当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY期刊下所有文献 > Effects of co-administered dexamethasone and nimesulide on pain, swelling, and trismus following third molar surgery: a randomized, triple-blind, controlled clinical trial.

Effects of co-administered dexamethasone and nimesulide on pain, swelling, and trismus following third molar surgery: a randomized, triple-blind, controlled clinical trial.

Abstract：

:This study aimed to determine the effect of the co-administration of dexamethasone 8mg and nimesulide 100mg given 1h before mandibular third molar surgery. A prospective, randomized, triple-blind, split-mouth clinical trial was developed at the study institution in Pernambuco, Brazil. A pilot study was first performed (95% confidence interval, 80% test power, and 5% error), and a sample of 40 patients aged between 18 and 40 years was selected. The patients were randomized and divided into two groups: dexamethasone+placebo and dexamethasone+nimesulide. The following parameters were evaluated: pain (visual analogue scale), total number of rescue analgesics taken, time taken to first rescue analgesic consumption, oedema, trismus, and patient satisfaction. The paired t-test and the Wilcoxon test were used to compare means. Statistically significant differences were found between the groups in pain values at 2, 4, and 12h postoperative, and in the total number of rescue analgesics and time taken to first rescue analgesic ingestion (P<0.05), with results in favour of dexamethasone+nimesulide administration. Oedema and trismus were similar in the two treatment groups and decreased over time postoperatively. The co-administration of dexamethasone and nimesulide reduces pain intensity and the need for rescue medication after third molar surgery.

journal_name

Int J Oral Maxillofac Surg

journal_title

International journal of oral and maxillofacial surgery

authors

Barbalho JC,Vasconcellos RJ,de Morais HH,Santos LA,Almeida RA,Rêbelo HL,Lucena EE,de Araújo SQ

doi

10.1016/j.ijom.2016.10.011

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

236-242

issue

2

eissn

0901-5027

issn

1399-0020

pii

S0901-5027(16)30284-3

journal_volume

46

pub_type

杂志文章,随机对照试验

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