Abstract:
PURPOSE:To measure subbasal nerve density and orientation in normal human corneas across a broad age range. METHODS:Sixty-five normal corneas of 65 subjects were examined by using tandem scanning confocal microscopy. Ages of subjects ranged from 15 to 79 years (mean 46 +/- 19 years), with 5 subjects from each hemidecade. Subbasal nerve fiber bundles appeared as bright, well-defined linear structures in confocal images of the central cornea. Images from 3 to 8 scans per eye (mean 4.6 +/- 1.8 scans) were randomly presented to a masked observer for analysis. The mean subbasal nerve density (total nerve length [microm] within a confocal image [area = 0.166 mm]), the mean nerve number per confocal scan, and the mean nerve orientation were determined by using a custom software program. Correlations between age and nerve density and age and nerve orientation were assessed by using Pearson correlation coefficients. RESULTS:The subbasal nerve plexus was visible in the central cornea of all subjects. The mean subbasal nerve density was 8404 +/- 2012 microm/mm (range 4735 to 14,018 microm/mm). The mean subbasal nerve number was 4.6 +/- 1.6 nerves (range 1 to 8 nerves). The mean subbasal nerve orientation was 94 +/- 16 degrees (range 58 to 146 degrees). There was no correlation between age and subbasal nerve density (r = 0.21, P = 0.09) or between age and subbasal nerve orientation (r = -0.19, P = 0.12). CONCLUSION:The density and orientation of the subbasal nerve plexus in the central human cornea does not change with age.
journal_name
Corneajournal_title
Corneaauthors
Erie JC,McLaren JW,Hodge DO,Bourne WMdoi
10.1097/01.ico.0000154387.51355.39subject
Has Abstractpub_date
2005-08-01 00:00:00pages
705-9issue
6eissn
0277-3740issn
1536-4798pii
00003226-200508000-00011journal_volume
24pub_type
杂志文章相关文献
CORNEA文献大全abstract:PURPOSE:To report a case of partial scleral rupture after laser in situ keratomileusis (LASIK) surgery. METHODS:This is a retrospective case report describing a late complication of LASIK surgery. RESULTS:A 32-year-old white woman with a history of LASIK surgery performed with a mechanical microkeratome 4 years previ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001850
更新日期:2019-04-01 00:00:00
abstract:PURPOSE:The aim of this study was to investigate the corneal thickness asymmetry indices in a large pool of patients with keratoconus derived using anterior segment optical coherence tomography (AS-OCT) in comparison with established Scheimpflug imaging-derived keratoconus classification indices. METHODS:Six specific ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000275
更新日期:2014-12-01 00:00:00
abstract:PURPOSE:To evaluate visual, refractive, and corneal topography outcomes in eyes with keratoconus that have undergone exchange/adjustment surgery with a new intrastromal corneal ring segment (ICRS) combination after unsuccessful visual and/or refractive outcomes after primary ICRS surgery. METHODS:A retrospective nonra...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001449
更新日期:2018-02-01 00:00:00
abstract::This paper reviews the data of Frank et al. in the light of increasing concern over the safety of contact lenses used for extended wear. Relative risks were calculated for four types of contact lenses (CLs): extended wear soft, daily wear soft, rigid gas-permeable (RGP), and polymethylmethacrylate (PMMA) lenses--worn ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199010001-00024
更新日期:1990-01-01 00:00:00
abstract:PURPOSE:To examine the cornea of patients with Marfan syndrome in comparison with a control group by using the in vivo confocal microscope. METHODS:Twenty-four eyes of 12 patients with Marfan syndrome had their corneas examined using the in vivo confocal microscope Heidelberg Retina Tomograph (HRT) II/Rostock Cornea M...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31806c7729
更新日期:2007-08-01 00:00:00
abstract:PURPOSE:To evaluate endothelial cell damage after eye bank preparation and passage through 1 of 2 different injectors for Descemet membrane endothelial keratoplasty grafts. METHODS:Eighteen Descemet membrane endothelial keratoplasty grafts were prepared by Lions VisionGift with the standard partial prepeel technique a...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000690
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:To evaluate and compare the in vitro antimicrobial activity of levofloxacin versus ciprofloxacin and ofloxacin against ocular isolates from patients with bacterial conjunctivitis. METHODS:The in vitro antimicrobial susceptibilities of ocular isolates to levofloxacin, ofloxacin, and ciprofloxacin were determine...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200104000-00012
更新日期:2001-04-01 00:00:00
