Abstract：
:Direct oral anticoagulants (dabigatran, rivaroxaban, apixaban and edoxaban; DOACs) have been introduced to improve safety and superior therapeutic value compared to their predecessors such as warfarin or enoxaparin. The aim of this systematic review and meta-analysis was to assess the postoperative bleeding risk of DOACs during oral surgery procedures. Systematic searches were performed in electronic databases including PubMed, Scopus, Web of Science and Cochrane Library. Thirteen studies were included in the qualitative synthesis: two retrospective case-control studies, five prospective case-control studies, three cross-sectional studies, two case series and a case report; while only six studies were statistically analysed. The risk ratio of postoperative bleeding in DOACs patients was significantly greater than in healthy patients (3.04; 95% confidence interval (CI)=1.31-7.04). This is especially true for rivaroxaban (4.13; 95% CI=1.25-13.69), and less so for dabigatran which presented a risk ratio similar to that of healthy patients (1.00; 95% CI=0.21-4.82). However, further research is required to support these results. Both apixaban and edoxaban were excluded from statistical analysis due to the lack of clinical studies.
journal_name
Int J Oral Maxillofac Surgjournal_title
International journal of oral and maxillofacial surgeryauthors
Bensi C,Belli S,Paradiso D,Lomurno Gdoi
10.1016/j.ijom.2018.03.016subject
Has Abstractpub_date
2018-07-01 00:00:00pages
923-932issue
7eissn
0901-5027issn
1399-0020pii
S0901-5027(18)30102-4journal_volume
47pub_type
杂志文章,meta分析abstract：:An example of a central odontogenic fibroma is presented. This is a rare, benign neoplasm which affected the molar region of the left side of the mandible of a 63-year-old female Caucasian. Histologically, it consisted of fibroblast-like cells lying in a rather myxomatous delicate collagenous stroma. Few islands of od...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/s0901-5027(88)80156-5
更新日期：1988-04-01 00:00:00
abstract：:Preoperative radiological evaluation of the extent of local invasion in maxillary squamous cell carcinoma (SCC) is very important in planning curative surgery. The aim of this study was to examine the accuracy of preoperative radiological evaluation with magnetic resonance imaging (MRI) for the extent of local invasio...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2013.11.017
更新日期：2014-06-01 00:00:00
abstract：:The purpose of this study was to compare the complications of patients treated for a benign parotid tumour (BPT) by extracapsular dissection (ECD) vs. partial superficial parotidectomy (PSP). A comprehensive literature investigation was conducted by searching electronic databases. A systematic review and meta-analysis...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章,meta分析
doi：10.1016/j.ijom.2019.01.030
更新日期：2019-07-01 00:00:00
abstract：:Rhabdomyosarcoma (RMS) is a malignant soft tissue neoplasm, with varying degrees of striated muscle cell differentiation and a relative predilection for the head and neck region. The objectives of this study were to determine the clinical and histological patterns of RMS, to assess the sociodemographic profile of repo...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2008.12.002
更新日期：2009-03-01 00:00:00
abstract：:The purpose of this study was to evaluate abnormal magnetic resonance imaging (MRI) findings related to temporomandibular joint (TMJ) pain. This study included 245 joints of 152 patients with temporomandibular disorders with anterior disc displacement; of these, 129 joints had joint pain whereas 116 joints had no join...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2019.06.028
更新日期：2020-02-01 00:00:00
abstract：:The purpose of this study was to investigate the relationship between the pressure drop in the pharyngeal airway space (ΔPPAS) and the minimum cross-sectional area (minCSA) of the pharyngeal airway before and after mandibular setback surgery using computational fluid dynamics, in order to prevent iatrogenic obstructiv...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2017.03.028
更新日期：2017-07-01 00:00:00
abstract：:The overall prognosis for tongue cancer patients in Taiwan is unpredictable, even when patients are treated following the guidelines according to TNM stages. In order to determine the optimal treatment modality for tongue cancer in Taiwan the authors aimed to correlate histopathological parameters with neck nodal meta...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2008.07.014
更新日期：2008-10-01 00:00:00
