Abstract：
:The loss of muscle mass during aging has been termed sarcopenia. Sarcopenia results in a decrease in physical strength during aging that results in important consequences for more severely affected individuals in terms of function and as a marker for disability and increased mortality. Despite the clinical importance of this condition, the pathophysiology leading to the development of sarcopenia is not well understood, and few treatments exist to prevent or reverse the condition. Recently, sarcopenia has been found to occur during aging in the nematode Caenorhabditis elegans, which is an organism increasingly used to study genetic and biochemical events involved in aging. Like in humans, sarcopenia in C. elegans leads to declines in mobility and serves as a marker for increased mortality. Interestingly, mutations affecting the age-1 gene, which slows aging of the animal, result in significant delays in the development of sarcopenia, suggesting a direct causal relationship between organismal aging and sarcopenia. These findings suggest that, in humans and worms, sarcopenia may represent a biomarker for the biological age, as opposed to chronological age, of the individual. These findings also suggest that C. elegans will develop into an important model system in which to study the biochemical and genetics events responsible for sarcopenia and to test therapeutics designed to prevent or reverse sarcopenia.
journal_name
J Am Geriatr Socjournal_title
Journal of the American Geriatrics Societyauthors
Fisher ALdoi
10.1111/j.1532-5415.2004.52320.xsubject
Has Abstractpub_date
2004-07-01 00:00:00pages
1185-90issue
7eissn
0002-8614issn
1532-5415pii
JGS52320journal_volume
52pub_type
杂志文章,评审abstract：BACKROUND:Baseline depressive symptoms have been consistently associated with the onset of cardiovascular disease (CVD). OBJECTIVES:Since depressive symptoms vary over time in elderly persons, and to help clarify whether or not depression is an etiological factor for CVD, we quantified the association between the cour...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章,多中心研究
doi：10.1111/jgs.13872
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVES:To examine recent trends in discharge disposition after hospitalization for hip fracture. DESIGN:Retrospective observational study using data from the 5% random sample of Medicare claims data from 2001 to 2005 that the Centers for Medicare and Medicaid Services makes available for research purposes. SETTIN...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2008.01688.x
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVES:To determine the frequency of aspiration pneumonitis in nursing home residents with an initial diagnosis of pneumonia and to compare the clinical characteristics, management, and outcome of aspiration pneumonitis with those of pneumonia. DESIGN:Retrospective chart review. SETTING:Hospital geriatric unit fo...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1034/j.1601-5215.2002.51004.x
更新日期：2003-01-01 00:00:00
abstract：OBJECTIVES:To determine the association between complementary and alternative medicine (CAM) use and antihypertensive medication adherence in older black and white adults. DESIGN:Cross-sectional. SETTING:Patients enrolled in a managed care organization. PARTICIPANTS:Two thousand were hundred eighty black and white a...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2009.02639.x
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVES:To determine whether heat waves (HWs) affect exposure to drugs with anticholinergic effects (DACEs) on admission and the effect of such on length of stay (LOS) and in-hospital mortality in older adults. DESIGN:Retrospective. SETTING:Metropolitan teaching hospital. PARTICIPANTS:Individuals aged 65 and olde...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/jgs.14100
更新日期：2016-05-01 00:00:00
abstract：OBJECTIVES:A common assumption is that life-sustaining treatments are much less cost-effective for older patients than for younger patients. We estimated the incremental cost-effectiveness of providing mechanical ventilation and intensive care for patients of various ages who had acute respiratory failure. DESIGN:Retr...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1046/j.1532-5415.2001.49080.x
