Abstract:
:This review aims to outline the effects of fluoride on the biological processes involved in the formation of tooth tissues, particularly dental enamel. Attention has been focused on mechanisms which, if compromised, could give rise to dental fluorosis. The literature is extensive and often confusing but a much clearer picture is emerging based on recent more detailed knowledge of odontogenesis. Opacity, characteristic of fluorotic enamel, results from incomplete apatite crystal growth. How this occurs is suggested by other changes brought about by fluoride. Matrix proteins, associated with the mineral phase, normally degraded and removed to permit final crystal growth, are to some extent retained in fluorotic tissue. Fluoride and magnesium concentrations increase while carbonate is reduced. Crystal surface morphology at the nano-scale is altered and functional ameloblast morphology at the maturation stage also changes. Fluoride incorporation into enamel apatite produces more stable crystals. Local supersaturation levels with regard to the fluoridated mineral will also be elevated facilitating crystal growth. Such changes in crystal chemistry and morphology, involving stronger ionic and hydrogen bonds, also lead to greater binding of modulating matrix proteins and proteolytic enzymes. This results in reduced degradation and enhanced retention of protein components in mature tissue. This is most likely responsible for porous fluorotic tissue, since matrix protein removal is necessary for unimpaired crystal growth. To resolve the outstanding problems of the role of cell changes and the precise reasons for protein retention more detailed studies will be required of alterations to cell function, effect on specific protein species and the nano-chemistry of the apatite crystal surfaces.
journal_name
Caries Resjournal_title
Caries researchauthors
Robinson C,Connell S,Kirkham J,Brookes SJ,Shore RC,Smith AMdoi
10.1159/000077766subject
Has Abstractpub_date
2004-05-01 00:00:00pages
268-76issue
3eissn
0008-6568issn
1421-976Xpii
77766journal_volume
38pub_type
杂志文章,评审相关文献
CARIES RESEARCH文献大全abstract::Studies have suggested that individuals affected by extrinsic black tooth stains have less dental caries experience in comparison to those without this condition. The aim of the present study was to perform a systematic review and meta-analysis to determine whether there is scientific evidence demonstrating that extri...
journal_title:Caries research
pub_type: 杂志文章,meta分析
doi:10.1159/000500476
更新日期:2019-01-01 00:00:00
abstract::The aim of this study was to identify risk determinants leading to early childhood caries (ECC) and visible plaque (VP) in toddlers. Data for mother-child pairs participating in the Growing Up in Singapore towards Healthy Outcomes (GUSTO) birth cohort were collected from pregnancy to toddlerhood. Oral examinations wer...
journal_title:Caries research
pub_type: 杂志文章
doi:10.1159/000471811
更新日期:2017-01-01 00:00:00
abstract::Streptococcus mutans and Streptococcus sobrinus are associated with the development of dental caries. The purpose of this study was to differentiate these bacteria by morphology, biochemical characteristics and PCR, and to compare their occurrence with the prevalence of dental caries in the Mosuo people. Plaque sample...
journal_title:Caries research
pub_type: 杂志文章
doi:10.1159/000072171
更新日期:2003-09-01 00:00:00
abstract::This study investigated the role of a matrix metalloproteinase (MMP) inhibitor (CHX 2%) in the development of secondary caries wall lesions in different interface conditions with small (run 1) and wider gaps (run 2). Dentin discs were restored and pretreated with or without CHX 2%. In run 1, interfaces were made with ...
journal_title:Caries research
pub_type: 杂志文章
doi:10.1159/000490195
更新日期:2019-01-01 00:00:00
abstract::The development of approximal carious lesions was monitored on annual bite-wing radiographs obtained from 315 children, participating in a controlled dentifrice trial; 157 of these children had used a dentifrice containing 250 ppm F and 158 a dentifrice containing 1,000 ppm F (both as NaF) during a 3-year period as th...
journal_title:Caries research
pub_type: 杂志文章
doi:10.1159/000261369
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to test the relationship between a newly developed sugar index and caries experience in 4th- and 6th-graders. MATERIALS AND METHODS:A total of 1,019 fourth-graders and 925 sixth-graders from 2 regions in Northern Germany participated in the study. Caries experience was recorded by ...
journal_title:Caries research
pub_type: 杂志文章
doi:10.1159/000486102
更新日期:2019-01-01 00:00:00
abstract::This in vivo study aimed to evaluate the performance of methods of approximal caries detection in primary molars and to assess the influence of the discomfort caused by these methods on their performance. Two examiners evaluated 76 children (4-12 years old) using visual inspection (ICDAS), radiography and a laser fluo...
