The role of exercise on platelet aggregation in patients with stable coronary artery disease: exercise induces aspirin resistant platelet activation.

abstract：:The Tissue Factor/Factor VIIa (TF/FVIIa) complex is an attractive target for pharmacological interruption of thrombin generation and hence blood coagulation, as this complex is the initiation point of the extrinsic pathway of coagulation. TF is a cell membrane-associated protein that interacts with soluble FVIIa to ac...

journal_title：Journal of thrombosis and thrombolysis

authors： Szalony JA,Taite BB,Girard TJ,Nicholson NS,LaChance RM

更新日期：2002-10-01 00:00:00

abstract：:The risk benefit decision in providing anticoagulation for patients with brain metastases is amongst the most difficult decisions faced by clinicians. The purpose of our study was to evaluate both the risk of intracerebral hemorrhage (ICH) associated with anticoagulation therapy and the effect of anticoagulation on su...

journal_title：Journal of thrombosis and thrombolysis

authors： Hunter BD,Minichiello T,Bent S

更新日期：2017-10-01 00:00:00

abstract：:Thrombophilia, commonly manifested as venous thromboembolism (VTE), is a worldwide concern but little is known on its genetic epidemiology in many parts of the globe particularly in the developing countries. Here we employed TaqMan genotyping and pyrosequencing to evaluate the prevalence of known common nucleotide pol...

journal_title：Journal of thrombosis and thrombolysis

authors： Abdi AA,Osman A

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Venous thromboembolism (VTE) is a significant cause of mortality and morbidity in medical patients. Although thromboprophylaxis with enoxaparin reduces the risk of VTE in these patients, the optimal duration of therapy is not currently known. The EXCLAIM (EXtended CLinical prophylaxis in Acutely Ill Medical ...

journal_title：Journal of thrombosis and thrombolysis

authors： Hull RD,Schellong SM,Tapson VF,Monreal M,Samama MM,Turpie AG,Wildgoose P,Yusen RD

更新日期：2006-08-01 00:00:00

abstract：:Among atrial fibrillation (AF) patients undergoing percutaneous coronary intervention (PCI), rivaroxaban with background antiplatelet therapy significantly reduced the first occurrence of bleeding compared to triple therapy with warfarin. This study hypothesized that total bleeding events, including those beyond the f...

journal_title：Journal of thrombosis and thrombolysis

authors： Chi G,Yee MK,Kalayci A,Kerneis M,AlKhalfan F,Mehran R,Bode C,Halperin JL,Verheugt FWA,Wildgoose P,van Eickels M,Lip GYH,Cohen M,Peterson ED,Fox KAA,Gibson CM

更新日期：2018-10-01 00:00:00

abstract：:The exact relationship between primary percutaneous coronary intervention (PCI) volume and mortality remains unclear. No data are available on how this relationship could be affected by time-to-presentation. The primary aim of this study was to evaluate the impact of hospital primary PCI volume on in-hospital mortalit...

journal_title：Journal of thrombosis and thrombolysis

authors： Navarese EP,De Servi S,Politi A,Martinoni A,Musumeci G,Boschetti E,Belli G,D'Urbano M,Piccaluga E,Lettieri C,Klugmann S

更新日期：2011-08-01 00:00:00

abstract：:To analyze the efficacy and safety of activated prothrombin complex concentrates (aPCC) and four-factor prothrombin complex concentrates (4F-PCC) to prevent hematoma expansion in patients taking apixaban or rivaroxaban with intracranial hemorrhage (ICH). In this multicenter, retrospective study, sixty-seven ICH patien...

journal_title：Journal of thrombosis and thrombolysis

authors： Castillo R,Chan A,Atallah S,Derry K,Baje M,Zimmermann LL,Martin R,Groysman L,Stern-Nezer S,Minokadeh A,Nova A,Huang W,Cang W,Schomer K

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Abciximab reduces the thrombotic complications of angioplasty. It is also used, as a 'bail out' treatment when angioplasty is complicated by thrombus but its speed of action is not known. This study sought to establish how quickly abciximab blocks the aggregation of both quiescent and activated platelets to ...

journal_title：Journal of thrombosis and thrombolysis

authors： Dalby MC,Davidson SJ,Burman JF,Sigwart U,Davies SW

更新日期：2002-06-01 00:00:00

abstract：:Atrial fibrillation (AF) is a common cardiac arrhythmia. Dabigatran etixalate (DE) is one of the new oral anticoagulant drugs being used in nonvalvular AF (NVAF). There is no adequate real world data in different populations about DE. The aim of this registry was to evaluate the efficacy and safety of DE Consecutive N...

journal_title：Journal of thrombosis and thrombolysis

authors： Yavuz B,Ayturk M,Ozkan S,Ozturk M,Topaloglu C,Aksoy H,Şabanoglu C,Tanalp AC,Dal K,Ata N,Yavuz BB

更新日期：2016-10-01 00:00:00

abstract：:The benefit of intravenous thrombolysis (IVT) has been questioned for patients with diabetes mellitus (DM) in cases of acute ischemic stroke (IS). Our objective was to analyze the differences in outcome according to prior diagnosis of DM and the use or not of IVT. Observational study with inclusion of consecutive IS p...

