当前位置： SCI文献检索 > BLOOD期刊下所有文献 > Development and validation of a clinical prediction rule for bone marrow involvement in patients with Hodgkin lymphoma.

Development and validation of a clinical prediction rule for bone marrow involvement in patients with Hodgkin lymphoma.

Abstract：

:We developed a clinical prediction rule for bone marrow involvement (BMI) in Hodgkin lymphoma based on 826 patients and validated it in 654 additional patients. Independent prognostic factors for BMI were x1, B symptoms; x2, stage III/IV prior to bone marrow biopsy; x3, anemia; x4, leukocytes fewer than 6 x 10(9)/L; x5, age 35 years or older; and x6, iliac/inguinal involvement. Each factor was graded as x(i)=1, if present, or x(i)=0, if absent. A simplified score Zs=8x1+6x2+5x3+5x4+3x5+3x6-8 was assigned to each patient. The sensitivity, specificity, and positive and negative predictive value of this prediction rule was 97.8%, 51.5%, 10.6%, and 99.8%, respectively. In the validation group, they were 98.1%, 40.3%, 12.7%, and 99.6%. According to Zs value, 3 risk groups for BMI were defined: low risk (Zs<0, 44% of patients, 0.3% risk), standard risk (Zs, 0-9; 37% of patients; 4.2% risk), and high risk (Zs>or=10, 20% of patients, 25.5% risk). Patients with low risk (stage IA/IIA without anemia and leukopenia; stage IA/IIA, younger than 35 years, with either anemia or leukopenia but no inguinal/iliac involvement; and stage IIIA/IVA without any of these 4 risk factors) do not need bone marrow (BM) biopsy. Patients with standard risk should be staged with unilateral biopsy, but patients with high risk may benefit from bilateral biopsy.

journal_name

Blood

journal_title

Blood

authors

Vassilakopoulos TP,Angelopoulou MK,Constantinou N,Karmiris T,Repoussis P,Roussou P,Siakantaris MP,Korkolopoulou P,Kyrtsonis MC,Kokoris SI,Dimopoulou MN,Variamis E,Viniou NA,Konstantopoulos K,Dimitriadou EM,Androulaki A,Pa

doi

10.1182/blood-2004-01-0379

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

1875-80

issue

5

eissn

0006-4971

issn

1528-0020

pii

2004-01-0379

journal_volume

105

pub_type

杂志文章

相关文献

BLOOD文献大全
  • Elevated intracellular level of basic fibroblast growth factor correlates with stage of chronic lymphocytic leukemia and is associated with resistance to fludarabine.

    abstract：:Chronic lymphocytic leukemia (CLL) is characterized by delayed senescence and slow accumulation of monoclonal, small lymphocytes. Basic fibroblast growth factor (bFGF) is a pleiotropic cytokine that plays a role in hematopoiesis and apoptosis. Elevated bFGF levels have been detected in urine from patients with a varie...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Menzel T,Rahman Z,Calleja E,White K,Wilson EL,Wieder R,Gabrilove J

    更新日期：1996-02-01 00:00:00

  • Regulation of thrombosis and vascular function by protein methionine oxidation.

    abstract：:Redox biology is fundamental to both normal cellular homeostasis and pathological states associated with excessive oxidative stress. Reactive oxygen species function not only as signaling molecules but also as redox regulators of protein function. In the vascular system, redox reactions help regulate key physiologic r...

    journal_title：Blood

    pub_type： 杂志文章,评审

    doi：10.1182/blood-2015-01-544676

    authors： Gu SX,Stevens JW,Lentz SR

    更新日期：2015-06-18 00:00:00

  • Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress.

    abstract：:Hematopoietic stem and progenitor cells (HSPCs) are vulnerable to endogenous damage and defects in DNA repair can limit their function. The 2 single-stranded DNA (ssDNA) binding proteins SSB1 and SSB2 are crucial regulators of the DNA damage response; however, their overlapping roles during normal physiology are incom...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2016-06-725093

    authors： Shi W,Vu T,Boucher D,Biernacka A,Nde J,Pandita RK,Straube J,Boyle GM,Al-Ejeh F,Nag P,Jeffery J,Harris JL,Bain AL,Grzelak M,Skrzypczak M,Mitra A,Dojer N,Crosetto N,Cloonan N,Becherel OJ,Finnie J,Skaar JR,Walkle

    更新日期：2017-05-04 00:00:00

  • Thirty years of hemophilia treatment in the Netherlands, 1972-2001.

