Abstract：
OBJECTIVES:Accumulation of Cholestasis Familiaris Groenlandica (CFG) or progressive familial intrahepatic cholestasis type 1 (PFIC1) occurs in indigenous Inuit families in Greenland. It is an autosomal recessive inherited liver disease. From early childhood the children suffer from failure to thrive, jaundice, pruritus and enlarged liver. Affected persons generally die very young. STUDY DESIGN:Patients' information has been collected from the Greenlandic death register and hospital records. METHODS:Detailed genealogy including clinical description and examination if possible. Interviews of parents and relatives, linkage and DNA analysis of the probands and the closest relatives have been studied. RESULTS:46 affected cases from a highly inbred population have been diagnosed since 1943. The disease is caused by a missense mutation in the FIC1 gene ATP8B1, chromosome 18q21. Six affected children are alive aged 1-21 years. Among the tested relatives 220 are heterozygote. One prenatal diagnosis has been performed. CONCLUSION:The mutation causing Cholestasis Familiaris Groenlandica is widespread in Greenland, but accumulation is seen in certain areas. The disease is burdensome for the child, the parents and the Greenlandic society. Genetic counselling and carrier screening are strongly recommended.
journal_name
Int J Circumpolar Healthjournal_title
International journal of circumpolar healthauthors
Nielsen IM,Eiberg Hdoi
10.3402/ijch.v63i0.17899subject
Has Abstractpub_date
2004-01-01 00:00:00pages
192-4eissn
1239-9736issn
2242-3982journal_volume
63 Suppl 2pub_type
杂志文章abstract：BACKGROUND:Despite a growing number of studies and reports indicating a very high and increasing prevalence of trauma exposure in Greenlandic adolescents, the knowledge on this subject is still very limited. The purpose of the present study was twofold: To estimate the lifetime prevalence of potentially traumatic event...
journal_title：International journal of circumpolar health
pub_type： 杂志文章,多中心研究
doi：10.3402/ijch.v71i0.18378
更新日期：2012-01-01 00:00:00
abstract：INTRODUCTION:Myocardial and cerebral infarction are held to be rare among the Inuit, whereas cerebral haemorrhage is thought to be frequent. Recent studies have questioned these beliefs. We report data form our institution. METHOD:Retrospective data collection and review of all charts from Greenlandic patients from th...
journal_title：International journal of circumpolar health
pub_type： 杂志文章
doi：10.3402/ijch.v63i0.17921
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND:With invasive Haemophilus influenzae serotype b (Hib) disease controlled by vaccination with conjugate Hib vaccines, there is concern that invasive disease due to non-serotype b strains may emerge. OBJECTIVE:This study characterized invasive H. influenzae (Hi) isolates from Nunavut, Canada, in the post-Hib ...
journal_title：International journal of circumpolar health
pub_type： 杂志文章
doi：10.3402/ijch.v75.29798
更新日期：2016-01-12 00:00:00
abstract：BACKGROUND:Changing Directions, Changing Lives, the Mental Health Strategy for Canada, prioritizes the development of coordinated continuums of care in mental health that will bridge the gap in services for Inuit populations. OBJECTIVE:In order to target ways of improving the services provided in these contexts to ind...
journal_title：International journal of circumpolar health
pub_type： 杂志文章
doi：10.3402/ijch.v74.27186
更新日期：2015-05-14 00:00:00
abstract：OBJECTIVES:The aim of the Tromstannen-Oral Health in Northern Norway (TOHNN) study was to investigate oral health and dental-related diseases in an adult population. This article provides an overview of the background of the study and a description of the sample characteristics and methods employed in data collection. ...
journal_title：International journal of circumpolar health
pub_type： 杂志文章
doi：10.3402/ijch.v75.30169
更新日期：2016-02-19 00:00:00
abstract：:Recent reports have found a rise in Hepatitis C virus (HCV) infection in reproductive age women in the USA. Surveillance data suggests one group that is at increased risk of HCV infection is the American Indian and Alaska Native population (AI/AN). Using the National Center for Health Statistics (NCHS) birth certifica...
journal_title：International journal of circumpolar health
pub_type： 杂志文章
doi：10.1080/22423982.2019.1608139
更新日期：2019-12-01 00:00:00
abstract：STUDY OBJECTIVE:To survey snowmobile injury events treated in Longyearbyen hospital, Svalbard and to report the injury distribution and characteristics for Svalbard residents and visitors driving snowmobiles. DESIGN:Prospective injury recording. SETTING:The Norwegian arctic archipelago, Svalbard during three years fr...
