Clinical value of C-reactive protein measurements in HIV-positive patients.

Abstract:

:The acute-phase protein C-reactive protein (CRP) is a sensitive marker of inflammation and tissue damage. We measured CRP in 109 HIV-1 antibody-positive patients admitted to hospital for investigation. In 67 patients with intercurrent infection (of whom 27 were afebrile at presentation) CRP levels were 2.2-483.5 mg/dL (normal value in the general population <3 mg/dL) and in 42 patients with alternative non-infection diagnoses CRP levels were 0.5-108.6 (median=5.9) mg/dL. Whereas in those with infections elevated CRP levels fell in response to specific therapy, values remained abnormal in those with non-infection diagnoses. CRP appears useful for diagnosis and monitoring of intercurrent infection in HIV-1 antibody-positive patients. In HIV-1 antibody-positive patients without intercurrent infection, CRP values higher than in the general population possibly reflect a sustained acute-phase response as a consequence of HIV infection per se.

journal_name

Int J STD AIDS

authors

Noursadeghi M,Miller RF

doi

10.1258/0956462054094006

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

438-41

issue

6

eissn

0956-4624

issn

1758-1052

journal_volume

16

pub_type

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