Abstract：
:Muscle contusions represent a major part of sports injuries. The suggested treatments are generally sufficient to support muscle healing, but require a relatively long period of time. Given that autologous blood products are safe treatments, we have used a technique which stimulates the release of certain growth factors in the autologous conditioned serum (ACS). Those growth factors are known to improve the proliferative activity of myogenic precursor cells. Mice were subjected to an experimental contusion injury to their gastrocnemius muscle; one group received local injections of ACS at 2 hrs, 24 hrs, and 48 hrs after injury, a control group received saline injections. The histology results showed that satellite cell activation at 30/48 hrs post injury was accelerated and the diameter of the regenerating myofibers was increased compared to the controls within the first week after injury. ELISA results on the ACS have shown that the elevations in FGF-2 (460 %) and TGF-beta1 (82 %) could be partly responsible for the accelerating effects on regeneration due to proliferative and chemotactic properties. We conclude that ACS injection is a promising approach to reduce the time of recovery from muscle injury. In terms of clinical targets, this new approach could be used in the treatment of sports injuries and may also be interesting in postoperative situations.
journal_name
Int J Sports Medjournal_title
International journal of sports medicineauthors
Wright-Carpenter T,Opolon P,Appell HJ,Meijer H,Wehling P,Mir LMdoi
10.1055/s-2004-821303subject
Has Abstractpub_date
2004-11-01 00:00:00pages
582-7issue
8eissn
0172-4622issn
1439-3964journal_volume
25pub_type
杂志文章abstract：:The purpose of this study was to: (1) verify the aerobic requirement (AR) of bench stepping (BS); (2) determine the effect of leg length (LL), bench height (BH), stepping rate (SR), body weight (BW), and fat free mass (FFM) on the AR of BS; and (3) compare the HR and VO2 of BS with treadmill walking/running (TM). Twen...
journal_title：International journal of sports medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1055/s-2007-1021156
更新日期：1993-04-01 00:00:00
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journal_title：International journal of sports medicine
pub_type： 杂志文章
doi：10.1055/s-2007-972629
更新日期：1997-05-01 00:00:00
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journal_title：International journal of sports medicine
pub_type： 杂志文章
doi：10.1055/s-0029-1202340
更新日期：2009-07-01 00:00:00
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journal_title：International journal of sports medicine
pub_type： 杂志文章
doi：10.1055/s-2007-1024655
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journal_title：International journal of sports medicine
pub_type： 杂志文章
doi：10.1055/s-2007-972828
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journal_title：International journal of sports medicine
pub_type： 杂志文章
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journal_title：International journal of sports medicine
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2002-01-01 00:00:00
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journal_title：International journal of sports medicine
pub_type： 杂志文章
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更新日期：1995-05-01 00:00:00
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journal_title：International journal of sports medicine
pub_type： 杂志文章
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更新日期：1990-04-01 00:00:00
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journal_title：International journal of sports medicine
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2002-07-01 00:00:00
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journal_title：International journal of sports medicine
pub_type： 杂志文章
doi：10.1055/s-2008-1038785
更新日期：2009-01-01 00:00:00
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journal_title：International journal of sports medicine
pub_type： 杂志文章
doi：10.1055/s-2007-1024722
更新日期：1991-10-01 00:00:00
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journal_title：International journal of sports medicine
pub_type： 杂志文章
doi：10.1055/s-2007-1021048
更新日期：1994-05-01 00:00:00
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journal_title：International journal of sports medicine
pub_type： 杂志文章
doi：10.1055/s-0029-1234058
更新日期：2009-11-01 00:00:00
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journal_title：International journal of sports medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1055/s-2008-1025897
更新日期：1984-06-01 00:00:00
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journal_title：International journal of sports medicine
pub_type： 杂志文章
doi：10.1055/s-0034-1385864
更新日期：2015-01-01 00:00:00
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journal_title：International journal of sports medicine
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：International journal of sports medicine
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journal_title：International journal of sports medicine
pub_type： 杂志文章
doi：10.1055/s-2007-972921
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journal_title：International journal of sports medicine
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：International journal of sports medicine
pub_type： 杂志文章
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更新日期：1995-01-01 00:00:00
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journal_title：International journal of sports medicine
pub_type： 杂志文章
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journal_title：International journal of sports medicine
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2001-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-04-01 00:00:00
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journal_title：International journal of sports medicine
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pub_type： 杂志文章
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更新日期：2020-09-01 00:00:00
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journal_title：International journal of sports medicine
pub_type： 杂志文章,随机对照试验
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更新日期：2015-04-01 00:00:00
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journal_title：International journal of sports medicine
pub_type： 杂志文章
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更新日期：2009-12-01 00:00:00
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journal_title：International journal of sports medicine
pub_type： 杂志文章
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更新日期：2011-08-01 00:00:00
abstract：:Meniscocapsular separations are often seen in knees with other intra-articular pathology. The consequences of these tears with regard to knee contact mechanics are currently unknown, and the biomechanical advantages of repair have not been measured. We hypothesize that tears to the meniscocapsular junction will cause ...
journal_title：International journal of sports medicine
pub_type： 杂志文章
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更新日期：2015-06-01 00:00:00
