Abstract：
:Acute inflammatory lung injury is often a delayed complication of critical illness and is associated with increased mortality. High mobility group box 1 (HMGB1) protein, in addition to its role as a transcriptional regulator factor, has been identified as a late mediator of endotoxin lethality and might be also involved in the development and progression of acute lung injury. HMGB1 protein itself can cause an acute inflammatory response manifested by increased production of proinflammatory cytokines and neutrophil accumulation. The delayed kinetics of HMGB1 protein release indicate that this protein is a distal mediator of acute inflamatory lung injury. Anti-HMGB1 protein antibodies attenuated endotoxin-induced lung injury, but not the early release of TNF-alpha and IL-1beta, indicating that HMGB1 protein is a late mediator of endotoxin-induced acute lung injury. HMGB1 protein is not released by apoptotic cells but is passively released by necrotic or damaged somatic and immune cells and it functions as a major stimulus of necrosis-induced inflammation. HMGB1 protein is also released by activated monocytes/macrophages and induces delayed and biphasic release of proinflammatory mediators from these cells. HMGB1 protein failed to stimulate cytokines release in lymphocytes, indicating that cellular stimulation is specific. We would like to suggest that HMGB1 protein may be also a primary mediator of the inflammatory responses to lung cells injury caused by toxic environmental chemicals.
journal_name
Int J Occup Med Environ Healthauthors
Lutz W,Stetkiewicz Jsubject
Has Abstractpub_date
2004-01-01 00:00:00pages
245-54issue
2eissn
1232-1087issn
1896-494Xjournal_volume
17pub_type
杂志文章,评审abstract：:The effect of sodium fluoride on the content of adenine nucleotides, adenine nucleotide pool and energy potential of erythrocytes was studied in male Wistar rats, depending on the dose and time of exposure. Sodium fluoride was administered for 4 and 8 weeks at 4 or 16 ppm through a gastric tube. The concentration of f...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:Mice were administered with chloroform at 10 a.m., 2 p.m. and 6 p.m. and the signs of hepatotoxicity were measured 18 or 24 hrs later. The levels of alanine aminotransferase (ALT) in serum, and malondialdehyde (MDA) in the liver were higher after the evening administration compared to the morning one. The decrements o...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:The study includes a detailed analysis of patients' exposure to ionising radiation resulting from diagnostic radiology in Poland. Data concerning the number and types of examinations were collected by wide-range questionnaire surveys conducted in 1986 and 1995. As the result, the number of examinations per 1000 inhabi...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:This paper reviews the investigations of the effects of pre- and/or postnatal exposure to environmental tobacco smoke (ETS) on children health reported in the literature. The evidence from epidemiological studies demonstrate that children's exposure to ETS is a risk factor for a variety of diseases, including respirat...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章,评审
doi：
更新日期：2002-01-01 00:00:00
abstract：OBJECTIVES:In Poland, occupational exposure to cold microclimate is quite common (5.1 workers/1000 occupationally active people). Reports on health effects of this exposure are rather scarce. The aim of the study was to evaluate the physiological reaction in workers occupationally exposed to cold microclimate. MATERIA...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.2478/v10001-006-0020-y
更新日期：2006-01-01 00:00:00
abstract：INTRODUCTION:It is still uncertain if having at least moderate physical fitness is a necessary and sufficient condition for lowering the risk of death. The aforementioned statement constituted the basis for undertaking the study concerning the effect of particular health-related behaviours on the likelihood of survival...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.2478/s13382-013-0112-4
更新日期：2013-08-01 00:00:00
abstract：OBJECTIVES:Methylmercury (MeHg) and polychlorinated biphenyls (PCBs) are ubiquitous and persistent environmental pollutants and food contaminants. Both are neurotoxic, especially for the developing nervous system. MATERIAL AND METHODS:Female rats were exposed from day 7 of pregnancy up to day 21 after the delivery to ...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.2478/v10001-009-0015-6
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVES:Anxiety is a negative emotion that acts as a mediator between stress stimuli and emotional (physiological) reaction patterns. The myofascial system is particularly sensitive to stress. The aim of this study was to determine which of the 2 popular methods used to reduce psychophysical tension, i.e., soft tiss...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.13075/ijomeh.1896.01457
更新日期：2019-11-15 00:00:00
abstract：OBJECTIVES:Limited research on the health situation of teachers on long-term sick leave is available. The aim of this study has been to describe the health status of female teachers on long-term sick leave (LSFT) in comparison to working female teachers (WFT) and to determine predictors for their state of mental health...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.13075/ijomeh.1896.01115
更新日期：2018-01-07 00:00:00
abstract：OBJECTIVES:Nurses are at elevated risk of burnout, anxiety and depressive disorders, and may then become less productive. This begs the question if a preventive intervention in the work setting might be cost-saving from a business perspective. MATERIAL AND METHODS:A cost-benefit analysis was conducted to evaluate the ...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章,随机对照试验
doi：10.13075/ijomeh.1896.00465
更新日期：2015-01-01 00:00:00
abstract：:Morphine is an opiate alkaloid characterized by various clinical effects, among which the most prominent are its analgesic and psychoactive effects. It also has a prominent depressive effect on the respiratory and cardiovascular system. Because of its psychoactive effect, morphine is very addictive and often used as a...
