Nandrolone inhibits VEGF mRNA in rat muscle.

Abstract:

:Vascular endothelial growth factor (VEGF) is a key compound for induction of angiogenesis in both physiological and pathological conditions. The aim of this study was to investigate the effect of androgenic-anabolic steroids (AAS) administration on VEGF mRNA expression in the rat soleus muscle after jumping training. Wistar rats were grouped into: sedentary (S); nandrolone decanoate-treated sedentary (AAS); trained without AAS (T) and trained and treated with AAS (AAST). Exercised groups performed a 7-weeks water-jumping program. Animals killed immediately after the last exercise bout showed significantly increased VEGF mRNA expression; however, the AAS treatment completely inhibited this effect. These results suggest that the AAS may be strongly prejudicial to muscle remodeling and performance at least partially due to an impaired angiogenesis.

journal_name

Int J Sports Med

authors

Paschoal M,de Cássia Marqueti R,Perez S,Selistre-de-Araujo HS

doi

10.1055/s-0029-1234058

subject

Has Abstract

pub_date

2009-11-01 00:00:00

pages

775-8

issue

11

eissn

0172-4622

issn

1439-3964

journal_volume

30

pub_type

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