journal_title：Journal of thrombosis and thrombolysis

authors： Fuentes B,Cruz-Herranz A,Martínez-Sánchez P,Rodríguez-Sanz A,Ruiz Ares G,Prefasi D,Sanz-Cuesta BE,Lara-Lara M,Díez-Tejedor E

更新日期：2014-11-01 00:00:00

abstract：:This study was intended to evaluate the cost-effectiveness of anticoagulation clinic care and self-testing for the management of patients on chronic warfarin therapy. Using a 5-year Markov model, we evaluated the health and economic outcomes associated with each of three different anticoagulation management approaches...

journal_title：Journal of thrombosis and thrombolysis

authors： Lafata JE,Martin SA,Kaatz S,Ward RE

更新日期：2000-06-01 00:00:00

abstract：:Pregnancy due to its physiological changes is a procoagulant state. The rate of cardiac valve prosthesis thrombosis, deep venous thrombosis and pulmonary embolism are all increased. Thrombolytic therapy with tissue plasminogen activator (rt-PA) is an approved therapy for ischemic stroke, myocardial infarction, pulmona...

journal_title：Journal of thrombosis and thrombolysis

authors： Leonhardt G,Gaul C,Nietsch HH,Buerke M,Schleussner E

更新日期：2006-06-01 00:00:00

abstract：:Hyperhomocysteinemia (HHcy) affects haemostasis and shifts its balance in favour of thrombosis. In vitro and in vivo studies suggested that HHcy may impair fibrinolysis either by influencing the plasma levels of fibrinolytic factors or by altering the fibrinogen structure. We investigated the influence of mild HHcy le...

journal_title：Journal of thrombosis and thrombolysis

authors： Cellai AP,Lami D,Antonucci E,Liotta AA,Rogolino A,Fedi S,Fiorillo C,Becatti M,Cenci C,Marcucci R,Abbate R,Prisco D

更新日期：2014-07-01 00:00:00

abstract：:Cancer is associated with an increased risk of venous thromboembolism of four to sixfold. Cancer-related interventions such as chemotherapy, hormonal therapy and indwelling central venous catheters also increase the risk of venous thromboembolism. Low molecular weight heparin for at least 3-6 months is the current sta...

journal_title：Journal of thrombosis and thrombolysis

authors： Franco-Moreno A,Cabezón-Gutiérrez L,Palka-Kotlowsa M,Villamayor-Delgado M,García-Navarro M

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Pharmacoinvasive therapy for the treatment of ST elevation myocardial infarction (STEMI) is a strategy that combines early restoration of coronary flow via pharmacologically induced thrombolysis with subsequent, prompt percutaneous coronary intervention (PCI). Prior studies suggesting a heightened bleeding r...

journal_title：Journal of thrombosis and thrombolysis

authors： Gutierrez MJ,Aggarwal A,Gilbert K,Sobel BE,Dauerman HL

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:We investigated the safety and efficacy of several dosing regimens of catheter-directed staphylokinase (SY162) bolus administration for the treatment of long-term venous access catheter occlusion. METHODS:This open-label, ascending dose study enrolled 24 subjects. Three doses of SY162 were evaluated in thre...

journal_title：Journal of thrombosis and thrombolysis

authors： Verhamme P,Goossens G,Maleux G,Collen D,Stas M

更新日期：2007-08-01 00:00:00

abstract：:Postmenopausal hormone replacement therapy (HRT), such as estrogen with a progestin (E+P), is associated with an increased risk of myocardial infarction (MI), stroke, and venous thrombosis. Subgroups of susceptible women for these clinical outcomes have not been clearly identified, although women with a prior history ...

journal_title：Journal of thrombosis and thrombolysis

authors： Cushman M

更新日期：2003-08-01 00:00:00

abstract：:Tenecteplase, a mutant form of alteplase, possesses pharmacological properties that might favor its use for emergent fibrinolysis of acute pulmonary embolism. Contemporaneous search of the World's literature reveals 14 humans with acute pulmonary embolism treated with tenecteplase. Here, we summarize those cases and r...

journal_title：Journal of thrombosis and thrombolysis

authors： Kline JA,Hernandez-Nino J,Jones AE

更新日期：2007-04-01 00:00:00

abstract：:Point-of-care whole blood coagulation tests are critical in the management of patients who undergo percutaneous coronary intervention. The Hemochron and HemoTec devices have been traditionally used to measure the activated clotting time (ACT) in the cardiac catheterization laboratory. The heparin management test (HMT)...

journal_title：Journal of thrombosis and thrombolysis

authors： Tsimikas S,Beyer R,Hassankhani A

更新日期：2001-05-01 00:00:00

abstract：:The best strategy in atrial fibrillation (AF) after > 12 months after an acute coronary syndrome or in patients with chronic coronary syndrome without an indication for interventional revascularization remains unclear. European guidelines generally recommend therapy with oral anticoagulation (OAC) alone, whereas North...

