Abstract:
:The aim of this in vitro study was to determine whether the sinus mucosa holds cells with an osteogenic potential. Frozen sections of sinus mucosa from three adult pigs were investigated for the expression of STRO-1, a marker of mesenchymal progenitor cells, and alkaline phosphatase activity, an enzyme expressed by cells committed to the osteogenic lineage and by mature osteoblasts. To determine their osteogenic potential, mucosa-derived cells were incubated with bone morphogenetic protein (BMP)-6 and BMP-7, and alkaline phosphatase activity, osteocalcin expression, and mineralization of the extracellular matrix was measured. We found sinus mucosa cells staining positive for STRO-1 and alkaline phosphatase activity. When sinus mucosa tissue was placed in culture, alkaline phosphatase positive cells grew out from the explants and further increased alkaline phosphatase activity in response to BMP-6 and BMP-7. The expression level of the osteoblast-specific extracellular matrix protein osteocalcin, and the amount of calcium accumulation within the extracellular matrix was also increased in response to BMPs. We conclude that the sinus mucosa holds mesenchymal progenitor cells and cells committed to the osteogenic lineage that can respond to BMP-6 and BMP-7 by an increase of their osteogenic differentiation.
journal_name
Clin Oral Implants Resjournal_title
Clinical oral implants researchauthors
Gruber R,Kandler B,Fuerst G,Fischer MB,Watzek Gdoi
10.1111/j.1600-0501.2004.01062.xsubject
Has Abstractpub_date
2004-10-01 00:00:00pages
575-80issue
5eissn
0905-7161issn
1600-0501pii
CLR1062journal_volume
15pub_type
杂志文章abstract:OBJECTIVES:Collagen membranes are not limited to be occlusive barriers as they actively support bone regeneration. However, the impact of bone-derived growth factors on their osteoconductive competence has not been examined. METHODS:Twenty adult Sprague Dawley rats were included in the study. Calvaria defects with a d...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13133
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the synergistic effect of bone morphogenetic protein 2 (BMP-2) and vascular endothelial growth factor (VEGF) on the repair of bone defects around dental implants. MATERIAL AND METHODS:Five groups of scaffold were fabricated by a freeze-drying method, including pure chitosan/collagen scaffold; sca...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2011.02164.x
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:During the fourth Summer Camp (SC) held by the European Association of Osseointegration (EAO), 20 junior representatives from various European and non-European universities and associations were selected to partake in oral presentation and communication skill development. AIMS:The aim of the EAO Summer Camp...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13625
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVES:To analyze the clinical performance and bone-to-implant contact (BIC) rate of two loading concepts on successfully healed and explanted palatal implants in humans. METHODS:From 2000 to 2006, two independent groups of patients, requiring maximum anchorage, were treated. Group 1 (n=36) was subjected to immedi...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2009.01732.x
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVE:A precise and scientifically established method for the evaluation of the bone quality/primary stability is the measure of the insertion torque (IT). The aim of this study was a comparison between the IT values and the bone-implant contact percentage (BIC) of human implants retrieved after a 4/8-week healing ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2008.01599.x
更新日期:2009-08-01 00:00:00
abstract::In the present multi-center study, non-submerged ITI implants were prospectively followed to evaluate their long-term prognosis in fully and partially edentulous patients. In a total of 1003 patients, 2359 implants were consecutively inserted. Following a healing period of 3-6 months, the successfully integrated impla...
journal_title:Clinical oral implants research
pub_type: 杂志文章,多中心研究
doi:10.1034/j.1600-0501.1997.080302.x
更新日期:1997-06-01 00:00:00
abstract::This paper describes a surgical technique that permits the achievement of bilateral simultaneous augmentation of the maxillary sinus floor with the use of autologous bone harvested from the mandibular symphysis alone. Out of a group of 26 partially edentulous patients consecutively treated for sinus augmentation in an...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.2003.140210.x
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVES:This study aimed at evaluating the biological response of titanium implants coated with UV-irradiated 7-dehydrocholesterol (7-DHC) and vitamin E (VitE) in vivo and analyzing the effects of aging on their stability and bioactivity in vitro. MATERIAL AND METHODS:Titanium surfaces were coated with 7-DHC and Vi...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12815
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVES:Interforaminal implant surgery requires anatomical knowledge of the area and adequate information on the location of the various landmarks of significance such as the mental foramen, the anterior loop of the inferior alveolar nerve and the mandibular incisive canal. Cone beam computed tomography (CBCT) is a ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2011.02261.x
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate a new design of the cervical portion of dental implant with the objective to increase the volume of peri-implant tissues in the crestal area. MATERIALS AND METHODS:Forty-eight tapered dental titanium implants with internal conical connection were implanted in healed alve...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12978
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the bone regenerative properties of a heat treated cross-linked GBR membrane with zinc hydroxyapatite powders in the rat calvarial defect model over a 6-week period. MATERIAL AND METHODS:In vitro physio-chemical characterization involved X-ray diffraction analysis, s...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12520
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVES:To evaluate the early cellular attachment and viability to modified polyethylene glycol (PEG) hydrogels with the influence of arginine-glycine-aspartic acid (RGD) in an in vitro model system. MATERIAL AND METHODS:Human gingival fibroblasts (HGF-1) were cultured on 6 different modalities of PEG hydrogel in h...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12076
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:To compare ear, nose, and throat (ENT) specialists and dentists assessing health or pathology of maxillary sinuses using cone beam computed tomography (CBCT). MATERIAL AND METHODS:Two ENT specialists and two oral surgeons assessed 100 CBCT datasets of healthy patients referred for dental implant placement i...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13582
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVES:The aim of the present study was to evaluate and compare naturally occuring and ligature-induced peri-implantitis bone defects in humans and dogs. MATERIAL AND METHODS:Twenty-four partially and fully edentulous patients undergoing peri-implant bone augmentation procedures due to advanced peri-implant infect...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2006.01320.x
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the outcomes of the installation of two implant-supported overdentures until such treatment is complete. Although this treatment is well established in the literature, there are no studies comparing what happens to muscles and the quality of life (QoL) of patients dur...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12980
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVES:The aim of this study is twofold: to assess the esthetic outcome of single dental implant restorations in the anterior maxillary area after up to 3 years of function, and to evaluate the relationship between the esthetic outcome and oral health-related quality of life. MATERIALS AND METHODS:Twenty patients ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12922
更新日期:2017-09-01 00:00:00
abstract:AIM:The aim of this prospective study was to evaluate the outcome of computer-guided flapless placement and immediate loading of four conical screw-type implants in the interforaminal region. PATIENTS AND METHODS:From May to August 2003, 25 consecutive patients (m : f=16 : 9) with edentulous mandibles were included in...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2007.01370.x
更新日期:2007-08-01 00:00:00
abstract::This study details the structural and ultrastructural features of the interfaces between titanium implants and their surrounding tissues. The material stemmed from an experiment in dogs in which guided tissue regeneration with Gore-Tex membranes was used to treat peri-implant, ligature-induced tissue breakdown around ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1994.050201.x
更新日期:1994-06-01 00:00:00
abstract::Currently, 3 treatment options are available for patients with denture complaints and an edentulous mandible with a height of at least 15 mm: meticulous construction of a new set of dentures (CD), construction of a new set of dentures following preprosthetic surgery to enlarge the denture-bearing area (PPS), and const...
