Abstract：
:Reduction of the expression of catenin is a crucial step in the pathogenesis, progression and prognosis of many epithelial cancers including squamous cell carcinomas (SCCs). Catenin expression in oral carcinomas was evaluated in relation to clinico-pathological features in order to determine its value as a prognostic marker. Eighty-five patients with histologically proven T1/2 squamous cell carcinoma of the oral floor who underwent surgical treatment were eligible for the study. A tissue microarray consisting of multiple representative tissue cores of each carcinoma was composed. The expression levels of alpha, beta and gamma-catenins were determined immunohistologically. Correlation between clinical features and the expression of catenin proteins was evaluated statistically using Kaplan-Meier curves, log-rank tests and chi(2)-tests. Loss of alpha-catenin expression in carcinoma of the floor of the mouth correlated significantly with poor prognosis (P=0.05). Conversely, significantly reduced rates of lymph-node metastases were observed in alpha- and beta-catenin-positive T1 and T2 SCCs. Loss of gamma-catenin expression indicated a reduced survival rate in nodal-negative tumours (P=0.02). Catenin expression in carcinomas of the floor of the mouth seems to be a predictive parameter in the prognosis of T1 and T2 SSCs.
journal_name
Int J Oral Maxillofac Surgjournal_title
International journal of oral and maxillofacial surgeryauthors
Fillies T,Buerger H,Gaertner C,August C,Brandt B,Joos U,Werkmeister Rdoi
10.1016/j.ijom.2005.03.010subject
Has Abstractpub_date
2005-12-01 00:00:00pages
907-11issue
8eissn
0901-5027issn
1399-0020pii
S0901-5027(05)00098-6journal_volume
34pub_type
杂志文章abstract：:This study was performed to evaluate the use of three-dimensional (3D) strut plates for the surgical management of mandibular angle fractures and to determine the subsequent postoperative complication rate. Two hundred and twenty-two patients met the inclusion criteria for mandible angle fracture at the university hos...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2016.05.023
更新日期：2016-11-01 00:00:00
abstract：:Two cases of ameloblastic fibrodentinoma localized in the posterior mandibular area are presented. The clinical and histological findings are discussed. ...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/s0901-5027(97)80013-6
更新日期：1997-12-01 00:00:00
abstract：:Septic arthritis of the temporomandibular joint (TMJ) has a high morbidity, is infrequently reported, and has been described almost exclusively in adults. We present two cases of septic arthritis of the TMJ that occurred in children after minor blunt trauma. Literature related to septic arthritis of the TMJ was review...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章,评审
doi：10.1016/s0901-5027(05)80519-3
更新日期：1993-10-01 00:00:00
abstract：:This study assessed the use of composite autogenous bone and deproteinized bovine bone (DBB) for repairing alveolar cleft compared with autogenous bone alone in terms of clinical outcomes and patient morbidity. 30 patients with a mean age of 10.2±1.7 years were randomly divided into two groups. Group I used autogenous...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ijom.2010.07.008
更新日期：2010-12-01 00:00:00
abstract：:Horner's syndrome and Harlequin syndrome are both caused by disruptions to the sympathetic supply to the face. They have a varied aetiology, including intraneural dysfunction, extra- or intraneural compression, and idiopathic as well as iatrogenic causes. Horner's syndrome can occur as a rare complication of thyroid s...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2015.01.008
更新日期：2015-06-01 00:00:00
abstract：:Central mucoepidermoid carcinomas are uncommon tumours, representing about 2 to 4% of all mucoepidermoid carcinomas. They are histologically low-grade cancers, usually affecting the mandible as uni- or multilocular radiographic lesions. The authors report four cases of central mucoepidermoid carcinomas affecting the m...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1054/ijom.2002.0374
更新日期：2003-08-01 00:00:00
abstract：:Macroglossia is observed in the majority of paediatric patients diagnosed with Beckwith-Wiedemann syndrome and surgical treatment may be indicated. A 20-year retrospective study was performed to evaluate all patients with Beckwith-Wiedemann syndrome who underwent tongue reduction surgery at the authors' institution. A...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章,评审
doi：10.1016/j.ijom.2011.10.021
更新日期：2012-03-01 00:00:00
abstract：:Seventy dental students (mean age: 20 years) with 130 asymptomatic, non-ectopic, impacted mandibular 3rd molars were followed for 4 years. At the initial visit 26 were impacted in soft tissue, 30 were partially impacted in bone, and 74 were completely impacted in bone. The following items were registered at each visit...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/s0901-5027(89)80094-3
更新日期：1989-10-01 00:00:00
abstract：:A 7-year-old boy presented in whom a metaphyseal fibrous defect was diagnosed. The lesion was enucleated under local anesthesia. The postoperative course was uneventful and there have been no signs of recurrence as of 14 months after operation. Although rare, metaphyseal fibrous defect should be included in the differ...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/s0901-5027(05)80834-3
更新日期：1997-04-01 00:00:00
abstract：:The histological fate of abdominal dermis-fat grafts implanted into the temporomandibular joint (TMJ) following condylectomy was studied. 21 rabbits underwent left TMJ discectomies and condylectomies; 6 were controls (Group A; no graft used); 15 (Group B) had autogenous abdominal grafts transplanted into the left TMJ....
