Abstract:
BACKGROUND:Cardiomyocyte grafting augments myocyte numbers in the heart. We investigated (1) how developmental stage influences graft survival; (2) whether acutely necrotic or healing cardiac lesions support grafts; and (3) the differentiation and integration of cardiomyocyte grafts in injured hearts. METHODS AND RESULTS:Cardiomyocytes from fetal, neonatal, or adult inbred rats were grafted into normal myocardium, acutely cryoinjured myocardium, or granulation tissue (6 days after injury). Adult cardiomyocytes did not survive under any conditions. In contrast, fetal and neonatal cardiomyocytes formed viable grafts under all conditions. Time-course studies with neonatal cardiomyocytes showed that the grafts recapitulated many aspects of normal development. The adherens junction protein N-cadherin was distributed circumferentially at day 1 but began to organize into intercalated disk-like structures by day 6. The gap junction protein connexin43 followed a similar but delayed pattern relative to N-cadherin. From 2 to 8 weeks, there was progressive hypertrophy and the formation of mature intercalated disks. In some hearts, graft cells formed adherens and gap junctions with host cardiomyocytes, suggesting electromechanical coupling. More commonly, however, grafts were separated from the host myocardium by scar tissue. Gap and adherens junctions formed between neonatal and adult cardiomyocytes in coculture, as evidenced by dye transfer and localization of cadherin and connexin43 at intercellular junctions. CONCLUSIONS:Grafted fetal and neonatal cardiomyocytes form new, mature myocardium with the capacity to couple with injured host myocardium. Optimal repair, however, may require reducing the isolation of the graft by the intervening scar tissue.
journal_name
Circulationjournal_title
Circulationauthors
Reinecke H,Zhang M,Bartosek T,Murry CEdoi
10.1161/01.cir.100.2.193subject
Has Abstractpub_date
1999-07-13 00:00:00pages
193-202issue
2eissn
0009-7322issn
1524-4539journal_volume
100pub_type
杂志文章相关文献
CIRCULATION文献大全abstract:BACKGROUND:The synthetic catecholamine dobutamine increases stroke volume in normal subjects and in patients with congestive heart failure. In addition to its direct influence on myocardial contractility, dobutamine may significantly modulate vascular tone because of its alpha- and beta-adrenergic agonist activity. ME...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.84.3.1210
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:The physiological assessment of angiographically intermediate-severity stenoses remains problematic. Functional measurements of poststenotic intracoronary Doppler coronary flow reserve can be performed in humans but have not been correlated with hyperemic myocardial perfusion imaging or angiographic data in ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.89.5.2150
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:Bereavement is a period of increased risk of cardiovascular death. There is limited understanding of the potential contribution of quality of cardiovascular disease management to this increased risk. METHODS AND RESULTS:In a UK primary-care database, 12 722 older individuals with preexisting cardiovascular ...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.113.004122
更新日期:2013-12-24 00:00:00
abstract::The concept of plaque stabilization was developed to explain how lipid lowering could decrease adverse coronary events without a substantial reduction in the regression of atherosclerosis. Plaques were stabilized by reducing serum cholesterol leading to several favorable pathobiological changes in the vessel wall of l...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000012528.89469.8e
更新日期:2002-04-23 00:00:00
abstract::We have applied the new technique of dual echocardiography to determine the sequence of atrial contraction as reflected in the simultaneously recorded movements of the tricuspid and mitral valves. The study group included 29 normal subjects and 23 patients with either atrial flutter, coarse atrial fibrillation or atri...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.58.2.314
更新日期:1978-08-01 00:00:00
abstract::A clinical study was conducted to evaluate the efficacy and safety of percutaneous coronary excimer laser angioplasty in 60 patients with coronary artery disease. Forty-nine patients had stable exertional angina, and 11 patients had unstable angina despite medical therapy. A novel 1.4-mm diameter catheter with 20 quar...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.81.6.1849
更新日期:1990-06-01 00:00:00
abstract:BACKGROUND:We investigated whether L-arginine induces regression of preexisting atheromatous lesions and reversal of endothelial dysfunction in hypercholesterolemic rabbits, whether similar effects can be obtained by cholesterol-lowering therapy with lovastatin, and which mechanism leads to these effects. METHODS AND ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.96.4.1282
更新日期:1997-08-19 00:00:00
abstract:BACKGROUND:Endocardial mapping using standard electrode catheters is often technically limited in ventricular tachycardia and constitutes a major obstacle to successful ablation. We wished to examine the utility of a basket-shaped multielectrode mapping catheter (MMC) in the mapping and ablation of ventricular tachycar...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.96.7.2430
