Hairy cell leukemia variant.

Abstract:

:A 59-year-old man presented with lymphocytosis with huge splenomegaly. The abnormal lymphocytes had a high nucleoplasm:cytoplasm ratio, a prominent nucleolus and hairy cytoplasmic projections. Immunophenotyping revealed B-cell leukemia with negative reactions to CD5 and CD25. Cytogenetic study showed 46,XY,der(5)t(5;6)(q35;p21), del(7)(p13)/46,idem,add(22)(q13). The patient did not respond to chlorambucil and a combination of cyclophosphamide, vincristine and prednisolone. Splenic irradiation induced partial remission. He developed progressive anemia and thrombocytopenia and died of Escherichia coli septicemia 33 months after the diagnosis of hairy cell leukemia variant.

journal_name

Acta Haematol

journal_title

Acta haematologica

authors

Dunn P,Shih LY,Ho YS,Tien HF

doi

10.1159/000203984

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

105-8

issue

2

eissn

0001-5792

issn

1421-9662

journal_volume

94

pub_type

杂志文章
  • Characterization of the fibrinolytic state by measuring stable cross-linked fibrin degradation products in disseminated intravascular coagulation associated with acute promyelocytic leukemia.

    abstract::Plasma samples from patients with disseminated intravascular coagulation (DIC) associated with acute promyelocytic leukemia (APL) exhibited higher levels of the D-fragment of fibrin and fibrinogen degradation products [FDP(D)], with relatively lower levels of cross-linked fibrin degradation products (XDP), than sample...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000205392

    authors: Okajima K,Koga S,Okabe H,Inoue M,Takatsuki K

    更新日期:1989-01-01 00:00:00

  • Immunological profile after splenectomy in children with beta-thalassaemia major.

    abstract::The in vitro immune functions of peripheral blood lymphocytes have been studied in 12 children with beta-thalassaemia major and hypersplenism. The study was performed prior to splenectomy and on the 2nd, 6th, 15th and 30th day after splenectomy. It was found that before splenectomy, patients had low numbers of blood l...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000205886

    authors: Mandalenaki-Lambrou K,Vrachnou E,Calogeropoulou C,Ladis V,Kattamis C

    更新日期:1987-01-01 00:00:00

  • Hyper-CVAD regimen in routine management of adult acute lymphoblastic leukemia: a retrospective multicenter study.

    abstract::Treatment of acute lymphoblastic leukemia is unsatisfactory in adults due to disease and patient-related factors and probably because adult chemotherapy regimens are weaker than pediatric protocols. Worries about inadequacy of adult regimens urged many hematologists, including us, to reconsider their routine treatment...

    journal_title:Acta haematologica

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1159/000351172

    authors: Buyukasik Y,Acar K,Kelkitli E,Uz B,Serefhanoglu S,Ozdemir E,Pamukcuoglu M,Atay H,Bektas O,Sucak GT,Turgut M,Aksu S,Yagci M,Sayınalp N,Ozcebe OI,Goker H,Haznedaroglu IC

    更新日期:2013-01-01 00:00:00

  • Nonsecretory myeloma: a study on hypoimmunoglobulinemia.

    abstract::In evaluating hypoimmunoglobulinemia in a patient with nonsecretory myeloma, studies of in vitro immunoglobulin synthesis were performed during a 3-year period. Impaired polyclonal response to mitogen stimulation associated with excessive suppressor activity was demonstrable at diagnosis. Despite successful chemothera...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000205622

    authors: Shustik C,Michel R,Karsh J

    更新日期:1988-01-01 00:00:00

  • A case of lymphoma-type alpha-chain disease.

    abstract::A 69-year-old man with a rare case of lymphoma-type alpha-chain disease was admitted to the hospital with marked cervical and inguinal lymph node swelling. Lymph node biopsy showed marked infiltration of plasma cells, plasmacytoid cells and immunoblastoid cells, alone or in combination. Immunoelectrophoresis and immun...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000204814

    authors: Itoh Y,Ohtaki H,Ono T,Mori N,Kawaoi A,Kawai T

    更新日期:1991-01-01 00:00:00

  • Increased expression of Fas (APO-1, CD95) on CD4+ and CD8+ T lymphocytes during total body irradiation.

    abstract::Fas/APO-1 (CD95) is a cell surface molecule that can transduce apoptotic signals into cells. We examined the expression of Fas antigen on CD4+ and CD8+ T cells of patients who received total body irradiation (TBI) as a preparative regimen for allogeneic bone marrow transplantation. Numbers of peripheral blood lymphocy...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000046514

    authors: Fujimori Y,Saheki K,Itoi H,Okamamoto T,Kakishita E

    更新日期:2000-01-01 00:00:00

  • An atypical von Willebrand's disease with hyperreactivity of platelet aggregation.

