Abstract：
:Previous reports have evidenced a strong relationship between high plasma insulin levels and blood pressure in diabetic and obese subjects but not in the elderly. During aging many patho-physiological changes in cardiovascular functions and autonomic nervous system occur, so that aging per se might be a cause of a 'physiological' increase in blood pressure. Nevertheless, an insulin resistance also develops during aging. The present study investigates the possible role of age-dependent insulin resistance in the genesis of increased blood pressure. Our data show that insulin resistance calculated by the glucose infusion rate during a euglycemic hyperinsulinemic glucose clamp procedure is significantly correlated with the insulin-mediated net decrease in erythrocyte Na+ content (r = 0.58, P < 0.05), as well as with net increase in erythrocyte K+ (r = 0.64, P < 0.05) and Mg2+ (r = 0.67, P < 0.01) content and to basal diastolic blood pressure (r = -0.63, P < 0.05). We conclude that in elderly subjects the age-related and normally occurring insulin resistance might contribute to the increase of arterial blood pressure through its effect on cell cation content.
journal_name
Arch Gerontol Geriatrjournal_title
Archives of gerontology and geriatricsauthors
Paolisso G,Marrazzo G,De Riu S,Sgambato S,Varricchio M,D'Onofrio Fdoi
10.1016/0167-4943(90)90053-9subject
Has Abstractpub_date
1990-07-01 00:00:00pages
23-32issue
1eissn
0167-4943issn
1872-6976pii
0167494390900539journal_volume
11pub_type
杂志文章abstract：:The study was to compare the ability of BMI, MAC and CC in predicting nutritional status, functional ability and follow-up mortality risk of older adults. The study purposively recruited 160 of 320 residents of a nursing home in Central Taiwan to serve as subjects. Residents who were ≥65 years old, cognitively normal,...
journal_title：Archives of gerontology and geriatrics
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journal_title：Archives of gerontology and geriatrics
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journal_title：Archives of gerontology and geriatrics
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journal_title：Archives of gerontology and geriatrics
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journal_title：Archives of gerontology and geriatrics
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journal_title：Archives of gerontology and geriatrics
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journal_title：Archives of gerontology and geriatrics
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journal_title：Archives of gerontology and geriatrics
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journal_title：Archives of gerontology and geriatrics
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journal_title：Archives of gerontology and geriatrics
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journal_title：Archives of gerontology and geriatrics
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journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
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journal_title：Archives of gerontology and geriatrics
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journal_title：Archives of gerontology and geriatrics
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journal_title：Archives of gerontology and geriatrics
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journal_title：Archives of gerontology and geriatrics
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journal_title：Archives of gerontology and geriatrics
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