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2010.09.022
更新日期：2011-02-01 00:00:00
abstract：:Arthroscopic procedures for diagnosis and treatment of temporomandibular joint (TMJ) diseases are widely used. Few adverse effects of the procedures have been reported. In this in vivo study, diagnostic arthroscopy was performed in the left TMJ of seven castrated male goats, the right TMJ serving as a control. The goa...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/s0901-5027(05)80326-1
更新日期：1994-02-01 00:00:00
abstract：:The purpose of this retrospective study was to assess the feasibility of using a free fibula flap (FFF) for reconstruction of the alveolar region of the severely atrophic mandible, by determining bone stability after dental implant insertion and prosthetic rehabilitation in a series of eight female patients aged 36-65...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2020.08.005
更新日期：2020-09-03 00:00:00
abstract：:The aim of this study was to evaluate the clinical efficacy of 4% articaine (Ar4) compared to 2% mepivacaine (Me2), both in combination with 1:100,000 epinephrine, in a unique soft tissue model. This was a randomized, double-blind, crossover clinical trial. The anaesthetic was applied to the lower lip using a computer...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ijom.2017.11.011
更新日期：2018-07-01 00:00:00
abstract：:Recent studies have suggested magnetic resonance imaging (MRI) as useful in the evaluation of soft-tissue changes that occur in the temporomandibular joint (TMJ) after acute condylar trauma. The aim of this study was to investigate whether MRI findings of disc displacement, capsular tear and haemarthrosis are linked t...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2006.09.013
更新日期：2007-03-01 00:00:00
abstract：:A new therapy for the treatment of oral leukoplakia by 5-aminolevulinic acid (ALA) and photodynamic therapy (PDT) is presented. ALA, a precursor in the biosynthesis of haeme, induces the production of the endogenous photosensitizer protoporphyrin IX which can be used for PDT. Twelve patients, who had been suffering fr...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 临床试验,杂志文章
doi：10.1016/s0901-5027(98)80040-4
更新日期：1998-12-01 00:00:00
abstract：:Direct oral anticoagulants (dabigatran, rivaroxaban, apixaban and edoxaban; DOACs) have been introduced to improve safety and superior therapeutic value compared to their predecessors such as warfarin or enoxaparin. The aim of this systematic review and meta-analysis was to assess the postoperative bleeding risk of DO...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章,meta分析
doi：10.1016/j.ijom.2018.03.016
更新日期：2018-07-01 00:00:00
abstract：:Temporomandibular joint (TMJ) dislocation can be classified into four groups (anterior, posterior, lateral, and superior) depending on the direction of displacement and the location of the condylar head. All the groups are rare except for anterior dislocation. 'Inverse' TMJ dislocation is a bilateral anterior and supe...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2011.02.012
更新日期：2011-08-01 00:00:00
abstract：:A case of osteomyelitis in a 71-year-old woman with paroxysmal nocturnal hemoglobinuria (PNH) is reported. Osteomyelitis of the jaw is a well known condition of the oral and maxillofacial region that may cause severe morbidity. It is well documented that vaso-occlusive crises in sickle cell anaemia, a hemolytic blood ...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2011.06.016
更新日期：2011-12-01 00:00:00
abstract：:Nitric oxide (NO) has a complex role in tumour biology. Most cancer research has focused on the enzyme nitric oxide synthase-2 (NOS2), an inducible isoform responsible for prolonged NO production. In normal cells exposed to high NO concentrations, the tumour-suppressor gene, p53, promotes apoptosis via the p21 pathway...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1054/ijom.2001.0214
更新日期：2002-04-01 00:00:00
abstract：:The purpose of this study was to evaluate a personalized orthognathic surgical guide (POSG) system for bimaxillary surgery without the use of surgical splint. Ten patients with dentofacial deformities were enrolled. Surgeries were planned with the computer-aided surgical simulation method. The POSG system was designed...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2017.03.025
