A case of pure red cell aplasia complicated with diffuse large B cell lymphoma, T-cell-rich/histiocyte-rich variant: effectiveness of rituximab and implications for a common immunopathogenic role of B lymphocytes.

abstract：:Janus kinases are critical components of signaling pathways that regulate hematopoiesis. Mutations of the non-receptor tyrosine kinase JAK2 are found in many BCR-ABL-negative myeloproliferative neoplasms. Preclinical results support that JAK2 inhibitors could show efficacy in treating chronic myeloproliferative neopla...

journal_title：Acta haematologica

authors： Ringel F,Kaeda J,Schwarz M,Oberender C,Grille P,Dörken B,Marque F,Manley PW,Radimerski T,le Coutre P

更新日期：2014-01-01 00:00:00

abstract：:The value of clearance of peripheral blood blasts (PBB) as a predictor of outcomes in acute myeloid leukemia (AML) is controversial. To investigate the prognostic significance of the time to clearance of PBB after induction in Chinese patients with AML, a retrospective analysis of 146 patients with newly diagnosed AML...

journal_title：Acta haematologica

authors： Li X,Zhu H,Zhang Y,Zhao W,Mi J,Hu J,Li J

更新日期：2016-01-01 00:00:00

abstract：:Hypersensitivity vasculitis occurs in response to various exogenous agents. A case of a serum sickness syndrome with cutaneous vasculitis is described in a patient given an intravenous iron-dextran infusion. ...

journal_title：Acta haematologica

authors： Bielory L

更新日期：1990-01-01 00:00:00

abstract：:We studied neutrophil chemotaxis and surface membrane glycoproteins in 12 patients suffering from myeloid disorders with abnormal karyotype using in vitro techniques in all 12. Chromosome studies were also carried out virtually simultaneously. We chose to study only patients showing a deficit of chemotaxis (p less tha...

journal_title：Acta haematologica

authors： Ricevuti G,Mazzone A,Notario A

更新日期：1989-01-01 00:00:00

abstract：:We report a patient with myelodysplastic syndrome (MDS), refractory anaemia with excess blasts in transformation, in whom complete remission (CR) was achieved with the administration of granulocyte colony-stimulating factor (G-CSF). The 76-year-old patient was admitted to our hospital with a fever and a productive cou...

journal_title：Acta haematologica

authors： Kondo H,Kasahara Y,Mori A

更新日期：2002-01-01 00:00:00

abstract：:Fetal liver transplantation was attempted in 7 patients with aplastic anemia. 4 of these patients showed a partial response as evidenced by decrease in blood transfusion requirements and increase in the peripheral blood counts and hematopoietic cells in the bone marrow. Bone marrow culture studies revealed evidence of...

journal_title：Acta haematologica

authors： Kansal V,Sood SK,Batra AK,Adhar G,Malviya AK,Kucheria K,Balakrishnan K

更新日期：1979-01-01 00:00:00

abstract：:A 59-year-old man presented with lymphocytosis with huge splenomegaly. The abnormal lymphocytes had a high nucleoplasm:cytoplasm ratio, a prominent nucleolus and hairy cytoplasmic projections. Immunophenotyping revealed B-cell leukemia with negative reactions to CD5 and CD25. Cytogenetic study showed 46,XY,der(5)t(5;6...

journal_title：Acta haematologica

authors： Dunn P,Shih LY,Ho YS,Tien HF

更新日期：1995-01-01 00:00:00

abstract：:The activity of gamma-glutamyl transpeptidase was investigated in normal and leukemia leukocytes. Enzyme activity was positively correlated with the proportion of mature neutrophils and monocytes. In isolated leukocytes from patients with acute myeloid leukemia low values were obtained compared to controls. ...

journal_title：Acta haematologica

authors： Hultberg B,Sjögren U

更新日期：1980-01-01 00:00:00

abstract：:The Philadelphia chromosome-negative myeloproliferative disorders (MPDs) polycythemia vera (PV), essential thrombocytosis (ET) and primary myelofibrosis (PMF) are characterized by increased proliferation of terminally differentiated myeloid cells. Although these disorders were recognized as clonal hematopoietic stem c...

journal_title：Acta haematologica

authors： Koppikar P,Levine RL

更新日期：2008-01-01 00:00:00

abstract：:Herein, we describe a case of a female patient in whom B cell chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) were diagnosed simultaneously. She presented with anemia, thrombocytopenia and splenomegaly. Flow cytometry demonstrated two immunophenotypically distinct CD5-positive monoclonal B cell popul...