journal_title：International journal of circumpolar health
pub_type： 杂志文章
doi：
更新日期：2001-11-01 00:00:00
abstract：:In August 2012, a literature search with the aim of describing indicators on food and water security in an Arctic health context was initialized in collaboration between the Arctic Human Health Expert Group, SDWG/AHHEG and the AMAP (Arctic Monitoring and Assessment Programme within the Arctic Council) Human Health Ass...
journal_title：International journal of circumpolar health
pub_type： 杂志文章
doi：10.3402/ijch.v72i0.21530
更新日期：2013-08-07 00:00:00
abstract：OBJECTIVES:The purpose of this study was to develop a dietary instrument (food frequency questionnaire [FFQ]) that measured total dietary intake over 1 year among Alaska Native people in 2 regions. Ways of assessing diet are needed in order to accurately evaluate how the diets of Alaska Natives relate to their health. ...
journal_title：International journal of circumpolar health
pub_type： 杂志文章
doi：10.3402/ijch.v68i2.18319
更新日期：2009-04-01 00:00:00
abstract：:Data have been lacking on the prevalence of HIV and hepatitis B (HB) infections in the North American Indian population in Canada. In January 1992, surveillance was introduced into two residential First Nations alcohol and drug treatment centers in British Columbia as part of an AIDS/STD education program. Male and fe...
journal_title：International journal of circumpolar health
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVES:To estimate the age specific prevalence of diagnosed type 2 diabetes mellitus (T2DM) in Greenland in 2008, and to evaluate the influence of electronic database access on the quality of the clinical management of the disease. STUDY DESIGN:Observational and cross-sectional study, review of medical records and...
journal_title：International journal of circumpolar health
pub_type： 杂志文章
doi：10.3402/ijch.v68i1.18296
更新日期：2009-02-01 00:00:00
abstract：:In recent decades, there has been a decline in active school transportation (AST). Parents play an important role as the key decision-makers of children's AST, and there is a need of more knowledge about the decision-making process and parents' beliefs towards AST. The overall aim of this study was to explore parents'...
journal_title：International journal of circumpolar health
pub_type： 杂志文章
doi：10.1080/22423982.2020.1798113
更新日期：2020-12-01 00:00:00
abstract：OBJECTIVES:To review suicide patterns among Inuit in Canada and highlight new developments in Inuit-driven and community-based suicide prevention. Study design. Narrative overview of suicide among Inuit in Canada, strides towards Inuit autonomy, and community and government action towards suicide prevention. METHODS:R...
journal_title：International journal of circumpolar health
pub_type： 杂志文章
doi：10.3402/ijch.v68i3.18330
更新日期：2009-06-01 00:00:00
abstract：:Our research in high latitudes has allowed the identification of a special class of deadaptive disorders, northern cardiometeopathies, which integrates cardiovascular functional violations connected to biologically significant modifications of meteorological, geomagnetic, electrical, gravitational, rhythmological and ...
journal_title：International journal of circumpolar health
pub_type： 杂志文章
doi：
更新日期：2001-04-01 00:00:00
abstract：:The article describes national, regional and community-level activities that contributed to the Manitoba First Nation partnership in maternal and child health programming. The activities reveal a potential for health change that is possible through working together across jurisdictional boundaries. Although we are onl...
journal_title：International journal of circumpolar health
pub_type： 杂志文章
doi：10.3402/ijch.v70i4.17837
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:There is a paucity of research on Alaska Natives and their views on whether or not they believe they will age successfully in their home and community. There is limited understanding of aging experiences across generations. OBJECTIVE:This research explores the concept of successful aging from an urban Alask...
journal_title：International journal of circumpolar health
pub_type： 杂志文章
doi：10.3402/ijch.v72i0.21186
更新日期：2013-08-05 00:00:00
abstract：:Diagnostic ultrasound in remote sites is limited by attendant delay in interpretation and reporting. Technology advances were incorporated in an ultrasound program based in Churchill, Manitoba, and designed to meet the needs of the Central Canadian Arctic. Still-frame ultrasound images are digitized via a sonographer'...
journal_title：International journal of circumpolar health
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:Cold causes cardiopulmonary stress often perceived as shortness of breath or chest pain, and causes exacerbation of these symptoms in persons suffering heart or lung disease. We investigated the prevalence of these symptoms and their association with sex, age and cold exposure in a population-based sample of 1,785 per...
journal_title：International journal of circumpolar health
pub_type： 杂志文章,多中心研究
doi：
更新日期：2000-10-01 00:00:00
abstract：:For decades the spread of sexually transmitted infections (STIs) has been a health concern in Greenland, especially within the age group of 15-34 year olds. However, no overview exists of the potential differences in regional incidence and management of STIs. This study investigates the age, gender and region specific...
