当前位置： SCI文献检索 > JOURNAL OF CLINICAL EPIDEMIOLOGY期刊下所有文献 > Hematocrit was not validated as a surrogate end point for survival among epoetin-treated hemodialysis patients.

Hematocrit was not validated as a surrogate end point for survival among epoetin-treated hemodialysis patients.

Abstract：

OBJECTIVE:To evaluate the use of hematocrit as a surrogate end point for survival among end-stage renal disease (ESRD) patients treated with epoetin. STUDY DESIGN AND SETTING:Using United States Renal Data System (USRDS) data, we conducted an observational prospective study to analyze the relationships among epoetin dose, hematocrit, and survival for 31,301 facility-based hemodialysis patients incident to ESRD therapy in 1998. To address our objective, we used criteria developed by Prentice based on results from a Cox regression model. RESULTS:Results indicate that hematocrit is inversely associated with epoetin dose. For the same epoetin treatment-related achieved hematocrit levels, there were widely varying treatment-related survival outcomes, thereby challenging a central criterion required to empirically validate a surrogate end point. CONCLUSION:Our results support earlier clinical trial and epidemiological data suggesting that hematocrit may not be a valid surrogate for survival among the epoetin-treated renal failure population. We hypothesize that hematocrit may not be in the causal pathway or that epoetin may have important mechanisms of action apart from increasing hematocrit. Effective treatment for anemia may therefore not be simply a matter of increasing hematocrit. This study has potential implications for revising the existing treatment guidelines for anemia management and selecting an appropriate treatment regimen.

journal_name

J Clin Epidemiol

journal_title

Journal of clinical epidemiology

authors

Cotter DJ,Stefanik K,Zhang Y,Thamer M,Scharfstein D,Kaufman J

doi

10.1016/j.jclinepi.2004.05.002

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

1086-95

issue

10

eissn

0895-4356

issn

1878-5921

pii

S0895-4356(04)00139-8

journal_volume

57

pub_type

杂志文章

相关文献

JOURNAL OF CLINICAL EPIDEMIOLOGY文献大全
  • Statistical power of clinical trials increased while effect size remained stable: an empirical analysis of 136,212 clinical trials between 1975 and 2014.

    abstract：OBJECTIVES:To study the statistical power of randomized clinical trials and examine developments over time. STUDY DESIGN AND SETTING:We analyzed the statistical power in 136,212 clinical trials between 1975 and 2014 extracted from meta-analyses from the Cochrane database of systematic reviews. We determined study powe...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/j.jclinepi.2018.06.014

    authors： Lamberink HJ,Otte WM,Sinke MRT,Lakens D,Glasziou PP,Tijdink JK,Vinkers CH

    更新日期：2018-10-01 00:00:00

  • Clinical replicability of rehabilitation interventions in randomized controlled trials reported in main journals is inadequate.

    abstract：OBJECTIVE:The objective of this study was to study if randomized controlled trials (RCTs) in rehabilitation (a field where complex interventions prevail) published in main journals include all the details needed to replicate the intervention in clinical practice (clinical replicability). STUDY DESIGN AND SETTING:Forty...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/j.jclinepi.2019.06.008

    authors： Negrini S,Arienti C,Pollet J,Engkasan JP,Francisco GE,Frontera WR,Galeri S,Gworys K,Kujawa J,Mazlan M,Rathore FA,Schillebeeckx F,Kiekens C,REREP study participants.

    更新日期：2019-10-01 00:00:00

  • Examination by logistic regression modelling of the variables which increase the relative risk of elderly women falling compared to elderly men.

    abstract：:In a community based, prospective study to determine risk factors for falls, 465 women and 296 men 70 years and over were followed for 1 year and 507 falls were documented. A greater proportion of women (32.7%) than men (23.0%) experienced at least one fall in which there was no or minimal external contribution. Using...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/0895-4356(90)90110-b

    authors： Campbell AJ,Spears GF,Borrie MJ

    更新日期：1990-01-01 00:00:00

  • A 67-item stress resilience item bank showing high content validity was developed in a psychosomatic sample.

    abstract：OBJECTIVES:To develop the first item bank to measure stress resilience (SR) in clinical populations. STUDY DESIGN AND SETTING:Qualitative item development resulted in an initial pool of 131 items covering a broad theoretical SR concept. These items were tested in n = 521 patients at a psychosomatic outpatient clinic. ...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/j.jclinepi.2018.04.004

    authors： Obbarius N,Fischer F,Obbarius A,Nolte S,Liegl G,Rose M

    更新日期：2018-08-01 00:00:00

  • Developing a condition-specific measure of health for patients with dyspepsia and ulcer-related symptoms.

