Serum polychlorinated biphenyls, cytochrome P-450 1A1 polymorphisms, and risk of breast cancer in Connecticut women.

Abstract:

:Recent epidemiologic studies have suggested that genetic polymorphisms in the cytochrome P-450 1A1 gene (CYP1A1) may affect the relation between environmental exposure to polychlorinated biphenyls (PCBs) and breast cancer risk. The authors report results from a case-control study evaluating the potential effect of gene-environment interaction between CYP1A1 and serum PCB levels on breast cancer risk among Caucasian women in Connecticut. The study included 374 case women with histologically confirmed breast cancer and 406 noncancerous controls with information on both serum PCB level and CYP1A1 genotype (1999-2002). Compared with women who had the homozygous wild-type CYP1A1 m2 genotype, significantly increased risks of breast cancer were found for women with the CYP1A1 m2 variant genotype (odds ratio (OR) = 2.1, 95% confidence interval (CI): 1.1, 3.9), especially postmenopausal women (OR = 2.4, 95% CI: 1.1, 5.0). Risks associated with the CYP1A1 m2 variant genotype were highest for all women (OR = 3.6, 95% CI: 1.5, 8.2) and postmenopausal women (OR = 4.3, 95% CI: 1.6, 12.0) with higher serum PCB levels (611-2,600 ng/g). The CYP1A1 m1 and m4 genotypes were not associated with breast cancer risk independently or in combination with PCB exposure. In summary, the CYP1A1 m2 genetic polymorphism was associated with increased risk of female breast cancer and may modify the relation between PCB exposure and breast cancer risk.

journal_name

Am J Epidemiol

authors

Zhang Y,Wise JP,Holford TR,Xie H,Boyle P,Zahm SH,Rusiecki J,Zou K,Zhang B,Zhu Y,Owens PH,Zheng T

doi

10.1093/aje/kwh346

subject

Has Abstract

pub_date

2004-12-15 00:00:00

pages

1177-83

issue

12

eissn

0002-9262

issn

1476-6256

pii

160/12/1177

journal_volume

160

pub_type

杂志文章
  • Is More Area-Level Crime Associated With More Sitting and Less Physical Activity? Longitudinal Evidence From 37,162 Australians.

    abstract::Does a rise in crime result in increased sitting time and a reduction in physical activity? We used unobserved ("fixed")-effects models to examine associations between change in objectively measured crime (nondomestic violence, malicious damage, breaking and entering, and stealing, theft, and robbery) in Australia and...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kww106

    authors: Astell-Burt T,Feng X,Kolt GS,Jalaludin B

    更新日期:2016-12-15 00:00:00

  • The emergence of infection surveillance and control programs in US hospitals: an assessment, 1976.

    abstract::To assess the current state of hospitals' infection surveillance and control programs (ISCPs) nationwide and to provide a sampling frame for selecting hospitals for later phases of the SENIC Project, the authors mailed a screening questionnaire in March, 1976, to virtually all US hospitals; 86% of those in the SENIC t...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a112935

    authors: Haley RW,Shachtman RH

    更新日期:1980-05-01 00:00:00

  • Menstrual cycle patterns and risk of breast cancer.

    abstract::Menstrual cycle characteristics may reflect underlying endocrine patterns that influence the risk of breast cancer. Most previous studies of menstrual function and breast cancer risk have used retrospective reports of menstrual bleeding, which may be unreliable. To examine this association, the authors conducted a mai...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a117208

    authors: Whelan EA,Sandler DP,Root JL,Smith KR,Weinberg CR

    更新日期:1994-12-15 00:00:00

  • Birth weight and mortality: causality or confounding?

    abstract::The association between birth weight and mortality is among the strongest seen in epidemiology. While preterm delivery causes both small babies and high mortality, it does not explain this association. Fetal growth restriction has also been proposed, although its features are unclear because it lacks a definition inde...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwj237

    authors: Basso O,Wilcox AJ,Weinberg CR

    更新日期:2006-08-15 00:00:00

  • Relation between body mass index and lung cancer risk in men and women never and former smokers.

    abstract::The authors assessed body mass index (BMI), measured as Quetelet's index (weight in kilograms divided by the square of height in meters), in relation to lung cancer risk in never and former smokers by using data from a population-based, individually matched, case-control study conducted in New York State from 1982 to ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/152.6.506

    authors: Rauscher GH,Mayne ST,Janerich DT

    更新日期:2000-09-15 00:00:00

  • Amyotrophic lateral sclerosis and parkinsonism-dementia on Guam, 1945-1972. II. Familial and genetic studies.

