Abstract：
:Our previous study indicated that taste information via the chorda tympani (CT) activates the central histaminergic system in anesthetized rats. However, the physiological roles of taste-induced histamine release remain unknown, thus to further investigate the relationship between histamine release and gustatory information, in the present study we investigated the effect of taste stimuli infused intraorally on histamine release using in vivo microdialysis in free moving rats. Consistent with findings from our previous study, application of NaCl and HCl caused significant increases in histamine levels further supporting the suggestion that this phenomenon is attributed to the excitation of the CT. When rats were intraorally infused with quinine HCl (QHCl) solution, a significant increase in hypothalamic histamine release was observed. On the other hand, histamine release was decreased by sucrose and saccharin solutions. When rats were conditioned to acquire taste aversion to sucrose solution or saccharin solution, instead of the histamine decrease seen by the palatable solutions, the pattern of histamine release was similar to that seen by QHCl solution. From these observations, it is concluded that the histamine release by the infusion of these tastants may be explained by two mechanisms-by causing a transient increase after taste stimulation and by causing a decrease relative to the tastant's palatability.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Treesukosol Y,Ishizuka T,Yamamoto C,Senda K,Tsutsumi S,Yamatodani A,Yamamoto Tdoi
10.1016/j.bbr.2005.06.004subject
Has Abstractpub_date
2005-10-14 00:00:00pages
67-72issue
1eissn
0166-4328issn
1872-7549pii
S0166-4328(05)00234-2journal_volume
164pub_type
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