Abstract:
:Locked nucleic acid (LNA) is a nucleic acid analogue containing one or more LNA nucleotide monomers with a bicyclic furanose unit locked in an RNA mimicking sugar conformation. LNA oligonucleotides display unprecedented hybridization affinity toward complementary single-stranded RNA and complementary single- or double-stranded DNA. Structural studies have shown that LNA oligonucleotides induce A-type (RNA-like) duplex conformations. The wide applicability of LNA oligonucleotides for gene silencing and their use for research and diagnostic purposes are documented in a number of recent reports, some of which are described herein.
journal_name
Biochemistryjournal_title
Biochemistryauthors
Vester B,Wengel Jdoi
10.1021/bi0485732subject
Has Abstractpub_date
2004-10-26 00:00:00pages
13233-41issue
42eissn
0006-2960issn
1520-4995journal_volume
43pub_type
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