更新日期:1997-10-07 00:00:00
abstract:BACKGROUND:Fortilin, a recently characterized nuclear antiapoptotic factor structurally distinct from inhibitor of apoptosis proteins (IAPs) and Bcl-2 family member proteins, has been suggested to be involved in cell survival and regulation of apoptosis within the cardiovascular system. In this continued investigation,...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000047675.86603.eb
更新日期:2003-01-07 00:00:00
abstract:BACKGROUND:After repair of aortic coarctation, patients may develop restenosis, aneurysms, and pseudoaneurysms at the site of prior repair. We assessed the outcomes of late reintervention on the descending aorta after aortic coarctation repair. METHODS AND RESULTS:From March 1954 to July 2008, 130 patients had operati...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.109.925172
更新日期:2010-09-14 00:00:00
abstract:BACKGROUND:The DENERHTN trial (Renal Denervation for Hypertension) confirmed the blood pressure-lowering efficacy of renal denervation added to a standardized stepped-care antihypertensive treatment for resistant hypertension at 6 months. We report the influence of adherence to antihypertensive treatment on blood press...
journal_title:Circulation
pub_type: 杂志文章,随机对照试验
doi:10.1161/CIRCULATIONAHA.116.022922
更新日期:2016-09-20 00:00:00
abstract:BACKGROUND:Mechanisms favoring the occurrence of paroxysmal atrial fibrillation (PAF) are complex and poorly defined. This study was designed to analyze dynamic changes in autonomic tone preceding the onset of PAF in a large group of patients. METHODS AND RESULTS:Holter tapes from 77 unselected consecutive patients (6...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000018443.44005.d8
更新日期:2002-06-11 00:00:00
abstract:BACKGROUND:The aim of the study was to establish the influence of proximal coronary artery atheroma and smoking habit on the stimulated release of tissue plasminogen activator (tPA) from the heart. METHODS AND RESULTS:After diagnostic coronary angiography in 25 patients, the left anterior descending coronary artery (L...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.103.15.1936
更新日期:2001-04-17 00:00:00
abstract:BACKGROUND:Type 2 diabetes (DM-2) and impaired glucose metabolism (IGM) are associated with an increased cardiovascular disease risk. In nondiabetic individuals, increased arterial stiffness is an important cause of cardiovascular disease. Associations between DM-2 and IGM and arterial stiffness have not been systemati...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000065222.34933.FC
更新日期:2003-04-29 00:00:00
abstract:BACKGROUND:Ventricular tachyarrhythmias present a unique set of stimuli to arterial and cardiopulmonary baroreceptors by increasing cardiac filling pressures and decreasing arterial pressure. The net effect on the control of sympathetic nerve activity (SNA) in humans is unknown. The purpose of this study was to determi...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.100.6.628
更新日期:1999-08-10 00:00:00
abstract:BACKGROUND:Femoropopliteal percutaneous transluminal angioplasty (PTA) remains limited by restenosis. Although vascular brachytherapy may be effective in reducing restenosis, external beam radiation would be more practical to administer after PTA. METHODS AND RESULTS:After femoropopliteal PTA without stent placement, ...
journal_title:Circulation
pub_type: 杂志文章,随机对照试验
doi:10.1161/CIRCULATIONAHA.104.502179
更新日期:2005-06-21 00:00:00
abstract:BACKGROUND:There is an elevated risk for poor outcomes after heart transplant (HTx) in patients sensitized to human leukocyte antigens including graft dysfunction, acute cellular and antibody-mediated (AMR) rejection, and cardiac allograft vasculopathy. We report our experience with human leukocyte antigens-sensitized ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.107.709022
更新日期:2007-09-11 00:00:00
abstract:BACKGROUND:Up to 50% of patients fail to meet ST-segment-elevation myocardial infarction (STEMI) guideline goals recommending a first medical contact-to-device time of <90 minutes for patients directly presenting to percutaneous coronary intervention-capable hospitals and <120 minutes for transferred patients. We sough...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.115.019474
更新日期:2016-08-02 00:00:00
abstract::Left main coronary artery disease (i.e., greater than or equal to 50% stenosis) was found in 1,477 of 20,137 patients in the Coronary Artery Surgery Study (CAS) registry. Of these patients, 53 (3.6%) were asymptomatic. Asymptomatic and symptomatic patients were similar in regard to 1) severity of left main coronary ar...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.79.6.1171
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND:Oral anticoagulation (OAC) therapy is effective in atrial fibrillation but requires vigilance to maintain the international normalized ratio in the therapeutic range. This report examines how differences in time in therapeutic range (TTR) between centers and between countries affect the outcomes of OAC thera...