更新日期：2017-10-01 00:00:00
abstract：:The study aimed to evaluate the removal torque and bone tissue response to titanium implants supported by one or two cortical layers. A total of 72 screw titanium implants, either 10 or 16 mm in length and 3.75 mm in diameter, were inserted in right and left tibiae of 18 adult New Zealand rabbits. The implants engaged...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/s0901-5027(96)80036-1
更新日期：1996-06-01 00:00:00
abstract：:Recreating a harmonious gingival contour for contiguous missing teeth in the anterior maxilla is challenging. The aim of this study was to evaluate a split pedicle roll envelope technique designed for pontics. Twelve patients presented a labial flat or concave profile at the implant and pontic sites before second-stag...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2015.04.012
更新日期：2015-10-01 00:00:00
abstract：:Solitary myeloma may be the first manifestation of the disseminated form, known as multiple myeloma, and characterized by multiple skeletal lesions, general metabolic alterations, impairment of renal function and eventually death. Involvement of the jaws is not unusual, although infrequently reported. We present 2 cas...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/s0901-5027(87)80095-4
更新日期：1987-08-01 00:00:00
abstract：:The purpose of this study was to evaluate as well as to compare the effect of intra-articular versus intra-peritoneal injection of dexamethasone on synovitis induced by trauma to the rat's TMJ. Twenty-seven male Wister rats were included in the present study. Induced forced condylar hypermobility achieved through open...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2004.05.004
更新日期：2005-05-01 00:00:00
abstract：:Lack of sufficient bone to place an implant at the functionally and aesthetically most appropriate position is a common problem, especially in the upper anterior jaw. A surgical technique is proposed to augment the alveolar ridge for vertical and horizontal defects through a localized alveolar osteotomy and interposit...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2007.05.006
更新日期：2007-10-01 00:00:00
abstract：:A case of metastatic osteosarcoma in the submental vestibule of the oral cavity and the lung is described in an 18-year-old male with primary osteosarcoma occurring in the sacrum. Dissemination of osteosarcoma to other organs, especially early to the lung, is common, but its metastasis to the oral mucosa has been rare...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2006.04.004
更新日期：2006-11-01 00:00:00
abstract：:This study aimed to determine the effect of the co-administration of dexamethasone 8mg and nimesulide 100mg given 1h before mandibular third molar surgery. A prospective, randomized, triple-blind, split-mouth clinical trial was developed at the study institution in Pernambuco, Brazil. A pilot study was first performed...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ijom.2016.10.011
更新日期：2017-02-01 00:00:00
abstract：:The use of a combination of intraoperative cone-beam computed tomography (CBCT) and a navigation system via a spinal software platform for the navigated implantation of oral implants after microsurgical bone transfer is described. Intraoperative data sets were generated using Arcadis Orbic 3D (Siemens, Medical Solutio...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2007.06.011
更新日期：2008-01-01 00:00:00
abstract：:Cocaine is a very potent vasoconstrictor that is used by ENT specialists to reduce blood loss and enhance visibility during nasal surgery. In orthognathic surgery, especially Le Fort I procedures, excessive blood loss is a relatively frequent complication. In this study, a prospective randomized clinical trial on the ...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ijom.2007.07.017
更新日期：2008-01-01 00:00:00
abstract：:Preoperative radiological evaluation of the extent of local invasion in maxillary squamous cell carcinoma (SCC) is very important in planning curative surgery. The aim of this study was to examine the accuracy of preoperative radiological evaluation with magnetic resonance imaging (MRI) for the extent of local invasio...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2013.11.017
更新日期：2014-06-01 00:00:00