    abstract::Two family members (daughter and mother) with a bleeding disorder showed prolonged bleeding time and activated partial thromboplastin time associated with decreased plasma levels of factor VIII procoagulant activity, factor VIII-related antigen, and factor VIII-ristocetin cofactor activity. The ristocetin-induced plat...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000206579

    authors: Niiya K,Kubonishi I,Taguchi H,Miyoshi I

    更新日期:1984-01-01 00:00:00

  • Clones with 3 Ph1 and 4 Ph1 in the terminal phase of three cases of chronic myeloid leukemia.

    abstract::G-banded cytogenetic studies of 3 male patients in the terminal phase of chronic myeloid leukemia showed the following abnormalities: in the first case, the presence of a medullar cell line with 51 chromosomes and 3 Ph1; in the second case, a clone with 65 chromosomes and 4 Ph1, and in the third patient a clone with 5...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000207047

    authors: Cabrol C,Peytremann R,Maurice PA

    更新日期:1982-01-01 00:00:00

  • Alterations of the cell surface morphology in human T-rosetting lymphocytes. An ultrastructural study.

    abstract::A study of E-rosette ultrathin sections has been undertaken in an attempt to analyze changes induced during the T-lymphocyte-sheep red blood cell interaction on the rosetted lymphocyte surface architecture. The formation of nonimmune rosettes implies different types of attachment between lymphocytes and sheep red bloo...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000207570

    authors: Renau-Piqueras J,Cervera J

    更新日期:1979-01-01 00:00:00

  • Treatment of synchronous mantle cell lymphoma and small lymphocytic lymphoma with bendamustine and rituximab.

    abstract::Herein, we describe a case of a female patient in whom B cell chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) were diagnosed simultaneously. She presented with anemia, thrombocytopenia and splenomegaly. Flow cytometry demonstrated two immunophenotypically distinct CD5-positive monoclonal B cell popul...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000324193

    authors: Kourelis TV,Kahl BS,Benn P,Delach JA,Bilgrami SF

    更新日期:2011-01-01 00:00:00

  • Serum folate binding capacity in leukemias, liver diseases and pregnancy.

    abstract::Total and unsaturated folate binding capacity (TFBC, UFBC) have been measured in sera of selective groups of patients to study the role of cell turnover, cell necrosis and the effect of pregnancy in determining their concentrations in blood. The mean value of TFBC in 35 normal sera was 151 +/- (SD) 53 pg/ml with a sat...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000207657

    authors: Corrocher R,Bambara LM,Pachor ML,Biasi D,Stanzial A,De Sandre G

    更新日期:1979-01-01 00:00:00

  • Functional adrenocortical adenoma in a case with B cell chronic lymphoproliferative disorder.

    abstract::We describe a B cell chronic lymphocytic leukemia/lymphoma (B-CLL) patient with an adrenocortical adenoma. He was treated initially with oral cyclophosphamide and prednisolone for 2 months, followed by low-dose prednisolone for an additional 2 years, which resulted in the prompt disappearance of CLL cells. After a per...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000203692

    authors: Adachi Y,Adachi M,Hinoda Y,Fukushima H,Takahashi T,Imai K

    更新日期:1997-01-01 00:00:00

  • Littoral cell angioma associated with portal hypertension and resected colon cancer.

    abstract::Littoral cell angioma (LCA) is a rare vascular tumor of the spleen with an unknown etiology and unclear natural history. An association with synchronous malignancy has been described. We report the case of a 54-year-old woman who had progressive splenomegaly over 3 years following resection of a colon adenocarcinoma. ...

    journal_title:Acta haematologica

    pub_type: 杂志文章,评审

    doi:10.1159/000039747

    authors: Steensma DP,Morice WG

    更新日期:2000-01-01 00:00:00

  • The use of 75Se-methionine as a tracer of thrombocytopoiesis. I. In vivo incorporation of the tracer into platelet proteins: a biochemical study.

    abstract::This study was undertaken to define to which platelet components 75Se-methionine is bound after its injection to normal rats, and to study the curves of specific radioactivity of each labelled fraction. It has been shown that, for a part, platelet labelling is due to adsorption of plasma proteins (albumin and fibrinog...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000207633

    authors: Dassin E,Najean Y

    更新日期:1979-01-01 00:00:00

  • The New -474(C→T) Substitution Discovered in the HBG2 Promoter of a Sardinian δβ-Thalassemia Carrier.

