Abstract：
:The present study was outlined in order to provide additional behavioral validation to the elevated T-maze as a model of anxiety and memory. In this model, rats acquire an inhibitory avoidance response after successive exposures, and memory can be estimated by retesting later. Two experiments were carried out with rats initially tested at the ages of 30, 60, 90 and 120 days. Experiment 1 showed that, while 100% of subjects studied learned inhibitory avoidance, regardless of their ages, 60-day-old rats needed a higher number of trials in order to reach the criterion to stay 300 s inside the enclosed arm. Experiment 2 explored the relevancy of the aversive stimulus in maintaining the learned experience by retesting the subjects monthly. The results showed that after acquisition of inhibitory avoidance there is remarkable long-lasting memory retrieval. Risk assessment behavior, increasing in the first trial of the retest day, revealed also the approach-avoidance conflict while on the enclosed arm. The results are discussed in terms of age effects and the implications of an enduring learned emotional response in animal models of anxiety and memory.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Sanson LT,Carobrez APdoi
10.1016/s0166-4328(98)00140-5subject
Has Abstractpub_date
1999-05-01 00:00:00pages
59-64issue
1eissn
0166-4328issn
1872-7549pii
S0166432898001405journal_volume
101pub_type
杂志文章abstract：:Memory deficits may develop from a variety of neuropathologies including Alzheimer's disease dementia. During neurodegenerative conditions there are contributory factors such as neuroinflammation and amyloidogenesis involved in memory impairment. In the present study, dual properties of S100A9 protein as a pro-inflamm...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2016.03.016
更新日期：2016-06-01 00:00:00
abstract：:Trisomy 21 or Down syndrome (DS) is the most common form of human aneuploid disorder. Increase in the copy number of human chromosome 21 genes leads to several alterations including mental retardation, heart and skeletal dysmorphologies with additional physiological defects. To better understand the genotype and pheno...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.10.023
更新日期：2011-03-01 00:00:00
abstract：:In this study we have explored differences in animal reactivity to conditioned aversive stimuli using the conditioned fear test (a contextual fear-freezing response), in rats subjected to the selective lesion of the prefrontal cortex serotonergic innervation, and differing in their response to the acute painful stimul...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2008.04.003
更新日期：2008-10-10 00:00:00
abstract：:Learning impairment is a common feature of the neuronal ceroid lipofuscinoses (NCL), a family of lysosomal storage disorders associated with progressive neurodegeneration. Murine models for the neuronal ceroid lipofuscinoses include the well-characterized motor neuron degeneration (mnd/mnd) model for one variant of la...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2005.02.024
更新日期：2005-06-20 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(96)00118-0
更新日期：1996-01-01 00:00:00
abstract：:This study of leg flexion conditioning in dogs, which were trained under both avoidance and classical contingencies consecutively, confirmed and extended the results from the Wahlsten and Cole study (In Classical Conditioning II: Current Research and Theory, Appleton Century-Crofts, New York, 1972). Briefly, dogs were...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(95)00174-3
更新日期：1996-05-01 00:00:00
abstract：:This study is part of an ongoing project concerned with the analysis of the neural substrates of discriminative avoidance learning in rabbits. Multi-unit activity was recorded in 5 anterior and lateral thalamic nuclei and in 4 layers of 2 posterior cingulate cortical areas (29c/d and 29b) during learning. The rabbits ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(05)80111-1
更新日期：1991-12-20 00:00:00
abstract：:Nedd4 is a widely expressed ubiquitin ligase that is necessary for normal neuronal development and function. However, largely due to the lethality of Nedd4 homozygous knockout mice, little is known about the physiological roles of Nedd4 in the adult brain. In this study we used Nedd4 heterozygous mice, which are viabl...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2013.11.024
更新日期：2014-03-01 00:00:00
abstract：:The structural characteristics of the area postrema, its anatomical connections, participation in the detection of emesis-provoking substances and the effects of area postrema lesions on taste aversion learning acquisition, are all factors which speak in favor of a role as a chemoreceptor zone involved in the detectio...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(88)90172-6
更新日期：1988-10-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2005.03.007
更新日期：2005-07-30 00:00:00
abstract：:Diabetes mellitus, which causes hyperglycemia, affects the central nervous system and can impairs cognitive functions, such as memory. The aim of this study was to investigate the effects of hyperglycemia on memory as well as on the activity of acethylcholinesterase. Hyperglycemia was induced in adult zebrafish by imm...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.08.033
更新日期：2014-11-01 00:00:00
abstract：:Amplitude and habituation of the acoustic startle response were assessed in four recombinant inbred (RI) rat strains. One group from each strain underwent repeated restraint stress, the last session of which was 24h before startle testing while, a second group from each strain was not stressed prior to testing. Additi...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(03)00061-5
更新日期：2003-09-15 00:00:00
abstract：:Expression of Schaffer collateral-CA1 long-term potentiation (LTP) and long-term depression (LTD) was not affected in hippocampal slices from wild-type mice pretreated with lipopolysaccharide (0.25mg/kg, i.p.), to increase interleukin-18 (IL-18) concentrations in the brain. For IL-18 knock-out (IL-18 KO) mice, the LTP...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2009.08.033
