Abstract：
BACKGROUND:Understanding the distribution of C-reactive protein (CRP) concentration among adult women in the US helps to establish the magnitude of women at increased risk for cardiovascular disease. METHODS:We examined the distribution and correlates of CRP, using data from 2205 women >or=20 years of age from the National Health and Nutrition Examination Survey 1999-2000. CRP was measured with a high-sensitivity latex-enhanced turbidimetric assay. RESULTS:CRP concentration ranged from 0.1 to 296.0 mg/L (median, 2.7 mg/L). After exclusion of women with a CRP concentration >10 mg/L, the median was 2.2 mg/L. Approximately 25.7% of women, representing approximately 26.8 million women, did not report using hormone replacement therapy and had a CRP concentration >3.0 to 10 mg/L, a category considered to indicate high risk for cardiovascular disease. Multiple linear regression analysis included age, race or ethnicity, education, smoking status, total cholesterol concentration, triglyceride concentration, systolic blood pressure, waist circumference, and concentrations of glucose, insulin, c-peptide, and glycated hemoglobin. CRP concentration varied by race or ethnicity (Mexican American > white) and hormone replacement therapy (users > nonusers). In addition, significant and independent associations existed between CRP and waist circumference, total cholesterol and triglyceride concentrations, and systolic blood pressure but not age, smoking status, alcohol use, insulin concentration, glycated hemoglobin, and c-peptide concentration. CONCLUSION:Large numbers of US women have an increased concentration of CRP.
journal_name
Clin Chemjournal_title
Clinical chemistryauthors
Ford ES,Giles WH,Mokdad AH,Myers GLdoi
10.1373/clinchem.2003.027359subject
Has Abstractpub_date
2004-03-01 00:00:00pages
574-81issue
3eissn
0009-9147issn
1530-8561pii
clinchem.2003.027359journal_volume
50pub_type
杂志文章abstract：BACKGROUND:Several proteolytically derived fragments from the proline-rich region (PRR) of human inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) have been identified by surface-enhanced or matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS or MALDI-TOF-MS) as potential diseas...
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abstract：:This enzyme immunoassay procedure for pregnancy-associated plasma protein type A involves a "sandwich"-type system in microtitration plates. One can detect 0.27 mg of the protein per liter of serum, with a between-batch CV of 10.2%, and the antiserum used does not cross react with any of the other placentally derived ...
journal_title：Clinical chemistry
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doi：
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abstract：BACKGROUND:Concomitant quantification of multiple mutant KRAS (v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) alleles may provide information in addition to that provided by standard mutation-detection procedures. We assessed the feasibility of a nanofluidic digital PCR array platform to detect and quantify KRAS...
journal_title：Clinical chemistry
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doi：10.1373/clinchem.2012.186577
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abstract：:Measurement of the mass concentration of serum enzymes by radioimmunoassay provides direct quantitation of specific isoenzymes and may be less subject to some of the limitations of traditional assay procedures for enzymes. We describe the development of a sensitive and specific radioimmunoassay for the muscle isoenzym...
journal_title：Clinical chemistry
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doi：
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abstract：:We studied the pattern of acute-phase proteins (orosomucoid, C-reactive protein, and haptoglobin) in hepatocellular deficiency due to chronic alcohol consumption, characterized by a decrease in serum transferrin concentration. We found that their patterns could vary independently of hepatocellular deficiency, but depe...
journal_title：Clinical chemistry
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doi：
更新日期：1983-01-01 00:00:00
abstract：:We describe an enzyme-linked two-site immunoassay for quantitation of intact insulin in human serum and plasma. The method uses two murine monoclonal antibodies that bind to two different epitopes on the insulin molecule. The immunoassay is specific. Human proinsulin is not bound by the antibodies, and the binding of ...
journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1993-04-01 00:00:00
abstract：:We examined the cholesterol/protein ratio and the apoprotein composition of serum lipoproteins in a randomly selected population of maturity-onset diabetics and in a group of nondiabetics of similar age. We found no differences in cholesterol distribution between the groups as a whole, but diabetics with above-normal ...
journal_title：Clinical chemistry
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doi：
更新日期：1980-08-01 00:00:00
abstract：:An optimized assay for alkaline phosphatase (EC 3.1.3.1) is reported. A discrete analyzer, the DuPont Automatic Clinical Analyzer (aca), was used for this study. The assay is based on results of response-surface experimental co-optimization techniques, and response is enhanced over the present aca assay. A key feature...
journal_title：Clinical chemistry
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doi：
更新日期：1981-07-01 00:00:00
abstract：:We evaluated a dual-precipitation method for determining cholesterol in high-density lipoprotein (HDL) and its subfractions HDL2 and HDL3. After total HDL was isolated by precipitation of very-low-density (VLDL) and low-density (LDL) lipoproteins with polyethylene glycol (Mr 8000), HDL2 was isolated from total HDL by ...
journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1988-11-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1988-08-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1976-10-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1986-05-01 00:00:00
abstract：BACKGROUND:Human chorionic gonadotropin (hCG) is a heterodimeric glycoprotein hormone that exists in multiple forms. Immunoassays commonly used in clinical laboratories measure intact hCG, total beta hCG (intact hCG + hCG free beta-subunit), and/or hCG free beta-subunit. Measurement of serum concentrations of hCG is us...
journal_title：Clinical chemistry
pub_type： 杂志文章
doi：10.1373/clinchem.2007.098822
更新日期：2008-04-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1978-11-01 00:00:00
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journal_title：Clinical chemistry
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doi：10.1373/clinchem.2005.057216
更新日期：2006-02-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1982-04-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1996-06-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:Agarose column chromatography has been used to separate plasma lipoproteins into very-low-density lipoproteins (VLDL), low-density lipoproteins (LDL) and high-density lipoproteins (HDL). Applied to the diagnosis of primary type III hyperlipoproteinemia, the procedure is capable of demonstrating three characteristic an...
journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1975-12-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1994-03-01 00:00:00
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journal_title：Clinical chemistry
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doi：10.1373/clinchem.2006.071589
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journal_title：Clinical chemistry
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doi：
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journal_title：Clinical chemistry
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doi：
更新日期：1980-02-01 00:00:00
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journal_title：Clinical chemistry
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doi：
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journal_title：Clinical chemistry
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doi：
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journal_title：Clinical chemistry
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doi：
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journal_title：Clinical chemistry
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doi：
更新日期：1987-06-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1990-12-01 00:00:00