更新日期：2001-04-01 00:00:00
abstract：OBJECTIVE:To determine the frequency of falls and identify risk factors for falls among older Mexican-American women. DESIGN:A prospective cohort study with an average follow-up of 2.7 years. SETTING:A clinical center at the Palo Alto Veterans Affairs Medical Center, California. PARTICIPANTS:152 community-dwelling M...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：
更新日期：1999-11-01 00:00:00
abstract：:Delirium is a common and serious condition that is underrecognized in older adults in a variety of healthcare settings. It is poorly recognized because of deficiencies in provider knowledge and its atypical presentation. Early recognition of delirium is warranted to better manage the disease and prevent the adverse ou...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章,评审
doi：10.1111/jgs.12522
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:To explore the opinion of the Dutch general public and of physicians regarding euthanasia in patients with advanced dementia. DESIGN:A cross-sectional survey. SETTING:The Netherlands. PARTICIPANTS:Random samples of 1,965 citizens (response = 1,965/2,641 [75%]) and 1,147 physicians (response = 1...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/jgs.16692
更新日期：2020-10-01 00:00:00
abstract：:Case examples of doctor-patient interactions are used to examine educational strategies employed by physicians to obtain compliance with medication regimens from elderly patients. The problems addressed by the physicians included the complexities of pharmaco-therapy in the elderly (the patients each presented multiple...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1984.tb06138.x
更新日期：1984-08-01 00:00:00
abstract：OBJECTIVE:To determine whether mortality is independently associated with urinary incontinence. DESIGN:6-year prospective study that started in 1983/84. SETTING:A Midwestern County. PARTICIPANTS:Probability sample of 1956 community-residing persons 60 years of age and older in 1983/84. MEASUREMENTS:The independent ...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1994.tb01749.x
更新日期：1994-03-01 00:00:00
abstract：:Despite recent gains in establishing academic sections, divisions, and departments of geriatrics in medical schools, much remains to be done to meet the medical needs of an aging population. To better understand how medical schools are educating students in geriatric-related topics, all U.S. allopathic and osteopathic...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2005.53023.x
更新日期：2005-01-01 00:00:00
abstract：OBJECTIVES:To quantify the prevalence of documented urinary tract infection (UTI), nonspecific symptoms, and antibiotic treatment of suspected UTI in nursing homes (NHs) in the tropics and to describe the typical resident likely to receive antibiotic treatment for suspected UTI and factors associated with the developme...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/jgs.15179
更新日期：2018-02-01 00:00:00
abstract：:Brain atrophy in 154 men and 147 women without neurologic deficits was quantitatively studied by means of computed tomography. The ages ranged from 20 to 79 years. The volume percentage of brain to cranial cavity (Craniocerebral Index, or CCI) was calculated by means of computer programs available in CT systems. The m...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1982.tb07092.x
更新日期：1982-04-01 00:00:00
abstract：OBJECTIVES:To compare the ability of five measures of comorbidity to predict mortality and incident disability in basic activities of daily living (BADLs) in unselected older persons. DESIGN:An assessment of the data obtained from the Insufficienza Cardiaca negli Anziani Residenti a Dicomano (ICARe Dicomano) Study, a ...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2005.00572.x
更新日期：2006-02-01 00:00:00
abstract：OBJECTIVE:To study the effectiveness of rehabilitative and medically oriented day hospital care on community-based long-term care patients. DESIGN:A randomized, controlled trial. SETTING AND PARTICIPANTS:177 patients on home-care in a rural area were randomized into two groups. Patients in one group were offered a 2-...