journal_title：International journal of occupational medicine and environmental health
pub_type：
doi：10.13075/ijomeh.1896.01629
更新日期：2021-01-07 00:00:00
abstract：OBJECTIVES:The aim of this study was to investigate the cyto- and genotoxicity of nanocomposites (NCs) and generation of reactive oxygen species (ROS) as a result of particle-cell interactions. MATERIALS AND METHODS:Titanium dioxide (TiO(2)-Ag) and ion-exchange resin (Res-Ag), both coated with silver (Ag), were examin...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.2478/s13382-011-0041-z
更新日期：2011-12-01 00:00:00
abstract：OBJECTIVES:There is a growing body of data showing that low frequency noise (LFN), defined as broadband noise with dominant content of low frequencies (10-250 Hz) differs in its nature from other environmental noises at comparable levels. The aim of the study was to investigate whether exposure to LFN at levels normall...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2005-01-01 00:00:00
abstract：OBJECTIVES:The primary aim of this work was to assess the effect of electromagnetic field (EMF) from the GSM mobile phone system on human brain function. The assessment was based on the assay of event related potentials (ERPs). MATERIAL AND METHODS:The study group consisted of 15 volunteers, including 7 men and 8 wome...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.2478/v10001-010-0021-8
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVES:Vocal cord dysfunction (VCD) is an uncommon respiratory disease characterized by the paradoxical adduction of vocal cords during inspiration, that may mimic bronchial asthma. The pathogenesis of VCD has not been clearly defined but it is possible to recognize non-psychologic and psychologic causes. The major...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.2478/v10001-009-0038-z
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVES:The aim of this study is to assess chromosomal damage in Tunisian hospital workers occupationally exposed to low levels of ionizing radiation (IR). MATERIALS AND METHODS:The cytokinesis-block micronucleus (CBMN) assay in the peripheral lymphocytes of 67 exposed workers compared to 43 controls matched for ge...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章,多中心研究
doi：10.2478/s13382-013-0084-4
更新日期：2013-03-01 00:00:00
abstract：OBJECTIVES:Police officers run a risk of injury that is higher than in most other occupations. This study aims to quantify injury prevalence and identify common musculoskeletal injuries (MSIs) among police officers, using injury data from a municipal police service in Alberta, Canada. MATERIAL AND METHODS:This is a de...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.13075/ijomeh.1896.01454
更新日期：2020-01-17 00:00:00
abstract：:Isoprostanes are prostaglandin-like compounds that are produced by free radical mediated peroxidation of polyunsaturated fatty acids. There is a direct evidence showing that F2-isoprostanes can be utilized as a marker of lipid peroxidation due to the mechanism of their formation (nonenzymatic oxidation of arachidonic ...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章,评审
doi：
更新日期：2002-01-01 00:00:00
abstract：OBJECTIVES:The objectives of this study have been to: 1) describe and compare urban and rural injured worker populations in Alberta, Canada; 2) identify return-to-work outcomes in urban and rural populations; 3) examine the relationship between geographic location of residence and recovery from work-related musculoskel...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.13075/ijomeh.1896.00926
更新日期：2017-07-14 00:00:00
abstract：BACKGROUND:Benzalkonium chloride (BAC) is a quaternary ammonium compound (QAC) with a C8 to C18 chain length of alkyl groups. Since BAC exerts toxic effects on microorganisms, it has been used as an effective germicide and preservative, mostly in cosmetic industry and medicine. However, the toxic potential of BAC may b...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.2478/v10001-008-0020-1
