Abstract：
:The most important morphological aspects of the physiological changes of the liver with age are decreases in the numbers of hepatocytes and their mitochondria, coupled with increases in their volumes. The latter is considered to partially compensate for the decrease in numbers of hepatocytes and mitochondria, but leads to a more limited reserve capacity and thus to a condition in which liver function can be more readily exhausted. The binuclearity and polyploidization of the hepatocytes increase with age and are considered to be due to inhibition of their cell division process. Our studies on the parabiosis between young and old rats and mice, on the implantation of isolated hepatocytes in the spleens of rats of different ages, and on the regenerative process after partial hepatectomy in rats of different ages, suggested the existence of humoral inhibitory factor(s) for the division of the cells and their mitochondria. Morphological studies on the native and Hawaiian Japanese, as well as on the USA Caucasians and the Costa Rican Latinos revealed that a difference in the process of the age-related decrease in hepatocyte number among different ethnicities is mainly due to differences in nutritional conditions rather than to genetic factors. Experimental studies are now being carried out on the effect(s) of various dietary conditions on age-related changes of the liver, and the results obtained support the findings of the geographical studies.
journal_name
Arch Gerontol Geriatrjournal_title
Archives of gerontology and geriatricsauthors
Tauchi H,Sato T,Ito Ydoi
10.1016/0167-4943(94)90035-3subject
Has Abstractpub_date
1994-09-01 00:00:00pages
135-44issue
2eissn
0167-4943issn
1872-6976pii
0167-4943(94)90035-3journal_volume
19pub_type
杂志文章abstract：:This study was aimed at the mechanism of the circulatory failure characteristic of the elderly through elucidating the cause of leg edema frequently found in patients under treatment in health care facilities for physical or mental handicaps. ECG and measurement of atrial (ANP) and brain (BNP) natriuretic peptides wer...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(01)00098-x
更新日期：2001-08-01 00:00:00
abstract：:In a single-blind, placebo-controlled study the acute and chronic antianginal effects of three slow-release (SR) new formulations of isosorbide dinitrate (ISDN 60, 80, 100 mg) have been comparatively evaluated in a group of aged affected by chronic stable effort-induced angina. Compared to placebo, overall the active ...
journal_title：Archives of gerontology and geriatrics
pub_type： 临床试验,杂志文章
doi：10.1016/0167-4943(92)90007-q
更新日期：1992-01-01 00:00:00
abstract：:It is important to develop an accurate method of measuring controlled force exertion. This study examined the age differences between the controlled force exertion measured by a sinusoidal waveform and a bar chart display. The participants comprised 175 right-handed male adults aged 20-86 years. The participants were ...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2013.02.002
更新日期：2013-07-01 00:00:00
abstract：:Positional vertigo can be successfully treated by exercises (Vestibular Habituation Training, VHT) in elderly patients as well as in younger ones. Provided the patients have been correctly selected, this type of treatment is the only way for an adequate treatment of such a type of vertigo. Application of VHT has to be...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/0167-4943(89)90055-1
更新日期：1989-03-01 00:00:00
abstract：:As the population is ageing, health promotion is becoming increasingly important to prevent disease and disability. Cigarette smoking is strongly associated with excess mortality and smoking cessation even after the age of 65 years, improves health and lowers mortality. The voluntary sector is an under-utilised resour...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(01)00212-6
更新日期：2002-07-01 00:00:00
abstract：:The purpose of the study was to determine oral health status and the prevalence of oral mucosal lesions among hospitalized elderly patients with physical disabilities. The study group consisted of 111 (43 male and 68 female) elderly patients with physical disabilities. Clinical examination and interview methods were e...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2004.11.005
更新日期：2005-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Systematic reviews on healthy ageing interventions have primarily focused on assessing their effectiveness, not the implementation processes underpinning them, and the factors influencing program effectiveness. This has created a knowledge gap about what are effective implementation approaches...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章,评审
doi：10.1016/j.archger.2020.104263
更新日期：2021-01-01 00:00:00
abstract：:The purpose of this study was to investigate whether mitochondrial DNA (mtDNA) content of peripheral blood leukocyte is related to depression in community-dwelling old women. A total of 142 community-dwelling women, older than 60 years, were included in the study. The mtDNA copy number, which represents the mtDNA cont...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2010.11.019
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:Research on aging has shown a significant decline in ToM after 65 years of age. Despite these age-related difficulties, no study has yet investigated the possibility to improve ToM in older adults. To address this gap we tested the efficacy of a conversation-based ToM training with age-appropriate ToM tasks ...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2014.10.001
更新日期：2015-01-01 00:00:00
abstract：:Although otherwise extensively researched, one aspect of social functioning in older people that has received less attention is its association with staying at home for as long as possible. This 10-year follow-up examines factors of social functioning that support older people's independent living in their own homes a...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2007.12.001
更新日期：2009-03-01 00:00:00
abstract：:Codergocrine mesylate (dihydroergotoxine; DHET), which is an ergot derivative, has been reported to counteract some age-induced impairments in brain function, but the mechanism of these effects is not known. We examined the effect of chronic DHET administration on the somatostatinergic system in the brains of aged rat...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/0167-4943(92)90013-t
更新日期：1992-09-01 00:00:00
abstract：:The purpose of this study was to investigate how bladder management, rather than urinary incontinence, may affect the functional outcome of ischemic stroke patients. We studied 919 consecutive patients admitted for ischemic stroke rehabilitation. Level of bladder management was determined by Functional Independence Me...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2010.07.007
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:The muscle mass decreases with age, leading to frailty and weakness; however, the role of acetylcholine receptors in this process has not been properly studied. In this article, we hypothesize that diaphragmatic as well as peripheral muscle weakness may be caused by the up-regulation of gamma and alpha 7 nic...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2016.02.005
