Invited Commentary: Lessons for Research on Cognitive Aging From a Study of Children.

Abstract:

:As the population ages, the burden of disease from cognitive decline and dementing illness is rising. In the absence of treatments to reverse cognitive decline, prevention is a public health priority. Physical fitness and physical activity have emerged as prevention targets based on evidence of "neuroprotective" benefits in observational studies. However, observational studies linking active lifestyle with successful cognitive aging might be subject to bias from "neuroselection," in which adults with better cognitive functioning are more likely to engage in healthy behaviors and avoid unhealthy ones. In their analysis of longitudinal data on several thousand children from the United Kingdom's Millennium Cohort Study, Aggio et al. (Am J Epidemiol. 2016;183(12):1075-1082) revealed that this pattern of neuroselection is already apparent in childhood. However, they also report data that suggest there are cognitive benefits to engaging in certain types of active behaviors over and above this selection. Their findings argue for greater attention to confounding by neuroselection in research on cognitive aging, and they suggest the possibility that early interventions to promote certain health behaviors may instill a virtuous cycle with benefits that accumulate across the lifespan.

journal_name

Am J Epidemiol

authors

Belsky DW

doi

10.1093/aje/kww029

subject

Has Abstract

pub_date

2016-06-15 00:00:00

pages

1083-5

issue

12

eissn

0002-9262

issn

1476-6256

pii

kww029

journal_volume

183

pub_type

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