Screening for maternal coeliac disease as a potential risk factor for orofacial clefts--a pilot study.

Abstract:

:There is increasing evidence that dietary folic acid deficiency in utero may increase the risk of developing the 'cleft lip with or without cleft palate' (CL±P) variant of orofacial cleft. Coeliac disease is a common cause of folic acid malabsorption, and in the majority of cases remains undiagnosed. This pilot study assessed the seroprevalence of undiagnosed coeliac disease in a cohort of mothers of infants with CL±P in the Hyderabad area of India. The seroprevalence of coeliac disease of 1.15% (95% confidence interval 0.37-2.66%) was little different from the expected figure based on published population studies, making a clinically significant association unlikely.

authors

Reddy SG,Reddy RR,Vaidhyanathan A,Markus A,Snook J

doi

10.1016/j.ijom.2013.03.021

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

1424-6

issue

11

eissn

0901-5027

issn

1399-0020

pii

S0901-5027(13)00161-6

journal_volume

42

pub_type

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