    abstract::During a screening for hemoglobinopathies, we found a carrier of the Sardinian δβ-thalassemia condition. The proband's hematology and hemoglobin (Hb) profile agreed with those of the other carriers previously identified during our diagnostic program except for the fetal Hb (HbF) composition, which consisted of both α2...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000447942

    authors: Trova S,Mereu P,Cocco E,Masala B,Manca L,Pirastru M

    更新日期:2016-01-01 00:00:00

  • Colony-stimulating activity production by hemopoietic organ fibroblastoid cells in vitro.

    abstract::We have demonstrated that hemopoietic organ fibroblastoid cells can produce colony-stimulating activity (CSA) in vitro. Skin fibroblasts also produced CSA. The colonies which formed were restricted to the granulocyte/macrophage differentiation pathways. A linear relationship was obtained for granulocyte/macrophage col...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000206924

    authors: Brockbank KG,van Peer CM

    更新日期:1983-01-01 00:00:00

  • Effect of granulocyte/colony-stimulating factor on the onset of the adult respiratory distress syndrome.

    abstract::To evaluate the effect of granulocyte/colony-stimulating factor (G-CSF) on the onset of the adult respiratory distress syndrome (ARDS), we investigated whether the incidence of ARDS due to pulmonary infection differed between the G-CSF group which received chemotherapy with G-CSF and historical controls without G-CSF....

    journal_title:Acta haematologica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000040937

    authors: Takahashi Y,Kobayashi Y,Chikayama S,Ikeda M,Kondo M

    更新日期:1999-01-01 00:00:00

  • Treatment of beta-thalassemia patients with recombinant human erythropoietin: effect on transfusion requirements and soluble adhesion molecules.

    abstract::The most common single genetic disorder and a major public health issue in Greece and other Mediterranean countries is beta-thalassemia. Current therapeutic approaches for homozygous beta-thalassemia entail blood transfusions and iron chelation therapy with deferoxamine or deferiprone for preventing tissue hemosideros...

    journal_title:Acta haematologica

    pub_type: 临床试验,杂志文章

    doi:10.1159/000077551

    authors: Chaidos A,Makis A,Hatzimichael E,Tsiara S,Gouva M,Tzouvara E,Bourantas KL

    更新日期:2004-01-01 00:00:00

  • Binding of nuclear factors to the proximal and distal CACCC motifs of the beta-globin gene promoter: implications for the -101 (C-->T) 'silent' beta-thalassemia mutation.

    abstract::We have used the gel retardation assay to investigate the binding of nuclear proteins to the duplicated CACCC boxes in the beta-globin gene promoter region. The effect of beta-thalassemia mutations affecting both of these consensus sequences (the -88 C-->T and -101 C-->T mutations) were studied by using appropriate mu...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000204237

    authors: Baysal E,Ribeiro ML,Huisman TH

    更新日期:1994-01-01 00:00:00

  • A glucose-6-phosphate dehydrogenase variant, Gd(-) Santamaria found in Costa Rica.

    abstract::Red cell glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-chromosomal-linked abnormality often associated with hemolytic anemia. The G6PD variants obtained from 2 unrelated males, one associated with enzyme deficiency and history of hemolytic jaundice, and the other associated with enzyme deficiency but no ...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000206354

    authors: Sáenz GF,Chaves M,Berrantes A,Elizondo J,Montero AG,Yoshida A

    更新日期:1984-01-01 00:00:00

  • Low-dose cytosine arabinoside in the treatment of relapsed and refractory acute non-lymphocytic leukaemia.

    abstract::Low-dose cytosine arabinoside (ARA-C) induced complete remissions in 6 of 10 patients with acute non-lymphocytic leukaemia (ANLL) who were either refractory to combination chemotherapy with anthracyclines and conventional doses of ARA-C, or were in relapse. Three patients relapsed after 4, 19, and 20 months, whereas 3...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000206036

    authors: Krogh Jensen M,Stentoft J

    更新日期:1986-01-01 00:00:00

  • Myelodysplastic syndrome and acquired factor VIII inhibitor with severe subcutaneous haemorrhage.

    abstract::A case of acquired haemophilia A presenting with extensive spontaneous bruising and anaemia is reported. The anaemia was due to myelodysplastic syndrome (FAB: refractory anaemia with ringed sideroblasts). A factor-VII:C-specific inhibitor was also found. Prednisone and pyridoxine were given, and the inhibitor became u...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000204894

    authors: Lin CK,Liang R,Liu HW,Tse PW,Chan GT

    更新日期:1991-01-01 00:00:00

  • Detection of granulocyte-macrophage colony-stimulating factor in cerebrospinal fluid of patients with aseptic meningitis.

