Quantification of regional myocardial blood flow using 13N-ammonia and reoriented dynamic positron emission tomographic imaging.

abstract：:Since quinidine is one of the few agents available to treat and prevent ventricular arrhythmias in ambulatory patients, its hemodynamic effects have been reevaluated. When given in therapeutic doses to anesthetized mongrel dogs, quinidine significantly reduced heart rate, aortic pressure and flow, but it did not signi...

journal_title：Circulation

authors： Markiewicz W,Winkle R,Binetti G,Kernoff R,Harrison DC

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND:Children stable at home with dilated cardiomyopathy remain at risk of death; there is evidence of survival benefit for transplantation out to 4 years postoperatively. The limited supply of donor organs makes risk stratification imperative, but although cardiopulmonary exercise test is well established as a p...

journal_title：Circulation

authors： Giardini A,Fenton M,Andrews RE,Derrick G,Burch M

更新日期：2011-10-18 00:00:00

abstract：:Diagnosis of rejection after cardiac transplantation is currently made by right ventricular endomyocardial biopsy. To evaluate antimyosin imaging as a noninvasive means of detecting human cardiac rejection, the Fab fragment of murine monoclonal antimyosin antibodies was labeled with indium-111 and given intravenously ...

journal_title：Circulation

authors： Frist W,Yasuda T,Segall G,Khaw BA,Strauss HW,Gold H,Stinson E,Oyer P,Baldwin J,Billingham M

更新日期：1987-11-01 00:00:00

abstract：:The predictive value of the myocardial scintigraphy with 99mTc-pyrophosphate was studied in 100 patients admitted to the coronary care unit with suspected acute myocardial infarction. None of the 21 patients with normal scintigrams had acute myocardial infraction by other criteria. Fifty-five percent of patients with ...

journal_title：Circulation

authors： Holman BL,Chisholm RJ,Braunwald E

更新日期：1978-02-01 00:00:00

abstract：BACKGROUND:Body fat distribution has been cross-sectionally associated with atherosclerotic disease risk factors, but the prospective relation with coronary heart disease remains uncertain. METHODS AND RESULTS:We examined the prospective relation between fat distribution indices and coronary heart disease among 24,508...

journal_title：Circulation

authors： Canoy D,Boekholdt SM,Wareham N,Luben R,Welch A,Bingham S,Buchan I,Day N,Khaw KT

更新日期：2007-12-18 00:00:00

abstract：BACKGROUND:Initially based on histology, the diagnosis of renal artery fibromuscular dysplasia (FMD) is now based mostly on angiographic appearance because arterial tissue samples are rarely available. This retrospective cross-sectional study aimed to assess the clinical relevance of a binary angiographic classificatio...

journal_title：Circulation

authors： Savard S,Steichen O,Azarine A,Azizi M,Jeunemaitre X,Plouin PF

更新日期：2012-12-18 00:00:00

abstract：BACKGROUND:The use of atherosclerotic cardiovascular disease (ASCVD) risk to personalize systolic blood pressure (SBP) treatment goals is a topic of increasing interest. Therefore, we studied whether coronary artery calcium (CAC) can further guide the allocation of anti-hypertensive treatment intensity. METHODS:We inc...

journal_title：Circulation

authors： McEvoy JW,Martin SS,Dardari ZA,Miedema MD,Sandfort V,Yeboah J,Budoff MJ,Goff DC Jr,Psaty BM,Post WS,Nasir K,Blumenthal RS,Blaha MJ

更新日期：2017-01-10 00:00:00

abstract：BACKGROUND:It is not known whether subspecialty care by cardiologists improves outcomes in heart failure patients from the community over care by other physicians. METHODS AND RESULTS:Using administrative data, we monitored 38 702 consecutive patients with first-time hospitalization for heart failure in Ontario, Canad...

journal_title：Circulation

authors： Jong P,Gong Y,Liu PP,Austin PC,Lee DS,Tu JV

更新日期：2003-07-15 00:00:00

abstract：BACKGROUND:Coxsackieviruses B (CBVs) are dominant causative agents in myocarditis and are associated with pathogenesis is some cases of dilated cardiomyopathy, a clinical entity with a poor survival without heart transplantation. METHODS AND RESULTS:In vitro, the antiviral agent WIN 54 954 was shown to inhibit replica...

journal_title：Circulation

authors： Fohlman J,Pauksen K,Hyypiä T,Eggertsen G,Ehrnst A,Ilbäck NG,Friman G

更新日期：1996-11-01 00:00:00

abstract：:One hundred consecutive patients who underwent coronary artery bypass surgery at the Columbia-Presbyterian Medical Center from December 1972 through February 1975 were evaluated at surgery and then followed for as long as 4 1/2 years to study their postoperative psychosocial and behavioral course. One patient died dur...

journal_title：Circulation

authors： Kornfeld DS,Heller SS,Frank KA,Wilson SN,Malm JR

更新日期：1982-11-01 00:00:00

abstract：BACKGROUND:Although angina is often caused by atherosclerotic obstruction of the coronary arteries, patients with similar amounts of myocardial ischemia may vary widely in their symptoms. We sought to compare clinical and psychosocial characteristics associated with more frequent angina after adjusting for the amount o...