journal_title:Caries research
pub_type: 杂志文章,随机对照试验
doi:10.1159/000320266
更新日期:2010-01-01 00:00:00
abstract::This in vitro study evaluated the protective effect of fluoride varnishes containing sodium trimetaphosphate (TMP) against dentin erosion and abrasion. Specimens of coronal dentin were divided into: placebo, 2.5% NaF, 5% NaF, 2.5% NaF + 5% TMP, and 5% NaF + 5% TMP groups (n =24/group). After single application of the ...
journal_title:Caries research
pub_type: 杂志文章
doi:10.1159/000505179
更新日期:2020-01-01 00:00:00
abstract::The aim of this study was to evaluate the anti-erosive effect of solutions containing sodium fluoride (F: 225 ppm F-), stannous chloride (Sn: 800 ppm Sn2+), and some film-forming polymers (Gantrez: Poly [methylvinylether-alt-maleic anhydride]; PGA: propylene glycol alginate; Plasdone: poly[vinylpyrrolidone]; and CMC: ...
journal_title:Caries research
pub_type: 杂志文章
doi:10.1159/000493388
更新日期:2019-01-01 00:00:00
abstract::Erythritol is a sugar alcohol produced by Aureobasidium sp. from glucose. It is 75-80% as sweet as sucrose and is also nonhygroscopic. The aim of this study was to evaluate this sugar substitute from a cariological point of view. Erythritol was neither utilized as a substrate for the lactic acid production nor for pla...
journal_title:Caries research
pub_type: 杂志文章
doi:10.1159/000261468
更新日期:1992-01-01 00:00:00
abstract::The aim of this study was to enumerate and identify bifidobacteria from occlusal carious lesions in permanent and deciduous teeth. Samples of infected dentine were obtained from 24 active occlusal lesions in deciduous teeth and from 15 occlusal lesions in permanent teeth. Plaque samples from sound occlusal surfaces of...
journal_title:Caries research
pub_type: 杂志文章
doi:10.1159/000222659
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:To assess the ability of fluorescence imaging with reflectance enhancement (FIRE) to quantify early enamel demineralization in vitro. METHODS:A total of 30 bovine enamel specimens were immersed in demineralizing solution to produce artificial caries. Specimens were examined by FIRE, quantitative light-induc...
journal_title:Caries research
pub_type: 杂志文章
doi:10.1159/000365298
更新日期:2015-01-01 00:00:00
abstract::The Nyvad classification is a visual-tactile caries classification system devised to enable the detection of the activity and severity of caries lesions with special focus on low-caries populations. The criteria behind the classification reflect the entire continuum of caries, ranging from clinically sound surfaces th...
journal_title:Caries research
pub_type: 杂志文章,评审
doi:10.1159/000480522
更新日期:2018-01-01 00:00:00
abstract::This study was undertaken to examine the influence of occlusion on the fluoride distribution in cementum following an experiment in which the occlusion in rats was locally altered by extracting the upper left molar. These and control rats with normal occlusion were given water containing 0 or 100 ppm fluoride for 12 w...
journal_title:Caries research
pub_type: 杂志文章
doi:10.1159/000261480
更新日期:1992-01-01 00:00:00
abstract::In this study we evaluated the effect of chitosan nanoparticles on the acid tolerance response (ATR) of adhered Streptococcus mutans. An ATR was induced by exposing S. mutans to pH 5.5 for 2 h and confirmed by exposing the acid-adapted cells to pH 3.5 for 30 min, with the majority of cells appearing viable according t...
journal_title:Caries research
pub_type: 杂志文章
doi:10.1159/000331206
更新日期:2011-01-01 00:00:00
abstract::Casein phosphopeptides (CPP) stabilize amorphous calcium phosphate (ACP) and may be used to localize ACP in dental plaque, maintaining a state of supersaturation with respect to tooth enamel, reducing demineralization and enhancing remineralization [Reynolds, J Dent Res 1997;76:1587-1595]. The aim of this paper is to ...
journal_title:Caries research
pub_type: 杂志文章
doi:10.1159/000016618
更新日期:2000-09-01 00:00:00
abstract::Although chlorhexidine is one of the most efficacious antimicrobial agents used for the prevention of dental caries, side effects limit its application. The effects of gaegurin 6 (GGN6), an animal-derived cationic peptide, and its derivatives PTP6 and PTP12 on the growth of oral streptococci were investigated to asses...
journal_title:Caries research
pub_type: 杂志文章
doi:10.1159/000073394
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVE:The aim of this retrospective study was to analyze the survival probability of selective caries removal (SCR) treatments in the primary teeth of children with high caries experience and factors potentially associated with treatment failure. METHODS:The sample included SCR treatments conducted in anterior and...
journal_title:Caries research
pub_type: 杂志文章
doi:10.1159/000478535
更新日期:2017-01-01 00:00:00
abstract::The aim of this study is to investigate the influence of demineralisation on the fluorescent properties of dentine. The fluorescence emission at 529 nm due to 515 nm excitation of in vitro demineralised lesions was determined with a micro-Raman spectroscope as a function of location. Results were compared with the min...