journal_title：Acta haematologica

authors： Kourelis TV,Kahl BS,Benn P,Delach JA,Bilgrami SF

更新日期：2011-01-01 00:00:00

abstract：:A 61-year-old Japanese man was referred to our hospital in 2002 due to severe pancytopenia. Bone marrow and peripheral blood findings indicated he had severe aplastic anemia (AA). A whole-body CT scan and Ga scintigraphy revealed no abnormal findings. Antithymocyte globulin and cyclosporine A (CyA) were administered a...

journal_title：Acta haematologica

authors： Suzuki Y,Niitsu N,Hayama M,Katayama T,Ishii R,Osaka M,Miyazaki K,Danbara M,Horie R,Yoshida T,Nakamura N,Higashihara M

更新日期：2009-01-01 00:00:00

abstract：:Iron deficiency is the main cause of anemia in both sexes, with women being more commonly affected. Iron therapy is currently considered an effective and safe remedy to replenish the iron storages. Iron can be administrated both orally and intravenously. In particular, intravenous (IV) iron therapy is widely used when...

journal_title：Acta haematologica

authors： Di Girolamo A,Albanesi M,Loconte F,Di Bona D,Caiaffa MF,Macchia L

更新日期：2020-01-01 00:00:00

abstract：:The thrombogenicity of prothrombin complex concentrates (PCCs) has been known as a risk factor since their first clinical use about 30 years ago. The development of in vivo models to define the thrombogenic components in PCCs was instrumental in providing a logical basis for selecting in vitro assays to screen for the...

journal_title：Acta haematologica

authors： MacGregor I,McLaughlin L,Drummond O,Prowse C,Ferguson J

更新日期：1995-01-01 00:00:00

abstract：:To clarify the role of thrombopoietin (c-Mpl ligand, TPO) in 'hypersplenic' thrombocytopenia, we used an enzyme-linked immunosorbent assay to examine changes in serum TPO levels accompanied with splenectomy in 6 patients with liver cirrhosis, 4 patients with gastric cancer, and 2 patients with lymphoid malignancies. W...

journal_title：Acta haematologica

authors： Ichikawa N,Kitano K,Shimodaira S,Ishida F,Ito T,Kajikawa S,Tahara T,Kato T,Kiyosawa K

更新日期：1998-12-01 00:00:00

abstract：:Pleural effusion in chronic lymphocytic leukemia (CLL) is a relatively rare phenomenon. We report a case of a pleural effusion associated with B-cell CLL but with predominantly reactive T lymphocytes in the effusion. A cell surface phenotype study showed that T lymphocytes predominated in the pleural effusion, althoug...

journal_title：Acta haematologica

authors： Miyahara M,Shimamoto Y,Sano M,Nakano H,Shibata K,Matsuzaki M

更新日期：1996-01-01 00:00:00

abstract：:One of the major determinants of erythrocyte survival is membrane deformability, and an important intrinsic parameter of membrane deformability is the shear elastic modulus (mu) with higher mu values corresponding to increased membrane rigidity. Using a micropipette technique, we determined the shear elastic modulus o...

journal_title：Acta haematologica

authors： Athanassiou G,Symeonidis A,Kourakli A,Missirlis YF,Zoumbos NC

更新日期：1992-01-01 00:00:00

abstract：:A study of E-rosette ultrathin sections has been undertaken in an attempt to analyze changes induced during the T-lymphocyte-sheep red blood cell interaction on the rosetted lymphocyte surface architecture. The formation of nonimmune rosettes implies different types of attachment between lymphocytes and sheep red bloo...

journal_title：Acta haematologica

authors： Renau-Piqueras J,Cervera J

更新日期：1979-01-01 00:00:00

abstract：:Automated cytochemistry by the Hemalog D carries out leukocyte differential counts in a continuous flow mode on whole blood EDTA-collected samples, through the optical measurement of enzyme activity and cell size. This operative principle thus parallels the basis of the FAB classification of acute leukemias. Although ...

journal_title：Acta haematologica

authors： d'Onofrio G,Mango G

更新日期：1984-01-01 00:00:00

abstract：:The 8p11 myeloproliferative syndrome (EMS) is an aggressive neoplasm associated with chromosomal translocations involving the fibroblast growth factor receptor 1 (FGFR1) tyrosine kinase gene on chromosome 8p11-12. A new case of a 9-year-old boy with leukocytosis, eosinophilia, and general lymphadenopathy is reported i...

journal_title：Acta haematologica

authors： Lv H,Hu S,Lu J,Zhai Q,Zhai Z,Du Z,Sun Y,Li J,He H,Wang Y

更新日期：2018-01-01 00:00:00

abstract：:A diester lipase activity is described in human red blood cells (RBC). Diester lipase activity acts as a membrane-bound enzyme and is assayed using intact RBC as the enzyme source. An emulsion of di-[3H]-oleoylglycerol (0.6 mM) serves as the substrate. The optimum pH for the reaction is 7.8 at 37 degrees C. Lipolytic ...

