Abstract:
:Oxygen free radicals are implicated to cause tissue injury during ischemia and reperfusion and may play a central role in the no-reflow phenomena. Modulation of these substances has been suggested as a means of decreasing the amount of tissue loss due to ischemia and subsequent reperfusion. Pretreatment of tissues with a variety of agents has been reported to minimize the production of oxygen radicals and augment tissue survival after an ischemic insult. Ischemic clinical situations, however, usually present unexpectedly and thus pretreatment is not feasible. Our study evaluated the activity and effect of free radical scavengers delivered systemically during the ischemic interval to an ischemia/reperfusion rat intestinal model. Superoxide dismutase and dimethylthiourea were given systemically after occlusion and reperfusion to simulate a clinical sequence of a failing flap, that is, the vascular compromise, the diagnosis, and the successful resolution of the vascular embarrassment. Measurements of malonyldialdehyde (MDA), the end product of lipoperoxidation of cell walls, were compared with controls. Tissue histology was assessed and correlated with the use of these agents. A third group of rats was systemically alkalinized to attempt to shift the Bohr curve and decrease free oxygen substrate in the ischemic tissues on reperfusion. Rats treated with superoxide dismutase and dimethylthiourea showed significant reductions of MDA compared with nontreated rats (p less than 0.05), indicating attenuation of reperfusion lipoperoxidation. Systemic alkalinization of the rats did not significantly change the levels of MDA. Tissue histology showed severe injury in all ischemic groups regardless of the level of MDA.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Ann Plast Surgjournal_title
Annals of plastic surgeryauthors
Izquierdo R,Swartz WM,Sutker KB,Boydell CL,Almand Jdoi
10.1097/00000637-199202000-00008subject
Has Abstractpub_date
1992-02-01 00:00:00pages
175-9issue
2eissn
0148-7043issn
1536-3708journal_volume
28pub_type
杂志文章abstract:BACKGROUND:This study sought to examine the feasibility and effectiveness of the use of ultrasound (US) as a clinical adjunct in the delivery of botulinum toxin for the treatment of Raynaud disease of the hand. METHODS:One cadaver hand was injected with a colored simulation material using the current traditional surfa...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000002303
更新日期:2020-06-01 00:00:00
abstract::Using a newly developed Doppler probe, we have found that a standard suture anastomosis in a rat femoral artery is accompanied by significant (30-60%) cross-sectional area stenosis, which dissipates to baseline levels within 24 hours. We hypothesized that spasm, deposition of coagulation products, or the suture techni...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199503000-00015
更新日期:1995-03-01 00:00:00
abstract:BACKGROUND:According to the American Society of Plastic Surgeons (2007), the number of cosmetic procedures has increased to over 10 million in 2006, representing a 48% increase from 2000. This increase in cosmetic surgery prevalence is paralleled by a surge in reality cosmetic surgery television programming. METHODS:T...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31817e2cb8
更新日期:2009-01-01 00:00:00
abstract::Fat necrosis in transverse rectus abdominis musculocutaneous (TRAM) flap is considered to be mainly affected by blood supply. This prospective study compares the incidence of fat necrosis between zones II and III in 400 consecutive patients who had undergone unipedicled TRAM flap breast reconstruction. Fifty-eight pat...
