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Regulation of osteoclast protease expression by RANKL.

Abstract：

:Receptor activator of NF-kappaB ligand (RANKL) is essential for osteoclast (OC) differentiation/activation and functions through its receptor RANK at the surface of the osteoclastic cells. This study investigated for the first time the direct effects of hRANKL on protease/protease inhibitor expressions and protease activities in purified rabbit osteoclast cultures, using semi-quantitative RT-PCR, gelatin zymography, and enzymatic assays. RANKL was shown to exert in vitro pro-resorptive effects by increasing osteoclast marker expressions (Tartrate resistant acid phosphatase (TRAP) and cathepsin K), MMP-9 expression, and pro-MMP-9 activity and by diminishing TIMP-1 expression, leading to an up-regulation of the MMP-9/TIMP-1 ratio.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Wittrant Y,Theoleyre S,Couillaud S,Dunstan C,Heymann D,Rédini F

doi

10.1016/j.bbrc.2003.09.084

subject

Has Abstract

pub_date

2003-10-24 00:00:00

pages

774-8

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006291X03018813

journal_volume

310

pub_type

杂志文章

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