journal_title：Circulation

authors： Arnold SV,Spertus JA,Ciechanowski PS,Soine LA,Jordan-Keith K,Caldwell JH,Sullivan MD

更新日期：2009-07-14 00:00:00

abstract：BACKGROUND:Both glucose-insulin-potassium (GIK) and tri-iodothyronine (T3) may improve cardiovascular performance after coronary artery surgery (CABG) but their effects have not been directly compared and the effects of combined treatment are unknown. METHODS AND RESULTS:In 2 consecutive randomized double-blind placeb...

journal_title：Circulation

authors： Ranasinghe AM,Quinn DW,Pagano D,Edwards N,Faroqui M,Graham TR,Keogh BE,Mascaro J,Riddington DW,Rooney SJ,Townend JN,Wilson IC,Bonser RS

更新日期：2006-07-04 00:00:00

abstract：BACKGROUND:Previous studies have shown that hypertrophy of surviving myocytes after myocardial infarction (MI) is limited. Progressive ventricular dilatation after MI may occur when compensatory hypertrophy cannot restore left ventricular (LV) wall stress to normal. METHODS AND RESULTS:To test whether induction of add...

journal_title：Circulation

authors： Litwin SE,Raya TE,Anderson PG,Litwin CM,Bressler R,Goldman S

更新日期：1991-10-01 00:00:00

abstract：:Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome with an increasingly recognized heterogeneity in pathophysiology. Exercise intolerance is the hallmark of HFpEF and appears to be caused by both cardiac and peripheral abnormalities in the arterial tree and skeletal muscle. Mitochondrial abno...

journal_title：Circulation

authors： Kumar AA,Kelly DP,Chirinos JA

更新日期：2019-03-12 00:00:00

abstract：BACKGROUND:Disintegrin metalloproteinases (ADAMs) may contribute to structural cardiac remodeling by altering cell-surface matrix receptors (integrins) and activating potent biomolecules. We compared expression of ADAMs, their endogenous inhibitor tissue inhibitor of metalloproteinases (TIMP)-3, and integrins in human ...

journal_title：Circulation

authors： Fedak PW,Moravec CS,McCarthy PM,Altamentova SM,Wong AP,Skrtic M,Verma S,Weisel RD,Li RK

更新日期：2006-01-17 00:00:00

abstract：BACKGROUND:Postmortem-derived findings support the common beliefs that lipid-rich coronary plaques with a thin, fibrous cap are prone to rupture and that rupture and superimposed thrombosis are the primary mechanisms causing acute coronary syndromes. In vivo imaging with intracoronary techniques may disclose difference...

journal_title：Circulation

authors： de Feyter PJ,Ozaki Y,Baptista J,Escaned J,Di Mario C,de Jaegere PP,Serruys PW,Roelandt JR

更新日期：1995-09-15 00:00:00

abstract：BACKGROUND:Dispatcher-assisted cardiopulmonary resuscitation (CPR) instructions can increase bystander CPR and thereby increase the rate of survival from cardiac arrest. The risk of bystander CPR for patients not in arrest is uncertain and has implications for how assertive dispatch is in instructing CPR. We determined...

journal_title：Circulation

authors： White L,Rogers J,Bloomingdale M,Fahrenbruch C,Culley L,Subido C,Eisenberg M,Rea T

更新日期：2010-01-05 00:00:00

abstract：BACKGROUND:Ghrelin is a novel growth hormone-releasing peptide that has been shown to improve cachexia in heart failure and cancer and to ameliorate the hemodynamic and metabolic disturbances in septic shock. Because cytokine-induced inflammation is critical in these pathological states and because the growth hormone s...

journal_title：Circulation

authors： Li WG,Gavrila D,Liu X,Wang L,Gunnlaugsson S,Stoll LL,McCormick ML,Sigmund CD,Tang C,Weintraub NL

更新日期：2004-05-11 00:00:00

abstract：BACKGROUND:Major gender-based differences in the incidence of ventricular tachyarrhythmia after myocardial infarction have been shown in humans. Although the underlying mechanisms are unclear, earlier studies suggest that estrogen receptor-mediated effects play a major role in this process. METHODS AND RESULTS:We exam...

journal_title：Circulation

authors： Korte T,Fuchs M,Arkudas A,Geertz S,Meyer R,Gardiwal A,Klein G,Niehaus M,Krust A,Chambon P,Drexler H,Fink K,Grohé C

更新日期：2005-05-10 00:00:00

abstract：:To define the mechanisms of unexpected cardiac arrest in advanced heart failure, we reviewed the causes of cardiac arrest as established from electrocardiographic monitoring and from clinical and autopsy data in patients hospitalized for cardiac transplantation evaluation and management of advanced heart failure (mean...

journal_title：Circulation

authors： Luu M,Stevenson WG,Stevenson LW,Baron K,Walden J

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND:Plaque rupture with subsequent thrombosis is recognized as the underlying pathophysiology of most acute coronary syndromes and stroke. Thus, direct thrombus visualization may be beneficial for both diagnosis and guidance of therapy. We sought to test the feasibility of direct imaging of acute and subacute th...