journal_title:Annals of plastic surgery
pub_type: 临床试验,杂志文章
doi:10.1097/01.sap.0000252770.15946.14
更新日期:2007-09-01 00:00:00
abstract::Reestablishing anterior rectus fascial integrity remains a clinical challenge after transverse rectus abdominis myocutaneous (TRAM) flap breast reconstruction. The main concerns include herniation and bulging due to abdominal weakness. Mesh-assisted closure of the fascial defect has improved bulging and herniation rat...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31822af89d
更新日期:2012-03-01 00:00:00
abstract::The prophylactic use of antibiotic for pediatric burns has been suggested as a possible means of reduction of toxic shock syndrome. In our study, we review 1250 burn cases during a 16-year period (1983-1999). There was a change in protocol during this period (after 1991, all pediatric burn received prophylactic antibi...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31829be8be
更新日期:2014-01-01 00:00:00
abstract::Traditional gastrocnemius flap harvest requires a long skin incision, starting from the popliteal fossa to the mid leg. The authors designed three instruments to facilitate harvest of this flap through a small incision without the help of an endoscope in 10 patients. All 10 gastrocnemius muscle flaps survived with a 1...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200108000-00005
更新日期:2001-08-01 00:00:00
abstract::B vitamins rescue cleft palate induced by glucocorticoids in rodents; however, the mechanism of this effect remains largely unknown. The objective of our study was to assess the effect of dexamethasone and Vitamin B12 on cell proliferation and apoptosis during palatogenesis. In our study, mesenchymal cell proliferatio...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e3181b4bc8d
更新日期:2010-04-01 00:00:00
abstract::A case of a closed rupture of a single slip of flexor digitorum superficialis to the little finger is described. Closed rupture injuries of the flexor digitorum profundus tendon are quite common, but closed injuries to the superficialis tendon have been rarely reported. A single slip avulsion rupture of this tendon wo...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200110000-00012
更新日期:2001-10-01 00:00:00
abstract::Four cases of unilateral temporomandibular (TM) joint ankylosis were successfully treated by metatarsophalangeal to TM joint replacement by microvascular technique. Results 6 to 20 months postoperatively were encouraging. Further follow-up studies are necessary to evaluate the long-term results. ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198512000-00008
更新日期:1985-12-01 00:00:00
abstract:BACKGROUND:International adoptees with cleft lip and palate (CLP) are a growing population in the United States. They represent a clinical challenge, presenting at various ages and stages of cleft repair. METHODS:A retrospective review of patients seen at the CLP Program at the Children's Hospital of Philadelphia (CHO...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000000863
更新日期:2016-10-01 00:00:00
abstract::Fibromuscular dysplasia is an uncommon angiopathy that is principally observed in the renal and carotid arteries. Digital ischemia resulting from fibromuscular dysplasia of the forearm arteries is a rare occurrence. This article describes a case of distal radial and ulnar artery fibromuscular dysplasia presenting as p...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199412000-00017
更新日期:1994-12-01 00:00:00
abstract::There is still controversy about the correlation of thrombocytosis and thrombosis complication. Using a rodent splenectomy-induced thrombocytosis model and a thrombogenic endothelial damage model (inverted suture resulting in an intraluminal thrombogenic adventitia of divided femoral artery), the authors investigated ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200301000-00010
更新日期:2003-01-01 00:00:00
abstract::The onlay fascia-cartilage graft technique for malar or maxillary projections can be used for recontouring the middle third of the face. Covering onlay grafts with fascia achieves a smoother contour, concealing the edges in addition to obtaining a more natural anatomical look for the face. The technique has provided a...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198705000-00006
更新日期:1987-05-01 00:00:00
abstract:BACKGROUND:This study of stage III (locally advanced) breast cancer patients evaluated the survival improvement conferred by immediate breast reconstruction by transverse rectus abdominis musculocutaneous (TRAM) flap reconstruction after modified radical mastectomy (MRM) in comparison with MRM alone. METHODS:This retr...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000000251
更新日期:2014-09-01 00:00:00
abstract::Simultaneous multiple free flaps have become a useful option in head and neck reconstructions. We performed a 10-year retrospective study between 2001 and 2010. There were 58 men and 1 woman. The overall mortality rate was 51.7%. The longest surviving patient is 9 years and 4 months, whereas the shortest surviving pat...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e318274a49f
更新日期:2012-12-01 00:00:00
abstract::The objective of the study was to evaluate the lung function of patients with median sternotomy wound complication during the early postmedian sternotomy period and to compare the long-term pulmonary effects of reconstruction using pectoralis major and rectus abdominis muscle flaps. The percentage of predicted, standa...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199707000-00006
