Abstract：
:A new therapy for the treatment of oral leukoplakia by 5-aminolevulinic acid (ALA) and photodynamic therapy (PDT) is presented. ALA, a precursor in the biosynthesis of haeme, induces the production of the endogenous photosensitizer protoporphyrin IX which can be used for PDT. Twelve patients, who had been suffering from leukoplakia of the oral mucosa for several years, were treated by ALA-mediated PDT. ALA was used as a topical photosensitizer and 20% ALA cream was applied to the leukoplakia lesion of the oral mucosa for two hours and then light activated at 630 nm, 100 mW/cm2 and 100 J/cm2. Five patients showed complete response to the treatment, four patients showed a partial response and in three patients treatment was unsuccessful. One patient with partial response was retreated, after which the lesion disappeared.
journal_name
Int J Oral Maxillofac Surgjournal_title
International journal of oral and maxillofacial surgeryauthors
Kübler A,Haase T,Rheinwald M,Barth T,Mühling Jdoi
10.1016/s0901-5027(98)80040-4subject
Has Abstractpub_date
1998-12-01 00:00:00pages
466-9issue
6eissn
0901-5027issn
1399-0020journal_volume
27pub_type
临床试验,杂志文章abstract：:The aim of this study was to investigate the correlation between tumour thickness (TT) on intraoral ultrasound (US) and magnetic resonance imaging (MRI) with the histologically determined TT of tongue cancers. Secondary objectives included evaluation of potential confounders that affect this association and the predic...
journal_title：International journal of oral and maxillofacial surgery
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journal_title：International journal of oral and maxillofacial surgery
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journal_title：International journal of oral and maxillofacial surgery
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journal_title：International journal of oral and maxillofacial surgery
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journal_title：International journal of oral and maxillofacial surgery
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journal_title：International journal of oral and maxillofacial surgery
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