    abstract：:A patient-administered instrument for dyspepsia and symptoms suggestive of duodenal or gastric ulcer, based on the type of questions asked when taking a patient's history, was developed and tested using the following steps: literature reviews, devising the questions, testing the responses to the questions using factor...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/0895-4356(95)00584-6

    authors： Garratt AM,Ruta DA,Russell I,Macleod K,Brunt P,McKinlay A,Mowat A,Sinclair T

    更新日期：1996-05-01 00:00:00

  • Measuring health status using the Health Utilities Index: agreement between raters and between modalities of administration.

    abstract：:The aim of this study was to evaluate interrater and intermodality agreement in assessing health status using the Health Utilities Index. A random sample from a Dutch cohort of 14-year-old Very Low Birth Weight children and their parents were invited to participate in a face-to-face (n = 150) or telephone (n = 150) in...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/s0895-4356(00)00317-6

    authors： Verrips GH,Stuifbergen MC,den Ouden AL,Bonsel GJ,Gemke RJ,Paneth N,Verloove-Vanhorick SP

    更新日期：2001-05-01 00:00:00

  • Clustering of cancer in families of patients with primary lung cancer.

    abstract：:We have previously shown that patients with a positive family history of lung cancer did not exhibit characteristics expected if the familial association was a surrogate for a genetic mechanism which was absent in those without such a history. In this study, we examine the incidence of cancer (all sites) in two groups...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/0895-4356(91)90202-k

    authors： McDuffie HH

    更新日期：1991-01-01 00:00:00

  • Relationship of domain-specific measures of health to perceived overall health among older subjects.

    abstract：:The associations between nine domain-specific measures of health (e.g., depressive symptoms, psychological distress, mental health, physical functioning, role functioning, social functioning, bodily pain, somatic symptoms, and chronic medical morbidity) and a single-item measure for perceived overall health were studi...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/s0895-4356(97)00234-5

    authors： Kempen GI,Miedema I,van den Bos GA,Ormel J

    更新日期：1998-01-01 00:00:00

  • The utility of the international child and adolescent overweight guidelines for predicting coronary heart disease risk factors.

    abstract：:The purpose of this study was to assess the association between the international overweight cutoffs for children and youth and coronary heart disease risk factors. The sample included 410 boys and 337 girls 9-18 years of age from the Québec Family Study. Participants were classified as normal weight or overweight usi...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/s0895-4356(02)00595-4

    authors： Katzmarzyk PT,Tremblay A,Pérusse L,Després JP,Bouchard C

    更新日期：2003-05-01 00:00:00

  • Latent class growth analysis successfully identified subgroups of participants during a weight loss intervention trial.

    abstract：INTRODUCTION:Weight loss interventions often present small mean weight changes over time, despite the fact that a substantial proportion of the participants lost more weight. This effect is often leveled out by the substantial proportion of participants who gained weight during the trial. The aim of this study is to id...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jclinepi.2014.03.007

    authors： de Vos BC,Runhaar J,Verkleij SP,van Middelkoop M,Bierma-Zeinstra SM

    更新日期：2014-08-01 00:00:00

  • Changing author counts in five major general medicine journals: effect of author contribution forms.

    abstract：OBJECTIVES:Objective and indirect evidence was used to determine whether required author contribution forms were associated with a decrease in author counts in four major general medicine journals (British Medical Journal [BMJ], Journal of the American Medical Association [JAMA], Canadian Medical Association Journal [C...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/j.jclinepi.2009.03.010

    authors： Baerlocher MO,Gautam T,Newton M,Tomlinson G

    更新日期：2009-08-01 00:00:00

  • Reducing population stratification bias: stratum matching is better than exposure.

    abstract：OBJECTIVE:Genetic studies of complex human diseases rely heavily on the epidemiologic association paradigm, particularly the population-based case-control designs. This study aims to compare the matching effectiveness in terms of bias reduction between exposure matching and stratum matching. STUDY DESIGN AND SETTING:F...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/j.jclinepi.2008.02.016

    authors： Lee WC,Wang LY

    更新日期：2009-01-01 00:00:00

  • Improved self-confidence was a mechanism of action in two geriatric trials evaluating physical interventions.

    abstract：OBJECTIVE:To evaluate the mechanisms of action in two successful geriatric clinical trials that tested multicomponent physical conditioning programs and to determine whether the pathways for overall benefit were through improvement in physical ability and/or self-confidence. STUDY DESIGN AND SETTING:PREHAB and DRIVER ...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jclinepi.2006.04.009

    authors： Peduzzi P,Guo Z,Marottoli RA,Gill TM,Araujo K,Allore HG

    更新日期：2007-01-01 00:00:00

  • Current challenges in clinimetrics.