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVES:Subchondral carpometacarpal cysts are classic and almost pathognomonic lesions found in workers using vibrating instruments over prolonged periods of time. MATERIALS AND METHODS:We present the case of a 53-year-old woman who worked for 30 years sewing shoe uppers, a task which required grasping firmly a pea...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.2478/s13382-011-0042-y
更新日期：2011-12-01 00:00:00
abstract：OBJECTIVES:This study has investigated the prevalence of work-related musculoskeletal disorders (WMSDs), the most commonly affected body parts, the risk factors of WMSDs and the coping strategies adopted by hairdressers. MATERIAL AND METHODS:The study design was a cross-sectional descriptive survey design. Two hundred...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.13075/ijomeh.1896.00291
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to determine the lag between exposure to air pollutants and changes in human eosinophil counts. MATERIAL AND METHODS:This was a retrospective study employing 246 425 physical examination records dated December 2013 - December 2016 from Chengdu, China. The authors determined the pre...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.13075/ijomeh.1896.01528
更新日期：2020-04-30 00:00:00
abstract：OBJECTIVES:It has been decided to identify the most frequent diseases of the larynx in people occupationally exposed to a considerable voice load and to assess the feasibility of using videostroboscopy to diagnose voice disorders and their organic effects in order to improve the reliability of certification of occupati...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：OBJECTIVES:The study objective was to assess hydration status by measuring USG among construction workers in Iran. MATERIALS AND METHODS:The study design was comparative and experimental. Sixty participants were randomly selected from the construction workers from a construction campus with a similar type of work, cli...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.2478/s13382-013-0143-x
更新日期：2013-10-01 00:00:00
abstract：OBJECTIVES:The method for the determination of As, Al, Cd, Ni, Pb (toxic elements) and Cr, Co, Cu, Fe, Mn, Zn (essential elements) in human urine by the use of Inductively Coupled Plasma Mass Spectrometry (quadrupole ICP-MS DRCe Elan, Perkin Elmer) with the dynamic reaction cell (DRC) was developed. MATERIALS AND METH...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.2478/s13382-013-0106-2
更新日期：2013-04-01 00:00:00
abstract：OBJECTIVE:One of the practical models for assessment of stressful working conditions due to job strain is "job demand and control" or Karasek's job strain model. This model explains how adverse physical and psychological effects including cardiovascular disease risk factors can be established due to high work demand. T...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.2478/s13382-013-0127-x
更新日期：2013-08-01 00:00:00
abstract：OBJECTIVES:Exposure to environmental tobacco smoke (ETS) constitutes a threat to the health of many people. In order to diminish ETS exposure, countries (including Poland) implemented legal restrictions of smoking in public places and worksites. Currently more attention is also paid to reduce overall and residential ET...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章
doi：10.13075/ijomeh.1896.00435
更新日期：2016-01-01 00:00:00
abstract：:The incidence of malignant lymphoma, especially non-Hodgkin's lymphoma has increased over the last few decades. This statement is true despite the fact that methods for diagnosing malignant lymphoma have changed and misclassification has become a problem. The present review is mainly concerned with occupational aspect...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章,评审
doi：
更新日期：1996-01-01 00:00:00
abstract：:Cytostatics not only induce significant side-effects in patients treated oncologically but also pose a threat to the health of occupationally exposed healthcare workers: pharmacists, physicians, nurses and other personnel. Since the 1970s numerous reports from various countries have documented the contamination of wor...
journal_title：International journal of occupational medicine and environmental health
pub_type： 杂志文章,评审
doi：10.13075/ijomeh.1896.01248
更新日期：2019-04-03 00:00:00