abstract:PURPOSE:To evaluate the accuracy and precision of corneal flap thickness following laser in situ keratomileusis (LASIK) performed using the 140-, 160-, and 180-microm heads for the Amadeus microkeratome (AMO, Irvine, CA). SETTING:The study took place at the Cullen Eye Institute, Baylor College of Medicine, Houston. M...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200308000-00003
更新日期:2003-08-01 00:00:00
abstract:PURPOSE:To investigate the feasibility of using Brillouin microscopy for assessment of corneal edema in patients with Fuchs endothelial corneal dystrophy (FECD). Brillouin microscopy analyzes the frequency shift of light inelastically scattered by naturally occurring acoustic waves in a small volume of tissue. The resu...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002191
更新日期:2020-02-01 00:00:00
abstract:PURPOSE:To assess the surgical and clinical outcomes of anterior lamellar keratoplasty using anterior corneal buttons from Descemet stripping automated endothelial keratoplasty (DSAEK) donor tissue. METHODS:Retrospective data from 8 patients with unilateral limbal dermoids, treated between February 2011 and January 20...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001021
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:To evaluate the morphological features of the corneal limbus as measured by in vivo confocal microscopy (IVCM) following standard and accelerated corneal collagen cross-linking (CXL) for keratoconus. METHODS:Patients with progressive keratoconus scheduled to undergo standard CXL (group 1; 31 patients, 3 mW/cm,...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001029
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:To describe the clinical characteristics, diagnosis, treatment, and visual outcome of 61 cases of Fusarium keratitis in Mexico. METHODS:Retrospective, comparative study of 61 patients with clinically and culture-confirmed Fusarium keratitis, who were attended at an eye hospital in Mexico City from 1981 to 2001...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31819bc2ea
更新日期:2009-07-01 00:00:00
abstract:PURPOSE:To determine the effectiveness of prophylactic fluoroquinolone treatment against staphylococci in a rabbit keratitis model. METHODS:Prophylactic ciprofloxacin or ofloxacin was applied as one topical drop 15 minutes before infection or as one drop at three time points (19, 17, and 15 minutes) before infection. ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200111000-00020
更新日期:2001-11-01 00:00:00
abstract::An evaluation of the final "sutures out" postoperative astigmatism in two groups of keratoconus patients undergoing penetrating keratoplasty is presented. Group I consists of a retrospective evaluation of keratoconus patients who underwent penetrating keratoplasty without using the Troutman Keratometer prior to suturi...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199309000-00005
更新日期:1993-09-01 00:00:00
abstract::A modified relaxing incision technique for postkeratoplasty astigmatism is described in this article. Following the initial, standard relaxing incision techniques, a planned spreading and recutting of the initial relaxing incision was performed at 1-3-week intervals following the initial surgery. The wound may be deep...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract:PURPOSE:To evaluate the current standard of care of ophthalmologists who are likely to encounter ocular surface squamous neoplasia (OSSN) in their practices and to compare this with data gathered in 2003. METHODS:Invitations to a web-based survey were sent to members of the Ocular Microbiology and Immunology Group. In...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3182a6ea6c
更新日期:2013-12-01 00:00:00
abstract::Penetrating keratoplasty is currently the only treatment for corneal endothelial dysfunction. Although corneal transplantation has a high success rate, a few problems still remain, such as the limited availability of donor grafts, the change in refraction after penetrating keratoplasty, and the higher chance of immune...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199403000-00011
更新日期:1994-03-01 00:00:00
abstract::The iridocorneal endothelial (ICE) syndrome is potentially a blinding condition as a result of glaucoma and/or corneal decompensation. The basic pathology seems to be in the corneal endothelium, which many studies confirm takes on a characteristic slit lamp appearance of hammered silver and image reversal with the spe...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199105000-00009
更新日期:1991-05-01 00:00:00
abstract:PURPOSE:To report on the safety and clinical use of combined subconjunctival and intracorneal bevacizumab for corneal neovascularization. METHODS:The charts of 12 consecutive patients with corneal neovascularization who received combined subconjunctival and intracorneal injections of bevacizumab (2.5 mg/0.1 mL) were r...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31821379aa