    abstract::The extraordinarily high rate of amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia (PD) in the Chamorro linguistic group on Guam suggested a genetic etiology for these diseases. Results of three studies are described. Two involved comparisons of the rates of disease in relatives and spouses of index patien...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a112098

    authors: Reed DM,Torres JM,Brody JA

    更新日期:1975-04-01 00:00:00

  • The relation of diet, cigarette smoking, and alcohol consumption to plasma beta-carotene and alpha-tocopherol levels.

    abstract::The relation of diet and nutritional supplements, cigarette use, alcohol consumption, and blood lipids to plasma levels of beta-carotene and alpha-tocopherol was studied among 330 men and women aged 18-79 years. Dietary carotene, preformed vitamin A, and vitamin E intake were estimated by a self-administered semiquant...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a114804

    authors: Stryker WS,Kaplan LA,Stein EA,Stampfer MJ,Sober A,Willett WC

    更新日期:1988-02-01 00:00:00

  • Examination of how neighborhood definition influences measurements of youths' access to tobacco retailers: a methodological note on spatial misclassification.

    abstract::Measurements of neighborhood exposures likely vary depending on the definition of "neighborhood" selected. This study examined the extent to which neighborhood definition influences findings regarding spatial accessibility to tobacco retailers among youth. We defined spatial accessibility to tobacco retailers (i.e., t...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwt251

    authors: Duncan DT,Kawachi I,Subramanian SV,Aldstadt J,Melly SJ,Williams DR

    更新日期:2014-02-01 00:00:00

  • Coronary heart disease prevalence and its relation to risk factors in American Indians. The Strong Heart Study.

    abstract::Although coronary heart disease (CHD) is currently the leading cause of death among American Indians, information on the prevalence of CHD and its association with known cardiovascular risk factors is limited. The Strong Heart Study was initiated in 1988 to quantify cardiovascular disease and its risk factors among th...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a117632

    authors: Howard BV,Lee ET,Cowan LD,Fabsitz RR,Howard WJ,Oopik AJ,Robbins DC,Savage PJ,Yeh JL,Welty TK

    更新日期:1995-08-01 00:00:00

  • Blood pressure differences between blacks and whites in relation to body size among US children and adolescents.

    abstract::No large national studies of ethnic differences in blood pressure among children accounting for body size differences have been published, to the authors' knowledge. This report details the similarities and differences in systolic and diastolic blood pressures between Black children and White children in the United St...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a010129

    authors: Rosner B,Prineas R,Daniels SR,Loggie J

    更新日期:2000-05-15 00:00:00

  • Factors associated with pilot fatality in work-related aircraft crashes, Alaska, 1990-1999.

    abstract::Work-related aircraft crashes are the leading cause of occupational fatality in Alaska, with civilian pilots having the highest fatality rate (410/100,000/year). To identify factors affecting survivability, the authors examined work-related aircraft crashes that occurred in Alaska in the 1990s (1990-1999), comparing c...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/154.11.1037

    authors: Bensyl DM,Moran K,Conway GA

    更新日期:2001-12-01 00:00:00

  • Neural tube defects among Mexican Americans living on the US-Mexico border: effects of folic acid and dietary folate.

    abstract::Populations of Mexican descent have high occurrences of neural tube defects (NTDs). A recent study suggested that folic acid supplements may not protect these populations from NTDs. In a case-control study, the authors investigated the role of folic acid and dietary folate intake in NTD risk among Mexican Americans li...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/152.11.1017

    authors: Suarez L,Hendricks KA,Cooper SP,Sweeney AM,Hardy RJ,Larsen RD

    更新日期:2000-12-01 00:00:00

  • Prospective study of diet and pancreatic cancer in male smokers.

    abstract::There have been few prospective studies relating diet to pancreatic cancer, with most having fewer than 100 cases and only one examining dietary nutrients. The authors prospectively examined dietary factors hypothesized to be associated with exocrine pancreatic cancer in the Alpha-Tocopherol, Beta-Carotene Cancer Prev...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/155.9.783

    authors: Stolzenberg-Solomon RZ,Pietinen P,Taylor PR,Virtamo J,Albanes D

    更新日期:2002-05-01 00:00:00

  • Methods for meta-analyses of genome-wide association studies: critical assessment of empirical evidence.

    abstract::There has been a steep increase in the number of meta-analyses of genome-wide association (GWA) studies aimed at identifying genetic variants with increasingly smaller effects, but pressure to publish findings of new genetic associations has limited the time available for careful consideration of all of their methodol...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,评审

    doi:10.1093/aje/kwr385

    authors: Gögele M,Minelli C,Thakkinstian A,Yurkiewich A,Pattaro C,Pramstaller PP,Little J,Attia J,Thompson JR