    abstract：:Since the introduction of replacement therapy in the early 1960s by the infusion of plasma-derived factor VIII and IX preparations, important changes have occurred for hemophilia patients. We studied the medical and social developments over 30 years of hemophilia treatment. Since 1972, 5 cross-sectional national posta...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2004-05-2008

    authors： Plug I,van der Bom JG,Peters M,Mauser-Bunschoten EP,de Goede-Bolder A,Heijnen L,Smit C,Zwart-van Rijkom JE,Willemse J,Rosendaal FR

    更新日期：2004-12-01 00:00:00

  • The architectural pattern of FOXP3-positive T cells in follicular lymphoma is an independent predictor of survival and histologic transformation.

    abstract：:Previous studies of follicular lymphoma (FL) patients treated heterogeneously have suggested that decreased numbers of regulatory T cells correlates with improved survival. We studied advanced-stage FL patients from a single institution phase 2 trial. All patients were treated uniformly with multiagent chemotherapy an...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2009-07-235598

    authors： Farinha P,Al-Tourah A,Gill K,Klasa R,Connors JM,Gascoyne RD

    更新日期：2010-01-14 00:00:00

  • T cell receptor (alpha, beta, gamma) gene rearrangements and expression in normal and leukemic large granular lymphocytes/natural killer cells.

    abstract：:The large granular lymphocyte (LGL) population, which effects a natural killer (NK) function, consists of cells whose lineage derivation has not been clearly established on the basis of phenotypic and functional properties. To clarify the relationship of LGL/NK cells to T cells we studied patterns of rearrangement and...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Pelicci PG,Allavena P,Subar M,Rambaldi A,Pirelli A,Di Bello M,Barbui T,Knowles DM 2nd,Dalla-Favera R,Mantovani A

    更新日期：1987-11-01 00:00:00

  • Venous thrombosis risk associated with plasma hypofibrinolysis is explained by elevated plasma levels of TAFI and PAI-1.

    abstract：:Elevated plasma clot lysis time (CLT) increases risk of venous and arterial thrombosis. It is unclear which fibrinolytic factors contribute to thrombosis risk. In 743 healthy control subjects we investigated determinants of CLT. By comparison with 770 thrombosis patients, we assessed plasma levels of fibrinolytic prot...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2010-02-267740

    authors： Meltzer ME,Lisman T,de Groot PG,Meijers JC,le Cessie S,Doggen CJ,Rosendaal FR

    更新日期：2010-07-08 00:00:00

  • Kinetics and mechanism of the bactericidal action of human neutrophils against Escherichia coli.

    abstract：:A mutant strain of Escherichia coli (E. coli ML-35) was used to follow the kinetics of phagocytosis, perforation of the bacterial cell envelope, and inactivation of bacterial proteins by human neutrophils. This particular E. coli mutant strain has no lactose permease, but constitutively forms the cytoplasmic enzyme be...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Hamers MN,Bot AA,Weening RS,Sips HJ,Roos D

    更新日期：1984-09-01 00:00:00

  • Phase 2 study of subcutaneous omacetaxine mepesuccinate after TKI failure in patients with chronic-phase CML with T315I mutation.

    abstract：:Chronic myeloid leukemia (CML) patients with the BCR-ABL T315I mutation do not benefit from therapy with currently approved tyrosine kinase inhibitors. Omacetaxine mepesuccinate is a protein synthesis inhibitor that has demonstrated activity in cells harboring the T315I mutation. This phase 2 trial assessed the effica...

    journal_title：Blood

    pub_type： 杂志文章,多中心研究

    doi：10.1182/blood-2012-03-415307

    authors： Cortes J,Lipton JH,Rea D,Digumarti R,Chuah C,Nanda N,Benichou AC,Craig AR,Michallet M,Nicolini FE,Kantarjian H,Omacetaxine 202 Study Group.