journal_title:Clinical oral implants research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1034/j.1600-0501.2000.011003195.x
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate the preference of a patients' population, according to the index of willingness to pay (WTP), against two treatments to restore a single-tooth gap: the implant-supported crown (ISC) and the 3-unit fixed partial denture prosthesis (FPDP) on natural teeth. MATERIALS ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12264
更新日期:2014-11-01 00:00:00
abstract::Well integrated and clinically functional titanium dental implants retrieved in humans after 14 and 40 months of settlement were used for the characterization of the interfacial area between the plasma-sprayed coating and the surrounding mineralized bone. Electron microscopic studies were performed from undecalcified ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.2000.011004279.x
更新日期:2000-08-01 00:00:00
abstract:OBJECTIVE:To evaluate how bone-level implants maintain crestal bone stability after thickening of thin mucosal tissues with allogenic membrane. MATERIALS AND METHODS:Ninety-seven bone-level implants of 4.1 mm diameter (Institute Straumann AG, Switzerland) were evaluated in 97 patients (28 men and 69 women, mean age 47...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12301
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVE:To evaluate osseointegration in rabbit tibiae and to investigate surface characteristics of novel zirconia implants made by powder injection molding (PIM) technique, using molds with and without roughened inner surfaces. MATERIAL AND METHODS:A total of 20 rabbits received three types of external hex implants...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2012.02468.x
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:Graft consolidation follows a gradient that reflects the properties of bone substitutes at sites of sinus augmentation. Here we present an analytical method to investigate the process of graft consolidation taking the distance from the maxillary host bone into account. MATERIAL AND METHODS:We therefore evalu...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2009.01733.x
更新日期:2009-10-01 00:00:00
abstract::Ramírez-Fernández MP, Calvo-Guirado JL, Arcesio Delgado-Ruiz R, Maté-Sánchez del Val JE, Gómez-Moreno G, Guardia J. Experimental model of bone response to xenografts of bovine origin (Endobon® ): a radiological and histomorphometric study. Clin Oral Impl Res. 2011;22: 727-734. The above article, published online on 29...
journal_title:Clinical oral implants research
pub_type: 杂志文章,撤回出版物
doi:10.1111/clr.13085
更新日期:2018-06-01 00:00:00
abstract::The purpose of this study was to compare the clinical and microbiological (microscopic) parameters during the development of experimental gingivitis and experimental peri-implant mucositis. Twenty partially edentulous patients were treated for moderate to advanced periodontal disease. Following active periodontal ther...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1994.050409.x
更新日期:1994-12-01 00:00:00
abstract:OBJECTIVES:A removable implant-retained dental prosthesis in an edentulous mandible can use telescopic crowns or a bar superstructure as anchorage elements for an overdenture. The aim of this study was to compare the clinical results for bar-anchored and telescopic crown-retained overdentures in implant prosthetic trea...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-0501.2007.01500.x
更新日期:2008-05-01 00:00:00
abstract::This study aimed to investigate the effect of hyperbaric oxygen (HBO) therapy on the tissue reactions to commercially pure (c.p.) titanium implants placed in free autogenous bone graft by a 1-stage procedure. Eighty c.p. titanium implants were placed in the bone grafted from iliac crest to bilateral mandible of 40 Jap...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1996.090604.x
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVES:The present study aimed at evaluating the marginal bone resorption and the peri-implant tissue conditions around Narrow-Neck ITI implants in the implant-prosthetic treatment of the agenesis of maxillary lateral incisors. MATERIAL AND METHODS:Thirty patients affected by monolateral or bilateral agenesis of t...
journal_title:Clinical oral implants research
pub_type: 临床试验,杂志文章
doi:10.1111/j.1600-0501.2005.01188.x
更新日期:2006-02-01 00:00:00
abstract:AIM:The purpose of this study was to systematically review the literature on the survival rates of palatal implants, Onplants((R)), miniplates and mini screws. MATERIAL AND METHODS:An electronic MEDLINE search supplemented by manual searching was conducted to identify randomized clinical trials, prospective and retros...
journal_title:Clinical oral implants research
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0501.2009.01754.x
更新日期:2009-12-01 00:00:00