    abstract：:Clinimetrics is a methodologic discipline that focuses on the quality of clinical measurements, for example, diagnostic characteristics and disease outcomes. Different clinimetric properties, such as reproducibility and responsiveness, are important in both the development and the evaluation of measurement instruments...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/j.jclinepi.2003.08.012

    authors： de Vet HC,Terwee CB,Bouter LM

    更新日期：2003-12-01 00:00:00

  • A novel research design can aid disinvestment from existing health technologies with uncertain effectiveness, cost-effectiveness, and/or safety.

    abstract：OBJECTIVES:Disinvestment is critical for ensuring the long-term sustainability of health-care services. Key barriers to disinvestment are heterogeneity between research and clinical settings, absence of evidence of effectiveness of some health technologies, and exposure of patients and organizations to risks and poor o...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jclinepi.2013.08.014

    authors： Haines T,O'Brien L,McDermott F,Markham D,Mitchell D,Watterson D,Skinner E

    更新日期：2014-02-01 00:00:00

  • Use of global assessment measures in dementia drug trials.

    abstract：:I argue in this paper that the use of a global clinical impression of change as a primary measure in dementia drug trials is appropriate, given that we do not yet understand clearly enough what Alzheimer's disease looks like as it gets better. ...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/0895-4356(94)90039-6

    authors： Rockwood K

    更新日期：1994-01-01 00:00:00

  • Oncology employees valued patient-oriented research over quality of work-life research: a qualitative study.

    abstract：OBJECTIVES:To assess the role of quality of work-life (QWL) research in a clinical research environment. STUDY DESIGN AND SETTING:A phenomenological qualitative research study was conducted. This research was conducted in a large Canadian ambulatory cancer treatment center that serves over 2.3 million people in Ontari...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/j.jclinepi.2006.03.003

    authors： Sale JE

    更新日期：2008-05-01 00:00:00

  • The number needed to treat (NNT) can be adjusted for bias when the outcome is measured with error.

    abstract：BACKGROUND AND OBJECTIVE:We consider the number needed to treat (NNT) when the event of interest is defined by dichotomizing a continuous response at a threshold level. If the response is measured with error, the resulting NNT is biased. We consider methods to reduce this bias. METHODS:Bias adjustment was studied usin...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/j.jclinepi.2004.01.021

    authors： Marschner IC,Emberson J,Irwig L,Walter SD

    更新日期：2004-12-01 00:00:00

  • Age at natural menopause and total mortality and mortality from ischemic heart disease: the Adventist Health Study.

    abstract：:We studied the relationship between age at natural menopause and total mortality as well as mortality from ischemic heart disease in a cohort of 6182 California Seventh-Day Adventist women who reported a natural menopause. During follow-up from 1976 through 1988, there were 1831 deaths. A total of 308 deaths due to is...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/s0895-4356(98)00170-x

    authors： Jacobsen BK,Knutsen SF,Fraser GE

    更新日期：1999-04-01 00:00:00

  • Text message reminders to improve questionnaire response rates.

    abstract：OBJECTIVES:To assess whether short message service (SMS) text messages sent as prenotification or postnotification reminders improve questionnaire response rates in randomized controlled trial (RCT) follow-up. STUDY DESIGN AND SETTING:Three "trials within a trial" assessed text message notifications sent before or aft...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/j.jclinepi.2016.05.011

    authors： Keding A,Brabyn S,MacPherson H,Richmond SJ,Torgerson DJ

    更新日期：2016-11-01 00:00:00

  • When philosophers shoot from the hip.

    abstract：:A visible result of the 20-year old applied ethics movement is the use of moral philosophers as quotable newspaper sources. In situations like the op-ed page, adequate space and time allows for serious reflection, and the columns provide accessible, quality ideas for the general public. Quality usually disappears wh...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/0895-4356(92)90058-u

    authors： Rachels J

    更新日期：1992-07-01 00:00:00

  • The epidemiological relationship of hypercholesterolemia, hypertension, diabetes mellitus and obesity to coronary heart disease and atherogenesis.

    abstract：:Coronary heart disease (CHD) is an imprecise, inappropriate monitor of atherosclerosis severity and by inapplicable extrapolation CHD risk factors are incorrectly assumed to be causes of atherosclerosis. Taking into account (1) the misuse and substantial diagnostic error of CHD, (2) errors in determining the prevalenc...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章,评审

    doi：10.1016/0895-4356(90)90231-d

    authors： Stehbens WE

    更新日期：1990-01-01 00:00:00

  • Asymptomatic peripheral arterial occlusive disease predicted cardiovascular morbidity and mortality in a 7-year follow-up study.