abstract：:Staphylococcus aureus mandibular osteomyelitis was produced in 20 rabbits by injection of a sclerosing agent and 1 X 10(9) colony-forming units of Staphylococcus aureus V8 into the medullary cavity of the mandible. After 2 weeks all rabbits developed infections. 10 of the rabbits were then treated with dicloxacillin (...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/s0300-9785(86)80069-2
更新日期：1986-10-01 00:00:00
abstract：:Central giant cell granuloma (CGCG) is a benign lesion with unpredictable biological behaviour ranging from a slow-growing asymptomatic swelling to an aggressive lesion associated with pain, bone and root resorption and also tooth displacement. The aetiology of the disease is unclear with controversies in the literatu...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2011.04.003
更新日期：2011-08-01 00:00:00
abstract：:The aim of this study was to compare the satisfaction of skeletal class III patients following treatment with three different methods of orthognathic surgery. Eighty-two patients were divided into three groups according to the surgical procedure performed to correct their class III dentofacial deformity, and answered ...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2014.09.015
更新日期：2015-02-01 00:00:00
abstract：:An otherwise-healthy 2-year-old Japanese female presented with a polyp-like lesion on the palatal surface at the incisive papilla. The appearance of the lesion was similar to that of a congenital epulis. The histological findings showed proliferating mesenchymal components that contained mainly smooth muscle admixed w...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2011.05.009
更新日期：2011-11-01 00:00:00
abstract：:The purpose of this study was to analyse the causes of venous compromise and flap failure in radial forearm free flap (RFFF) surgery for intraoral reconstruction. One hundred seventy-eight RFFF reconstructions were reviewed retrospectively for intraoral defects. Of the 13 flaps with venous obstruction, 9 flaps were sa...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2012.01.016
更新日期：2012-04-01 00:00:00
abstract：:Data regarding the development of head and neck metastases are limited, with the majority of the studies focusing on single cases affecting mainly the oral cavity and surrounding tissues. This study describes the incidence of head and neck metastases from primary tumours originating elsewhere. The medical records of s...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2013.05.020
更新日期：2013-11-01 00:00:00
abstract：:The aims of this study were to evaluate volumetric changes in the nasal cavity (NC) and pharyngeal airway space (PAS) after Le Fort I maxillary distraction osteogenesis (MDO) using a three-dimensional (3D) simulation program, and to determine the effects of MDO on respiratory function during sleep with polysomnography...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2014.10.021
更新日期：2015-04-01 00:00:00
abstract：:Arthroscopic procedures for diagnosis and treatment of temporomandibular joint (TMJ) diseases are widely used. Few adverse effects of the procedures have been reported. In this in vivo study, diagnostic arthroscopy was performed in the left TMJ of seven castrated male goats, the right TMJ serving as a control. The goa...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/s0901-5027(05)80326-1
更新日期：1994-02-01 00:00:00
abstract：:A case of oral focal epithelial hyperplasia (FEH) treated with CO2 laser surgery is presented. Histological diagnosis is discussed. The association of human papillomavirus (HPV) type 32 with the lesions is demonstrated with DNA in situ hybridization technique. Laser surgery is suggested as a treatment of choice. ...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/s0901-5027(05)80391-1
更新日期：1990-08-01 00:00:00
abstract：:Spontaneous herniation of the condylar head into the external auditory canal (EAC) through the foramen of Huschke is extremely rare, with approximately 30 cases reported in the international literature. The typical presentation is a constellation of non-specific symptoms including otalgia, temporomandibular joint (TMJ...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2016.03.006
更新日期：2016-08-01 00:00:00
abstract：:The objective of this study was to assess changes in patient quality of life (QoL) after orthognathic surgery at the Kuwait University Dental Clinic. A self-administered Arabic version of the Orthognathic Quality of Life Questionnaire (OQLQ) and two different visual analogue scales (VAS) were used. Sixty-six patients ...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2017.12.010
更新日期：2018-06-01 00:00:00
abstract：:Analysis of peri-implant crevicular fluid (PICF) offers a non-invasive means of studying the host response in peri-implant disease and may provide an early indication of patients at risk for active disease. This study examined the PICF levels of interleukin-1beta (IL-1beta), tumour necrosis factor alpha (TNF-alpha), i...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2010.01.014