journal_title：International journal of circumpolar health
pub_type： 杂志文章
doi：10.1080/22423982.2018.1445938
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:The influence of environmental conditions early in life - including temperature and season - on health later in life has so far not attracted much attention. OBJECTIVE:Using data from the Helsinki Birth Cohort Study of 13,345 men and women, the influence of temperature and season at month of conception on b...
journal_title：International journal of circumpolar health
pub_type： 杂志文章
doi：10.3402/ijch.v72i0.21466
更新日期：2013-10-15 00:00:00
abstract：:Ethical appraisal of medical protocols for research is now well accepted, and needed when research may carry side effects and risks that may be difficult to understand for the people invited to take part in research. We argue that time has come for Greenland to establish a formal medical research ethics committee with...
journal_title：International journal of circumpolar health
pub_type： 杂志文章
doi：10.3402/ijch.v63i0.17878
更新日期：2004-01-01 00:00:00
abstract：OBJECTIVES:To describe the method, data collection procedure and participation in The Population-based Study on Health and Living Conditions in Areas with both Sami and Norwegian Settlements - the SAMINOR 2 questionnaire study. STUDY DESIGN:Cross-sectional and semi-longitudinal. METHODS:In 2012, all inhabitants aged ...
journal_title：International journal of circumpolar health
pub_type： 杂志文章
doi：10.3402/ijch.v73.23147
更新日期：2014-06-18 00:00:00
abstract：OBJECTIVES:A population-based birth registry has been set up for the Arctic town of Moncegorsk in north-western Russia. This investigation describes the health status of the delivering population, including pregnancy history and the prevalence of obesity, infections, smoking and alcohol abuse during the pregnancy perio...
journal_title：International journal of circumpolar health
pub_type： 杂志文章
doi：10.3402/ijch.v63i1.17647
更新日期：2004-03-01 00:00:00
abstract：BACKGROUND:Primary care in remote communities in northern Canada is delivered primarily by nurses who receive clinical support from physicians in regional centres and the patient transportation system. To improve continuity, quality and access to care in remote northern communities, it is important to understand the pe...
journal_title：International journal of circumpolar health
pub_type： 杂志文章
doi：10.3402/ijch.v75.32159
更新日期：2016-09-14 00:00:00
abstract：:Over the last 60 years, Alaska's mean annual temperature has increased by 1.6°C, more than twice the rate of the rest of the United States. As a result, climate change impacts are more pronounced here than in other regions of the United States. Warmer temperatures may allow some infected host animals to survive winter...
journal_title：International journal of circumpolar health
pub_type： 杂志文章
doi：10.3402/ijch.v72i0.19562
更新日期：2013-01-01 00:00:00
abstract：:Infertility is an increasing problem for both individuals and societies. The number of couples seeking treatment for infertility is increasing each year, and public interest seems to be rising along with the new treatment methods and the improving results. Male infertility is also of great interest now that several st...
journal_title：International journal of circumpolar health
pub_type： 杂志文章,评审
doi：
更新日期：1998-07-01 00:00:00
abstract：:We exposed six healthy men to 1-h cold air (10 degrees C) daily for 11 days and measured adrenal and thyroid hormones and TSH in serum before and after the cold air exposure on days 0, 5 and 10. We observed that on days 0, 5 and 10 the resting levels and the levels after the cold exposure in serum adrenaline, thyroid ...
journal_title：International journal of circumpolar health
pub_type： 杂志文章
doi：
更新日期：2001-11-01 00:00:00
abstract：OBJECTIVES:To compare 3 questionnaires used to evaluate early developmental problems, emotional disturbances and competence in 18-month-old infants. STUDY DESIGN:A follow-up study with parents of infants 8 to 36 months of age who responded to a developmental questionnaire. METHODS:Fifty infants (18 months of age) wer...
journal_title：International journal of circumpolar health
pub_type： 杂志文章
doi：10.3402/ijch.v68i4.17365
更新日期：2009-09-01 00:00:00
abstract：OBJECTIVES:This study deals with the effects of regular winter swimming on the mood of the swimmers. METHODS:Profile of Mood State (POMS) and OIRE questionnaires were completed before (October) and after (January) the four-month winter swimming period. RESULTS:In the beginning, there were no significant differences i...
journal_title：International journal of circumpolar health
pub_type： 杂志文章
doi：10.3402/ijch.v63i2.17700
更新日期：2004-05-01 00:00:00
abstract：OBJECTIVES:The objective of this study was to predict the prevalence of type 2 diabetes and the associated burden to the health care system in Greenland posed by diabetic complications by 2014. The predictions were based on changes in demographic variables and obesity. STUDY DESIGN:Projection model based on two cross-...
journal_title：International journal of circumpolar health
pub_type： 杂志文章
doi：10.3402/ijch.v65i3.18106
更新日期：2006-06-01 00:00:00