更新日期:1997-07-01 00:00:00
abstract::This study evaluated the outcomes of extensor indicis proprius (EIP) transfer based on varying degrees of thumb extension after EIP transfer and elongation of the EIP. A total of 24 cases with extensor pollicis longus (EPL) ruptures who underwent EIP to EPL transfer were analyzed prospectively. The EIP transfer was pe...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,随机对照试验
doi:10.1097/SAP.0000000000000593
更新日期:2015-12-01 00:00:00
abstract:INTRODUCTION:The peripheral adipose tissue is a vital component of many procedures in reconstructive and esthetic surgery. There is a limited knowledge on hemodynamic changes of adipose tissue. A direct intravital microscopic observation method is needed for the measurement of microcirculatory changes occurring in peri...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31814da751
更新日期:2008-06-01 00:00:00
abstract::Gynecomastia is an abnormal enlargement of the breast tissue in men. It is the most common disorder of the male breast. Surgical sharp resection of the excess breast tissue is still the mainstay of treatment when medical treatment modalities are proved to be ineffective. The authors believe that areolar incisions give...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000143513.77819.7a
更新日期:2005-02-01 00:00:00
abstract::A technique used concomitantly with Rethi's incision to reach and treat the secondary nasal tip is described. The technique involves removing the cartilage remnants of both domes and placing a shaped cartilage autograft that is immobilized by sutures. No hypertrophic scarring has been observed in the 546 patients trea...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198604000-00008
更新日期:1986-04-01 00:00:00
abstract::Sixteen years ago the result of an operation that was performed on a 5-year-old boy with Romberg's disease was described in this journal. Nineteen years have passed since the first operation, and the authors now report the long-term follow-up. The volume of the transferred free groin flaps was maintained. Although the...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199812000-00012
更新日期:1998-12-01 00:00:00
abstract:PURPOSE:To establish outcome of brow suspension techniques, a reliable and clinically suitable measurement tool is required. Most of the published methods lack statistical validation, and in none of the reviewed studies, the standardized photograph protocols were validated. METHODS AND TECHNIQUES:Fifteen subjects were...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31826d298e
更新日期:2014-07-01 00:00:00
abstract::Surgeons at our center previously reported a case of a 2-month-old infant who underwent closure of an infected sternal wound following open cardiac surgery with debridement followed by closure with bilateral pectoralis muscle flaps and a unilateral rectus abdominis muscle flap. The success of the procedure has spawned...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000183681.56595.0a
更新日期:2005-11-01 00:00:00
abstract:INTRODUCTION:A greater supply of tendinous tissue can be obtained through tissue engineering technology with increasing application of adult stem cells. It is well known that adipose-derived stem cells (ADSCs), found in abundance in adipose tissue, have the same differentiating capacity as mesenchymal stem cells yet ha...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e3182583e99
更新日期:2013-12-01 00:00:00
abstract:INTRODUCTION:Common upper body findings after massive weight loss (MWL) include breast ptosis, projection loss, flattening, inframammary fold descent, and back rolls. Although implants address volume loss, manifestations of circumferential excess (ie, back rolls) are ignored. We review our experience with extended late...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000000413
更新日期:2015-05-01 00:00:00
abstract::A 69-year-old woman with a history of mastectomy and radiotherapy for breast carcinoma demonstrated extensive anterior thoracic wall radionecrosis 22 years later. The latissimus dorsi musculocutaneous flap was chosen to repair two distant ulcerative defects. Chest wall coverage was performed by dividing the muscle int...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199410000-00011
更新日期:1994-10-01 00:00:00
abstract::The authors encountered a case of elongated uvula with a pleomorphic adenoma originating from the minor salivary gland, causing frequent upper airway obstruction. A 75-year-old woman had obstructive sleep apnea syndrome brought about by the swallowing impact of the pendulous tumor into the hypopharyngeal and supralary...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200045010-00011
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:Scalp melanoma is aggressive and has a proclivity for regional metastasis. We hypothesize that subperiosteal scalp melanoma resection reduces in-transit/satellite recurrence, when compared with subgaleal resection. METHODS:We identified patients with intermediate to deep, primary scalp melanoma referred to ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31822592e7
更新日期:2012-08-01 00:00:00
abstract::Upper thoracic wounds with exposed hardware from spinal instrumentation and previous radiation presents a subset of back wound coverage problems that lend themselves to a unique opportunity to use the distal trapezius musculocutaneous flap. The unradiated, healthy skin paddle can be transposed between the radiated ski...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.SAP.0000054242.00928.06
更新日期:2003-07-01 00:00:00