journal_title：Journal of thrombosis and thrombolysis

authors： Wernly B,Bhatt DL,Polzin A,Jung C

更新日期：2020-02-01 00:00:00

abstract：:This article focuses on lessons learned from clinical trials of antiplatelet therapies-in particular, that the degree of inhibition of ex vivo platelet aggregation does not necessarily directly translate into clinical efficacy. As an example, the case of the oral platelet glycoprotein IIb/IIIa inhibitors is presented,...

journal_title：Journal of thrombosis and thrombolysis

authors： Steinhubl SR,Schneider DJ,Berger PB,Becker RC

更新日期：2008-08-01 00:00:00

abstract：:The predictive value of and the influencing factors associated with early neurological improvement (ENI) among patients with acute basilar artery occlusion (BAO) have not been well studied. The present study aimed to evaluate whether ENI predicted a better functional outcome and to identify the influencing factors of ...

journal_title：Journal of thrombosis and thrombolysis

authors： Sun X,Zhang H,Tong X,Gao F,Deng Y,Ma G,Ma N,Mo D,Song L,Liu L,Huo X,Miao Z

更新日期：2021-01-01 00:00:00

abstract：:On stimulation of platelets with agonists, for example, thrombin, a rapid rise in intracellular pH is observed. This alkalinization is mediated by an increase in transport activity of the Na(+)/H(+) exchanger isoform NHE1. In addition to this Na(+)/H(+) exchange mechanism, platelets express bicarbonate/chloride exchan...

journal_title：Journal of thrombosis and thrombolysis

authors： Rosskopf D

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:There are several new strategies proposed to improve the outcome of patients with ST-elevation myocardial infarction (STEMI). One approach is the resurgent use of facilitated percutaneous coronary interventions (PCI). Until recently, deciding whether immediate PCI after combined treatment (facilitated PCI) i...

journal_title：Journal of thrombosis and thrombolysis

authors： Di Pasquale P,Cannizzaro S,Parrinello G,Giambanco F,Vitale G,Fasullo S,Scalzo S,Ganci F,La Manna N,Sarullo F,La Rocca G,Paterna S

更新日期：2006-04-01 00:00:00

abstract：:Sickle cell disease (SCD) is characterised by abnormal coagulopathy and angiogenesis although their relationships in two common genotypes, homozygous (HbSS) SCD and sickle-haemoglobin C disease (HbSC), are unexplored. We measured markers of platelet activation (soluble P-selectin [sP-selectin]), fibrinolysis (D-dimer)...

journal_title：Journal of thrombosis and thrombolysis

authors： Blann AD,Mohan JS,Bareford D,Lip GY

更新日期：2008-04-01 00:00:00

abstract：:Many hospitals have implemented warfarin dosing nomograms to improve patient safety. To our knowledge, no study has assessed the impact inpatient warfarin initiation has in both medical and surgical patients, on safety outcomes post discharge. To evaluate the impact of a suggested institutional nomogram for the initia...

journal_title：Journal of thrombosis and thrombolysis

authors： Chamoun N,Macías CG,Donovan JL,Klugman R,Gore J,Salameh P,Tran MT

更新日期：2017-05-01 00:00:00

abstract：:Whitmania pigra Whitman (W. pigra) has been widely employed in decoction for the treatment of blood stasis syndrome for many years in China. The aim of the present study was to explore the anti-venous thrombosis (VT) mechanism of the aqueous extract of W. pigra (AEW) in rats. Rats were orally administered with AEW. A ...

journal_title：Journal of thrombosis and thrombolysis

authors： Li P,Lin B,Tang P,Ye Y,Wu Z,Gui S,Zhan Y,Yang W,Lin B

更新日期：2020-11-17 00:00:00

abstract：:Hospital acquired venous thromboembolism (VTE) is a major source of morbidity and mortality, yet proven prevention measures are often underutilized. The lack of a validated VTE risk assessment model, difficulty integrating VTE risk assessment and prevention protocols into the routine process of care, and the lack of s...

journal_title：Journal of thrombosis and thrombolysis

authors： Maynard G,Stein J

更新日期：2010-02-01 00:00:00

abstract：:The dosage of warfarin is restricted due to its narrow therapeutic index, so, the required dose must be adapted individually to each patient. Variations in warfarin dosage are influenced by genetic factors, the changes in patient diet, anthropometric and clinical parameters. To determine whether VKORC1 G3730A and CYP4...

journal_title：Journal of thrombosis and thrombolysis

authors： Tatarunas V,Lesauskaite V,Veikutiene A,Grybauskas P,Jakuska P,Jankauskiene L,Bartuseviciute R,Benetis R

更新日期：2014-01-01 00:00:00

abstract：:Amlodipine, commonly used for relief of ischemic symptoms in coronary artery disease (CAD), may affect clopidogrel-induced antiplatelet effects. It remains unknown if ranolazine, an antianginal drug that constitutes a pharmacologic alternative to calcium channel blockade, interferes with clopidogrel-induced antiplatel...

journal_title：Journal of thrombosis and thrombolysis

authors： Pelliccia F,Greco C,Gaudio C,Rosano G,Vitale C,Marazzi G,Rollini F,Angiolillo DJ

更新日期：2015-10-01 00:00:00