    更新日期:2012-04-15 00:00:00

  • Forced vital capacity and the risk of hypertension. The Normative Aging Study.

    abstract::This report describes the development of hypertension among 1,270 males (aged 23-80 years at the time of entry into the study) observed prospectively for 10 years who had a baseline blood pressure of less than 140/90 mmHg and who underwent baseline spirometry. Subjects were participants in the Normative Aging Study, a...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a114854

    authors: Sparrow D,Weiss ST,Vokonas PS,Cupples LA,Ekerdt DJ,Colton T

    更新日期:1988-04-01 00:00:00

  • Diet and other risk factors for laryngeal cancer in Shanghai, China.

    abstract::A population-based, case-control study of laryngeal cancer was conducted in Shanghai, China, during 1988-1990, in which 201 incident cases (177 males, 24 females) and 414 controls (269 males, 145 females) were interviewed. Cigarette smoking was the major risk factor, accounting for 86% of the male and 54% of the femal...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a116484

    authors: Zheng W,Blot WJ,Shu XO,Gao YT,Ji BT,Ziegler RG,Fraumeni JF Jr

    更新日期:1992-07-15 00:00:00

  • Risk factors for nosocomial urinary tract infection.

    abstract::In a prospective study carried out in June 1979-April 1981, 134 of 1,458 adult inpatients at New England Deaconess Hospital, Boston, Massachusetts, acquired 136 urinary tract infections during 1,474 indwelling bladder catheterizations. Multiple logistic regression analysis identified nine factors that were significant...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a114487

    authors: Platt R,Polk BF,Murdock B,Rosner B

    更新日期:1986-12-01 00:00:00

  • Illicit drug use and HIV-1 disease progression: a longitudinal study in the era of highly active antiretroviral therapy.

    abstract::This study assessed the association between longitudinal patterns of illicit drug use and clinical progression of human immunodeficiency virus (HIV) disease. Confidential computer-based interviews, which addressed illicit drug use and other factors, were completed by HIV-infected participants in Baltimore, Maryland, a...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwj059

    authors: Lucas GM,Griswold M,Gebo KA,Keruly J,Chaisson RE,Moore RD

    更新日期:2006-03-01 00:00:00

  • Additive and Multiplicative Interactions Between Genetic Risk Score and Family History and Lifestyle in Relation to Risk of Type 2 Diabetes.

    abstract::We examined interactions between lifestyle factors and genetic risk of type 2 diabetes (T2D-GR), captured by genetic risk score (GRS) and family history (FH). Our initial study cohort included 20,524 European-ancestry participants, of whom 1,897 developed incident T2D, in the Nurses' Health Study (1984-2016), Nurses' ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwz251

    authors: Ding M,Ahmad S,Qi L,Hu Y,Bhupathiraju SN,Guasch-Ferré M,Jensen MK,Chavarro JE,Ridker PM,Willett WC,Chasman DI,Hu FB,Kraft P

    更新日期:2020-05-05 00:00:00

  • All-cause and cardiovascular mortality among Mexican-American and non-Hispanic White older participants in the San Antonio Heart Study- evidence against the "Hispanic paradox".

    abstract::The observation that Hispanics have lower all-cause and cardiovascular mortality rates despite increased rates of diabetes and obesity and lower socioeconomic status has been termed the "Hispanic paradox." The authors therefore examined the relation between ethnicity and mortality in 1,438 Mexican-American and 921 non...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwg249

    authors: Hunt KJ,Resendez RG,Williams K,Haffner SM,Stern MP,Hazuda HP

    更新日期:2003-12-01 00:00:00

  • Predicting coronary heart disease in siblings--a multivariate assessment: the Framingham Heart Study.

    abstract::The incidence of clinically recognized coronary heart disease and its relation to risk factors have been studied for 596 sibships in the Framingham Heart Study cohort. Only the 186 pairs of brothers were considered in the multivariate analysis, since the rate of coronary heart disease in women is low. Multiple logisti...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a113293

    authors: Snowden CB,McNamara PM,Garrison RJ,Feinleib M,Kannel WB,Epstein FH

    更新日期:1982-02-01 00:00:00

  • Invited Commentary: Lessons for Research on Cognitive Aging From a Study of Children.

    abstract::As the population ages, the burden of disease from cognitive decline and dementing illness is rising. In the absence of treatments to reverse cognitive decline, prevention is a public health priority. Physical fitness and physical activity have emerged as prevention targets based on evidence of "neuroprotective" benef...