    更新日期：2012-09-27 00:00:00

  • In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-beta1.

    abstract：:Transforming growth factor-beta1 (TGF-beta1) has potent physiologic and pathologic effects on a variety of cell types at subnanomolar concentrations. Platelets contain 40 times as much TGF-beta1 as other cells and secrete it as an inactive (latent) form in complex with latency-associated peptide (LAP), which is disulf...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2008-04-151753

    authors： Ahamed J,Burg N,Yoshinaga K,Janczak CA,Rifkin DB,Coller BS

    更新日期：2008-11-01 00:00:00

  • Heterogeneity in human prothrombin: analysis of cause.

    abstract：:Two fractions of human prothrombin can be isolated from single donor plasma by the technique of heparin-agarose chromatography in (sodium) citrate buffer, pH 7.5, as previously reported for pooled plasma. The two fractions, designated H-II1 and H-II2, are found in a ratio of approximately 4:1. Both forms comigrate in ...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Bajaj SP,Rapaport SI,Prodonos C,Russell WA

    更新日期：1981-11-01 00:00:00

  • N-Glycans of ADAMTS13 modulate its secretion and von Willebrand factor cleaving activity.

    abstract：:Severe deficiency of ADAMTS13, a plasma metalloprotease, leads to thrombotic thrombocytopenic purpura. ADAMTS13 contains 10 putative N-glycosylation sites in or near its metalloprotease sequence, spacer region, thrombospondin type 1 repeat no. 4 (TSR no. 4), and CUB domains. Tunicamycin treatment markedly decreased th...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2008-07-167775

    authors： Zhou W,Tsai HM

    更新日期：2009-01-22 00:00:00

  • Menin regulates the function of hematopoietic stem cells and lymphoid progenitors.

    abstract：:Men1 is a tumor suppressor gene mutated in endocrine neoplasms. Besides its endocrine role, the Men1 gene product menin interacts with the mixed lineage leukemia (MLL) protein, a histone H3 lysine 4 methyltransferase. Although menin and MLL fusion proteins cooperate to activate Homeobox (Hox) gene expression during tr...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2009-01-135012

    authors： Maillard I,Chen YX,Friedman A,Yang Y,Tubbs AT,Shestova O,Pear WS,Hua X

    更新日期：2009-02-19 00:00:00

  • AML cells are differentially sensitive to chemotherapy treatment in a human xenograft model.

    abstract：:As acute myeloid leukemia (AML) xenograft models improve, the potential for using them to evaluate novel therapeutic strategies becomes more appealing. Currently, there is little information on using standard chemotherapy regimens in AML xenografts. Here we have characterized the immunodeficient mouse response to comb...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2012-10-464677

    authors： Wunderlich M,Mizukawa B,Chou FS,Sexton C,Shrestha M,Saunthararajah Y,Mulloy JC

    更新日期：2013-03-21 00:00:00

  • Association of pharmacokinetic (CYP2C9) and pharmacodynamic (factors II, VII, IX, and X; proteins S and C; and gamma-glutamyl carboxylase) gene variants with warfarin sensitivity.

    abstract：:We analyzed mutations of 7 vitamin K-dependent protein and cytochrome P450 2C9 genes in 45 patients and investigated whether any contribute to the large interpatient variability in the warfarin dose-effect relationship. Total clearance and daily dose, INR and INR/Cp, were used as pharmacokinetic and pharmacodynamic in...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2003-09-3043

    authors： Shikata E,Ieiri I,Ishiguro S,Aono H,Inoue K,Koide T,Ohgi S,Otsubo K

    更新日期：2004-04-01 00:00:00

  • Hypoxic induction of gene expression in chronic granulomatous disease-derived B-cell lines: oxygen sensing is independent of the cytochrome b558-containing nicotinamide adenine dinucleotide phosphate oxidase.

    abstract：:Reduced oxygenation of a variety of cells results in transcriptional upregulation of several genes, including the hematopoietic hormone erythropoietin, the angiogenic vascular endothelial growth factor (VEGF), and glycolytic enzymes such as aldolase. Recently, the heme protein cytochrome b558 of the nicotinamide adeni...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Wenger RH,Marti HH,Schuerer-Maly CC,Kvietikova I,Bauer C,Gassmann M,Maly FE

    更新日期：1996-01-15 00:00:00

  • Single-cell molecular analysis defines therapy response and immunophenotype of stem cell subpopulations in CML.

    abstract：:Understanding leukemia heterogeneity is critical for the development of curative treatments as the failure to eliminate therapy-persistent leukemic stem cells (LSCs) may result in disease relapse. Here we have combined high-throughput immunophenotypic screens with large-scale single-cell gene expression analysis to de...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2016-07-728873

    authors： Warfvinge R,Geironson L,Sommarin MNE,Lang S,Karlsson C,Roschupkina T,Stenke L,Stentoft J,Olsson-Strömberg U,Hjorth-Hansen H,Mustjoki S,Soneji S,Richter J,Karlsson G