journal_title:Circulation
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/CIRCULATIONAHA.107.750000
更新日期:2008-11-11 00:00:00
abstract::We compared the effects of a cardioselective beta-adrenergic blocking drug, metoprolol, with a nonselective beta-adrenergic blocker, propranolol, on the response of 10 normal men to dynamic treadmill exercise. The volunteers underwent a standard graded exercise test to exhaustion while receiving placebo; propranolol, ...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.65.5.894
更新日期:1982-05-01 00:00:00
abstract:BACKGROUND:The potential biological significance of hydrogen sulfide (H(2)S) has attracted growing interest in recent years. The aim of this study was to characterize a novel, water-soluble, slow-releasing H(2)S compound [morpholin-4-ium 4 methoxyphenyl(morpholino) phosphinodithioate (GYY4137)] and evaluate its use as ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.107.753467
更新日期:2008-05-06 00:00:00
abstract:BACKGROUND:Unfractionated heparin has been the primary anticoagulant therapy for percutaneous coronary intervention for >20 years. Despite the availability of rapid "point of care" testing, little clinical data defining the optimal level of anticoagulation are available. Furthermore, recent reports have advocated the u...
journal_title:Circulation
pub_type: 杂志文章,meta分析
doi:10.1161/01.cir.103.7.961
更新日期:2001-02-20 00:00:00
abstract:BACKGROUND:β1-2-adrenergic receptors (AR) are key regulators of cardiac contractility and remodeling in response to catecholamines. β3-AR expression is enhanced in diseased human myocardium, but its impact on remodeling is unknown. METHODS AND RESULTS:Mice with cardiac myocyte-specific expression of human β3-AR (β3-TG...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.113.004940
更新日期:2014-01-28 00:00:00
abstract::Audible atrial sounds were noted in a patient with congestive cardiomyopathy and atrial fibrillation with slow ventricular rate. Oscillatory motion of similar periodicity as fibrillation waves in the ECG and the sounds in the phonocardiogram was demonstrated in aortic and left ventricular walls, mitral, tricuspid and ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.53.3.569
更新日期:1976-03-01 00:00:00
abstract:BACKGROUND:Recent studies indicate that serotonin (5-HT) has a growth-promoting effect on several different cell types, including smooth muscle cells. After percutaneous transluminal coronary angioplasty, there is damage and denudation of vascular endothelial cells, which promotes platelet aggregation at the site of in...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.90.4.1919
更新日期:1994-10-01 00:00:00
abstract::To estimate the extent of myocardial infarction after coronary artery reperfusion, serum levels of cardiac myosin light chain (LC) I and creatine kinase (CK) were determined serially in 49 patients with acute myocardial infarction. Intracoronary thrombolysis was successful in 25 patients (reperfusion group), and 24 pa...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.76.6.1251
更新日期:1987-12-01 00:00:00
abstract:BACKGROUND:Stress cardiomyopathy (SCM) is a peculiar form of reversible left ventricular dysfunction seen predominantly in women and occurs in response to emotional or physical stress. Because dysfunction in SCM is reversible and that of acute myocardial infarction (MI) is not, we hypothesized that these fundamental me...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.113.002781
更新日期:2014-04-22 00:00:00
abstract:BACKGROUND:Transcatheter aortic valve replacement (TAVR) represents a paradigm shift in the therapeutic options for patients with severe aortic stenosis. However, rapid and exponential growth in TAVR demand may overwhelm capacity, translating to inadequate access and prolonged wait times. Our objective was to evaluate ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.117.033432
更新日期:2018-07-31 00:00:00
abstract:BACKGROUND:Age-adjusted stroke incidence has decreased over the past 50 years, likely as a result of changes in the prevalence and impact of various stroke risk factors. An updated version of the Framingham Stroke Risk Profile (FSRP) might better predict current risks in the FHS (Framingham Heart Study) and other cohor...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.115.021275
更新日期:2017-03-21 00:00:00