    abstract：OBJECTIVE:Asymptomatic peripheral arterial occlusive disease (PAOD) is a common atherosclerotic disorder among the elderly population. Scarce data are available on the risk of nonfatal and fatal cardiovascular diseases in these subjects. We investigated cardiovascular morbidity and mortality of asymptomatic PAOD subjec...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jclinepi.2003.09.003

    authors： Hooi JD,Kester AD,Stoffers HE,Rinkens PE,Knottnerus JA,van Ree JW

    更新日期：2004-03-01 00:00:00

  • Fracture risk following bilateral oophorectomy.

    abstract：:To assess fracture risk following bilateral oophorectomy, we conducted a population-based retrospective cohort study among the 463 Rochester, Minnesota women who underwent bilateral oophorectomy for benign ovarian conditions in 1950-1979. During 7220 person-years of observation, there appeared to be a modest increase ...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/0895-4356(96)00211-9

    authors： Melton LJ 3rd,Crowson CS,Malkasian GD,O'Fallon WM

    更新日期：1996-10-01 00:00:00

  • Geriatrics index of comorbidity was the most accurate predictor of death in geriatric hospital among six comorbidity scores.

    abstract：OBJECTIVES:To compare the abilities of six validated comorbidity indices (Charlson index, cumulative illness rating scale [CIRS], index of coexistent diseases, Kaplan scale, geriatrics index of comorbidity [GIC], and chronic disease score) to predict adverse hospitalization outcomes (death during hospitalization, lengt...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/j.jclinepi.2009.11.013

    authors： Zekry D,Loures Valle BH,Lardi C,Graf C,Michel JP,Gold G,Krause KH,Herrmann FR

    更新日期：2010-09-01 00:00:00

  • The practice of meta-analysis.

    abstract：:Meta-analysis seems to have a potentially useful role in carefully selected situations where the primary literature is of good quality, heterogeneity in the response to treatment of the tested population is small and well-understood, interest centers on estimation of a specific, critical parameter of outcome, and the ...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章,评审

    doi：10.1016/0895-4356(94)00149-k

    authors： Bailar JC 3rd

    更新日期：1995-01-01 00:00:00

  • Administrative database code accuracy did not vary notably with changes in disease prevalence.

    abstract：OBJECTIVES:Previous mathematical analyses of diagnostic tests based on the categorization of a continuous measure have found that test sensitivity and specificity varies significantly by disease prevalence. This study determined if the accuracy of diagnostic codes varied by disease prevalence. STUDY DESIGN AND SETTING...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章

    doi：10.1016/j.jclinepi.2016.05.009

    authors： van Walraven C,English S,Austin PC

    更新日期：2016-11-01 00:00:00

  • The evolving clinical status of patients after a myocardial infarction: the importance of post-hospital data for mortality prediction.

    abstract：:Studies predicting mortality after myocardial infarction (MI) usually rely on in-hospital data, and combine patients admitted for the first MI with recurrent MI patients. Since treatment decisions are often made or modified at the first outpatient clinic visit, this study was designed to evaluate the importance of pos...

    journal_title：Journal of clinical epidemiology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0895-4356(96)00221-1

    authors： Elmore JG,Viscoli CM,Horwitz RI

    更新日期：1996-11-01 00:00:00

  • Most meta-analyses of drug interventions have narrow scopes and many focus on specific agents.

    abstract：OBJECTIVE:To assess the extent to which meta-analysis publications of drugs and biologics focus on specific named agents or even only a single agent, and identify characteristics associated with such focus. STUDY DESIGN AND SETTING:We evaluated 499 articles with meta-analyses published in 2010 and estimated how many d...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jclinepi.2012.10.014

    authors： Haidich AB,Pilalas D,Contopoulos-Ioannidis DG,Ioannidis JP

    更新日期：2013-04-01 00:00:00

  • Deficiencies in addressing effect modification in network meta-analyses: a meta-epidemiological survey.

    abstract：OBJECTIVE:The objectives of this study were to evaluate the current state of reporting and handling of effect modification in network meta-analyses (NMAs) and perform exploratory analyses to identify variables that are potentially associated with incomplete reporting of effect modifiers in NMAs. STUDY DESIGN AND SETTI...

    journal_title：Journal of clinical epidemiology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.jclinepi.2017.06.004

    authors： Kovic B,Zoratti MJ,Michalopoulos S,Silvestre C,Thorlund K,Thabane L

    更新日期：2017-08-01 00:00:00