更新日期:2011-10-01 00:00:00
abstract:PURPOSE:To investigate the pachymetric changes of collagen cross-linking in corneas with edema because of endothelial dysfunction. METHODS:Interventional case series included 25 eyes of 25 consecutive patients with corneal edema for at least 4 months related to Fuchs endothelial dystrophy, corneal graft failure, and p...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181c296c2
更新日期:2010-06-01 00:00:00
abstract:PURPOSE:Endogenous hyaluronan (HA) has previously been shown to be a part of corneal wound healing after photorefractive keratectomy (PRK). HA is known to bind considerable amounts of water. This study aimed to show whether HA colocalized with water in the wound area after PRK. METHODS:Five New Zealand White rabbits w...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1997-09-01 00:00:00
abstract:PURPOSE:This study investigated the topographic corneal thickness in four groups of Hong Kong Chinese. METHODS:The corneal thickness was determined with an ultrasound pachometer mounted on a X-Y plate. A head rest was used to reduce further any movement from the subject during the measurement. After the central cornea...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199807000-00008
更新日期:1998-07-01 00:00:00
abstract:PURPOSE:To determine the effects of single radial or horizontal suture placement in 2-step clear corneal incision (CCI) wound apposition and permeability to particles of India ink. METHODS:Five fresh human globes were included. Two 25-gauge needles connected to a saline solution bag and to a digital manometer were ins...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31824d0d45
更新日期:2013-03-01 00:00:00
abstract:PURPOSE:In a Strampelli osteo-odonto-keratoprosthesis, a patch of oral mucosa is frequently used to cover the ocular surface after implantation of an osteodental lamina into the eye. In many cases, gross modifications in the eye covering become apparent a few years later. The aim of this study was to investigate the hi...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000170695.98078.42
更新日期:2006-02-01 00:00:00
abstract::Although corneal epithelial stem cells (SCs) are located at the limbus between the cornea and the conjunctiva, not all limbal basal epithelial cells are SCs. Using 2 dispase digestions to remove different amounts of limbal basal epithelial cells for cross-sections, flat mounts, and cytospin preparations, double immuno...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181ea4b13
更新日期:2010-11-01 00:00:00
abstract:PURPOSE:To investigate the long-term effect and safety of collagen cross-linking (CXL) on patients with bullous keratopathy (BK) in a randomized control manner. It is, to our knowledge, the first randomized control study on the effect of CXL on BK. METHODS:Subjects were randomized to receive CXL as in the standard pro...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002395
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:To investigate the regulation of matrix metalloproteinase (MMP)-3 and MMP-13 expression over time and in the presence of cyclosporine A (CsA) in primary cultured human pterygium fibroblasts. We also examined the effects of CsA on cultured human pterygium fibroblasts. METHODS:Primary cultured human pterygium fi...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000477
更新日期:2015-09-01 00:00:00
abstract:PURPOSE:To evaluate a new method of calculation of total corneal astigmatism based on Gaussian optics and the power design of a spherocylindrical lens (C) in the healthy eye and to compare it with keratometric (K) and power vector (PV) methods. METHODS:A total of 92 healthy eyes of 92 patients (age, 17-65 years) were ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001577
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:To study the possible changes in Scheimpflug corneal densitometry 6 months after mitomycin C-augmented trabeculectomy and to compare these measurements with healthy controls. METHODS:Corneal densitometry was monitored with the Pentacam HR3 before and 6 months after first-time uncomplicated mitomycin C-augmente...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002439
更新日期:2020-07-27 00:00:00
abstract:PURPOSE:To report a cluster of postoperative Acanthamoeba endophthalmitis after routine cataract surgeries. METHODS:A brief summary of sentinel events leading to the referral of 4 patients of postoperative endophthalmitis to our hospital is followed by clinical descriptions and the various diagnostic approaches and in...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002603
更新日期:2021-02-01 00:00:00