journal_title：Circulation

authors： Botnar RM,Perez AS,Witte S,Wiethoff AJ,Laredo J,Hamilton J,Quist W,Parsons EC Jr,Vaidya A,Kolodziej A,Barrett JA,Graham PB,Weisskoff RM,Manning WJ,Johnstone MT

更新日期：2004-04-27 00:00:00

abstract：BACKGROUND:Although metabolomic profiling offers promise for the prediction of coronary heart disease (CHD), and metabolic risk factors are more strongly associated with CHD in women than men, limited data are available for women. METHODS:We applied a liquid chromatography-tandem mass spectrometry metabolomics platfor...

journal_title：Circulation

authors： Paynter NP,Balasubramanian R,Giulianini F,Wang DD,Tinker LF,Gopal S,Deik AA,Bullock K,Pierce KA,Scott J,Martínez-González MA,Estruch R,Manson JE,Cook NR,Albert CM,Clish CB,Rexrode KM

更新日期：2018-02-20 00:00:00

abstract：BACKGROUND:Defining the arrhythmogenic substrate is essential for successful ablation of scar-related ventricular tachycardia. The visual characteristics of endocardial ischemic scar have not been described in vivo. The goal of this study was (1) to quantify the visual characteristics of normal tissue, scar border zone...

journal_title：Circulation

authors： Betensky BP,Jauregui M,Campos B,Michele J,Marchlinski FE,Oley L,Wylie B,Robinson D,Gerstenfeld EP

更新日期：2012-10-23 00:00:00

abstract：:Patients undergoing carotid endarterectomy were pretreated with low-dose, oral beta carotene to determine whether the carotenoid content of plaque could be increased in vivo. Beta carotene-treated patients had a 50-fold increase in their plaque beta carotene level from 0.066 to 3.3 micrograms beta carotene/g plaque. M...

journal_title：Circulation

authors： Prince MR,LaMuraglia GM,MacNichol EF Jr

更新日期：1988-08-01 00:00:00

abstract：BACKGROUND:The timing of onset of angina before myocardial infarction in relation to outcome is unknown. METHODS AND RESULTS:We prospectively determined the importance of the time of onset of preinfarction angina in relation to 30-day outcomes in the TIMI-9B study from standardized forms. Of the 3002 patients entered ...

journal_title：Circulation

authors： Kloner RA,Shook T,Antman EM,Cannon CP,Przyklenk K,Yoo K,McCabe CH,Braunwald E

更新日期：1998-03-24 00:00:00

abstract：BACKGROUND:The purpose of this study was to compare differential effects of a segment of slow conduction during ventricular tachycardia (VT) due to depression of the action potential and electrical uncoupling. METHODS AND RESULTS:In 33 Langendorff-perfused rabbit hearts, a ring of anisotropic left ventricular subepica...

journal_title：Circulation

authors： Haberl K,Allessie M

更新日期：1999-02-23 00:00:00

abstract：BACKGROUND:Ultrasonic angioplasty was recently shown to ablate thrombi and atherosclerotic plaques in vitro and to recanalize occluded arteries in experimental animal models. The goal of the present study was to examine the clinical feasibility of ultrasonic angioplasty. METHODS AND RESULTS:Intraoperative ultrasonic a...

journal_title：Circulation

authors： Rosenschein U,Rozenszajn LA,Kraus L,Marboe CC,Watkins JF,Rose EA,David D,Cannon PJ,Weinstein JS

更新日期：1991-06-01 00:00:00

abstract：:From January 1968 to June 1975 tricuspid regurgitation was encountered in 238 patients of a total of 1074 patients undergoing operations on the mitral valve. During this time tricuspid annuloplasty (TA) was performed in 137 patients and the tricuspid valve was replaced (TVR) in 101 patients. Comparison of hospital mor...

journal_title：Circulation

authors： Reed GE,Boyd AD,Spencer FC,Engelman RM,Isom OW,Cunningham JN Jr

更新日期：1976-12-01 00:00:00

abstract：BACKGROUND:Coronary calcification detected by electron beam tomography may improve cardiovascular risk prediction. The technique is particularly promising in the elderly because the predictive power of cardiovascular risk factors weakens with age. We investigated the prognostic value of coronary calcification for cardi...

journal_title：Circulation

authors： Vliegenthart R,Oudkerk M,Hofman A,Oei HH,van Dijck W,van Rooij FJ,Witteman JC

更新日期：2005-07-26 00:00:00

abstract：BACKGROUND:Cardiomyocyte grafting augments myocyte numbers in the heart. We investigated (1) how developmental stage influences graft survival; (2) whether acutely necrotic or healing cardiac lesions support grafts; and (3) the differentiation and integration of cardiomyocyte grafts in injured hearts. METHODS AND RESU...

journal_title：Circulation

authors： Reinecke H,Zhang M,Bartosek T,Murry CE

更新日期：1999-07-13 00:00:00