更新日期：2010-05-01 00:00:00
abstract：INTRODUCTION:The articular disk has a central role in the pathology of internal derangement of the Temporomandibular Joint (TMJ). What is less clear is the role of osteoarthrosis in the development of internal derangement. The aim of this study is to determine the prevalence of osteoarthrosis in cases of advanced and r...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2004.10.013
更新日期：2005-06-01 00:00:00
abstract：:A case of peripheral calcifying odontogenic cyst is presented. The nature of the lesion as a neoplasm is discussed including review of the literature. The terminology proposed for this lesion is "dentinogenic ghost cell tumor." ...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/s0901-5027(87)80117-0
更新日期：1987-10-01 00:00:00
abstract：:Micro-computed tomography (microCT) is a new tool to image and quantify trabecular bone. The aim of this study is to compare the two measurement methods when evaluating the early healing of intramembranous (IM) and endochondral (EC) autogenous bone grafts using micro-computed tomography and Q-win computer image analyz...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2003.09.009
更新日期：2004-06-01 00:00:00
abstract：:The prognostic validity of the DNA-malignancy-grade (DNA-MG), ranging on a continuous scale from 0.00 to 3.00 was tested in a preliminary study on 7 patients with oral squamous cell carcinomas. Monolayer smears were prepared after a cell separation procedure from paraffin-embedded surgical tumor specimens. Feulgen sta...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/s0901-5027(89)80015-3
更新日期：1989-02-01 00:00:00
abstract：:A case of metastatic osteosarcoma in the submental vestibule of the oral cavity and the lung is described in an 18-year-old male with primary osteosarcoma occurring in the sacrum. Dissemination of osteosarcoma to other organs, especially early to the lung, is common, but its metastasis to the oral mucosa has been rare...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2006.04.004
更新日期：2006-11-01 00:00:00
abstract：:A 7-year-old boy presented in whom a metaphyseal fibrous defect was diagnosed. The lesion was enucleated under local anesthesia. The postoperative course was uneventful and there have been no signs of recurrence as of 14 months after operation. Although rare, metaphyseal fibrous defect should be included in the differ...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/s0901-5027(05)80834-3
更新日期：1997-04-01 00:00:00
abstract：:The use of a rectangular flap is a well known technique for upper lip repair in cleft lip, but is less common for lower lip repair after tumour resection. We have found this type of flap to be favourable for lower lip reconstruction, especially for the lip to mental region. We describe herein an improvement to the tec...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2014.06.001
更新日期：2014-09-01 00:00:00
abstract：:This study assessed the impact of oral and maxillofacial trauma and surgical treatment on the quality of life of patients. The study included 66 patients (age range 18-65 years) with facial fractures; 33 required surgical treatment and 33 required conservative (non-surgical) treatment. Quality of life was evaluated by...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2015.11.022
更新日期：2016-05-01 00:00:00
abstract：:Horner's syndrome and Harlequin syndrome are both caused by disruptions to the sympathetic supply to the face. They have a varied aetiology, including intraneural dysfunction, extra- or intraneural compression, and idiopathic as well as iatrogenic causes. Horner's syndrome can occur as a rare complication of thyroid s...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2015.01.008
更新日期：2015-06-01 00:00:00
abstract：:The present study aimed to verify the importance of postoperative articulatory rehabilitation in patients with oral cancer and to clarify the neurological changes underlying articulatory functional recovery. A longitudinal assessment of oral function and accompanying brain activity was performed using non-invasive fun...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2014.02.013
更新日期：2014-08-01 00:00:00
abstract：:Despite the progress made in tumor and reconstructive surgery of the maxillofacial region, postoperative problems, such as malnutrition and dysfunction of the oral-oesophageal tract are still encountered. Nutrition via a nasogastric tube often complicates the rehabilitation process of these patients. Percutaneous endo...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/s0901-5027(05)80693-9
更新日期：1991-02-01 00:00:00