    更新日期：2017-04-27 00:00:00

  • Glucose-6 phosphate dehydrogenase mutations and haplotypes in various ethnic groups.

    abstract：:Mutations that produce glucose-6-phosphate dehydrogenase (G6PD) deficiency have been identified in samples from patients with hemolytic disease in the United States, and in G6PD-deficient samples from Greece, the Canary Islands, the Czech and Slovak Republics, South China, and in samples from the Coriell Cell Reposito...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Xu W,Westwood B,Bartsocas CS,Malcorra-Azpiazu JJ,Indrák K,Beutler E

    更新日期：1995-01-01 00:00:00

  • RNA interference screening identifies lenalidomide sensitizers in multiple myeloma, including RSK2.

    abstract：:To identify molecular targets that modify sensitivity to lenalidomide, we measured proliferation in multiple myeloma (MM) cells transfected with 27 968 small interfering RNAs in the presence of increasing concentrations of drug and identified 63 genes that enhance activity of lenalidomide upon silencing. Ribosomal pro...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2014-05-577130

    authors： Zhu YX,Yin H,Bruins LA,Shi CX,Jedlowski P,Aziz M,Sereduk C,Kortuem KM,Schmidt JE,Champion M,Braggio E,Keith Stewart A

    更新日期：2015-01-15 00:00:00

  • Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype.

    abstract：:Since their discovery in patients with autosomal dominant (AD) chronic mucocutaneous candidiasis (CMC) in 2011, heterozygous STAT1 gain-of-function (GOF) mutations have increasingly been identified worldwide. The clinical spectrum associated with them needed to be delineated. We enrolled 274 patients from 167 kindreds...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2015-11-679902

    authors： Toubiana J,Okada S,Hiller J,Oleastro M,Lagos Gomez M,Aldave Becerra JC,Ouachée-Chardin M,Fouyssac F,Girisha KM,Etzioni A,Van Montfrans J,Camcioglu Y,Kerns LA,Belohradsky B,Blanche S,Bousfiha A,Rodriguez-Gallego C,Meyts

    更新日期：2016-06-23 00:00:00

  • Development of a vascular niche platform for expansion of repopulating human cord blood stem and progenitor cells.

    abstract：:Transplantation of ex vivo expanded human umbilical cord blood cells (hCB) only partially enhances the hematopoietic recovery after myelosuppressive therapy. Incubation of hCB with optimal combinations of cytokines and niche cells, such as endothelial cells (ECs), could augment the efficiency of hCB expansion. We have...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2011-12-398115

    authors： Butler JM,Gars EJ,James DJ,Nolan DJ,Scandura JM,Rafii S

    更新日期：2012-08-09 00:00:00

  • Human CD8+ T cells store CXCR1 in a distinct intracellular compartment and up-regulate it rapidly to the cell surface upon activation.

    abstract：:Activation and subsequent differentiation of naive CD8+ T cells lead to the development of memory subsets with distinct homing and effector capacities. On nonlymphoid homing subsets, expression of "inflammatory" chemokine receptors (such as CXCR3, CCR5, CX3CR1, and CXCR1) is believed to promote migration into sites of...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2005-04-1366

    authors： Gasser O,Missiou A,Eken C,Hess C

    更新日期：2005-12-01 00:00:00

  • Monocyte Fc gamma receptor recognition of cell-bound and aggregated IgG.

    abstract：:Monocyte and macrophage Fc gamma receptors are important components in the recognition of IgG-coated cells and IgG-containing immune complexes. Two proteins have been identified on human peripheral blood monocytes that can function as Fc gamma receptors, Fc gamma RI (70 Kd) and Fc gamma RII (40 Kd). We studied the rol...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Gomez F,Chien P,King M,McDermott P,Levinson AI,Rossman MD,Schreiber AD

    更新日期：1989-08-15 00:00:00

  • Lenalidomide targets clonogenic side population in multiple myeloma: pathophysiologic and clinical implications.

    abstract：:Recurrence of multiple myeloma (MM) after therapy suggests the presence of tumor-initiating subpopulations. In our study, we performed flow cytometry-based Hoechst 33342 staining to evaluate the existence of a MM population with stem-like features known as side population (SP) cells. SP cells exhibit substantial heter...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2010-02-267344

    authors： Jakubikova J,Adamia S,Kost-Alimova M,Klippel S,Cervi D,Daley JF,Cholujova D,Kong SY,Leiba M,Blotta S,Ooi M,Delmore J,Laubach J,Richardson PG,Sedlak J,Anderson KC,Mitsiades CS

