showed no association between them. In order to provide an accurate assessment of this, we conducted a meta-analysis on tea consumption and bladder cancer risk. Studies were id...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章,meta分析
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journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
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journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::The aim of this study was to determine the acute and chronic effects of low doses of long chain (LC) n-3 polyunsaturated fatty acids (PUFA) (<100 mg per day) on plasma LC n-3 PUFA levels using a novel delivery form; bread containing microencapsulated tuna oil (MTO). Six omnivores (three men and three women) participat...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
doi:10.1046/j.1440-6047.2002.00309.x
更新日期:2002-01-01 00:00:00
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journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
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abstract:BACKGROUND AND OBJECTIVES:Obesity has become a public health problem and is a cause of some preventable illnesses. Among several methods for treating obesity, the use of food supplements is highly common. A commonly used food supplement is green coffee bean extract. The objective of this study was to evaluate the effic...
journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
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更新日期:2017-01-01 00:00:00
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journal_title:Asia Pacific journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-01-01 00:00:00
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journal_title:Asia Pacific journal of clinical nutrition
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journal_title:Asia Pacific journal of clinical nutrition
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更新日期:2006-01-01 00:00:00
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journal_title:Asia Pacific journal of clinical nutrition
pub_type: 杂志文章
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更新日期:2007-01-01 00:00:00