Abstract:
OBJECTIVE:Calcium channel blockers (CCBs) are among the most frequently prescribed cardiovascular drugs. It has been shown that these drugs have antiatherosclerotic effects in both experimental and clinical settings. However, calcium channel blockers have markedly different chemical structures and different effects on the cardiovascular system. We investigated the effect of CD-832, a Ca(+2) channel antagonist, on collar-induced intimal thickening, as well as accompanied reactivity changes in rabbit carotid artery. METHODS AND RESULTS:Rabbits received 5 mg/kg/day CD-832 or vehicle (polyethylene glycol, 0.5 ml/kg/day) intramuscularly for a week before and 2 weeks after the collar application. Histological and isometric force measurements were performed in segments from sham and collared carotid arteries. A three-week treatment with CD-832 did not inhibit the intimal thickening caused by perivascular application of a silicone collar. Potassium chloride (KCl), phenylephrine, 5-hydroxytryptamine (5-HT, serotonin) and histamine induced concentration-dependent contractions in both sham-operated (sham) and collared arteries. Collar-induced attenuations in maximum KCl, histamine, phenylephrine and 5-HT contractions were not affected by CD-832. Collaring caused an increase in pD2 values of 5-HT and a decrease in those of phenylephrine, histamine and acetylcholine. CD-832 did not affect the altered sensitivity to these agonists. CONCLUSIONS:These results demonstrate that, in rabbit carotid artery, CD-832 did not inhibit the collar-induced intimal thickening and did not affect the accompanying changes in vascular reactivity.
journal_name
Acta Cardioljournal_title
Acta cardiologicaauthors
Kerry Z,Yasa M,Sevin G,Reel B,Yetik Anacak G,Ozer Adoi
10.2143/AC.60.5.2004970subject
Has Abstractpub_date
2005-10-01 00:00:00pages
493-9issue
5eissn
0001-5385issn
1784-973Xjournal_volume
60pub_type
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journal_title:Acta cardiologica
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doi:10.2143/AC.61.5.2017765
更新日期:2006-10-01 00:00:00
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更新日期:2015-04-01 00:00:00
abstract::An 18-year-old male patient, known with familial hypertrophic obstructive cardiomyopathy underwent a septal myectomy 10 years ago for significant left ventricular outflow tract (LVOT) obstruction. During follow-up a progressive increase in LVOT gradient was noted in association with severe mitral valve regurgitation. ...
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更新日期:2008-04-01 00:00:00
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更新日期:2006-02-01 00:00:00
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更新日期:2014-12-01 00:00:00
abstract::Diffuse intra-alveolar haemorrhage is a rare complication of thrombolytic therapy (TT). We report a patient who developed haemoptysis due to pulmonary haemorrhage. This diagnosis should be considered in any patients with respiratory distress, diffuse pulmonary infiltrates, and haemoptysis and otherwise unexplained dec...
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更新日期:2011-08-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2013-10-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
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doi:
更新日期:1979-01-01 00:00:00
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doi:
更新日期:1998-01-01 00:00:00
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更新日期:2003-12-01 00:00:00
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pub_type: 杂志文章
doi:10.2143/AC.57.5.2005459
更新日期:2002-10-01 00:00:00
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更新日期:2014-06-01 00:00:00
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更新日期:2007-08-01 00:00:00
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更新日期:2011-10-01 00:00:00
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journal_title:Acta cardiologica
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doi:
更新日期:1996-01-01 00:00:00
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更新日期:2004-10-01 00:00:00
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doi:
更新日期:1984-01-01 00:00:00
abstract::The authors present a case of permanent atrial standstill with syncopal attacks, in a patient with chronic Chagas' Heart Disease. The recognition of this dysrhythmia was based upon the conventional and intracavity electrocardiographic tracings in addition to phonomecanographic and hemodynamic data. The recording of th...
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doi:
更新日期:1975-01-01 00:00:00
abstract::Real-time two-dimensional echocardiographic studies of the mitral valve in short-axis view were obtained from 10 normal subjects. Stop-action frames of the video-taped echocardiograms were then photographed to obtain diastolic cross-sectional images of the valve at maximal opening. Tracings from the interior of the le...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract::We present two cases of Ortner's syndrome, a syndrome with hoarseness caused by unilateral left recurrent laryngeal nerve palsy as a complication of cardiovascular diseases. In the first case, aneurysmatic dilatation of the aorta and in the second case a dilated pulmonary trunk was thought to be the cause. ...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.65.6.2059871
更新日期:2010-12-01 00:00:00
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journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.2143/AC.60.2.2005025
更新日期:2005-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1080/ac.67.1.2146566
更新日期:2012-02-01 00:00:00
abstract:UNLABELLED:OBJECTIVE; ; The objective of this study was to identify developmental changes in vascular smooth muscle cells (VSMC) during aneurysm formation using an elastase-induced rabbit carotid artery aneurysm model. METHODS:- Aneurysms were induced in carotid arteries of rabbits by exposure to elastase. Tissues fro...
journal_title:Acta cardiologica
pub_type: 杂志文章
doi:10.1080/ac.65.5.2056235
更新日期:2010-10-01 00:00:00