    journal_title:American journal of epidemiology

    pub_type: 评论,杂志文章

    doi:10.1093/aje/kww029

    authors: Belsky DW

    更新日期:2016-06-15 00:00:00

  • Cardiovascular risk factors clustering features of insulin resistance syndrome (Syndrome X) in a biracial (Black-White) population of children, adolescents, and young adults: the Bogalusa Heart Study.

    abstract::Recently, independent factors representing different features of insulin resistance syndrome (Syndrome X) have been identified by factor analysis in middle-aged and elderly adult populations. In this study, factor analysis was applied to the clustering characteristics of Syndrome X in a biracial (Black-White) communit...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a010069

    authors: Chen W,Srinivasan SR,Elkasabany A,Berenson GS

    更新日期:1999-10-01 00:00:00

  • Educational status and blood pressure: the Second National Health and Nutrition Examination Survey, 1976-1980, and the Hispanic Health and Nutrition Examination Survey, 1982-1984.

    abstract::An inverse association between socioeconomic status, as measured by years of education, and blood pressure has been reported in a number of studies. However, two secular trends may have changed the nature of this relation: a higher mean level of education in the population and intervention for high blood pressure in t...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a116245

    authors: Sorel JE,Ragland DR,Syme SL,Davis WB

    更新日期:1992-06-15 00:00:00

  • Prevalence of hepatitis B antibody in prostitutes.

    abstract::The possibility that hepatitis B is transmitted venereally was examined by determining the prevalence of hepatitis B antibody (anti-HB(S)) in populations with different levels of promiscuity. Of 258 prostitutes, 31% were anti-HB(S) positive, compared to 10% of 258 female age-matched blood donors, 10% of 48 nuns living...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a112153

    authors: Frösner GG,Buchholz HM,Gerth HJ

    更新日期:1975-09-01 00:00:00

  • Protection against ischemic heart disease in the Belgian Physical Fitness Study: physical fitness rather than physical activity?

    abstract::Occupational and leisure time physical activity and conventional risk factors were determined in the Belgian Physical Fitness Study, a prospective study of 2,363 healthy male factory workers who were aged 40-55 years at entry in 1976-1978 and who were followed for five years. Physical fitness, defined as the interpola...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a114573

    authors: Sobolski J,Kornitzer M,De Backer G,Dramaix M,Abramowicz M,Degre S,Denolin H

    更新日期:1987-04-01 00:00:00

  • Correction for biases in a population-based study of family history and coronary heart disease. The Newcastle Family History Study I.

    abstract::In this paper, the authors report on the design of a population-based case-control study of family history as a risk factor for coronary heart disease (CHD). They studied the characteristics of subjects who completed a detailed family history questionnaire in 1992-1994 as well as the accuracy of recall of family histo...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a009410

    authors: Silberberg JS,Wlodarczyk J,Fryer J,Ray CD,Hensley MJ

    更新日期:1998-06-15 00:00:00

  • Placental vascular pathology findings and pathways to preterm delivery.

    abstract::The authors examined the associations between placental vascular findings and preterm delivery in 1,053 subcohort women (239 preterm, 814 term) from a Michigan pregnancy cohort study (1998-2004). Twenty-nine placental vascular variables from microscopic examinations were grouped into 5 constructs: 3 maternal construct...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwp131

    authors: Kelly R,Holzman C,Senagore P,Wang J,Tian Y,Rahbar MH,Chung H

    更新日期:2009-07-15 00:00:00

  • Serologic profile of children in a Mexican highland community: prevalence of complement-fixing antibodies to Mycoplasma pneumoniae, respiratory syncytial virus and parainfluenza viruses.

    abstract::The study investigated the prevalence of antibodies to five leading agents of childhood respiratory disease in the county of Huixquilucan, Mexico. Tests of sera from a random sample of children between 3 months and 18 years of age confirmed serologically the presence of Mycoplasma pneumoniae, respiratory syncytial (RS...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a112113

    authors: Golubjatnikov R,Allen VD,Olmos-Blancarte MP,Inhorn SL

    更新日期:1975-05-01 00:00:00

  • Tracking of risk factors for coronary heart disease over a 14-year period: a comparison between lifestyle and biologic risk factors with data from the Amsterdam Growth and Health Study.

    abstract::Because the magnitude of tracking coefficients (i.e., stability coefficients and tracking for subjects at risk) greatly depends on the initial age of subjects, the number and spacing of longitudinal measurements, and the length of the total time period, it is difficult to compare tracking coefficients from different s...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a009048

    authors: Twisk JW,Kemper HC,van Mechelen W,Post GB

    更新日期:1997-05-15 00:00:00