Abstract:
:The aim of this study was to genotype Candida albicans strains isolated from patients with invasive and non-invasive deep-seated infections. For this purpose, 301 C. albicans isolates (81 invasive and 220 non-invasive) were genotyped by using specific PCR primers designed to span the transposable group I intron of the 25S rDNA gene. Fifty-three of the 81 invasive isolates were genotype A (65.4%), eight were genotype B (9.9%) and 20 were genotype C (24.7%), while 98 of the 220 non-invasive isolates were genotype A (44.6%), 46 were genotype B (20.9%) and 76 were genotype C (34.5%). Genotype A was more prevalent among invasive isolates and genotypes B and C were more prevalent among non-invasive isolates (P = 0.0046). Genotypes D and E which represent C. dubliniensis were not found. These results indicate that there may be a relationship between C. albicans genotypes and invasiveness; genotype A being more invasive than others. The presence or absence of the transposable group I intron in the 25S rDNA gene may be important in determining the invasiveness of C. albicans.
journal_name
Mycosesjournal_title
Mycosesauthors
Karahan ZC,Güriz H,Ağirbaşli H,Balaban N,Göçmen JS,Aysev D,Akar Ndoi
10.1111/j.1439-0507.2004.01022.xsubject
Has Abstractpub_date
2004-12-01 00:00:00pages
465-9issue
11-12eissn
0933-7407issn
1439-0507pii
MYC1022journal_volume
47pub_type
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