更新日期：2010-01-05 00:00:00
abstract：:The core symptoms of autism spectrum disorder (ASD) include deficits in social interaction, impaired communication, and repetitive behaviors with restricted interests. Mouse models with behavioral phenotypes relevant to these core symptoms offer an experimental approach to advance the investigation of genes associated...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.06.025
更新日期：2010-12-25 00:00:00
abstract：:Administration of beta-phenylpyruvate at high concentrations reduces blood glucose levels and causes neurophysiological deterioration in insulin-deprived mice. We investigated whether beta-phenylpyruvate administration would cause long-term neurobehavioral and structural central neural damage in mice. Neonatal ICR mic...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(03)00075-5
更新日期：2003-07-14 00:00:00
abstract：:Sex steroids exert potent effects on mood and mental state in the human. Our previous experimental findings in female rats suggest that these effects may be mediated, in part, by the action of estrogen on the 5-hydroxytryptamine2A receptor (5-HT(2A)R) and serotonin transporter (SERT) in brain. Here we review our recen...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/s0166-4328(99)00082-0
更新日期：1999-11-01 00:00:00
abstract：:Weight gain and sexual dysfunction are serious side effects of certain antipsychotic drugs. Ziprasidone, a novel antipsychotic with a unique receptor binding profile, is reported to have a low propensity for such side effects. Previous results from this laboratory have demonstrated substantial weight gain following su...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2004.12.015
更新日期：2005-05-28 00:00:00
abstract：:Our previous work provided evidence that hippocampal opioid peptides form an important neurochemical substrate underlying the gene-dependent exploratory behavior of mice. A prominent hippocampal opioid is dynorphin B, which resides in the mossy fibers exclusively. In order to seek support for causal relationships betw...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(05)80052-x
更新日期：1991-04-18 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.02.016
更新日期：2015-05-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(01)00195-4
更新日期：2001-08-27 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/j.bbr.2014.08.065
更新日期：2015-01-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(99)00070-4
更新日期：1999-11-15 00:00:00
abstract：:In rats lesioned with 6-hydroxydopamine (6-OHDA) the effect of the noncompetitive N-methyl D-aspartate (NMDA) receptor antagonist, MK-801, the dopamine (DA) D2 receptor agonist quinpirole and the A2A adenosine antagonist SCH 58261 was studied on acetylcholine (ACh) release in the lesioned striatum and contralateral tu...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(99)00038-8
更新日期：1999-09-01 00:00:00
abstract：:When rats are placed in a novel environment, they alternate between progression and stopping: in the course of a session they stop briefly in many places, but in one or two places they also stop for very long periods. The place in which they stay for the longest cumulative time is defined as the rat's home base. In th...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(89)80102-0
更新日期：1989-09-01 00:00:00
abstract：:We investigated the neurobiological bases of variation in response to predator stress (PS). Sixteen days after treatment (PS or handling), rats were grouped according to anxiety in the elevated plus maze (EPM). Acoustic startle was also measured. We examined the structure of dendritic trees of basolateral amygdala (BL...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.09.009
更新日期：2012-01-01 00:00:00
abstract：:Attention plays an important role in perception and cognition, and developing an effective method to train and improve attention is an essential and challenging task. In this study, fingertip-based adaptive force control tasks (AFCT) were explored for attention training, and the visual-channel task called an attention...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2019.03.028
更新日期：2019-12-30 00:00:00
abstract：:Maternal nutrition impacts fetal development, and may play a role in determining resilience to stress and vulnerability to stress-precipitated psychiatric disorders, such as anxiety and depression. In this study, we examined the effect of a reduction in maternal dietary protein during pregnancy on the brain neurochemi...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2018.03.038
更新日期：2018-09-03 00:00:00
abstract：:The amygdala (AM) and the periaqueductal gray (PAG) represent the rostral and the caudal pole, respectively, of a longitudinally organized neural system, that is responsible for the integration of behavioral and physiological manifestations of defensive reactions against innate and learned threats. Microinjection of b...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/0166-4328(93)90097-a
更新日期：1993-12-20 00:00:00
abstract：:This study determined if the hippocampal theta rhythm showed phase relationships or changes in amplitude and frequency with the onset of stimuli and locomotion in a task in which auditory cues initiated and suppressed approach locomotion. Rats with electrodes in the dorsal hippocampus lapped at a milk dipper and were ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2004.12.006
更新日期：2005-05-28 00:00:00
abstract：:One of the routine memory abilities impaired in amnesic patients with temporal-lobe damage is object-recognition memory--the ability to discriminate the familiarity of previously encountered objects. Reproducing this impairment has played a central role in animal models of amnesia during the past two decades, and unti...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/s0166-4328(01)00367-9
更新日期：2001-12-14 00:00:00
