Abstract：
:Our aim was to study the migration of retinal pigmented epithelium (RPE) into the retinal layer during infection of C57BL/6 mice with Toxoplasma gondii. Eyes from infected and non-infected animals were analyzed on the 60th day of infection by light and transmission electron microscopy. Non-infected eyes showed a normal morphology. In contrast, we observed free parasites in the retinal vasculature, the presence of mononuclear inflammatory infiltrate (MNII) and parasites in the vasculature of choroids in infected eyes. No inflammatory infiltrate was observed; RPE cells were identified near the MNII in nuclear and plexiforme layers. RPE cells were also found on the ganglion cell layer and in the outer segments of the photoreceptor. The morphology showed that RPE cells caused a discontinuity in the nuclear and plexiforme layers. Clusters of parasites were found surrounded by RPE cells and MNII in the inner plexiforme layers. Ultrastructural analysis showed that RPE cells migrated through the epithelium into the inner retinal layers. We did not observe Toxoplasma cysts in many eyes in which pathological changes were detected. Only 8.3% of the animals had Toxoplasma cysts in the inner nuclear layer in the absence of inflammatory cells. The migration of RPE cells can be triggered by a disruption of the RPE monolayer or injury to the neural retina, as in the case of toxoplasmosis.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Tedesco RC,Smith RL,Corte-Real S,Calabrese KSdoi
10.1007/s00436-003-1031-2subject
Has Abstractpub_date
2004-04-01 00:00:00pages
467-72issue
6eissn
0932-0113issn
1432-1955journal_volume
92pub_type
杂志文章abstract：:Biomphalaria glabrataembryonic (Bge) cells have been shown to provide favourable environmental conditions for the development of Schistosoma mansoni sporocysts. We investigated the effect of Bge excretory-secretory products on metabolic activity and gene transcription in S. mansoni mother sporocysts. Using the differe...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-002-0643-2
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journal_title：Parasitology research
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-001-0542-y
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journal_title：Parasitology research
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Parasitology research
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2008-02-01 00:00:00
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更新日期：2018-07-01 00:00:00
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journal_title：Parasitology research
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2015-06-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2007-10-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00931823
更新日期：1993-01-01 00:00:00