journal_title:Caries research
pub_type: 杂志文章
doi:10.1159/000262143
更新日期:1996-01-01 00:00:00
abstract::An oral health care programme in secondary schools using the atraumatic restorative treatment (ART) approach for dental caries was started in 1993. Glass ionomer (restorative type II, 1) was used as the restorative and sealant material. Sealants were placed using the 'press-finger' technique. Results after 3 years rev...
journal_title:Caries research
pub_type: 杂志文章
doi:10.1159/000016441
更新日期:1998-01-01 00:00:00
abstract::The aim of the study was to determine the pharmacokinetics of a new hydroxyapatite-Eudragit RS100 diffusion-controlled fluoride-releasing system designed for intraoral use with a 0.15 mg F(-)/day release for a 1-month period. Matrix tablets, each containing 18 mg of sodium fluoride, were bonded to the buccal surface o...
journal_title:Caries research
pub_type: 杂志文章
doi:10.1159/000084797
更新日期:2005-05-01 00:00:00
abstract::Mutans streptococci (MS) and lactobacillus (LB) counts (CRT Bacteria chair-side test) were compared and correlated with the respective caries experience (DMF) of cystic fibrosis (CF) homozygotes (n = 20), CF heterozygotes (n = 20) and healthy controls (n = 20). Each group of subjects was divided into two equal age gro...
journal_title:Caries research
pub_type: 杂志文章
doi:10.1159/000047483
更新日期:2001-11-01 00:00:00
abstract::One aim of the present laboratory study was to determine whether a visual scoring system (ERK) developed for occlusal caries could be applied to approximal lesions. A new histological technique (autofluorescence, AF) recognises dentine that is soft and would be removed with an excavator during operative treatment. A s...
journal_title:Caries research
pub_type: 杂志文章
doi:10.1159/000069018
更新日期:2003-03-01 00:00:00
abstract::The aim of this study was to use ultrasonication as a method to measure subsurface demineralisation of enamel. Polished human enamel samples with surface profiles within +/-0.3 microm were divided into 6 groups of 10 specimens. The groups of specimens were exposed to 0. 3% citric acid (pH 3.2) for 30 min, 1, 2, 3 or 4...
journal_title:Caries research
pub_type: 杂志文章
doi:10.1159/000016604
更新日期:2000-07-01 00:00:00
abstract::The aim of the study was to examine the relationship between oral hygiene level and caries experience in 14-year-olds using fluoride dentifrices on a regular basis. Oral hygiene expressed as Gingival Bleeding Points (GBP) was recorded in 267 individuals in the county of Lillehammer in Norway. Total caries experience a...
journal_title:Caries research
pub_type: 杂志文章
doi:10.1159/000262133
更新日期:1996-01-01 00:00:00
abstract::The purpose of the present study was to determine the antibacterial activity of oolong tea extract on oral streptococci, including Streptococcus mutans and Streptococcus sobrinus, and to identify the response to its components. Antibacterial activity was found when the extract was added to S. mutans cells in chemicall...
journal_title:Caries research
pub_type: 杂志文章
doi:10.1159/000073913
更新日期:2004-01-01 00:00:00
abstract::The influence of temporary dietary restriction with and without fluoridated drinking water on the progression of caries was studied in 60 desalivated Sprague-Dawley rats. Dietary restriction alone had little effect on caries progression when the challenge was interrupted and then resumed, in contrast to the effects of...
journal_title:Caries research
pub_type: 杂志文章
doi:10.1159/000261974
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of a low-fluoride (F) toothpaste supplemented with sodium trimetaphosphate (TMP) on enamel remineralization in situ. DESIGN:Bovine enamel blocks were selected on the basis of their surface hardness (SH) after caries-like lesions had been induced, and randomly divided into 4 treatment g...
journal_title:Caries research
pub_type: 杂志文章
doi:10.1159/000449358
更新日期:2016-01-01 00:00:00
abstract::In 90, 60- to 80-year-old patients with teeth retained in both jaws (mean 20.4 +/- 4.3), a total of 1,092 root surface lesions were recorded. Of these 156 were diagnosed as active caries lesions, whereas 509 were considered inactive, and 427 were filled. About 60% of the elderly had one or more active lesions and 79% ...
journal_title:Caries research
pub_type: 杂志文章
doi:10.1159/000261396
更新日期:1991-01-01 00:00:00
abstract::Bone morphogenetic proteins (BMPs) play an important role during the initial process of enamel development and therefore may play a role in caries susceptibility. The purpose of this study was to evaluate the association between the polymorphisms in the BMP2, BMP4 and BMP7 genes and their association with caries exper...
journal_title:Caries research
pub_type: 杂志文章
doi:10.1159/000371715
更新日期:2015-01-01 00:00:00