Evaluation of a new intraoral controlled fluoride release device.

Abstract:

:The aim of the study was to determine the pharmacokinetics of a new hydroxyapatite-Eudragit RS100 diffusion-controlled fluoride-releasing system designed for intraoral use with a 0.15 mg F(-)/day release for a 1-month period. Matrix tablets, each containing 18 mg of sodium fluoride, were bonded to the buccal surface of the first maxillary molar teeth of 20 subjects (age 20-23 years). Morning and evening salivary and urinary samples were collected 5 days before the study and every day for the 1st week, then once a week for 1 month. Fluoride ion measurements were done using the microdiffusion method. The salivary and urinary fluoride concentrations were significantly raised during the treatment period (p < 0.05). Morning salivary fluoride levels were higher than evening salivary fluoride levels (p < 0.05) whereas evening urinary fluoride levels were higher than morning urinary fluoride levels (p < 0.05). The statistically significant increase in salivary fluoride levels indicates a caries-preventive role for this device.

journal_name

Caries Res

journal_title

Caries research

authors

Altinova YB,Alaçam A,Aydin A,Sanisoglu SY

doi

10.1159/000084797

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

191-4

issue

3

eissn

0008-6568

issn

1421-976X

pii

84797

journal_volume

39

pub_type

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