journal_title：Journal of the American Geriatrics Society
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1532-5415.1998.tb06645.x
更新日期：1998-09-01 00:00:00
abstract：OBJECTIVES:To examine racial differences in readmissions of older adults undergoing elective total hip and knee replacement, to determine the relationship between nurse staffing and readmission, and to study whether the relationship between staffing and readmission differs for older black and white adults. DESIGN:Cros...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章,多中心研究
doi：10.1111/jgs.14367
更新日期：2016-12-01 00:00:00
abstract：OBJECTIVE:To assess the validity of the Neurobehavioral Rating Scale (NRS) in patients with Alzheimer's disease (AD) or multi-infarct dementia (MID) and to characterize the cognitive, psychiatric, and behavioral disturbances that occur in these patients. DESIGN:Cross-sectional evaluation. SETTING:West Los Angeles VAM...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1992.tb02101.x
更新日期：1992-06-01 00:00:00
abstract：:A series of histopathologic, morphologic, and pharmacologic criteria are proposed to establish the significance of neurochemical deficits in Alzheimer's disease. The underlying pathogenic biochemistry of a better understood neurotransmitter-deficiency syndrome, Parkinson's disease, validates these criteria. The major ...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章,评审
doi：10.1111/j.1532-5415.1983.tb04877.x
更新日期：1983-05-01 00:00:00
abstract：OBJECTIVES:To determine whether cognitive test scores and cognitive decline predict incidence of first diagnosed stroke. DESIGN:Stroke-free Health and Retirement Study participants were followed on average 7.6 years for self- or proxy-reported first stroke (1,483 events). Predictors included baseline performance on a ...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2008.02132.x
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Patient activation encompasses the knowledge, skills, and confidence that equip adults to participate actively in their healthcare. Patients with hearing loss may be less able to participate due to poor aural communication. We examined whether difficulty hearing is associated with lower patient ac...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/jgs.15833
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:To optimize health and well-being for all older people, we must collectively develop leaders to pioneer models of care, educate the healthcare workforce, advance research, and engage the community. METHODS:The Emerging Leaders in Aging (ELIA) program was created to train a multiprofessional cadre...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/jgs.15702
更新日期：2019-03-01 00:00:00
abstract：OBJECTIVES:To examine the associations between amyloid-β brain deposition and physical activity (PA) in elderly adults without dementia and to investigate whether the association has a dose-response relationship. DESIGN:Cross-sectional study. SETTING:French community-dwelling people. PARTICIPANTS:Elderly adults with...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/jgs.13530
更新日期：2015-08-01 00:00:00
abstract：:As life expectancy increases, so do the problems of the elderly population. One major problem is that of protein calorie malnutrition; another is the susceptibility of this population to pressure sores. The purpose of this study was to determine if a correlation exists between deteriorating nutritional status and the ...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1986.tb03411.x
更新日期：1986-06-01 00:00:00
abstract：OBJECTIVES:To compare falls and fall-related injuries that a fall evaluator or hospital incident report identified with injuries identified according to discharge International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes for the same set of inpatient episodes of care. DESIGN:Pros...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/jgs.12539
更新日期：2013-12-01 00:00:00
abstract：OBJECTIVES:To determine the effect of cataract surgery on the occurrence of falls and mobility and balance problems in older adults with cataract. DESIGN:Longitudinal follow-up study. SETTING:Clinical Research Unit, University of Alabama at Birmingham. PARTICIPANTS:Persons aged 55 and older with a cataract were recr...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2006.00770.x
更新日期：2006-07-01 00:00:00
abstract：OBJECTIVES:To determine the proportion of untreated women who reported receiving treatment after incident fracture and to identify factors that predict treatment across an international spectrum of individuals. DESIGN:Prospective observational study. Self-administered questionnaires were mailed at baseline and 1 year....
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1532-5415.2011.03854.x
更新日期：2012-03-01 00:00:00
abstract：OBJECTIVE:The study describes the prevalence of medical nursing home practice. Further, it examines the extent to which physician characteristics and local county health care resources predict nursing home involvement. This information is relevant to evaluating and devising strategies that address the future provision ...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1997.tb02958.x
更新日期：1997-08-01 00:00:00
abstract：OBJECTIVES:To assess the effect of exposure to evidence-based medication after hospital discharge for Medicare beneficiaries with acute myocardial infarction (AMI). DESIGN:A discrete-time hazard model was used to estimate time to outcome associated with exposure to four drug classes (angiotensin-converting enzyme inhi...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2012.04165.x
更新日期：2012-10-01 00:00:00
abstract：:The objectives of this study were to review the diagnostic, International Classification of Disease, 9th Revision, Clinical Modification (ICD-9-CM), diagnosis related groups (DRGs), and common procedural terminology (CPT) coding and reimbursement issues (including Medicare Part B reimbursement for physicians) encounte...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章,评审
doi：10.1046/j.1532-5415.2002.50519.x
更新日期：2002-11-01 00:00:00