更新日期：2016-07-01 00:00:00
abstract：PURPOSE:The purpose of this study was to investigate the effects of eyeball exercise on balance and fall efficacy of the elderly who have experienced a fall. MATERIAL AND METHODS:Subjects were randomly assigned to the eyeball exercise group (n=30) or functional exercise group (n=31). All subjects received 30 sessions ...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.archger.2016.10.006
更新日期：2017-01-01 00:00:00
abstract：:The purpose of this study was to describe factors of importance for the quality of inpatient geriatric care from an inter-disciplinary team perspective, an area that has not been previously studied to our knowledge. The study design was qualitative descriptive with data being collected from focus-group interviews with...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2017.06.002
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:Research indicates that self-care affects lifestyle and health behaviors; however, little is known about whether or not self-care affects medical utilization. OBJECTIVES:Exploring the effects on self-care behaviors to medical utilizations by elderly with chronic conditions. METHOD:Data from the Taiwanese N...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2015.01.014
更新日期：2015-05-01 00:00:00
abstract：:We investigated the relationship between employment status and obesity prevalence in an elderly Korean, using a nationally representative sample. This cross-sectional study included 2991 participants (1396 men and 1595 women) aged 60 years or older. Employment status was categorized into full-time employees, part-time...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2013.02.004
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:A considerable proportion of individuals in late life experience dual sensory impairment (DSI), which can be defined as the combined presence of hearing and visual problems. However, there is little knowledge regarding the psychosocial correlates of DSI. Consequently, our objective of this study was to ident...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2020.104234
更新日期：2020-08-18 00:00:00
abstract：:Vascular risk factors play a significant role in the pathogenesis and progression of AD. MPV is an index of platelet activation and may be a potential marker of inflammation to demonstrate the vascular damage in AD. The aim of the present study is to assess whether platelet volume would be useful in predicting vascula...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2011.09.016
更新日期：2012-09-01 00:00:00
abstract：:This study was aimed to evaluate the cross-sectional and longitudinal associations between various perceived-stress and depressive symptoms in old Taiwanese men and women aged 50 years and over. Data were derived from the Taiwan Longitudinal Study on Aging. Stress for health, finance, and family members' related issue...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章,多中心研究
doi：10.1016/j.archger.2016.07.003
更新日期：2016-11-01 00:00:00
abstract：:There is increasing evidence for an association between WMH and large-artery atherosclerosis. We evaluated 268 patients with acute ischemic stroke to assess the relationship between intracranial (IC) atherosclerosis and WMH. The patients were classified into three groups according to the location of the stenosis; IC, ...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2010.07.008
更新日期：2011-09-01 00:00:00
abstract：:Using stress process theory and structural equation modelling, this study investigated the complex relationship between health status, family strain, dependency, and the life satisfaction of rural older adults with reported functional impairments in India. Data were extracted from a large-scale study of 903 randomly s...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2017.04.001
更新日期：2017-07-01 00:00:00
abstract：:The aim of the present study was to investigate levels of physical activity and risk factors for inactivity in older adults living in an urban area in the interior of the Amazonas state, Brazil. Data were collected between 2013 and 2015 from 274 individuals 60 years of age or older who resided in the interior of the B...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章,多中心研究
doi：10.1016/j.archger.2017.11.007
更新日期：2018-01-01 00:00:00
abstract：:We studied the factors influencing the choice of admission to Geriatrics units, instead of other acute hospital units after an emergency visit. We report the results from a cohort of 1283 randomly selected patients aged >75 years hospitalized in emergency and representative of the French University hospital system. Al...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2010.01.018
更新日期：2011-01-01 00:00:00
abstract：:Aim of the study was to investigate the replicability and reliability of the multi-dimensional health assessment questionnaire (MDHAQ) and visual analog scale (VAS) in young and elderly individuals with chronic pain. Ambulatory patients, 20 of them aged above 65 years and complaining about chronic pain and 20 patients...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2010.10.017
更新日期：2011-07-01 00:00:00
abstract：:The aim of this study was to determine gender discrimination and risk factors in the elderly population and to assess the impact of that discrimination on elderly health. One hundred and sixty-eight elderly individuals who were selected from the records by simple randomized sampling were enrolled in the study. Data we...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2007.01.060
更新日期：2007-11-01 00:00:00
abstract：:Because of chronicity and poor environments, elderly leprosy survivors might be at greater risk of developing obesity and sarcopenia than healthy individuals. This study aimed to investigate whether body composition and the prevalence of obesity and sarcopenia among elderly leprosy survivors with no or mild physical i...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2013.07.013
更新日期：2014-01-01 00:00:00
abstract：:The prevalence of orthostatic hypotension (OH) among the community-dwelling elderly is high, but the head-up tilt testing in the laboratory setting is time-consuming and costly. However, an objective index for screening for OH among older people recruited from community settings has not yet been established. Therefore...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2011.04.003
更新日期：2012-03-01 00:00:00
abstract：:The purpose of this cross-sectional survey study was to identify factors that increase the likelihood of enrolling in falls prevention programming among community dwelling older adults. A convenience sample of 369 participants completed a written, selfadministered questionnaire on history and beliefs related to falls,...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2019.01.006
更新日期：2019-01-01 00:00:00
abstract：:The calcium (Ca) antagonist flunarizine hydrochloride (FNZ) has been reported to induce parkinsonism, especially in the elderly. The effects of FNZ on dopamine receptors in rat striatal membranes, especially in aged rats, were studied using radiolabeled receptor assay. Similar displacing potencies in [(3)H]spiperone b...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/0167-4943(91)90049-v
更新日期：1991-11-01 00:00:00