    更新日期：2011-04-28 00:00:00

  • Low vs high hemoglobin trigger for transfusion in vascular surgery: a randomized clinical feasibility trial.

    abstract：:Current guidelines advocate to limit red blood cell (RBC) transfusion during surgery, but the feasibility and safety of such a strategy remain unclear, as the majority of evidence is based on postoperatively stable patients. We assessed the effects of a protocol aiming to restrict RBC transfusion throughout hospitaliz...

    journal_title：Blood

    pub_type： 杂志文章,随机对照试验

    doi：10.1182/blood-2018-10-877530

    authors： Møller A,Nielsen HB,Wetterslev J,Pedersen OB,Hellemann D,Winkel P,Marcussen KV,Ramsing BGU,Mortensen A,Jakobsen JC,Shahidi S

    更新日期：2019-06-20 00:00:00

  • Persistent activation of the tumor necrosis factor system in a subgroup of patients with common variable immunodeficiency--possible immunologic and clinical consequences.

    abstract：:In patients with common variable immunodeficiency (CVI), we have previously defined a subgroup of patients (CVIHyper) characterized by decreased numbers of CD4+ lymphocytes in peripheral blood, splenomegaly, and persistent immune activation in vivo, particularly of monocytes/macrophages. To further characterize this h...

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Aukrust P,Lien E,Kristoffersen AK,Müller F,Haug CJ,Espevik T,Frøland SS

    更新日期：1996-01-15 00:00:00

  • FGFR2 genotype and risk of radiation-associated breast cancer in Hodgkin lymphoma.

    abstract：:Women treated at young ages with supradiaphragmatic radiotherapy for Hodgkin lymphoma (HL) have a highly increased risk of breast cancer. For personalized advice and follow-up regimens for patients, information is needed on how the radiotherapy-related risk is affected by other breast cancer risk factors. Genome-wide ...

    journal_title：Blood

    pub_type： 杂志文章,meta分析

    doi：10.1182/blood-2011-10-383380

    authors： Ma YP,van Leeuwen FE,Cooke R,Broeks A,Enciso-Mora V,Olver B,Lloyd A,Broderick P,Russell NS,Janus C,Ashworth A,Houlston RS,Swerdlow AJ

    更新日期：2012-01-26 00:00:00

  • Rituximab blocks binding of radiolabeled anti-CD20 antibodies (Ab) but not radiolabeled anti-CD45 Ab.

    abstract：:Rituximab therapy is associated with a long in vivo persistence, yet little is known about the effect of circulating rituximab on B-cell non-Hodgkin lymphoma (B-NHL) targeting by the other available anti-CD20 monoclonal antibodies (MoAbs) (131)iodine-tositumomab and (90)yttrium-ibritumomab tiuxetan. Therefore we asses...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2008-01-132142

    authors： Gopal AK,Press OW,Wilbur SM,Maloney DG,Pagel JM

    更新日期：2008-08-01 00:00:00

  • Suppression of cell proliferation and the expression of a bcr-abl fusion gene and apoptotic cell death in a new human chronic myelogenous leukemia cell line, KT-1, by interferon-alpha.

    abstract：:A new human leukemia cell line, KT-1, was established from a patient in the blastic crisis phase of chronic myelogenous leukemia (CML). This cell line had a positive reaction for intracytoplasmic myeloperoxidase and two Philadelphia chromosomes (Ph1) [t(9;22)(q34;q11)] and lacked normal copies of chromosomes 9 and 22....

    journal_title：Blood

    pub_type： 杂志文章

    doi：

    authors： Yanagisawa K,Yamauchi H,Kaneko M,Kohno H,Hasegawa H,Fujita S

    更新日期：1998-01-15 00:00:00

  • Mechanisms of organelle transport and capture along proplatelets during platelet production.

    abstract：:Megakaryocytes generate platelets by remodeling their cytoplasm into long proplatelet extensions, which serve as assembly lines for platelet production. Platelet packaging and release concludes at the tips of each proplatelet. Essential in this process is the distribution of organelles and platelet-specific granules i...

    journal_title：Blood

    pub_type： 杂志文章

    doi：10.1182/blood-2005-06-2206

    authors： Richardson JL,Shivdasani RA,Boers C,Hartwig JH,Italiano JE Jr

    更新日期：2005-12-15 00:00:00