    abstract::The level of granulocyte-macrophage colony-stimulating factor (GM-CSF) in the cerebrospinal fluid from 14 infants and children with meningitis and 6 patients who suffered other diseases besides meningitis was measured by our sensitive enzyme linked immunosorbent assay for GM-CSF. The minimal detection level of GM-CSF ...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000204796

    authors: Shimoda K,Okamura S,Omori F,Mizuno Y,Hara T,Aoki T,Akeda H,Ueda K,Niho Y

    更新日期:1991-01-01 00:00:00

  • Characteristics of a cell line established from a case of acute megakaryoblastic leukemia.

    abstract::Acute megakaryoblastic leukemia is uncommon and comprises about 5% of acute nonlymphoid leukemias in the French-American-British classification. Cell lines from such leukemias are relatively rare with only about 8 reported in the literature. We established a cell line from a case of acute megakaryoblastic leukemia ari...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000203557

    authors: Skinnider LF,Pabello P,Zheng CY

    更新日期:1997-01-01 00:00:00

  • Combination therapy with interferon alfa-2b and hydroxyurea during the accelerated phase of chronic myelogenous leukemia.

    abstract::Inferferon alfa-2b (IFN) plays a major role in the current management of previously untreated patients with chronic myelogenous leukemia (CML) as well as patients with CML who have relapsed after bone marrow transplantation. Hydroxyurea (HU) is the best conventional drug for treatment of CML in the chronic phase. Ten ...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000203859

    authors: Bourantas KL,Syrou M,Tsiara S,Danella M,Konstantinides P

    更新日期:1996-01-01 00:00:00

  • Erythropoietin: clinical applications.

    abstract::The last few years have seen an enormous increase in our knowledge on the haematopoietic growth factor erythropoietin (Epo), firstly with its purification and determination of its primary amino acid sequence, and more recently with the isolation of the Epo gene and its expression in mammalian cell lines. This review a...

    journal_title:Acta haematologica

    pub_type: 杂志文章,评审

    doi:10.1159/000204826

    authors: Foa P

    更新日期:1991-01-01 00:00:00

  • Marker chromosome in myeloproliferative syndrome.

    abstract::Chromosomal aberrations in a case of atypic myeloproliferative syndrome are reported. The analysis was carried out on short-term cultures of sternal bone marrow with the ASG and fluorescence method. 90% of the metaphases studied showed pseudoliploidy: one of the chromosomes 12 was missing and one submedian marker chro...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000208052

    authors: Fleischmann T,Krizsa F

    更新日期:1975-01-01 00:00:00

  • Insights into the All-trans-Retinoic Acid and Arsenic Trioxide Combination Treatment for Acute Promyelocytic Leukemia: A Meta-Analysis.

    abstract:BACKGROUND:This study aimed to compare the curative effects of the combination therapy of all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO, As₂O₃) with ATRA monotherapy on newly diagnosed acute promyelocytic leukemia (APL). METHODS:The studies were retrieved from PubMed, EMBASE, Cochrane Library, ChinaInfo and...

    journal_title:Acta haematologica

    pub_type: 杂志文章,meta分析

    doi:10.1159/000369242

    authors: Ma H,Yang J

    更新日期:2015-01-01 00:00:00

  • The enzymatic activities and NBT reduction test of granulocytes in untreated and dialysed uraemic patients.

    abstract::It was found that neutrophils in untreated uraemic patients as well as in subjects on regular dialysis treatment displayed higher activity of acid phosphatase, alkaline phosphatase and peroxidase. Spontaneous reduction of nitro blue tetrazolium (NBT) by granulocytes was also higher in both groups in comparison to cont...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000207647

    authors: Sutowicz W,Komorowska Z,Hanicki Z,Cichocki T,Smoleński O

    更新日期:1979-01-01 00:00:00

  • Absence of mutations on the SNF5 gene in hematological neoplasms with chromosome 22 abnormalities.

    abstract:BACKGROUND:The relation with SNF5 mutation and chromosome 22 abnormalities is not clear in hematological neoplasms. METHODS:To elucidate the relevance of the SNF5 gene on 22q11.2, karyotypes were reviewed in 283 hematological neoplasms. Loss of heterozygosity (LOH) on 22q was analyzed in 21 plasma cell myelomas withou...

    journal_title:Acta haematologica

    pub_type: 杂志文章

    doi:10.1159/000324932

    authors: Mori N,Inoue K,Okada M,Motoji T

    更新日期:2011-01-01 00:00:00