journal_title：Acta haematologica

authors： Somma C,Arnaud J,Boyer J

更新日期：1983-01-01 00:00:00

abstract：:Preliminary results from the first 21 patients of a group of 30 with International Federation of Gynaecology and Obstetrics (FIGO) stage II-IV epithelial ovarian carcinoma and anaemia are reported. Patients entered this open-label, comparative-group, out-patient study and were randomized to receive conventional suppor...

journal_title：Acta haematologica

authors： James RD,Wilkinson PM,Belli F,Welch R,Cowan R

更新日期：1992-01-01 00:00:00

abstract：:Afibrinogenaemia in a female Saudi child is reported. Two siblings died of bleeding. The parents, who are first cousins, a brother and two sisters are asymptomatic heterozygotes with fibrinogen levels of less than 1.5 g/l. The presentation was described and compared to other cases reported. ...

journal_title：Acta haematologica

authors： Elseed FA,Karrar ZA

更新日期：1984-01-01 00:00:00

abstract：:Contamination of autologous graft by tumor, in addition to incomplete tumor eradication, can partly explain why relapse remains the commonest cause of treatment failure after autologous stem cell transplantation (ASCT) in patients with malignant hematologic disorders. Monitoring of minimal residual disease (MRD) is no...

journal_title：Acta haematologica

authors： Melillo L,Cascavilla N,Lerma E,Corsetti MT,Carella AM

更新日期：2005-01-01 00:00:00

abstract：:A case of angioimmunoblastic lymphadenopathy (AILD) with important autoimmune symptoms disappearing under Levamisole therapy is reported. Since Levamisole is thought to have no direct effect on B cells, it is supposed that in AILD it regulates B lymphocyte activity via the restoration of impaired T cell functions. ...

journal_title：Acta haematologica

authors： Andrieu JM,Youinou P,Herzog C

更新日期：1979-01-01 00:00:00

abstract：:Slow intravenous infusion of Na laurate (NaL) into guinea pigs caused a rapid appearance of platelet aggregates in the arterial blood and a precipitous fall in platelet counts. During the infusion of Na arachidonate (NaA) thrombocytopenia developed slowly, and few and smaller platelet aggregates appeared in the arteri...

journal_title：Acta haematologica

authors： Rafflenbeul D,Zbinden G

更新日期：1977-01-01 00:00:00

abstract：:Although multiple myeloma (MM) remains an incurable disease, its treatment has improved over the past decade. This improvement has been at least in part due to the introduction of novel antimyeloma agents with new mechanisms of action, including those that target both myeloma cells and the tumor microenvironment, with...

journal_title：Acta haematologica

authors： Cibeira MT,Mercadal S,Arenillas L,Muntañola A,Salamero O,Bladé J

更新日期：2006-01-01 00:00:00

abstract：:The in vitro immune functions of peripheral blood lymphocytes have been studied in 12 children with beta-thalassaemia major and hypersplenism. The study was performed prior to splenectomy and on the 2nd, 6th, 15th and 30th day after splenectomy. It was found that before splenectomy, patients had low numbers of blood l...

journal_title：Acta haematologica

authors： Mandalenaki-Lambrou K,Vrachnou E,Calogeropoulou C,Ladis V,Kattamis C

更新日期：1987-01-01 00:00:00

abstract：:Progenitor cell fractions from normal human marrow have been prepared by a method that enables low numbers of cells to be cultured and results in very little T cell or monocyte contamination. The enrichment of 14- and 21-day BFU-E was similar to that for CFU-GM and the readdition of sheep red blood rosette-forming cel...

journal_title：Acta haematologica

authors： Linch DC,Boyle D,Beverley PC

更新日期：1982-01-01 00:00:00

abstract：:Micromegakaryocytes (MMK) were defined morphologically by the cell area, nucleus form and cytoplasmic structure. Bone marrow smears of 7,156 patients were retrospectively analyzed. MMK were found most frequently and abundantly in acute non-lymphatic leukaemia, chronic myeloid leukaemia and pre-leukaemia. The presence ...

journal_title：Acta haematologica

authors： Wiesneth M,Pflieger H,Kubanek B,Heimpel H

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVE:To investigate a family with factor VII (FVII) deficiency from Argentina. PATIENTS AND METHODS:The proposita is a 14-year-old girl who presented with a mild to moderate bleeding tendency. Menorrhagia is controlled with periodical administration of small doses of recombinant FVII concentrate. The mother of th...

journal_title：Acta haematologica

authors： Girolami A,Paoletti M,Ferrari S,Garcia D

更新日期：2021-01-01 00:00:00